- Professor, Neurology
- Professor, Neurology (Banner)
- Professor, Medical Imaging
- Professor, BIO5 Institute
- M.D. Medicine
- University of Arizona, Tucson, Arizona, United States
- B.S. Psychology
- Duke University, Durham, North Carolina, United States
- University of Arizona Vascular Neurology Fellowship (2015 - Ongoing)
- University of Arizona Medical Center Primary Stroke Center (2014 - Ongoing)
- University of Arizona, Tucson, Arizona (2013 - Ongoing)
- University of Arizona, Tucson, Arizona (2013 - Ongoing)
- Georgetown University (2013 - Ongoing)
- Georgetown University (2008 - 2013)
- Georgetown Stroke Center (2006 - 2013)
- Georgetown University (2005 - 2008)
- Washington Hospital Center (2004 - 2008)
- University of California, Los Angeles, Los Angeles, California (2004 - 2008)
- University of California, Los Angeles, Los Angeles, California (2003 - 2004)
- University of California, Los Angeles, Los Angeles, California (2001 - 2003)
- University of California, Los Angeles, Los Angeles, California (1999 - 2003)
- University of California, Los Angeles, Los Angeles, California (1998 - 2003)
- University of California, Los Angeles, Los Angeles, California (1996 - 1998)
Licensure & Certification
- Certification in Neurosonology, American Society of Neuroimaging (1998)
- Medical License, Arizona Medical Board (2013)
- Diplomate, National Board of Medical Examiners (1993)
- Diplomate, American Board of Psychiatry and Neurologyy (1998)
- Medical License, District of Columbia Board of Medicine (2004)
No activities entered.
Neuro+Rehab Med ClerkshpNEUR 813C (Fall 2020)
Neuro+Rehab Med ClerkshpNEUR 813C (Fall 2019)
Neuro+Rehab Med ClerkshpNEUR 813C (Fall 2018)
Neuro+Rehab Med ClerkshpNEUR 813C (Fall 2017)
Neuro+Rehab Med ClerkshpNEUR 813C (Spring 2017)
Neurology Gen. Inpatient Svc.NEUR 850A (Spring 2017)
Neuro+Rehab Med ClerkshpNEUR 813C (Fall 2016)
Neuro+Rehab Med ClerkshpNEUR 813C (Spring 2016)
- Kidwell, S. M., & Nael, K. (2016). Neurobiology of Disease. Oxford University Press.
- Marini, S., Crawford, K., Morotti, A., Lee, M. J., Pezzini, A., Moomaw, C. J., Flaherty, M. L., Montaner, J., Roquer, J., Jimenez-Conde, J., Giralt-Steinhauer, E., Elosua, R., Cuadrado-Godia, E., Soriano-Tarraga, C., Slowik, A., Jagiella, J. M., Pera, J., Urbanik, A., Pichler, A., , Hansen, B. M., et al. (2019). Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis. JAMA neurology, 76(4), 480-491.More infoGenetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations.
- Powers, W. J., Rabinstein, A. A., Ackerson, T., Adeoye, O. M., Bambakidis, N. C., Becker, K., Biller, J., Brown, M., Demaerschalk, B. M., Hoh, B., Jauch, E. C., Kidwell, C. S., Leslie-Mazwi, T. M., Ovbiagele, B., Scott, P. A., Sheth, K. N., Southerland, A. M., Summers, D. V., & Tirschwell, D. L. (2019). Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke, 50(12), e344-e418.More infoBackground and Purpose- The purpose of these guidelines is to provide an up-to-date comprehensive set of recommendations in a single document for clinicians caring for adult patients with acute arterial ischemic stroke. The intended audiences are prehospital care providers, physicians, allied health professionals, and hospital administrators. These guidelines supersede the 2013 Acute Ischemic Stroke (AIS) Guidelines and are an update of the 2018 AIS Guidelines. Methods- Members of the writing group were appointed by the American Heart Association (AHA) Stroke Council's Scientific Statements Oversight Committee, representing various areas of medical expertise. Members were not allowed to participate in discussions or to vote on topics relevant to their relations with industry. An update of the 2013 AIS Guidelines was originally published in January 2018. This guideline was approved by the AHA Science Advisory and Coordinating Committee and the AHA Executive Committee. In April 2018, a revision to these guidelines, deleting some recommendations, was published online by the AHA. The writing group was asked review the original document and revise if appropriate. In June 2018, the writing group submitted a document with minor changes and with inclusion of important newly published randomized controlled trials with >100 participants and clinical outcomes at least 90 days after AIS. The document was sent to 14 peer reviewers. The writing group evaluated the peer reviewers' comments and revised when appropriate. The current final document was approved by all members of the writing group except when relationships with industry precluded members from voting and by the governing bodies of the AHA. These guidelines use the American College of Cardiology/AHA 2015 Class of Recommendations and Level of Evidence and the new AHA guidelines format. Results- These guidelines detail prehospital care, urgent and emergency evaluation and treatment with intravenous and intra-arterial therapies, and in-hospital management, including secondary prevention measures that are appropriately instituted within the first 2 weeks. The guidelines support the overarching concept of stroke systems of care in both the prehospital and hospital settings. Conclusions- These guidelines provide general recommendations based on the currently available evidence to guide clinicians caring for adult patients with acute arterial ischemic stroke. In many instances, however, only limited data exist demonstrating the urgent need for continued research on treatment of acute ischemic stroke.
