David Stephen Margolis

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Journals/Publications

• Margolis, D. S. (2023). Polymer Ceramic Composites for Fused Deposition Modeling of Biomimetic Bone Scaffolds.. Results in Engineering.
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  Figueroa G, Maldonado SR, Arciniaga LF, Gonzalez DA, Barron E, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. Polymer Ceramic Composites for Fused Deposition Modeling of Biomimetic Bone Scaffolds. In Review, September 2023 in Biomedical Engineering Advances.
• Margolis, D. S. (2023).

  Robot and ultrasound assisted needle insertion to the transverse carpal ligament.

  . Clinical Biomechanics, 101. doi:10.1016/j.clinbiomech.2022.105851
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  Hawk JL, Zhang H, Margolis DS, Li ZM. Robot and ultrasound assisted needle insertion to the transverse carpal ligament, Clinical Biomechanics 2023. 101:105851. PMID: 36516561.
• Margolis, D. S. (2023). Morphine-induced osteolysis and hypersensitivity is mediated via TLR4 in a murine model of metastatic breast cancer.. Pain, 164(11), 2463-2476. doi:10.1097/j.pain.0000000000002953
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  Thompson AL, Grenald SA, Ciccone HA, Mohty D, Smith AF, Coleman DL, Bahramnejad, E, DeLeon E, Kasper-Connella L, Uhrlaub JL, Margolis DS, Salvemini D, Largent-Milnes TM, Vanderah TW. Morphine-induced osteolysis and hypersensitivity is mediated via TLR4 in a murine model of metastatic breast cancer. Pain. Nov 1, 2023;164(11):2463-2476. PMID: 37326644.
• Margolis, D. S. (2021). A Large Segmental Mid-diaphyseal Femoral Defect Sheep Model: Surgical Technique. Journal of Investigative Surgery.
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  A Large Segmental Mid-diaphyseal Femoral Defect Sheep Model: Surgical Technique David S Margolis, Efren Barron Villalobos, Jordan L Smith, Cynthia J Doane, David A Gonzales, John A Szivek. Submitted to Journal of Investigative Surgery February 2021
• Margolis, D. S. (2022). Dose- and time-dependent effects of collagenase clostridium histolyticum injection on traverse carpal ligament elastic modulus and thickness in vitro. PLOS ONE, 17(12). doi:10.1371/journal.pone.0277187
• Margolis, D. S. (2022).  A large Mid-Diaphyseal Femoral Defect Sheep Model: Surgical Technique. Journal of Investigative Surgery, 35(6), 1287-1295. doi:doi: 10.1080/08941939.2022.2045393
• Margolis, D. S., Hawk, J., Daulat, S., & Li, Z. (2022). Dose- and time-dependent effects of collagenase clostridium histolyticum injection on transverse carpal ligament elastic modulus and thickness in vitro.  https://doi.org/10.1371/journal.pone.0277187. PLOS ONE.
• Margolis, D. S. (2021). Osseosurface electronics – wireless, fully-implantable electronics grown on the bone. Nature Communications.
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  Osseosurface electronics – wireless, fully-implantable electronics grown on the bone Le Cai1, David A. Gonzales2, Amirhossein Azami1, Roberto Peralta3, Megan Johnson1, Jacob A. Bakall Loewgren1, John A. Szivek2, David S. Margolis2*, Philipp Gutruf1,4*
• Margolis, D. S. (2016). Predicting Vancouver types B1 and B2 periprosthetic fractures of the femur.. University of New Mexico Orthpaedics Research Journal, 5, 36-39.
• Margolis, D. S., Bennett, D. M., Koehler, L. R., Radelet, M. J., Lu, Z., Pedri, T. G., Decker, M. M., & Miller, M. D. (2016). Predicting Vancouver types B1 and B2 periprosthetic fractures of the femur.. University of New Mexico Orthopaedics Research Journal, 5, 36-39.
• Matthews, J. R., Margolis, D. S., Wu, E., & Truchan, L. M. (2015). Brachial Plexopathy Following Use of Recombinant Human BMP-2 for Treatment of Atrophic Delayed Union of the Clavicle. JBJS case connector, 5(3), e81-e5.
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  Although recombinant human bone morphogenetic protein-2 (rhBMP-2) is approved for treatment of open tibial fractures and anterior lumbar interbody fusion, off-label use has been associated with complications such as local inflammation, osteolysis, and dysphagia. This case report describes a patient treated with rhBMP-2 for an atrophic delayed union of a clavicular fracture who subsequently developed a profound motor and sensory brachial plexopathy.
• Thai, J. N., Pacheco, J. A., Margolis, D. S., Swartz, T., Massey, B. Z., Guisto, J. A., Smith, J. L., & Sheppard, J. E. (2015). Evidence-based Comprehensive Approach to Forearm Arterial Laceration. The western journal of emergency medicine, 16(7), 1127-34.
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  Penetrating injury to the forearm may cause an isolated radial or ulnar artery injury, or a complex injury involving other structures including veins, tendons and nerves. The management of forearm laceration with arterial injury involves both operative and nonoperative strategies. An evolution in management has emerged especially at urban trauma centers, where the multidisciplinary resource of trauma and hand subspecialties may invoke controversy pertaining to the optimal management of such injuries. The objective of this review was to provide an evidence-based, systematic, operative and nonoperative approach to the management of isolated and complex forearm lacerations. A comprehensive search of MedLine, Cochrane Library, Embase and the National Guideline Clearinghouse did not yield evidence-based management guidelines for forearm arterial laceration injury. No professional or societal consensus guidelines or best practice guidelines exist to our knowledge.
• Margolis, D. S., Wu, E. W., & Truchan, L. M. (2013). Axonal loss in murine peripheral nerves following exposure to recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge. The Journal of bone and joint surgery. American volume, 95(7), 611-9.
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  With the proven efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) to treat open tibial fractures and promote spine fusion, there has been an increase in its off-label use. Recent studies have shown that BMPs play a role in nerve development and regeneration. Little is known about changes that result when rhBMP-2 is used in the vicinity of peripheral nerves. The purpose of this study is to characterize changes in peripheral nerves following exposure to rhBMP-2-soaked collagen sponges.
