Christian Elias Nasr

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Scholarly Contributions

Journals/Publications

• Nasr, C. E. (2023).

  Can one predict long-term growth of cytologically-benign thyroid nodules?

  . The Journal of Clinical Endocrinology & Metabolism, 108(10), e1155-e1156. doi:10.1210/clinem/dgad160
• Nasr, C. E. (2023). Can We Predict Long-term Growth of Cytologically Benign Thyroid Nodules?. The Journal of clinical endocrinology and metabolism, 108(10), e1155-e1156.
• Petersen, E. A., Stauss, T. G., Scowcroft, J. A., Jaasma, M. J., Brooks, E. S., Edgar, D. R., White, J. L., Sills, S. M., Amirdelfan, K., Guirguis, M. N., Xu, J., Yu, C., Nairizi, A., Patterson, D. G., Tsoulfas, K. C., Creamer, M. J., Galan, V., Bundschu, R. H., Mehta, N. D., , Sayed, D., et al. (2023). Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial. Diabetes research and clinical practice, 203, 110865.
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  To evaluate the long-term efficacy of high-frequency (10 kHz) spinal cord stimulation (SCS) for treating refractory painful diabetic neuropathy (PDN).
• Wu, S. S., Joshi, N., Sharrett, J., Rao, S., Shah, A., Scharpf, J., Burkey, B., Lamarre, E. D., Prendes, B., Siperstein, A., Shin, J., Berber, E., Jin, J., Krishnamurthi, V., Nasr, C., Hong, L., Buchberger, D. S., Woody, N., Koyfman, S. A., & Geiger, J. L. (2023). Risk Factors Associated With Recurrence and Death in Patients With Tall Cell Papillary Thyroid Cancer: A Single-Institution Cohort Study With Predictive Nomogram. JAMA otolaryngology-- head & neck surgery, 149(1), 79-86.
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  Tall cell morphology (TCM) is a rare and aggressive variant of papillary thyroid carcinoma (PTC) that has been associated with poor outcomes; however, the risk factors for worse survival are not well characterized.
• Wu, S. S., Lamarre, E. D., Yalamanchali, A., Brauer, P. R., Hong, H., Reddy, C. A., Yilmaz, E., Woody, N., Ku, J. A., Prendes, B., Burkey, B., Nasr, C., Skugor, M., Heiden, K., Chute, D. J., Knauf, J. A., Campbell, S. R., Koyfman, S. A., Geiger, J. L., & Scharpf, J. (2023). Association of Treatment Strategies and Tumor Characteristics With Overall Survival Among Patients With Anaplastic Thyroid Cancer: A Single-Institution 21-Year Experience. JAMA otolaryngology-- head & neck surgery, 149(4), 300-309.
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  Survival outcomes for anaplastic thyroid cancer (ATC), the most aggressive subtype of thyroid cancers, have remained poor. However, targeted therapies and immunotherapies present new opportunities for treatment of this disease. Evaluations of survival outcomes over time with new multimodal therapies are needed for optimizing treatment plans.
• Zimmer, D., Plitt, G., Prendes, B., Ku, J., Silver, N., Lamarre, E., Yilmaz, E., Geiger, J., Nasr, C., El Hage, L., Skugor, M., Cambpell, S., Koyfman, S., Miller, J., Woody, N., Heiden, K., Joshi, N., Elsheikh, T., Li, H., & Scharpf, J. (2023). Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer. The Laryngoscope, 133(9), 2430-2438.
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  Tall cell variant (TCV) papillary thyroid cancer (PTC) is a subtype of PTC associated with aggressive tumor behavior, advanced stage, and higher rates of recurrence and mortality. The present study aimed to test an established dynamic risk stratification tool in the TCV population, with the goal of better predicting the postoperative course of these patients.
• Kunte, S., Sharett, J., Wei, W., Nasr, C., Prendes, B., Lamarre, E., Ku, J., Lorenz, R. R., Scharpf, J., Burkey, B. B., Shah, A., Joshi, N., & Geiger, J. L. (2022). Poorly Differentiated Thyroid Carcinoma: Single Institution Series of Outcomes. Anticancer research, 42(5), 2531-2539.