- Wilson, S. M., Eriksson, D. K., Brandt, T. H., Schneck, S. M., Lucanie, J. M., Burchfield, A. S., Charney, S., Quillen, I. A., de Riesthal, M., Kirshner, H. S., Beeson, P. M., Ritter, L., & Kidwell, C. S. (2019). Patterns of Recovery From Aphasia in the First 2 Weeks After Stroke. Journal of speech, language, and hearing research : JSLHR, 62(3), 723-732.More infoPurpose Recovery from aphasia after stroke has a decelerating trajectory, with the greatest gains taking place early and the slope of change decreasing over time. Despite its importance, little is known regarding evolution of language function in the early postonset period. The goal of this study was to characterize the dynamics and nature of recovery of language function in the acute and early subacute phases of stroke. Method Twenty-one patients with aphasia were evaluated every 2-3 days for the first 15 days after onset of acute ischemic or hemorrhagic stroke. Language function was assessed at each time point with the Quick Aphasia Battery (Wilson, Eriksson, Schneck, & Lucanie, 2018), which yields an overall summary score and a multidimensional profile of 7 different language domains. Results On a 10-point scale, overall language function improved by a mean of 1.07 points per week, confidence interval [0.46, 1.71], with 19 of 21 patients showing positive changes. The trajectory of recovery was approximately linear over this time period. There was significant variability across patients, and patients with more impaired language function at Day 2 poststroke experienced greater improvements over the subsequent 2 weeks. Patterns of recovery differed across language domains, with consistent improvements in word finding, grammatical construction, repetition, and reading, but less consistent improvements in word comprehension and sentence comprehension. Conclusion Overall language function typically improves substantially and steadily during the first 2 weeks after stroke, driven mostly by recovery of expressive language. Information on the trajectory of early recovery will increase the accuracy of prognoses and establish baseline expectations against which to evaluate the efficacy of interventions. Supplemental Material https://doi.org/10.23641/asha.7811876.
- Bernhardt, J., Zorowitz, R. D., Becker, K. J., Keller, E., Saposnik, G., Strbian, D., Dichgans, M., Woo, D., Reeves, M., Thrift, A., Kidwell, C. S., Olivot, J. M., Goyal, M., Pierot, L., Bennett, D. A., Howard, G., Ford, G. A., Goldstein, L. B., Planas, A. M., , Yenari, M. A., et al. (2018). Advances in Stroke 2017. Stroke, 49(5), e174-e199.
- Bevers, M. B., Battey, T. W., Ostwaldt, A. C., Jahan, R., Saver, J. L., Kimberly, W. T., & Kidwell, C. S. (2018). Apparent Diffusion Coefficient Signal Intensity Ratio Predicts the Effect of Revascularization on Ischemic Cerebral Edema. Cerebrovascular diseases (Basel, Switzerland), 45(3-4), 93-100.More infoApparent diffusion coefficient (ADC) imaging is a biomarker of cytotoxic injury that predicts edema formation and outcome after ischemic stroke. It therefore has the potential to serve as a "tissue clock" to describe the extent of ischemic injury and potentially predict response to therapy. The goal of this study was to determine the relationship between baseline ADC signal intensity, revascularization, and edema formation.
