Alex Burant

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• Kelley, M., Burant, A., & Branca, R. T. (2020). Resolving the discrepancy between theoretical and experimental polarization of hyperpolarized 129Xe using numerical simulations and in situ optical spectroscopy. Journal of Applied Physics, 128(14), 144901. doi:10.1063/5.0019074
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  For emerging biomedical applications of hyperpolarized xenon, the ability to obtain reliably high nuclear spin polarization levels is paramount. Yet, experimental nuclear spin polarization levels of xenon are highly variable and, more than often than not, well below what theory predicts. Despite rigorous and well-studied theoretical models for hyperpolarization and continuous-flow spin-exchange optical pumping (SEOP), there remains a substantial discrepancy between the theoretical and experimental polarization of 129Xe; inexplicably, seemingly similar experimental parameters can yield very different polarization values. In this paper, the validity of the assumptions typically made about the thermodynamic state of the Rb vapor inside the optical pumping cell and the gas dynamics are investigated through finite element analysis simulations of realistic optical pumping cell models, while in situ optical and nuclear magnetic resonance spectroscopy measurements are used to validate the results of the simulations. Our results show that shorter xenon gas residence times and lower Rb vapor densities than those predicted by empirical saturated vapor pressure curves, along with incorrect SEOP parameters, are the primary cause of the discrepancy between theoretical and experimental polarization values reported in the literature.