• Wild, J. R., Askam, B. M., Margolis, D. S., Geffre, C. P., Krupinski, E. A., & Truchan, L. M. (2012). Biomechanical evaluation of suture-augmented locking plate fixation for proximal third fractures of the olecranon. Journal of orthopaedic trauma, 26(9), 533-8.
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  To describe a method of suture augmentation of locking plate fixation (PF) of proximal olecranon fractures and to evaluate the biomechanical effectiveness of the suture augmentation using a human cadaveric model.
• Geffre, C. P., Finkbone, P. R., Bliss, C. L., Margolis, D. S., & Szivek, J. A. (2010). Load measurement accuracy from sensate scaffolds with and without a cartilage surface. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 23(3), 156-62.
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  ABSTRACT The use of "sensate" scaffolds covered with tissue-engineered cartilage has emerged as a possible treatment option for focal articular cartilage defects. The ability to monitor joint loading provides several benefits that can be useful in both clinical and research situations. Previous studies have shown that these scaffolds can accurately monitor in vivo joint loading during various activities. However, the effect that an articular cartilage layer or soft tissue overgrowth has on scaffold sensitivity has not been tested. Eight scaffolds were tested with cartilage samples taken from four hounds. Three strain gauges were attached to each scaffold and a servo hydraulics system was used to test sensitivity while the scaffold was in contact with cartilage, metal, or silicone surfaces. Strain gauge sensitivity was calculated from load and strain measurements collected during testing. There was no significant difference between the mean strain gauge sensitivities when the scaffolds were in contact with the different surfaces: cartilage 30.9 +/- 16.2 muepsilon/N, metal 31.8 +/- 18.6 muepsilon/N, and silicone 30.6 +/- 12.3 muepsilon/N. These results indicate that "sensate" scaffolds can be calibrated and used to monitor load with the presence of an articular cartilage layer.
• Geffre, C. P., Ochoa, J., Margolis, D. S., & Szivek, J. A. (2010). Evaluation of the osteogenic performance of calcium phosphate-chitosan bone fillers. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 23(3), 134-41.
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  There has been recent interest in utilizing calcium phosphates (CaPs) that set in situ for treating bone defects due to the limitations associated with morselized autografts and allografts. However, CaP cements have long setting times, poor mechanical properties, and poor osteoinductivity. This has prompted research toward finding a nonprotein-based compound, such as chitosan, to accelerate setting times and increase osteoinductivity. The purpose of this study was to compare bone growth rates during the early bone healing response achieved using conventionally prepared chitosan-CaP bone filler to an extensively purified chitosan-CaP compound. Both compounds set quickly and stimulated bone formation. Histomorphometry demonstrated a 290% increase in new bone formation when using the conventional chitosan-CaP bone filler and a 172% increase with the highly purified chitosan-CaP compound compared to the increase in bone formation seen with the unfilled control group. The results of this study indicate that a highly purified chitosan-CaP paste stimulated less bone formation than a conventionally prepared chitosan-CaP paste but both pastes have the potential to stimulate bone formation.
• Geffre, C. P., Margolis, D. S., Ruth, J. T., DeYoung, D. W., Tellis, B. C., & Szivek, J. A. (2009). A novel biomimetic polymer scaffold design enhances bone ingrowth. Journal of biomedical materials research. Part A, 91(3), 795-805.
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  There has been recent interest in treating large bone defects with polymer scaffolds because current modalities such as autographs and allographs have limitations. Additionally, polymer scaffolds are utilized in tissue engineering applications to implant and anchor tissues in place, promoting integration with surrounding native tissue. In both applications, rapid and increased bone growth is crucial to the success of the implant. Recent studies have shown that mimicking native bone tissue morphology leads to increased osteoblastic phenotype and more rapid mineralization. The purpose of this study was to compare bone ingrowth into polymer scaffolds created with a biomimetic porous architecture to those with a simple porous design. The biomimetic architecture was designed from the inverse structure of native trabecular bone and manufactured using solid free form fabrication. Histology and muCT analysis demonstrated a 500-600% increase in bone growth into and adjacent to the biomimetic scaffold at five months post-op. This is in agreement with previous studies in which biomimetic approaches accelerated bone formation. It also supports the applicability of polymer scaffolds for the treatment of large tissue defects when implanting tissue-engineering constructs. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009.
• Tellis, B. C., Szivek, J. A., Bliss, C. L., Margolis, D. S., Vaidyanathan, R. K., & Calvert, P. (2009). Trabecular scaffolds created using micro CT guided fused deposition modeling. Materials science & engineering. C, Materials for biological applications, 28(1), 171-178.