- Chen, P. M., Nguyen, D. T., Ho, J. P., Pirastehfar, M., Narula, R., Rapp, K., Agrawal, K., Huisa, B., Modir, R., Meyer, D., Hemmen, T., Kidwell, C., & Meyer, B. C. (2018). Factors Influencing Acute Stroke Thrombolytic Treatments in Hispanics In the San Diego Region. Austin journal of cerebrovascular disease & stroke, 5(1).More infoSince the introduction of recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke, rt-PA rate and number of stroke centers have increased. Despite this, studies have shown racial and ethnic disparities in stroke care especially in Black and Hispanic populations. What factors are related to the administration of rt-PA within the Hispanic population has to date been unclear.
- Marini, S., Devan, W. J., Radmanesh, F., Miyares, L., Poterba, T., Hansen, B. M., Norrving, B., Jimenez-Conde, J., Giralt-Steinhauer, E., Elosua, R., Cuadrado-Godia, E., Soriano, C., Roquer, J., Kourkoulis, C. E., Ayres, A. M., Schwab, K., Tirschwell, D. L., Selim, M., Brown, D. L., , Silliman, S. L., et al. (2018). Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage. Stroke, 49(7), 1618-1625.More infoHematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH.
- Powers, W. J., Rabinstein, A. A., Ackerson, T., Adeoye, O. M., Bambakidis, N. C., Becker, K., Biller, J., Brown, M., Demaerschalk, B. M., Hoh, B., Jauch, E. C., Kidwell, C. S., Leslie-Mazwi, T. M., Ovbiagele, B., Scott, P. A., Sheth, K. N., Southerland, A. M., Summers, D. V., Tirschwell, D. L., & , A. H. (2018). 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke, 49(3), e46-e110.More infoThe purpose of these guidelines is to provide an up-to-date comprehensive set of recommendations for clinicians caring for adult patients with acute arterial ischemic stroke in a single document. The intended audiences are prehospital care providers, physicians, allied health professionals, and hospital administrators. These guidelines supersede the 2013 guidelines and subsequent updates.
- Rodriguez-Torres, A., Murphy, M., Kourkoulis, C., Schwab, K., Ayres, A. M., Moomaw, C. J., Young Kwon, S., Berthaud, J. V., Gurol, M. E., Greenberg, S. M., Viswanathan, A., Anderson, C. D., Flaherty, M., James, M. L., Birnbaum, L., Yong Sung, G., Parikh, G., Boehme, A. K., Mayson, D., , Sheth, K. N., et al. (2018). Hypertension and intracerebral hemorrhage recurrence among white, black, and Hispanic individuals. Neurology, 91(1), e37-e44.More infoTo clarify whether recurrence risk for intracerebral hemorrhage (ICH) is higher among black and Hispanic individuals and whether this disparity is attributable to differences in blood pressure (BP) measurements and their variability.
- Charidimou, A., Turc, G., Oppenheim, C., Yan, S., Scheitz, J. F., Erdur, H., Klinger-Gratz, P. P., El-Koussy, M., Takahashi, W., Moriya, Y., Wilson, D., Kidwell, C. S., Saver, J. L., Sallem, A., Moulin, S., Edjlali-Goujon, M., Thijs, V., Fox, Z., Shoamanesh, A., , Albers, G. W., et al. (2017). Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Stroke Thrombolysis: Individual Patient Data Meta-Analysis. Stroke.More infoWe assessed whether the presence, number, and distribution of cerebral microbleeds (CMBs) on pre-intravenous thrombolysis MRI scans of acute ischemic stroke patients are associated with an increased risk of intracerebral hemorrhage (ICH) or poor functional outcome.
