Nicholas Dewyer

Interests

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Courses

Scholarly Contributions

Chapters

• Abdul-Aziz, D., Dewyer, N., & Welling, D. B. (2020). Biology and Genetics of Vestibular Schwannomas. In Surgery of the Cerebellopontine Angle Second Edition. PMPH.
• Dewyer, N., Abdul-Aziz, D., & Welling, D. B. (2020). Stereotactic Radiotherapy for Skull Base Lesions. In Cummings Otology 7th Edition. Elsevier.
• Dewyer, N., Kiringoda, R., & McKenna, M. J. (2018). Inner ear infections (Labyrinthitis). In Infections of the Ears, Nose, Throat and Sinuses, First Edition. Springer International Publishing.

Journals/Publications

• Demirjian, N. L., Grande, D., Imbery, T. E., Muelleman, T., Walsh, E. M., Wick, C. C., & Dewyer, N. A. (2025). Temporal Bone Gunshot Wounds: A Multi-institutional Retrospective Study. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 46(1), 104-111.
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  To investigate management practices and outcomes in a retrospective cohort of patients who have sustained temporal bone gunshot wounds (TBGSW).
• Andres-Mateos, E., Landegger, L. D., Unzu, C., Phillips, J., Lin, B. M., Dewyer, N. A., Sanmiguel, J., Nicolaou, F., Valero, M. D., Bourdeu, K. I., Sewell, W. F., Beiler, R. J., McKenna, M. J., Stankovic, K. M., & Vandenberghe, L. H. (2022). Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate. Nature communications, 13(1), 1359.
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  Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate hearing and balance disorders. We previously established the benefits of Anc80L65 in targeting inner and outer hair cells in newborn mice. To accelerate translation to humans, we now report the feasibility and efficiency of the surgical approach and vector delivery in a nonhuman primate model. Five rhesus macaques were injected with AAV1 or Anc80L65 expressing eGFP using a transmastoid posterior tympanotomy approach to access the round window membrane after making a small fenestra in the oval window. The procedure was well tolerated. All but one animal showed cochlear eGFP expression 7-14 days following injection. Anc80L65 in 2 animals transduced up to 90% of apical inner hair cells; AAV1 was markedly less efficient at equal dose. Transduction for both vectors declined from apex to base. These data motivate future translational studies to evaluate gene therapy for human hearing disorders.
• Dewyer, N. (2021). Digital Otoscopes and Smartphones Can Facilitate Telehealth Head and Neck Exams. Medscape.
• Dewyer, N. (2021). The Best Ways to Communicate with Someone Who Doesn’t Hear Well. Banner Health Advise Me article.
• Dewyer, N. (2022). How Dirty Earbuds Can Make You Sick. Banner Health Teach Me article.
• Dewyer, N. (2021). Your Partner Says You Have Hearing Trouble--Now What?. Banner Health Better Me article.
• Dewyer, N. A., Smith, S., Herrmann, B., Reinshagen, K. L., & Lee, D. J. (2021). Pediatric Single-Sided Deafness: A Review of Prevalence, Radiologic Findings, and Cochlear Implant Candidacy. Annals of Otology, Rhinology & Laryngology, 131(3), 233-238. doi:10.1177/00034894211019519
• Dewyer, N., Koetsier, K. S., Hensen, E. F., Chapman, P. H., Lamba, N., Bussiere, M. R., vanVulpen, M., McKenna, M. J., Loeffler, J. S., & Shih, H. A. (2021). Outcome and Toxicity of Proton Therapy for Vestibular Schwannoma: A Cohort Study.. Otol Neurotol. doi:10.1097/MAO.0000000000003313
