Amy Chuang

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Journals/Publications

• Barrueto, F., Chuang, A., Cotter, B. W., Hoffman, R. S., & Nelson, L. S. (2005). Amiodarone fails to improve survival in amitriptyline-poisoned mice.. Clinical Toxicology, 43(3), 147-149. doi:10.1081/clt-53076
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  Objective. Amiodarone, a class III antidysrhythmic agent, blocks Na+, Ca2 +, and K+ channels as well as the β-adrenergic receptor. Despite increased use of amiodarone for wide-complex tachycardia, its efficacy in the treatment of dysrhythmias induced by tricyclic antidepressants has not been tested. We investigated the effect of amiodarone and amitriptyline in a mouse lethality model. Methods. The LD50 of amitriptyline obtained from reference sources was confirmed by giving 100 mg/kg to 40 mice by intraperitoneal (IP) injection. The safety of the treatment dose of amiodarone was confirmed by giving 50 mg/kg by IP injection to 10 mice. One hundred and nine mice were randomized to receive pretreatment with 50 mg/kg amiodarone (n = 55) or an equal volume of saline or water as a volume control (n = 54). Thirty minutes after pretreatment or control injection, the mice received amitriptyline, 100 mg/kg. Outcome was defined as death or survival 3 h after amitriptyline injection. Results. In our confirmation of t...
• Chuang, A., Thomas, R., & Hoffman, R. S. (2005). Disseminated coccidioidomycosis in an immunocompetent person living in New York City.. Journal of urban health : bulletin of the New York Academy of Medicine, 82(2), 339-45. doi:10.1093/jurban/jti057
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  Coccidioidomycosis is a disease caused by Coccidioides immitis, a soil-inhabiting fungus endemic to the desert climate of the southwestern United States and Central and South America. We report a case of disseminated coccidioidomycosis in a previously healthy person living in New York City, who was initially thought to have tuberculosis. The incidence of coccidioidomycosis has been increasing in both endemic and nonendemic areas, but diagnosis is often delayed or missed in nonendemic areas, resulting in extensive and unnecessary medical workup for other diseases or progression to serious disease. Therefore, clinicians should increase their awareness and consideration of this disease in patients with chronic systemic illness.