- Irvine, H. J., Ostwaldt, A. C., Bevers, M. B., Dixon, S., Battey, T. W., Campbell, B. C., Davis, S. M., Donnan, G. A., Sheth, K. N., Jahan, R., Saver, J. L., Kidwell, C. S., & Kimberly, W. T. (2017). Reperfusion after ischemic stroke is associated with reduced brain edema. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678X17720559.More infoRapid revascularization is highly effective for acute stroke, but animal studies suggest that reperfusion edema may attenuate its beneficial effects. We investigated the relationship between reperfusion and edema in patients from the Echoplanar Imaging Thrombolysis Evaluation Trial (EPITHET) and Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) cohorts. Reperfusion percentage was measured as the difference in perfusion-weighted imaging lesion volume between baseline and follow-up (day 3-5 for EPITHET; day 6-8 for MR RESCUE). Midline shift (MLS) and swelling volume were quantified on follow-up MRI. We found that reperfusion was associated with less MLS (EPITHET: Spearman ρ = -0.46; P
- Kidwell, C. S., Rosand, J., Norato, G., Dixon, S., Worrall, B. B., James, M. L., Elkind, M. S., Flaherty, M. L., Osborne, J., Vashkevich, A., Langefeld, C. D., Moomaw, C. J., & Woo, D. (2017). Ischemic lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage. Neurology, 88(8), 782-788.More infoTo evaluate the associations among diffusion-weighted imaging (DWI) lesions, blood pressure (BP) dysregulation, MRI markers of small vessel disease, and poor outcome in a large, prospective study of primary intracerebral hemorrhage (ICH).
- Nael, K., Knitter, J. R., Jahan, R., Gornbein, J., Ajani, Z., Feng, L., Meyer, B. C., Schwamm, L. H., Yoo, A. J., Marshall, R. S., Meyers, P. M., Yavagal, D. R., Wintermark, M., Liebeskind, D. S., Guzy, J., Starkman, S., Saver, J. L., & Kidwell, C. S. (2017). Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy. Stroke, 48(3), 664-670.More infoPatients with acute ischemic stroke are at increased risk of developing parenchymal hemorrhage (PH), particularly in the setting of reperfusion therapies. We have developed a predictive model to examine the risk of PH using combined magnetic resonance perfusion and diffusion parameters, including cerebral blood volume (CBV), apparent diffusion coefficient, and microvascular permeability (K2).
- Siddiqui, F. M., Langefeld, C. D., Moomaw, C. J., Comeau, M. E., Sekar, P., Rosand, J., Kidwell, C. S., Martini, S., Osborne, J. L., Stutzman, S., Hall, C., & Woo, D. (2017). Use of Statins and Outcomes in Intracerebral Hemorrhage Patients. Stroke, 48(8), 2098-2104.More infoStatin use may be associated with improved outcome in intracerebral hemorrhage patients. However, the topic remains controversial. Our analysis examined the effect of prior, continued, or new statin use on intracerebral hemorrhage outcomes using the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) data set.
- Anderson, C. D., Falcone, G. J., Phuah, C. L., Radmanesh, F., Brouwers, H. B., Battey, T. W., Biffi, A., Peloso, G. M., Liu, D. J., Ayres, A. M., Goldstein, J. N., Viswanathan, A., Greenberg, S. M., Selim, M., Meschia, J. F., Brown, D. L., Worrall, B. B., Silliman, S. L., Tirschwell, D. L., , Flaherty, M. L., et al. (2016). Genetic variants in CETP increase risk of intracerebral hemorrhage. Annals of neurology, 80(5), 730-740.More infoIn observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. Here, we test the hypothesis that CETP DNA sequence variants associated with higher HDL-C also increase risk for ICH.
- Grams, R. W., Kidwell, C. S., Doshi, A. H., Drake, K., Becker, J., Coull, B. M., & Nael, K. (2016). Tissue-Negative Transient Ischemic Attack: Is There a Role for Perfusion MRI?. AJR. American journal of roentgenology, 207(1), 157-62.More infoApproximately 60% of patients with a clinical transient ischemic attack (TIA) do not have DWI evidence of cerebral ischemia. The purpose of this study was to assess the added diagnostic value of perfusion MRI in the evaluation of patients with TIA who have normal DWI findings.
- Grams, R., Kidwell, S. M., Drake, K. W., Becker, J., Coull, B. M., & Nael, K. (2016). Tissue Negative-Transient Ischemic Attack: Is There a Role for MRI Perfusion?. American Journal of Roentgenology.
- Koch, S., Elkind, M. S., Testai, F. D., Brown, W. M., Martini, S., Sheth, K. N., Chong, J. Y., Osborne, J., Moomaw, C. J., Langefeld, C. D., Sacco, R. L., Woo, D., & , E. S. (2016). Racial-ethnic disparities in acute blood pressure after intracerebral hemorrhage. Neurology, 87(8), 786-91.More infoTo assess race-ethnic differences in acute blood pressure (BP) following intracerebral hemorrhage (ICH) and the contribution to disparities in ICH outcome.