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  Free form fabrication and high resolution imaging techniques enable the creation of biomimetic tissue engineering scaffolds. A 3D CAD model of canine trabecular bone was produced via micro CT and exported to a fused deposition modeler, to produce polybutylene terephthalate (PBT) trabeculated scaffolds and four other scaffold groups of varying pore structures. The five scaffold groups were divided into subgroups (n=6) and compression tested at two load rates (49 N/s and 294 N/s). Two groups were soaked in a 25 °C saline solution for 7 days before compression testing. Micro CT was used to compare porosity, connectivity density, and trabecular separation of each scaffold type to a canine trabecular bone sample. At 49 N/s the dry trabecular scaffolds had a compressive stiffness of 4.94±1.19 MPa, similar to the simple linear small pore scaffolds and significantly more stiff (p
• Geffre, C. P., Bliss, C. L., Szivek, J. A., Deyoung, D. W., Ruth, J. T., & Margolis, D. S. (2008). Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time. Journal of biomedical materials research. Part B, Applied biomaterials, 84(1), 263-70.
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  Polymer scaffolds have been used as a tool to provide growth and integration of engineered tissue substrates to repair damaged tissues in many organ systems including articular cartilage. Previous work has shown that "sensate" scaffolds, with integrated strain gauges have the potential for use as both a delivery vehicle for engineered cartilage as well as a device that can measure real time, in vivo joint loading. The purpose of this study was to use an implanted subminiature telemetry system to collect in vivo joint loading measurements over an extended period following placement of a "sensate" scaffold. Measurements were collected from seven of nine sensors that were implanted into the stifles of three canines. The limb loading rates and load distribution through gait were dependent on stride time but did not vary with time post op. The peak loads were not dependent on stride time but significantly increased with time post op. This demonstrated that peak loading measured with "sensate" scaffolds can be used to monitor healing. The portability of the "sensate" scaffolds coupled to telemetry systems highlights the potential use of this system in a clinical research setting to gather important information to improve tissue engineering and rehabilitation regimens.
• Margolis, D. S., Szivek, J. A., Lai, L. W., & Lien, Y. H. (2008). Phenotypic characteristics of bone in carbonic anhydrase II-deficient mice. Calcified tissue international, 82(1), 66-76.
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  Carbonic anhydrase II (CAII)-deficient mice were created to study the syndrome of CAII deficiency in humans including osteopetrosis, renal tubular acidosis, and cerebral calcification. Although CAII mice have renal tubular acidosis, studies that analyzed only cortical bones found no changes characteristic of osteopetrosis. Consistent with previous studies, the tibiae of CAII-deficient mice were significantly smaller than those of wild-type (WT) mice (28.7 +/- 0.9 vs. 43.6 +/- 3.7 mg; p < 0.005), and the normalized cortical bone volume of CAII-deficient mice (79.3 +/- 2.2%) was within 5% of that of WT mice (82.7 +/- 2.3%; p < 0.05), however, metaphyseal widening of the tibial plateau was noted in CAII-deficient mice, consistent with osteopetrosis. In contrast to cortical bone, trabecular bone volume demonstrated a nearly 50% increase in CAII-deficient mice (22.9 +/- 3.5% in CAII, compared to 15.3 +/- 1.6% in WT; p < 0.001). In addition, histomorphometry demonstrated that bone formation rate was decreased by 68% in cortical bone (4.77 +/- 1.65 microm3/microm2/day in WT vs. 2.07 +/- 1.71 microm3/microm2/day in CAII mice; p < 0.05) and 55% in trabecular bone (0.617 +/- 0.230 microm3/microm2/day in WT vs. 0.272 +/- 0.114 microm3/microm2/day in CAII mice; p < 0.05) in CAII-deficient mice. The number of osteoclasts was significantly increased (67%) in CAII-deficient mice, while osteoblast number was not different from that in WT mice. The metaphyseal widening and changes in the trabecular bone are consistent with osteopetrosis, making the CAII-deficient mouse a valuable model of human disease.
• Bliss, C. L., Szivek, J. A., Tellis, B. C., Margolis, D. S., Schnepp, A. B., & Ruth, J. T. (2007). Sensate scaffolds can reliably detect joint loading. Journal of biomedical materials research. Part B, Applied biomaterials, 81(1), 30-9.
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  Treatment of cartilage defects is essential to the prevention of osteoarthritis. Scaffold-based cartilage tissue engineering shows promise as a viable technique to treat focal defects. Added functionality can be achieved by incorporating strain gauges into scaffolds, thereby providing a real-time diagnostic measurement of joint loading. Strain-gauged scaffolds were placed into the medial femoral condyles of 14 adult canine knees and benchtop tested. Loads between 75 and 130 N were applied to the stifle joints at 30 degrees, 50 degrees, and 70 degrees of flexion. Strain-gauged scaffolds were able to reliably assess joint loading at all applied flexion angles and loads. Pressure sensitive films were used to determine joint surface pressures during loading and to assess the effect of scaffold placement on joint pressures. A comparison of peak pressures in control knees and joints with implanted scaffolds, as well as a comparison of pressures before and after scaffold placement, showed that strain-gauged scaffold implantation did not significantly alter joint pressures. Future studies could possibly use strain-gauged scaffolds to clinically establish normal joint loads and to determine loads that are damaging to both healthy and tissue-engineered cartilage. Strain-gauged scaffolds may significantly aid the development of a functional engineered cartilage tissue substitute as well as provide insight into the native environment of cartilage.
• Szivek, J. A., Margolis, D. S., Schnepp, A. B., Grana, W. A., & Williams, S. K. (2007). Selective cell proliferation can be controlled with CPC particle coatings. Journal of biomedical materials research. Part A, 81(4), 939-47.