• Dewyer, N., Smith, S., Hermann, B., Reinshagen, K. L., & Lee, D. J. (2021). Pediatric Single-Sided Deafness: A Review of Prevalence, Radiologic Findings, and Cochlear Implant Candidacy. Ann Otol Rhinol Laryngol. doi:10.1177/00034894211019519
• Dewyer, N. A., Sethi, R. K., Yamasaki, A., & Lee, D. J. (2020). Radial Forearm Free Flap for Cochlear Implant Coverage in a Post-Irradiated Field. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 41(2), 192-195.
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  To describe a novel use of a radial forearm free flap (RFFF) for soft tissue coverage over a cochlear implant (CI) in a post-irradiated field.
• Dewyer, N., Cole, J. T., Epprecht, L., Reinshagen, K. L., Barker II, F. G., & Lee, D. J. (2020). Diffusion tensor magnetic resonance imaging: an example of its usefulness in an unusual cerebellopontine angle tumor. Otol Neurotol, 41(1), e146-e148. doi:10.1097/MAO0000000000002435
• Dewyer, N., Kang, K. H., Schapira, E. F., Niemierko, A., Bussiere, M. R., Hession, J., McKenna, M. J., Lee, D. J., Loeffler, J. S., Busse, P. M., & Shih, H. A. (2020). Proton therapy for head and neck paragangliomas: A single institutional experience. Head Neck, 670-677. doi:10.1002/hed.26044
• Dewyer, N., Quesnel, A. M., & Santos, F. (2020). A case series of patients with concurrent otosclerosis and superior semicircular canal dehiscence. Otol Neurotol, 41(2), e172-e181. doi:10.1097/MAO0000000000002487
• Chao, J. R., Dewyer, N., & McKenna, M. J. (2019). Spontaneous resolution of cholesteatoma in a patient on long-term infliximab. Ann Otol Rhinol Laryngol, 128(4), 365-368. doi:10.1177/0003489418823790
• Dewyer, N., Jiradejvong, P., Lee, D. S., Kemmer, J. D., Henderson Sabes, J., & Limb, C. J. (2019). Automated smartphone audiometry: A preliminary validation of a bone-conduction threshold test app. Ann Otol Rhinol Laryngol, 128(6), 508-515. doi:10.1177/003489419828770
• Dewyer, N., Rosowski, J., Nadol Jr., J. B., & Quesnel, A. M. (2019). Otopathology findings in otosclerosis with lateral semicircular canal fenestration.. Laryngoscope Investigative Otology, 4(4), 425-428. doi:10.1002/lio2.286
• Noij, K. S., Wong, K., Duarte, M. J., Masud, S., Dewyer, N., Herrmann, B. S., Guinan Jr., J. J., Kozin, E. D., Jung, D. H., Rauch, S. D., & Lee, D. J. (2018). Audiometric and cVEMP thresholds show little correlation with symptoms in superior semicircular canal dehiscence syndrome. Otol Neurotol, 39(9), 1153-1162. doi:10.1097/MAO.0000000000001910
• Strohl, M. P., Dewyer, N., Sckolnick, J., & Ryan, W. R. (2018). A novel approach to oropharyngeal foreign body remoal. Otolaryngology Head and Neck Surg, 158(1), 194-196. doi:10.1177/0194599817737272
• Dewyer, N. A., Jiradejvong, P., Henderson, S. J., & Limb, C. J. (2017). Automated smartphone audiometry: validation of a word recognition test app.. Laryngoscope.
• Dewyer, N. A., Kram, Y. A., Long, S., & Russell, M. D. (2017). Impact of a pediatric anesthesiologist on operating room efficiency for pediatric adenotonsillectomies.. Ear Nose Throat Journal, 96(6), E24-E28.
• Dewyer, N., El-Sayed, O. M., Luke, C. E., Elfline, M., Kittan, N., Allen, R., Laser, A., Oostra, C., Comerota, A., Hogaboam, C., Kunkel, S. L., & Henke, P. K. (2015). Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury.. Thromb Haemost, 114(4).
