Barbara Y Bode

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• Bilal, J., Kollampare, S., Bode, B., Lisse, J. R., Hoover, S. E., Sudano, D., & Ampel, N. M. (2019). Management of asymptomatic coccidioidomycosis in patients with rheumatic diseases. Rheumatology international, 39(7), 1257-1262.
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  Coccidioidomycosis is an endemic fungal infection common in the southwestern United States. Some rheumatology clinics periodically screen patients with coccidioidal serology, resulting in the identification of patients who are serologically positive but without clinical symptoms. The management of such patients is unclear. A retrospective study was conducted between 2007 and 2015 at two arthritis centers in Tucson, Arizona. The asymptomatic patients were identified who were receiving disease-modifying antirheumatic agents and had a positive coccidioidal serology. Serological testing including IgM and IgG was performed by enzyme immunoassay (EIA), immunodiffusion (IDTP and IDCF), or complement fixation. Out of 71 patients who were identified with positive coccidioidal serologies, 19 were asymptomatic. 18/19 patients continued antirheumatic therapy, 13 without interruption. 13/19 patients received no antifungal treatment, including 10 who remained on antirheumatic treatment. The other six were started on fluconazole, ranging from 8 to 73 months (median 30.5 months). After a median follow-up of 43 months, no patient developed clinically active coccidioidomycosis. Overall, 14 had only a positive EIA serological test. These results suggest that continued antirheumatic therapy is safe in asymptomatic patients with positive coccidioidal serological tests and that routine implementation of antifungal treatment may not always be warranted. The findings also raise concern regarding the utility of routine serological testing of asymptomatic patients residing in the coccidioidal endemic area, mainly using the EIA test.
• Kumar, S., Sethi, S., Irani, F., & Bode, B. Y. (2009). Anticyclic citrullinated peptide antibody-positive paraneoplastic polyarthritis in a patient with metastatic pancreatic cancer. The American journal of the medical sciences, 338(6), 511-2.
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  Neoplasms may present as rheumatic disorders. Some of these rheumatologic manifestations may be paraneoplastic and can clinically and serologically mimic rheumatoid arthritis (RA). We report the case of a patient who initially presented with an asymmetrical, rapid onset polyarthritis. It resembled atypical RA with positive rheumatoid factor and anticyclic citrullinated peptide (CCP) antibodies. A good response to steroid therapy was noted. A few weeks later, he was diagnosed with metastatic pancreatic cancer that resulted in his mortality. His clinical course suggested that his rheumatic symptoms were a paraneoplastic manifestation of his underlying malignancy. Anticyclic citrullinated peptide antibodies have not been previously described in cancer polyarthritis. Awareness of this atypical, seropositive RA-like syndrome may prompt clinicians to investigate for an underlying malignancy.
• Maricic, M. J., Bode, B. Y., Pearlmutter, L. L., & Wilkinson, W. E. (1995). Shoulder range of motion in patients with osteoporosis.. Arthritis care and research : the official journal of the Arthritis Health Professions Association, 8(3), 194-8. doi:10.1002/art.1790080313
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  To determine the degree of loss of shoulder flexion in patients with osteoporosis, and to determine whether this was correlated with functional disability and pain as measured by the modified Health Assessment Questionnaire..Two different exercise regimens, one using traditional extension exercises of the spine (group A) and the other using both the extension exercises and exercises to stretch and strengthen scapular musculature (group B), were compared to determine their effects on range of motion, pain, and disability in 33 women with osteoporosis..A significant improvement in shoulder flexion occurred in both exercise groups compared to controls; however, there were no statistically significant differences either within or between exercise groups from baseline to study end. A decrease in pain correlated with an increase in shoulder flexion in group A (r = 0.56), while an improvement in functional disability scores correlated with an increase in shoulder flexion in group B (r = 0.46)..Traditional spinal exercises along with exercises that target scapular mobility help to improve shoulder flexion, pain, and function in women with osteoporosis.