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  To develop implantable, engineered, cartilage constructs supported by a scaffold, techniques to encourage rapid tissue growth into, and on the scaffold are essential. Preliminary studies indicated that human endothelial cells proliferated at different rates on different calcium phosphate ceramic (CPC) particles. Judicious selection of particles may encourage specific cell proliferation, leading to an ordered growth of tissues for angiogenesis, osteogenesis, and chondrogenesis. The goal of this study was to identify CPC surfaces that encourage bone and vascular cell growth, and other surfaces that support chondrocyte growth while inhibiting proliferation of vascular cells. Differences in bone and vascular cell proliferation were observed when using epoxy without embedded CPCs to encourage bone cells, and when three CPCs were tested, which encouraged vascular cell proliferation. One of these (CPC 7) also substantially depressed cartilage cell proliferation. Only one small-diameter crystalline CPC (CPC 2) supported rapid chondrocyte proliferation, and maintained the cartilage cell phenotype.
• Margolis, D. S., Kim, D., Szivek, J. A., Lai, L. W., & Lien, Y. H. (2006). Functionally improved bone in calbindin-D28k knockout mice. Bone, 39(3), 477-84.
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  In vitro studies indicate that Calbindin-D28k, a calcium binding protein, is important in regulating the life span of osteoblasts as well as the mineralization of bone extracellular matrix. The recent creation of a Calbindin-D28k knockout mouse has provided the opportunity to study the physiological effects of the Calbindin-D28k protein on bone remodeling in vivo. In this experiment, histomorphometry, microCT, and bend testing were used to characterize bones in Calbindin-D28k KO (knockout) mice. The femora of Calbindin-D28k KO mice had significantly increased cortical bone volume (60.4% +/- 3.1) compared to wild-type (WT) mice (45.4% +/- 4.6). The increased bone volume was due to a decrease in marrow cavity area, and significantly decreased endosteal perimeters (3.397 mm +/- 0.278 in Calbindin-D28k KO mice, and 4.046 mm +/- 0.450 in WT mice). Similar changes were noted in the analysis of the tibias in both mice. The bone formation rates were similar in the femoral and tibial cortical bones of both mice. microCT analysis of the trabecular bone in the tibial plateau indicated that Calbindin-D28k KO mice had an increased bone volume (35.2% +/- 3.1) compared to WT mice (24.7% +/- 4.9) which was primarily due to increased trabecular number (8.99 mm(-1) +/- 0.94 in Calbindin-D28k KO mice compared to 6.75 mm(-1) +/- 0.85 in WT mice). Bone mineral content analysis of the tibias indicated that there is no difference in the calcium or phosphorus content between the Calbindin-D28k KO and WT mice. Cantilever bend testing of the femora demonstrated significantly lower strains in the bones of Calbindin-D28k KO mice (4135 micro strain/kg +/- 1266) compared to WT mice (6973 micro strain/kg +/- 998) indicating that the KO mice had stiffer bones. Three-point bending demonstrated increased failure loads in bones of Calbindin-D28k KO mice (31.6 N +/- 2.1) compared to WT mice (15.0 N +/- 1.7). In conclusion, Calbindin-D28k KO mice had increased bone volume and stiffness indicating that Calbindin-D28k plays an important role in bone remodeling.
• Szivek, J. A., Bliss, C. L., Geffre, C. P., Margolis, D. S., DeYoung, D. W., Ruth, J. T., Schnepp, A. B., Tellis, B. C., & Vaidyanathan, R. K. (2006). An instrumented scaffold can monitor loading in the knee joint. Journal of biomedical materials research. Part B, Applied biomaterials, 79(2), 218-28.
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  No technique has been consistently successful in the repair of large focal defects in cartilage, particularly in older patients. Tissue-engineered cartilage grown on synthetic scaffolds with appropriate mechanical properties will provide an implant, which could be used to treat this problem. A means of monitoring loads and pressures acting on cartilage, at the defect site, will provide information needed to understand integration and survival of engineered tissues. It will also provide a means of evaluating rehabilitation protocols. A "sensate" scaffold with calibrated strain sensors attached to its surface, combined with a subminiature radio transmitter, was developed and utilized to measure loads and pressures during gait. In an animal study utilizing six dogs, peak loads of 120N and peak pressures of 11 MPa were measured during relaxed gait. Ingrowth into the scaffold characterized after 6 months in vivo indicated that it was well anchored and bone formation was continuing. Cartilage tissue formation was noted at the edges of the defect at the joint-scaffold interfaces. This suggested that native cartilage integration in future formulations of this scaffold configured with engineered cartilage will be a possibility.
• Szivek, J. A., Margolis, D. S., Garrison, B. K., Nelson, E., Vaidyanathan, R. K., & DeYoung, D. W. (2005). TGF-beta1-enhanced TCP-coated sensate scaffolds can detect bone bonding. Journal of biomedical materials research. Part B, Applied biomaterials, 73(1), 43-53.
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  Porous polybutylene terephthalate (PBT) scaffold systems were tested as orthopedic implants to determine whether these scaffolds could be used to detect strain transfer following bone growth into the scaffold. Three types of scaffold systems were tested: porous PBT scaffolds, porous PBT scaffolds with a thin beta-tricalcium phosphate coating (LC-PBT), and porous PBT scaffolds with the TCP coating vacuum packed into the scaffold pores (VI-PBT). In addition, the effect of applying TGF-beta1 to scaffolds as an enhancement was examined. The scaffolds were placed onto the femora of rats and left in vivo for 4 months. The amount of bone ingrowth and the strain transfer through various scaffolds was evaluated by using scanning electron microscopy, histology, histomorphometry, and cantilever bend testing. The VI-PBT scaffold showed the highest and most consistent degree of mechanical interaction between bone and scaffold, providing strain transfers of 68.5% (+/-20.6) and 79.2% (+/-8.7) of control scaffolds in tension and compression, respectively. The strain transfer through the VI-PBT scaffold decreased to 29.1% (+/-24.3) and 30.4% (+/-25.8) in tension and compression when used with TGF-beta1. TGF-beta1 enhancement increased the strain transfer through LC-PBT scaffolds in compression from 9.4% (+/-8.7) to 49.7% (+/-31.0). The significant changes in mechanical strain transfer through LC-PBT and VI-PBT scaffolds correlated with changes in bone ingrowth fraction, which was increased by 39.6% in LC-PBT scaffolds and was decreased 21.3% in VI-PBT scaffolds after TGF-beta1 enhancement. Overall, the results indicate that strain transfer through TCP-coated PBT scaffolds correlate with bone ingrowth after implantation, making these instrumented scaffolds useful for monitoring bone growth by monitoring strain transfer.