• Dewyer, N., Kiringoda, R., Kram, Y. A., Chang, J. L., Chang, C. J., & Cheung, S. W. (2015). Stapedectomy effects of tinnitus: relationship of change in loudness to change in severity.. Otolaryngology Head and Neck Surgery, 153(6), 1019-23.
• El-Sayed, O. M., Dewyer, N., Luke, C. E., Elfline, M., Laser, A., Hogaboam, C., Kunkel, S. L., & Henke, P. K. (2015). Intact toll-like receptor 9 signaling modulates normal thrombogenesis in mice.. Journal of Vascular Surgery, S0741-5214.
• Dewyer, N., Wolf, G. T., Light, E., Worden, F., Urba, S., Eisbruch, A., Lee, J., Bradford, C. R., Chepeha, D. B., Prince, M. E., Hogikyan, N., & Taylor, J. (2014). The UM Head and Neck SPORE Program: Circulating CD4-positive lymphocyte levels predict response to induction chemotherapy in patients with advanced larygeal cancer.. Head and Neck, 36(1), 9-14.
• Baldwin, J. F., Sood, V., Elfline, M. A., Luke, C. E., Dewyer, N., Diaz, J. A., Myers, D. D., Wakefield, T. W., & Henke, P. K. (2012). The role of urokinase plasminogen activator and plasmin activator inhibitor-1 on vein wall remodeling in experimental deep vein thrombosis.. J Vasc Surg, 56(4), 1089-97.
• Spector, M., Akbari, S., Dewyer, N., Nelson, C., Ward, B., McHugh, J., & Pynnonen, M. (2011). Pathology quiz case 2. Arch Otolaryngol Head Neck Surgery, 137(9), 965.
• Dewyer, N., Sood, V., Lynch, E. M., Luke, C. E., Upchurch Jr., G. R., Wakefield, T. W., Kunkel, S. L., & Henke, P. K. (2007). Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolution.. J Surg Res, 142(2), 357-63.
• Henke, P. K., Varma, M. R., Moaveni, D. K., Dewyer, N., Moore, A. J., Lynch, E. M., Longo, C., Deatrick, K. B., Kunkel, S. L., Upchurch Jr., G. R., & Wakefield, T. W. (2007). Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis.. Thromb Haemost, 98(5), 1045-1055.
• Henke, P. K., Pearce, C. G., Moaveni, D. M., Moore, A. J., Lynch, E. M., Longo, C., Varma, M., Dewyer, N., Deatrick, K. B., Upchurch Jr., G. R., Wakefield, T. W., Hogaboam, C., & Kunkel, S. L. (2006). Targeted deletion of CCR2 impairs deep vein thrombosis resolution in a mouse model.. J Immunol, 177(5), 3388-97.
• Henke, P. K., Varma, M. R., Deatrick, K. B., Dewyer, N., Lynch, E. M., Moore, A. J., Dubay, D. A., Sukheepod, P., Pearce, C. G., Upchurch Jr., G. R., Kunkel, S. L., Franz, M. G., & Wakefield, T. W. (2006). Neutrophils modulate post-thrombotic vein wall fibrosis but not thrombus neovascularization.. Thromb Haemost, 95(2), 272-81.
• Rectenwald, J. E., Deatrick, K. B., Sukheepod, P., Lynch, E. M., Moore, A. J., Moaveni, D. M., Dewyer, N., Luke, C. E., Upchurch Jr., G. R., Wakefield, T. W., Kunkel, S. L., & Henke, P. K. (2006). Experimental pulmonary embolism: effects of the thrombus and attenuation of pulmonary artery injury by low-molecular weight heparin.. J Vasc Surg, 43(4), 800-8.
• Deatrick, K. B., Eliason, J. L., Lynch, E. M., Moore, A. J., Dewyer, N., Varma, M. R., Pearce, C. G., Upchurch Jr., G. R., Wakefield, T. W., & Henke, P. K. (2005). Vein wall remodeling after deep vein throbosis involves matrix metalloproteinases and late fibrosis in a mouse model.. J Vasc Surg, 42(1), 140-8.
• Varma, M. R., Moaveni, D. M., Dewyer, N., Varga, A. J., Deatrick, K. B., Kunkel, S. L., Upchurch Jr., G. R., Wakefield, T. W., & Henke, P. K. (2004). Deep vein thrombosis (DVT) resolution is not accelerated with increased neovascularization.. J Vasc Surg, 40(3), 536-42.