- Qureshi, A. I., Palesch, Y. Y., Barsan, W. G., Hanley, D. F., Hsu, C. Y., Martin, R. L., Moy, C. S., Silbergleit, R., Steiner, T., Suarez, J. I., Toyoda, K., Wang, Y., Yamamoto, H., Yoon, B. W., & , A. T. (2016). Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. The New England journal of medicine, 375(11), 1033-43.More infoBackground Limited data are available to guide the choice of a target for the systolic blood-pressure level when treating acute hypertensive response in patients with intracerebral hemorrhage. Methods We randomly assigned eligible participants with intracerebral hemorrhage (volume,
- Khatri, P., Hacke, W., Fiehler, J., Saver, J. L., Diener, H., Bendszus, M., Bracard, S., Broderick, J., Campbell, B., Ciccone, A., Dávalos, A., Davis, S., Demchuk, A. M., Dippel, D., Donnan, G., Fiorella, D., Goyal, M., Hill, M. D., Jauch, E. C., , Jovin, T. G., et al. (2015). State of acute endovascular therapy: report from the 12th thrombolysis, thrombectomy, and acute stroke therapy conference. Stroke; a journal of cerebral circulation, 46(6), 1727-34.
- Kidwell, C. S., & Jahan, R. (2015). Endovascular treatment of acute ischemic stroke. Neurologic clinics, 33(2), 401-20.More infoEndovascular therapy for acute stroke has evolved with the use of intra-arterial thrombolytics, intravenous/intra-arterial bridging strategies, and mechanical thrombectomy/aspiration devices. Despite widespread use in clinical practice, randomized trials of first-generation devices failed to demonstrate improved outcomes compared with standard care. New-generation stent retriever devices demonstrate higher rates of revascularization and clinical outcomes compared with first-generation devices. Additional randomized trials are underway and have the potential to confirm clinical efficacy of new-generation devices compared with standard care. The role of additional advanced imaging for patient selection remains unclear, and further trials are needed to demonstrate the role of these techniques for patient selection.
- MacIsaac, R. L., Khatri, P., Bendszus, M., Bracard, S., Broderick, J., Campbell, B., Ciccone, A., Dávalos, A., Davis, S. M., Demchuk, A., Diener, H., Dippel, D., Donnan, G. A., Fiehler, J., Fiorella, D., Goyal, M., Hacke, W., Hill, M. D., Jahan, R., , Jauch, E., et al. (2015). A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration. International journal of stroke : official journal of the International Stroke Society, 10 Suppl A100, 136-44.More infoEndovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.
- Mackey, J., Wing, J. J., Norato, G., Sobotka, I., Menon, R. S., Burgess, R. E., Gibbons, M. C., Shara, N. M., Fernandez, S., Jayam-Trouth, A., Russell, L., Edwards, D. F., & Kidwell, C. S. (2015). High rate of microbleed formation following primary intracerebral hemorrhage. International journal of stroke : official journal of the International Stroke Society, 10(8), 1187-91.More infoWe sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation.
- Martinez, M., Prabhakar, N., Drake, K. W., Coull, B. M., Chong, J., Ritter, L., & Kidwell, S. M. (2015). Identification of Barriers to Stroke Awareness and Risk Factor Management Unique to Hispanics. International Journal of Environmental Researh and Public Health.