• Szivek, J. A., Roberto, R. F., & Margolis, D. S. (2005). In vivo strain measurements from hardware and lamina during spine fusion. Journal of biomedical materials research. Part B, Applied biomaterials, 75(2), 243-50.
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  Currently, spine fusion is determined using radiography and clinical evaluation. There are discrepancies between radiographic evidence and direct measurements of fusion, such as operative exploration and biomechanical or histological measurements. In order to facilitate the rapid return of patients to normal activities, a monitoring technique to accurately detect fusion in vivo and to prevent overload during the postoperative period would be useful. The objectives of this study were to develop an implantable monitoring system consisting of CPC-coated strain gauges and a radio transmitter to detect the onset of fusion and measure strain during postsurgical activities. A patient underwent anterior release and fusion, followed by posterior instrumentation and fusion with segmental spinal instrumentation. Four strain gauges were placed during surgery. One was attached to the left-side rod and one to each of the lamina at T9, T10, and T11. An externally powered implanted radio transmitter attached to the gauges was placed in a subcutaneous pouch. Strains were monitored weekly and tabulated during various activities for 7 months. Peak strains during twisting and bending were tabulated to detect the onset of fusion. Strains were also recorded during activities such as climbing off an examination table, rising from a chair, and climbing stairs. Strains collected from the left rod indicated that, immediately postoperatively, it was loaded at acceptable levels. The largest and most consistent strain changes measured from the lamina were recorded during twisting.
• Margolis, D. S., Lien, Y. H., Lai, L. W., & Szivek, J. A. (2004). Bilateral symmetry of biomechanical properties in mouse femora. Medical engineering & physics, 26(4), 349-53.
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  Bone healing and remodeling are commonly examined in animal models by comparing one femur (experimental) to the contralateral femur (control) with the assumption that they are identical with respect to their biomechanical properties. While past studies have characterized the symmetry in geometrical properties in many types of animal bones, few studies have compared the symmetry in the biomechanical properties. The purpose of this study was to determine whether there is symmetry in the mechanical properties of mouse femora. Strain gauges were attached to the posterior surface of the femora of C57BL/6 mice, parallel to the long axis of the bone. The femora were mechanically tested in cantilever bending while strain values were recorded. Moments of inertia, cortical areas, and moduli of elasticity were determined from strains and cross-sectional properties. Mouse femora demonstrated an average strain difference of 0.4% in tension and 1.4% in compression. Elastic moduli differed by 6.6% and 0.9% in tension and compression, respectively, and failure strength differed by an average of 2.0%. Statistical analysis showed there were no significant differences in strain, modulus, or failure load values for the mice, indicating mechanical and geometrical symmetry of mouse femora in cantilever bending.
• Fernandez, M. M., Szivek, J. A., & Margolis, D. S. (2003). Evaluation of a new CPC-to-gauge bonding technique with the use of in vitro fluid flow. Journal of biomedical materials research. Part B, Applied biomaterials, 66(2), 514-9.
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  Strain gauging enables the measurement of bone deformation during physical activity, leading to a better understanding of the physiological effects of loading on bone growth and remodeling. Development of a technology that will withstand long-term in vivo exposure and bond securely to bone is imperative for accurate, consistent measurement collection. Polysulfone is currently used to attach calcium-phosphate ceramic (CPC) particles, which promote bone-to-gauge bonding, to polyimide-backed strain gauges. This study evaluated the use of an implant-grade epoxy as an alternative CPC-polyimide adhesive. Polyimide-epoxy-CPC interfaces were loaded to failure and shear strengths calculated. In vitro studies providing a constant flow of medium over test specimens were designed, and long-term in vitro fluid exposure studies of the epoxy's shear strength were conducted. Average shear strength of polysulfone-polyimide interfaces were reported to be 7 MPa. The average shear strength of the epoxy-polyimide interface before long-term in vitro exposure was 17 MPa, which is stronger than the shear strength of the bone-CPC interface. The strength of the epoxy-polyimide interface decreased to 6.8 MPa after 24 weeks in vitro and 3 MPa after 24 weeks in vivo.
• Earp, J. C., Margolis, D. S., Tanjaroon, C., Bitterwolf, T. E., & Kukolich, S. G. (2002). The microwave spectrum of cyclopentadienyl niobium tetracarbonyl. JOURNAL OF MOLECULAR SPECTROSCOPY, 211(1), 82-85.
• Margolis, D. S., Tanjaroon, C., & Kukolich, S. G. (2002). Measurements of microwave spectra and structural parameters for methylferrocene. JOURNAL OF CHEMICAL PHYSICS, 117(8), 3741-3747.