Presentations

• Dewyer, N. (2024, February). Cochlear Implants: Updates for General Otolaryngologists. ENT in the Desert. Tucson, AZ.
• Dewyer, N. (2024, February). Medical and Surgical Considerations in Cochlear Implantation. Adult Loss of Hearing Association Meeting. Tucson, AZ.
• Dewyer, N. (2024, January). Management of Temporal Bone Gunshot Wounds: A Case Series of 15 Survivors. Triological Society Combined Sections Meeting.
• Dewyer, N. (2023, February). Might your patient need a cochlear implant?. Barrow Neurological Institute, Phoenix.
• Dewyer, N. (2023, February). Pulsatile Tinnitus. ENT in the Desert. Tucson, AZ.
• Dewyer, N. (2023, February). Topics in Otology: Ask the Experts - Panel. ENT in the Desert.
• Dewyer, N. (2023, January). Pulsatile Tinnitus. Arizona Society of Otolaryngology Annual Meeting. Phoenix, AZ.
• Dewyer, N. (2023, March). Management of temporal bone gunshot wounds: a case series of 14 survivors.. UA Medical Student Research Day, Tucson AZ.
• Dewyer, N. (2023, October). Are you up to date? Key OHNS systematic reviews: Part 2. American Academy of Otolaryngology - Head and Neck Surgery.
• Dewyer, N. (2021). Are you up to date? Key OHNS systematic reviews: Part 2. AAO-HNS Annual Meeting. Los Angeles, CA..
• Dewyer, N. (2022, February). A Hole in the Roof: Management of Tegmen Defects. ENT in the Desert Conference. Tucson, AZ.
• Dewyer, N. (2022, February). Cochlear Implants: an Overview. Neuroscience Grand Rounds, University of Arizona. Tucson, AZ.
• Dewyer, N. (2021). Medical and Surgical Considerations in Cochlear Implantation. ALOHA. Tucson, AZ.
• Dewyer, N. (2021). Vestibular Schwannoma: A Team Approach. Combined UA OHNS and Radiation Oncology Grand Rounds. Tucson, AZ.
• Dewyer, N. (2020, Sept). Cochlear implantation in an ear with an intracochlear schwannoma. W. House CI Study Group, ANS Super Saturday.
• Dewyer, N. (2019, Feb). Optimized surgical approach leads to highly efficient AAV gene transfer to inner hair cells in rhesus macaque. Association for Research in Otolaryngology Midwinter Meeting. Baltimore: Association for Research in Otolaryngology.
• Dewyer, N. (2019, June). Augmented reality to project critical landmarks over 3D printed models in endoscopic ear surgery. World Congress on Endoscopic Ear Surgery 3.0. Boston.
• Dewyer, N. (2019, Sept). Hearing Rehabilitation for single-sided deafness. ENT in the Desert Conference. Tucson: UA Department of Otolaryngology.
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  Presenter
• Dewyer, N. (2018, Feb). Automated smartphone audiometry. University of Chicago Division of Otolaryngology-Head and Neck Surgery. Chicago: University of Chicago.
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  Presenter
• Dewyer, N. (2018, March). Cochlear implant surgery for adults with single-sided deafness: update from a North American clinical trial. Emerging Issues in Cochlear Implantation Meeting.
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  Presenter
• Dewyer, N. (2017, Jan). Automated smartphone audiometry: validation of a word recognition test app. TRIO Society Meeting. New Orleans.
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  Presenter