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  Poorly differentiated thyroid cancer (PDTC) is a rare but aggressive subtype of thyroid cancer that portends a poor prognosis. There remains a paucity of literature on PDTC outcomes. The aim of our study was to evaluate outcomes of PDTC in our tertiary care facility.
• Nasr, C. E., Andrioli, M., Endo, M., Harrell, R. M., Livhits, M. J., Osakwe, I., Polavarapu, P., Siperstein, A., Wei, S., Zheng, X., Jiang, R., Hao, Y., Huang, J., Klopper, J. P., Kloos, R. T., Kennedy, G., & Angell, T. E. (2022). Real World Performance of The Afirma Genomic Sequencing Classifier (GSC) - A Meta-analysis. The Journal of clinical endocrinology and metabolism.
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  The Afirma® GSC aids in risk stratifying indeterminate thyroid nodule cytology (ITN). The 2018 GSC validation study (VS) reported a sensitivity (SN) of 91%, specificity (SP) of 68%, positive predictive value (PPV) of 47%, and negative predictive value (NPV) of 96%. Since then, 13 independent real world (RW) post-validation studies have been published.
• Petersen, E. A., Stauss, T. G., Scowcroft, J. A., Brooks, E. S., White, J. L., Sills, S. M., Amirdelfan, K., Guirguis, M. N., Xu, J., Yu, C., Nairizi, A., Patterson, D. G., Tsoulfas, K. C., Creamer, M. J., Galan, V., Bundschu, R. H., Mehta, N. D., Sayed, D., Lad, S. P., , DiBenedetto, D. J., et al. (2022). Durability of High-Frequency 10-kHz Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy Refractory to Conventional Treatments: 12-Month Results From a Randomized Controlled Trial. Diabetes care, 45(1), e3-e6.
• Petersen, E. A., Stauss, T. G., Scowcroft, J. A., Brooks, E. S., White, J. L., Sills, S. M., Amirdelfan, K., Guirguis, M. N., Xu, J., Yu, C., Nairizi, A., Patterson, D. G., Tsoulfas, K. C., Creamer, M. J., Galan, V., Bundschu, R. H., Mehta, N. D., Sayed, D., Lad, S. P., , DiBenedetto, D. J., et al. (2022). High-Frequency 10-kHz Spinal Cord Stimulation Improves Health-Related Quality of Life in Patients With Refractory Painful Diabetic Neuropathy: 12-Month Results From a Randomized Controlled Trial. Mayo Clinic proceedings. Innovations, quality & outcomes, 6(4), 347-360.
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  To evaluate high-frequency (10-kHz) spinal cord stimulation (SCS) treatment in refractory painful diabetic neuropathy.
• Xu, L., Sun, Z., Casserly, E., Nasr, C., Cheng, J., & Xu, J. (2022). Advances in Interventional Therapies for Painful Diabetic Neuropathy: A Systematic Review. Anesthesia and analgesia, 134(6), 1215-1228.
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  Painful diabetic neuropathy (PDN) is one of the major complications of diabetes mellitus. It is often debilitating and refractory to pharmaceutical therapies. Our goal was to systematically review and evaluate the strength of evidence of interventional management options for PDN and make evidence-based recommendations for clinical practice.
• Yuan, L., Nasr, C., Bena, J. F., & Elsheikh, T. M. (2022). Hürthle cell-predominant thyroid fine needle aspiration cytology: A four risk-factor model highly accurate in excluding malignancy and predicting neoplasm. Diagnostic cytopathology, 50(9), 424-435.
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  Interpretation of Hürthle cell-predominant cytologies (HCP) is very challenging as a majority is diagnosed as indeterminate. Prior studies have reported various cytologic features to help distinguish non-neoplastic (NN) from neoplastic and malignant lesions but had contradicting results. Our aim was to identify risk factors predictive of neoplasm and/or malignancy by correlating cytologic features with clinical and ultrasound findings.