Presentations

• Margolis, D. S. (2023).

  Local/Regional Conferences/Presentations

             1. Childers R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. The Effect of Biomimetic Composite Scaffolds on Osteogenesis In Vivo. Poster Presentation. Mayo Clinic Symposium on Regenerative Medicine and Surgery. Scottsdale, Arizona, April 2023

  National Conferences/Presentations

  1.      Childers R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. Histology and Histomorphometry of Bone Regenerating Composite Polymer Ceramic Scaffolds in a Rat Model. Poster Presentation. Orthopaedic Research Society. Dallas, Texas, February 2023.

   2.      Margolis DS, Figueroa G, Gonzales DA, Szivek JA. Biomimetic Sensate 3D Printed Scaffolds Support Rapid Bone Regeneration and Full Weight Bearing for 2 Years in a Large Segmental Femoral Defect Model in Sheep. Poster Presentation. Orthopaedic Research Society. Dallas, Texas, February 2023.

   3.      Maldonado SR, Figueroa G, Gonzalez DA, Margolis DS. Testing of Different Hydroxyapatite Particles in Cell Culture. Poster Presentation. Society of Biomaterials, San Diego, California, April 2023.

  4.      Figueroa G, Gonzales DA, Szivek JA, Margolis DS. Dynamization Increases Bone Stiffness in Regenerated Bone with Polymer Scaffolds. Poster Presentation. Society of Biomaterials, San Diego, California, April 2023.
  
  

  5.      Childers R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. The Future of Bone Regeneration: Histological Analysis of Biomimetic Composite Scaffolds in a Rat Model. Medical Student Orthopedic Society. Virtual Conference, April 2023.

   6.      Irby M, Froio J, Petit-Miller A, Gonzales DA, Figueroa G, Margolis DS. The Response of Human Osteoblasts to Biaxial Biomimetic Patterns of Load. Medical Student Orthopedic Society. Virtual Conference, April 2023.

   7.      Hawk J, Margolis DS, Li ZM. Transverse Carpal Ligament Elongation after Injection of Collagenase In Situ. Poster Presentation. Summer Biomechanics, Bioengineering and Biotransport Conference, Vail, Colorado, June 2023.

   8.      Margolis DS, Gonzales DA, Figueroa G, Smith J, Szivek JA. Large Segmental Bone Defects in Sheep Treated with 3D Printed Scaffolds and Autologous Adipose Derived Stem Cells Demonstrate Increased Stiffness Following Hardware Removal. Poster Presentation. Military Health System Research Symposium, Kissimmee, Florida. August 2023.

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  Local/Regional Conferences/PresentationsChilders R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. The Effect of Biomimetic Composite Scaffolds on Osteogenesis In Vivo. Poster Presentation. Mayo Clinic Symposium on Regenerative Medicine and Surgery. Scottsdale, Arizona, April 2023National Conferences/PresentationsChilders R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. Histology and Histomorphometry of Bone Regenerating Composite Polymer Ceramic Scaffolds in a Rat Model. Poster Presentation. Orthopaedic Research Society. Dallas, Texas, February 2023. Margolis DS, Figueroa G, Gonzales DA, Szivek JA. Biomimetic Sensate 3D Printed Scaffolds Support Rapid Bone Regeneration and Full Weight Bearing for 2 Years in a Large Segmental Femoral Defect Model in Sheep. Poster Presentation. Orthopaedic Research Society. Dallas, Texas, February 2023. Maldonado SR, Figueroa G, Gonzalez DA, Margolis DS. Testing of Different Hydroxyapatite Particles in Cell Culture. Poster Presentation. Society of Biomaterials, San Diego, California, April 2023. Figueroa G, Gonzales DA, Szivek JA, Margolis DS. Dynamization Increases Bone Stiffness in Regenerated Bone with Polymer Scaffolds. Poster Presentation. Society of Biomaterials, San Diego, California, April 2023. Childers R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. The Future of Bone Regeneration: Histological Analysis of Biomimetic Composite Scaffolds in a Rat Model. Medical Student Orthopedic Society. Virtual Conference, April 2023. Irby M, Froio J, Petit-Miller A, Gonzales DA, Figueroa G, Margolis DS. The Response of Human Osteoblasts to Biaxial Biomimetic Patterns of Load. Medical Student Orthopedic Society. Virtual Conference, April 2023. Hawk J, Margolis DS, Li ZM. Transverse Carpal Ligament Elongation after Injection of Collagenase In Situ. Poster Presentation. Summer Biomechanics, Bioengineering and Biotransport Conference, Vail, Colorado, June 2023. Margolis DS, Gonzales DA, Figueroa G, Smith J, Szivek JA. Large Segmental Bone Defects in Sheep Treated with 3D Printed Scaffolds and Autologous Adipose Derived Stem Cells Demonstrate Increased Stiffness Following Hardware Removal. Poster Presentation. Military Health System Research Symposium, Kissimmee, Florida. August 2023.
• Margolis, D. S. (2022). See attached list of 2022 presentations x 6. See attached list of 2022 presentations x 6.
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  See attached
• Margolis, D. S. (2019, Feb). Research Day Data Blitz (presentations x 4). Research Day Data Blitz (February 13, 2019). UA College of Medicine: UA.
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  1) Cartilage Tissue Regeneration with Custom 3D Printed Scaffolds & Stem Cells2) MP-2 and Peripheral Nerve3) Rapid Bone Tissue Regeneration with Custom 3D Printed Scaffolds & Stem Cells4) Real Time In Vivo Bone and Implant Strain Measurement
• Margolis, D. S. (2019, Jan). Patient Specific Scaffolds for Treatment of Scaphoid Fractures and Nonunions with Significant Bone Loss. Auual AAHS meeting. Palm Desert, California: AAHS.
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  Margolis DS, Larson DN, Gonzales DA, Szivek JA. Patient Specific Scaffolds for Treatment of Scaphoid Fractures and Nonunions with Significant Bone Loss. Annual Meeting of the American Association for Hand Surgery. Palm Desert, California, January 2019.
• Margolis, D. S. (2017, June). Development and Testing of a Long Bone Segment Regenerating Scaffold for Patients.. Summer Biomechanics, Bioengineering and Biotransport Conference.. Tucson, Arizona: SB3C.