• Dewyer, N. (2017, June). Automated smartphone audiometry: bone conduction thresholds. UCSF Department of Otolaryngology Resident Research Symposium. San Francico: UCSF.
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  Presenter
• Dewyer, N. (2017, May). Smartphone audiometry: validation of an automated word recognition test. Bay Area Residency Research Symposium. Oakland, CA.
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  Presenter
• Dewyer, N. (2016, Jun). Smartphone audiometry: validation of an automated word recognition test. UCSF Department of Otolaryngology Resident Research Symposium. San Francisco: UCSF.
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• Dewyer, N. (2015, Jan). Audiometric asymmetry as a predictor of tinnitus laterality in stapedectomy patients. TRIO Combined Sections Meting. San Diego: TRIO Combined Sections Meeting.
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  Presenter
• Dewyer, N. (2015, June). Relationship between changes in tinnitus loudness and tinnitus severity. UCSF Department of Otolaryngology Resident Research Symposium. San Francisco: UCSF.
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  Presenter
• Dewyer, N. (2015, June). Stapedectomy effects on tinnitus: relationship of change in loudness to change in severity. Bay Area Resident Research Symposium. Oakland, CA.
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  Presenter
• Dewyer, N. (2014, June). Impact of a pediatric anesthesiologist on OR efficiency for pediatric adenotsonsillectomies. UCSF Department of Otolaryngology Resident Research Symposium. San Francisco: UCSF.
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  Presenter
• Dewyer, N. (2014, Sept). Pediatric anesthesiologists increase operating room efficiency for pediatric adenotonsillectomies. AAO-HNSF. Orlando: American Academy of Otolaryngology-Head and Neck Surgery Foundaiton.
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• Dewyer, N. (2012, Feb). Experimental venous thrombosis in mice contains extracellular DNA but not extracellular RNA. 7th Annual Aademic Surgical Congress.
• Dewyer, N. (2012, Jan). Circulating CD4-positive lymphocyte levels predict responses to induction chemotherapy in patients with advanced laryngeal cancer. Multidisciplinary Head and Neck Cancer Symposium. Phoenix.
• Dewyer, N. (2011, May). Sterile inflammation is TLR9 dependent in experimental venous thrombosis resolution. 23rd Annual Moses Gunn Research Conference. Ann Arbor, MI.
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• Dewyer, N. (2011, May). Sterile inflammation is TLR9 dependent in experimental venous thrombosis resolution. Howard Hughes Medical Institute Meeting of Medical Fellows and Research Scholars. Chevy Chase, MD.
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• Dewyer, N. (2008, April). Video presentation: It turned everything upside down. UMMS Family Centered Experience Reception. Ann Arbor, MI.
• Dewyer, N. (2007, April). Pharmacological inhibition of the plasmin system increases matrix metalloproteinase-9 activity and decreases vein wall stiffness during venous thrombosis resolution. 19th Annual Moses Gunn Research Conference. Ann Arbor, MI.
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Poster Presentations

