Arista Chand

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Scholarly Contributions

Journals/Publications

• Chand, A., Filsoof, D., Manchen, P., & Soin, S. (2025). Transbronchial cryobiopsy to diagnose diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). BMJ Case Reports, 18(Issue 7). doi:10.1136/bcr-2025-266666
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  Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare precursor of neuroendocrine malignancy. Diagnosis is difficult as clinical and radiological findings can be non-specific. Histological confirmation is necessary, and surgical lung biopsy is still considered the gold standard technique to aid multidisciplinary discussion. There are increasing reports of using transbronchial lung cryobiopsy (TBLC) for tissue sampling, allowing a feasible and safe alternative to diagnosis. Here we present a case of cough, dyspnoea and hypoxia in a woman ultimately diagnosed with DIPNECH using TBLC.
• Chaudhary, S., Weigt, S. S., Ribeiro Neto, M. L., Benn, B. S., Pugashetti, J. V., Keith, R., Chand, A., Oh, S., Kheir, F., Ramalingam, V., Solomon, J. J., Harper, R., Lasky, J. A., & Oldham, J. M. (2023). Interstitial lung disease progression after genomic usual interstitial pneumonia testing. European Respiratory Journal, 61(Issue 4). doi:10.1183/13993003.01245-2022
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  Background A genomic classifier for usual interstitial pneumonia (gUIP) has been shown to predict histological UIP with high specificity, increasing diagnostic confidence for idiopathic pulmonary fibrosis (IPF). Whether those with positive gUIP classification exhibit a progressive, IPF-like phenotype remains unknown. Methods A pooled, retrospective analysis of patients who underwent clinically indicated diagnostic bronchoscopy with gUIP testing at seven academic medical centres across the USA was performed. We assessed the association between gUIP classification and 18-month progression-free survival (PFS) using Cox proportional hazards regression. PFS was defined as the time from gUIP testing to death from any cause, lung transplant, ≥10% relative decline in forced vital capacity (FVC) or censoring at the time of last available FVC measure. Longitudinal change in FVC was then compared between gUIP classification groups using a joint regression model. Results Of 238 consecutive patients who underwent gUIP testing, 192 had available follow-up data and were included in the analysis, including 104 with positive gUIP classification and 88 with negative classification. In multivariable analysis, positive gUIP classification was associated with reduced PFS (hazard ratio 1.58, 95% CI 0.86–2.92; p=0.14), but this did not reach statistical significance. Mean annual change in FVC was -101.8 mL (95% CI -142.7– -60.9 mL; p
• Chaudhary, S., Weigt, S. S., Neto, M. L., Benn, B. S., Vu Pugashetti, J., Keith, R., Chand, A., Oh, S., Kheir, F., Ramalingam, V., Solomon, J., Harper, R., Lasky, J. A., & Oldham, J. M. (2022). Interstitial lung disease progression after genomic usual interstitial pneumonia testing. The European respiratory journal.
  More info

  A genomic classifier for usual interstitial pneumonia (gUIP) has been shown to predict histologic UIP with high specificity, increasing diagnostic confidence for idiopathic pulmonary fibrosis (IPF). Whether those with positive gUIP classification exhibit a progressive, IPF-like phenotype remains unknown. A pooled, retrospective analysis of patients who underwent clinically indicated diagnostic bronchoscopy with gUIP testing at seven academic medical centers was performed. We assessed the association between gUIP classification and eighteen-month progression-free survival (PFS) using Cox proportional hazards regression. PFS was defined as the time from gUIP testing to death from any cause, lung transplant, ≥10% relative decline in forced vital capacity (FVC) or censoring at the time of last available FVC measure. Longitudinal change in FVC was then compared between gUIP classification groups using a joint regression model. Of 238 consecutive patients who underwent gUIP testing, 192 had available follow-up data and were included in the analysis, including 104 with positive gUIP classification and 88 with negative classification. In multivariable analysis, positive gUIP classification was associated with reduced PFS (HR 1.58, 95% CI 0.86-2.92; p=0.14), but this did not reach statistical significance. Mean annual change in FVC was -101.8 mL (95% CI -142.7 mL, -60.9 mL; p
• Chand, A. S., Clarke, A. W., McQueen, F. M., Williams, M., Dalbeth, N., Tan, Y. M., Reeves, Q., & McHaffie, A. (2011). Quantifying synovitis in rheumatoid arthritis using computer-assisted manual segmentation with 3 tesla MRI scanning. Journal of Magnetic Resonance Imaging. doi:10.1002/jmri.22524
• Clarke, A., Chand, A. S., Dalbeth, N., Mulders, D., Dong, J., Robinson, E., Williams, M., Reeves, Q., McHaffie, A., & McQueen, F. M. (2010). Assessment of cartilage loss at the wrist in rheumatoid arthritis using a new MRI scoring system. Annals of the Rheumatic Diseases. doi:10.1136/ard.2009.127324

Proceedings Publications

• Chand, A. (2023).

  Some Supplements Are Detriments of Health: A Case of Lysine Induced Eosinophilic Pneumonia

  . In ATS.
• Nguyen, T., Chand, A., Kolimas, A., Yannapudi, K., & Puthalapattu, S. (2022). Persistent Abnormal Imaging in Chronic Exogenous Lipoid Pneumonia: Surveillance of Complications. In CHEST.