Poster Presentations

• Margolis, D. S. (2022, February). In Situ Needle Insertion to the Transverse Carpal Ligament Using Robot-assisted Ultrasound. ORS Annual Meeting. Tampa, Florida: ORS.
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  In Situ Needle Insertion to the Transverse Carpal Ligament Using Robot-assisted Ultrasounds, Jocelyn Hawk, Hu Zhang, David Margolis, Zong-Ming-Li,, Orthopaedic Research Society, Tampa Florida, Feb. 2022
• Margolis, D. S. (2022, February). Mechanical Testing and Histological Analysis of Bone Growth into Bioresorbable Porous 3D Composite Scaffolds. ORS Annual Meeting. Tampa, Florida: ORS.
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  Mechanical Testing and Histological Analysis of Bone Growth into Bioresorbable Porous 3D Composite Scaffolds, Robert Childers, Gerardo Figueroa, David A. Gonzales, Efren Barron Villalobos, Luis F. Arciniaga, Douglas A. Loy, Krishna Muralidharan, Barrett G. Potter, John A. Szivek, David S. Margolis, Orthopaedic Research Society, Tampa Florida, Feb. 2022
• Margolis, D. S. (2022, January). Bone Ingrown Dynamized Long Bone Segment Regeneration Scaffolds Successfully Support Full Body Weight within 9 Months. Society for Biomaterials Combined Meeting. Honolulu HI: Society for Biomaterials Combined Meeting.
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  Bone Ingrown Dynamized Long Bone Segment Regeneration Scaffolds Successfully Support Full Body Weight within 9 Months, JA Szivek, DS Margolis, DA Gonzales, EB Villalobos, J Smith, Society for Biomaterials Combined Meeting, Honolulu HI, Jan 2022
• Margolis, D. S. (2022, January). Quantitative CT Analysis and Mechanical Coupling of Implanted Bioresorbable Composite Scaffolds to Bone (see attached). Society for Biomaterials Combined Meeting (Jan 7-10, 2022)Society for Biomaterials Combined Meeting.
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  Quantitative CT Analysis and Mechanical Coupling of Implanted Bioresorbable Composite Scaffolds to Bone, Gerardo Figueroa, David A. Gonzales, Erick DeLeon, Anthony Romero, Efren Villalobos, Louis F. Arciniaga, Doug A. Loy, Krishna Muralidharan, Barrett G. Potter, John A. Szivek, David S. Margolis, Society for Biomaterials Combined Meeting, Honolulu HI, Jan 2022.
• Margolis, D. S. (2022, January). Quantitative CT Analysis and Mechanical Coupling of Implanted Bioresorbable Composite Scaffolds to Bone. Society for Biomaterials Combined MeetingSociety for Biomaterials Combined Meeting.
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  Quantitative CT Analysis and Mechanical Coupling of Implanted Bioresorbable Composite Scaffolds to Bone, Gerardo Figueroa, David A. Gonzales, Erick DeLeon, Anthony Romero, Efren Villalobos, Louis F. Arciniaga, Doug A. Loy, Krishna Muralidharan, Barrett G. Potter, John A. Szivek, David S. Margolis, Society for Biomaterials Combined Meeting, Honolulu HI, Jan 2022.
• Margolis, D. S. (2020, Feb 2020). Peer Refereed Abstract: Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization and Rod Removal. Orthopaedic Research Society Annual MeetingORS.
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  Szivek JA, Barron E, Gonzales DA, Margolis DS. Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization and Rod Removal. Orthopaedic Research Society. Phoenix, Arizona, February 2020.
• Margolis, D. S. (2020, Feb 2020). Peer Refereed Abstract: Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds for Bone Tissue Regeneration. ORS Annual Meeting. Phoenix, AZ: ORS.
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  Arciniaga LF, Rajendran V, Loy DA, Barron E, Gonzales DA, Szivek JA, Margolis DS. Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds for Bone Tissue Regeneration. Orthopaedic Research Society. Phoenix, Arizona, February 2020
• Margolis, D. S. (2020, Feb 2020). Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation of Stem Cells.. ORS Annual Meeting. Phoenix, AZ: ORS.
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  Barron E, Arciniaga LF, Rajendran V, Gonzales DA, Loy DA, Szivek JA, Margolis DS. Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation of Stem Cells. Orthopaedic Research Society. Phoenix, Arizona, February 2020.
• Margolis, D. S. (2020, Feb). Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization and Rod Removal. Annual ORS Meeting. Phoenix, Arizona.
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  Szivek JA, Barron E, Gonzales DA, Margolis DS. Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization and Rod Removal. Orthopaedic Research Society. Phoenix, Arizona, February 2020.
• Margolis, D. S. (2020, Feb). Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds for Bone Tissue Regeneration. Annual ORS Meeting. Phoenix, Arizona: ORS.
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  Arciniaga LF, Rajendran V, Loy DA, Barron E, Gonzales DA, Szivek JA, Margolis DS. Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds for Bone Tissue Regeneration. Orthopaedic Research Society. Phoenix, Arizona, February 2020.
• Margolis, D. S. (2020, Feb). Polymer Ceramic Hybrid Scaffolds for Bone Tissue Regeneration. Annual ORS Meeting. Phoenix, Arizona: ORS.