- Martinez, M., Prabhakar, N., Drake, K., Coull, B., Chong, J., Ritter, L., & Kidwell, C. (2015). Identification of Barriers to Stroke Awareness and Risk Factor Management Unique to Hispanics. International journal of environmental research and public health, 13(1), ijerph13010023.More infoBarriers to risk factor control may differ by race/ethnicity. The goal of this study was to identify barriers to stroke awareness and risk factor management unique to Hispanics as compared to non-Hispanic whites (NHWs). We performed a prospective study of stroke patients from an academic Stroke Center in Arizona and surveyed members of the general community. Questionnaires included: the Duke Social Support Index (DSSI), the Multidimensional Health Locus of Control (MHLC) Scale, a stroke barriers questionnaire, and a Stroke Awareness Test. Of 145 stroke patients surveyed (72 Hispanic; 73 NHW), Hispanics scored lower on the Stroke Awareness Test compared to NHWs (72.5% vs. 79.1%, p = 0.029). Hispanic stroke patients also reported greater barriers related to medical knowledge, medication adherence, and healthcare access (p < 0.05 for all). Hispanics scored higher on the "powerful others" sub-scale (11.3 vs. 10, p < 0.05) of the MHLC. Of 177 members of the general public surveyed, Hispanics had lower stroke awareness compared to NHWs and tended to have lower awareness than Hispanic stroke patients. These results suggest that Hispanic stroke patients perceive less control over their health, experience more healthcare barriers, and demonstrate lower rates of stroke literacy. Interventions for stroke prevention and education in Hispanics should address these racial/ethnic differences in stroke awareness and barriers to risk factor control.
- Nael, K., Trouard, T. P., Lafleur, S. R., Krupinski, E. A., Salamon, N., & Kidwell, C. S. (2015). White matter ischemic changes in hyperacute ischemic stroke: voxel-based analysis using diffusion tensor imaging and MR perfusion. Stroke; a journal of cerebral circulation, 46(2), 413-8.More infoThe purpose of this study was to evaluate changes in fractional anisotropy (FA), as measured by diffusion tensor imaging, of white matter (WM) infarction and hypoperfusion in patients with acute ischemic stroke using a quantitative voxel-based analysis.
- Powers, W. J., Derdeyn, C. P., Biller, J., Coffey, C. S., Hoh, B. L., Jauch, E. C., Johnston, K. C., Johnston, S. C., Khalessi, A. A., Kidwell, C. S., Meschia, J. F., Ovbiagele, B., Yavagal, D. R., & , A. H. (2015). 2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke; a journal of cerebral circulation, 46(10), 3020-35.More infoThe aim of this guideline is to provide a focused update of the current recommendations for the endovascular treatment of acute ischemic stroke. When there is overlap, the recommendations made here supersede those of previous guidelines.
- Rannikmäe, K., Davies, G., Thomson, P. A., Bevan, S., Devan, W. J., Falcone, G. J., Traylor, M., Anderson, C. D., Battey, T. W., Radmanesh, F., Deka, R., Woo, J. G., Martin, L. J., Jimenez-Conde, J., Selim, M., Brown, D. L., Silliman, S. L., Kidwell, C. S., Montaner, J., , Langefeld, C. D., et al. (2015). Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, 84(9), 918-26.More infoWe hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease.
- Boden-Albala, B., Edwards, D. F., St Clair, S., Wing, J. J., Fernandez, S., Gibbons, M. C., Hsia, A. W., Morgenstern, L. B., & Kidwell, C. S. (2014). Methodology for a community-based stroke preparedness intervention: the Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities Study. Stroke, 45(7), 2047-52.More infoAcute stroke education has focused on stroke symptom recognition. Lack of education about stroke preparedness and appropriate actions may prevent people from seeking immediate care. Few interventions have rigorously evaluated preparedness strategies in multiethnic community settings.
- Heiss, W. D., & Kidwell, C. S. (2014). Advances in stroke: Imaging 2013. Stroke, 45(2), 363-4.
- Heiss, W. D., & Kidwell, C. S. (2014). Imaging for prediction of functional outcome and assessment of recovery in ischemic stroke. Stroke, 45(4), 1195-201.
- Nael, K., Khan, R., Choudhary, G., Meshksar, A., Villablanca, P., Tay, J., Drake, K., Coull, B. M., & Kidwell, C. S. (2014). Six-minute magnetic resonance imaging protocol for evaluation of acute ischemic stroke: pushing the boundaries. Stroke, 45(7), 1985-91.More infoIf magnetic resonance imaging (MRI) is to compete with computed tomography for evaluation of patients with acute ischemic stroke, there is a need for further improvements in acquisition speed.