• Dewyer, N. (2024, May). Recurrent Flight-Associated Facial Baroparesis Despite a Pressure Equalization Tube. Combined Otolaryngology Spring Meetings. Chicago, IL.
• Dewyer, N. (2023). Active Transcutaneous Bone Conduction Hearing Implants in Patients with Hearing Thresholds Exceeding Manufacturer Recommendations. Combined Otolaryngology Spring Meetings.
• Dewyer, N. (2023, January). Cochlear Implantation in the Very Elderly. Triological Combined Sections Meeting. Coronado, CA.
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  Senior author (mentored medical student)
• Dewyer, N. (2023, January). The Utility of Routine Preoperative Computed Tomography in Patients with Otosclerosis. Triological Combined Sections Meeting. Coronado, CA.
• Dewyer, N. (2021). Generation of Novel Surgeon-Focused Imaging Platforms for Otologic Surgical Planning. AAO-HNS Annual Meeting. Los Angeles, CA..
• Dewyer, N. (2021). Universal Augmented Reality for Current Camera Systems in Otologic Surgery. AAO-HNS Annual Meeting. Los Angeles, CA..
• Dewyer, N. (2020). Proton Radiotherapy for Vestibular Schwannomas: a Cohort Study. ASTRO.
• Dewyer, N. (2020, Sept). Analysis of transcanal reformatted compute tomography views in lateral skull base and endoscopic ear surgeries. AAO-HNS Annual Meeting. Boston: American Academy of Otolaryngology-Head and Neck Surgery.
• Dewyer, N. (2019, May). Radial forearm free flap for cochlear implant coverage in a post-irradiated field. Triological Society Annual Meeting at COSM. Austin, TX: TRIO at Combined Otolaryngology Spring Meeting.
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  Presenter
• Dewyer, N. (2019, Sept). Mobile augmented reality for pre-operative planning in endoscopic ear surgery. AAO-HNS Annual Meeting. New Orleans: American Academy of Otolaryngology-Head and Neck Surgery.
• Dewyer, N. (2018, April). Pediatric single-sided deafness cochlear implant candidacy: a study of prevalence and imaging characteristics. American Otological Society Spring Meeting. National Harbor, MD: American Otological Society.
• Dewyer, N. (2018, April). Spontaneous resolution of cholesteatoma in a patient on long-term infliximab. American Otological Society Spring Meeting. National Harbor, MD: American Otological Society Spring Meeting.
• Dewyer, N. (2018, Feb). Audiometric and cVEMP thresholds show little correlation with symptoms in SCD patients. Association for Research in Otolaryngology Winter Meeting. San Diego.
• Dewyer, N. (2018, Jan). Automated smartphone audiometry: a proof-of-concept for bone-conduction threshold testing. Triological Society Combined Section Meeting. Scottsdale, AZ.
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  Presenter
• Dewyer, N. (2018, Sept). Automated smartphone audiometry: validation of a pure-tone bone-conduction threshold test app. American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting. Atlanta: American Academy of Otolaryngolog-Head and Neck Surgery.
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• Dewyer, N. (2016, May). Otolaryngologic injuries resulting from a commercial passenger jet crash. COSM. Chicago: COSM.
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  Presenter
• Dewyer, N. (2011, April). Sterile inflammation is TLR9 dependent in experimental venous thrombosis resolution. Arteriosclerosis, Thrombosis and Vascular Biology 2011 Scientific Sessions. Chicago.
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  Presenter
• Dewyer, N. (2011, Feb). The role of urokinase plasminogen activator and plasmin activator inhibitor-1 on vein wall remodeling in experimental deep vein thrombosis. 23rd Annual Meeting of the American Venous Forum. San Diego.
• Dewyer, N. (2011, Nov). Thoracoscopy versus thoracotomy for pulmonary metastasectomy. 56th Annual Southern Thoracic Surgical Association Meeting. Marco Island, FL.
• Dewyer, N. (2007, Feb). Pharmacological inhibition of the plasmin system increases matrix metalloproteinase-9 activity and decreases vein wall stiffness during venous thrombosis resolution. 2nd Annual Academic Surgical Congress. Phoenix.
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• Dewyer, N. (2005, April). Thrombogenic conditions determine vein wall injury after deep vein thrombosis. Society for Vascular Surgery's Research Initiatives in Vascular Disease Conference. Washington DC.
• Dewyer, N. (2004, April). Deep venous thrombosis resolution occurs by a fibrotic process. 16th Annual Undergraduate Research Opportunity Program Spring Research Symposium. Ann Arbor, MI.
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• Dewyer, N. (2004, Oct). Deep venous thrombosis causes vein wall fibrosis. 90th Annual Clinical Congress of the American College of Surgeons. New Orleans.

Others

• Dewyer, N. (2020, Jan). Otology: tough cases and what we learned. ENT in the Desert Conference.
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  Panel moderator
• Dewyer, N. (2020, Jan). Topics in audiology: ask the experts. ENT in the Desert Conference.
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  Panel moderator
• Dewyer, N. (2020, June). Cochlear implants: a gift of sound. Banner Health Teach Me article.
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  Article:https://www.bannerhealth.com/healthcareblog/teach-me/cochlear-implants-a-gift-of-sound
• Dewyer, N. (2020, Oct). Are earbuds putting your hearing at risk?. Banner Health Teach Me article.
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  Article:https://www.bannerhealth.com/healthcareblog/teach-me/are-earbuds-putting-your-hearing-at-risk
• Dewyer, N. (2019, Jan). Topics in otology. ENT in the Desert Conference.
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  Panelist