- Roeltgen, D., & Kidwell, C. S. (2014). Neurologic complications of cardiac tumors. Handbook of clinical neurology, 119, 209-22.More infoCardiac tumors are an uncommon cause for neurologic disease, but if undiagnosed can be associated with devastating neurologic consequences. Primary cardiac tumors, both benign and neoplastic, and metastatic tumors occur. Primary cardiac tumors are more likely to be associated with neurologic embolic complications. Metastatic cardiac tumors are more likely to be associated with valvular distraction, arrhythmia, diminished cardiac output and indirect neurological dysfunction. Primary and metastatic cardiac tumors may result in cerebral metastatic disease. Atrial myxoma, a benign primary cardiac tumor, is the most common cardiac tumor associated with neurologic disease, and most commonly causes cerebral embolization and stroke. The use of thrombolytic therapy for these strokes is controversial. Additionally, delayed manifestations, including aneurysm formation and intracranial hemorrhage, are possible. Aneurysm formation has been described as occurring after removal of the primary tumor. The availability of noninvasive cardiac imaging has significantly helped decrease the neurologic morbidity of cardiac tumors and has led to frequent successful intervention.
- Woo, D., Falcone, G. J., Devan, W. J., Brown, W. M., Biffi, A., Howard, T. D., Anderson, C. D., Brouwers, H. B., Valant, V., Battey, T. W., Radmanesh, F., Raffeld, M. R., Baedorf-Kassis, S., Deka, R., Woo, J. G., Martin, L. J., Haverbusch, M., Moomaw, C. J., Sun, G., , Broderick, J. P., et al. (2014). Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. American journal of human genetics, 94(4), 511-21.More infoIntracerebral hemorrhage (ICH) is the stroke subtype with the worst prognosis and has no established acute treatment. ICH is classified as lobar or nonlobar based on the location of ruptured blood vessels within the brain. These different locations also signal different underlying vascular pathologies. Heritability estimates indicate a substantial genetic contribution to risk of ICH in both locations. We report a genome-wide association study of this condition that meta-analyzed data from six studies that enrolled individuals of European ancestry. Case subjects were ascertained by neurologists blinded to genotype data and classified as lobar or nonlobar based on brain computed tomography. ICH-free control subjects were sampled from ambulatory clinics or random digit dialing. Replication of signals identified in the discovery cohort with p < 1 × 10(-6) was pursued in an independent multiethnic sample utilizing both direct and genome-wide genotyping. The discovery phase included a case cohort of 1,545 individuals (664 lobar and 881 nonlobar cases) and a control cohort of 1,481 individuals and identified two susceptibility loci: for lobar ICH, chromosomal region 12q21.1 (rs11179580, odds ratio [OR] = 1.56, p = 7.0 × 10(-8)); and for nonlobar ICH, chromosomal region 1q22 (rs2984613, OR = 1.44, p = 1.6 × 10(-8)). The replication included a case cohort of 1,681 individuals (484 lobar and 1,194 nonlobar cases) and a control cohort of 2,261 individuals and corroborated the association for 1q22 (p = 6.5 × 10(-4); meta-analysis p = 2.2 × 10(-10)) but not for 12q21.1 (p = 0.55; meta-analysis p = 2.6 × 10(-5)). These results demonstrate biological heterogeneity across ICH subtypes and highlight the importance of ascertaining ICH cases accordingly.
- Menon, R., & Kidwell, C. (2013). Reply: To PMID 22367992. Annals of neurology, 73(6), 797.
- Ovbiagele, B., & Kidwell, C. S. (2013). Response to letter regarding article, "Association of chronic kidney disease with cerebral microbleeds in patients with primary intracerebral hemorrhage". Stroke, 44(12), e232.
- Ovbiagele, B., Wing, J. J., Menon, R. S., Burgess, R. E., Gibbons, M. C., Sobotka, I., German, L., Shara, N. M., Fernandez, S., Jayam-Trouth, A., Edwards, D. F., & Kidwell, C. S. (2013). Association of chronic kidney disease with cerebral microbleeds in patients with primary intracerebral hemorrhage. Stroke, 44(9), 2409-13.More infoTo investigate the relationship between chronic kidney disease (CKD) and MRI-defined cerebral microbleeds (CMB), a harbinger of future intracerebral hemorrhage (ICH), among patients with a recent history of primary ICH.
- Saver, J. L., Jovin, T. G., Smith, W. S., Albers, G. W., Baron, J. C., Boltze, J., Broderick, J. P., Davis, L. A., Demchuk, A. M., DeSena, S., Fiehler, J., Gorelick, P. B., Hacke, W., Holt, B., Jahan, R., Jing, H., Khatri, P., Kidwell, C. S., Lees, K. R., , Lev, M. H., et al. (2013). Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices. Stroke, 44(12), 3596-601.More infoThe goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of stroke therapies. At STAIR VIII, consensus recommendations were developed for clinical trial strategies to demonstrate the benefit of endovascular reperfusion therapies for acute ischemic stroke.
- Wintermark, M., Albers, G. W., Broderick, J. P., Demchuk, A. M., Fiebach, J. B., Fiehler, J., Grotta, J. C., Houser, G., Jovin, T. G., Lees, K. R., Lev, M. H., Liebeskind, D. S., Luby, M., Muir, K. W., Parsons, M. W., von Kummer, R., Wardlaw, J. M., Wu, O., Yoo, A. J., , Alexandrov, A. V., et al. (2013). Acute Stroke Imaging Research Roadmap II. Stroke, 44(9), 2628-39.
- Wintermark, M., Sanelli, P. C., Albers, G. W., Bello, J. A., Derdeyn, C. P., Hetts, S. W., Johnson, M. H., Kidwell, C. S., Lev, M. H., Liebeskind, D. S., Rowley, H. A., Schaefer, P. W., Sunshine, J. L., Zaharchuk, G., Meltzer, C. C., , A. S., , A. C., & , S. o. (2013). Imaging recommendations for acute stroke and transient ischemic attack patients: a joint statement by the American Society of Neuroradiology, the American College of Radiology and the Society of NeuroInterventional Surgery. Journal of the American College of Radiology : JACR, 10(11), 828-32.More infoIn the article entitled "Imaging Recommendations for Acute Stroke and Transient Ischemic Attack Patients: A Joint Statement by the American Society of Neuroradiology, the American College of Radiology and the Society of NeuroInterventional Surgery", we are proposing a simple, pragmatic approach that will allow the reader to develop an optimal imaging algorithm for stroke patients at their institution.
- Woo, D., Rosand, J., Kidwell, C., McCauley, J. L., Osborne, J., Brown, M. W., West, S. E., Rademacher, E. W., Waddy, S., Roberts, J. N., Koch, S., Gonzales, N. R., Sung, G., Kittner, S. J., Birnbaum, L., Frankel, M., Testai, F. D., Hall, C. E., Elkind, M. S., , Flaherty, M., et al. (2013). The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol. Stroke, 44(10), e120-5.More infoEpidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH.
- Kidwell, S. M., Norato, G., Osborn, J., Rosand, J., & Elkind, M. (2015, January). Race/Ethnic Differences in Microbleed Characteristics and Association of Microbleeds with Poor Outcomes in the ERICH Study. International Stroke Conference.
- Kidwell, S. M., Norato, G., Osborne, J., Worrall, B., & James, M. (2015, January). Ischemic Lesions in Intracerebral Hemorrhage Associated with Drop in Blood Pressure and Poor Outcomes in the ERICH Study. International Stroke Conference.
- Nael, K., Bauer, A., & Kidwell, S. M. (2015, Fall). Risk of Thrombolysis-induced Hemorrhagic Transformation in Patients with Acute Ischemic Stroke: A Predictive Model Using Combined MR Perfusion Biomarkers. International Stroke Conference.
- Chen, H., Dromerick, A., Kidwell, S. M., & Edwards, D. (2015, Fall). Early Executive Dysfunction Predicts Poor Stroke Outcomes One Year Following Mild Ischemic Stroke. International Stroke Conference.
- Coull, B. M., Kidwell, S. M., Norato, G., Dixon, S., & Osborne, J. (2015, Spring). An Analysis of Cerebral Amyloid Angiopathy by the Boston Criteria in the Ethnic/Racial Variation of Intracerebral Hemorrhage (ERICH) Cohort. European Stroke Organisation. Glasgow, Scotland: European Stroke Organisation.
- Kidwell, S. M., Jahan, R., Gornbein, J., Alger, J., & Nenov, V. (2015, Fall). Combining Clinical and Imaging Data to Develop a Highly Predictive Model of Outcomes in the MR RESCUE Trial. International Stroke Conference.
- Kidwell, S. M., & Jahan, R. (2015. Endovascular treatment of acute ischemic stroke(pp 401-420).