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  Arciniaga LF, Rajendran V, Loy DA, Barron E, Gonzales DA, Szivek JA, Margolis DS. Polymer Ceramic Hybrid Scaffolds for Bone Tissue Regeneration. Society of Hispanic Professional Engineers National Convention. Phoenix, Arizona, October 2019.
• Margolis, D. S. (2020, Feb). Poster Presentation: Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization And Rod Removal. ORS Annual Meeting, Feb 8-11, 2020. Phoenix: ORS.
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  Poster No. 910 Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization And Rod Removal John A. Szivek; Efren Barron Villalobos; David A. Gonzales; David S. Margolis
• Margolis, D. S. (2020, Feb). Poster Presentation: Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds For Bone Tissue Regeneration. ORS Annual Meeting, Feb 8-11, 2020. Phoenix: ORS.
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  Poster No. 558 Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds For Bone Tissue Regeneration Luis F. Arciniaga; Vishakk Rajendran; Douglas A. Loy; Efren Barron Villalobos; David A. Gonzales; John A. Szivek; David S. Margolis
• Margolis, D. S. (2020, Feb). Poster Presentation: Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation Of Stem Cells. ORS Annual Meeting, Feb 8-11, 2020. Phoenix: ORS.
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  Poster No. 1440 Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation Of Stem Cells Efren Barron Villalobos; Luis F. Arciniaga; Vishakk Rajendran; David A. Gonzales; Douglas A. Loy; John A. Szivek; David S. Margolis
• Margolis, D. S. (2020, Feb). Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation of Stem Cells. Annual ORS Meeting. Phoenix, Arizona: ORS.
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  Barron E, Arciniaga LF, Rajendran V, Gonzales DA, Loy DA, Szivek JA, Margolis DS. Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation of Stem Cells. Orthopaedic Research Society. Phoenix, Arizona, February 2020.
• Margolis, D. S. (2021, April). Poster Presentation. Society for Biomaterials Annual Meeting, April 20-23, 2021. Virtual: Society for Biomaterials.
• Margolis, D. S. (2021, Feb). Poster Presentation: Achilles Tendon Recovery After Ciprofloxacin Induced Tendinopathy. ORS Annual Meeting, Feb 12-16, 2021. Virtual: ORS.
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  POSTER #: 1680-LB POSTER TITLE: Achilles Tendon Recovery After Ciprofloxacin Induced Tendinopathy AUTHORS: DAVID FALGOUT; Efren Villalobos; Mikayla Campagne; David Gonzales; Filiberto Quintero; Jolene Hardy; David Margolis
• Margolis, D. S. (2021, Feb). Poster Presentation: High Strength Composite Polymer-Ceramic Biomimetic Scaffolds For Bone Tissue Engineering. ORS Annual Meeting, Feb 12-16, 2021. Virtual: ORS.
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  POSTER TITLE: High Strength Composite Polymer-Ceramic Biomimetic Scaffolds For Bone Tissue Engineering AUTHORS: Louis F. Arciniaga; Efren Barron Villalobos; Vishakk Rajendran; David A. Gonzales; Doug A. Loy; Krishna Muralidharan; Barrett G. Potter; John A. Szivek; David S. Margolis
• Margolis, D. S. (2021, Feb). Poster Presentation: Polymer Ceramic Biomimetic Scaffolds Support Osteoblastic Differentiation Of Stem Cells In Vitro. ORS Annual Meeting, Feb 12-16, 2021. Virtual: ORS.
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  POSTER #: 0440 POSTER TITLE: Polymer Ceramic Biomimetic Scaffolds Support Osteoblastic Differentiation Of Stem Cells In Vitro AUTHORS: David S. Margolis; Efren Barron Villalobos; Louis F. Arciniaga; Vishakk Rajendran; David A. Gonzales; Doug A. Loy; Krishna Muralidharan; Barrett G. Potter; John A. Szivek
• Margolis, D. S. (2019, April). Peer Reviewed Abstract: Stem Cells are Necessary to Bridge a Critical Size Gap when a Biomimetic Scaffold is used to Regenerate a Large Segmental Femoral Defect.. Society of Biomaterials 2019 Annual Meeting. Seattle, WA: Society of Biomaterials.
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  Margolis DS, Gonzales DA, Smith JL, Szivek JA. Stem Cells are Necessary to Bridge a Critical Size Gap when a Biomimetic Scaffold is used to Regenerate a Large Segmental Femoral Defect. Society of Biomaterials. Seattle, Washington, April 2019.
• Margolis, D. S. (2019, April). Stem Cells are Necessary to Bridge a Critical Size Gap when a Biomimetic Scaffold is used to Regenerate a Large Segmental Femoral Defect.. Society of Biomaterials. Seattle, Washington.
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  Margolis DS, Gonzales DA, Smith JL, Szivek JA. Stem Cells are Necessary to Bridge a Critical Size Gap when a Biomimetic Scaffold is used to Regenerate a Large Segmental Femoral Defect. Society of Biomaterials. Seattle, Washington, April 2019.
• Margolis, D. S. (2019, January). Peer Reviewed Abstract: Patient Specific Scaffolds for Treatment of Scaphoid Fractures and Nonunions with Significant Bone Loss.. Annual Meeting of the American Association for Hand Surgery. Palm Springs, California: AAHS.
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  Margolis DS, Larson DN, Gonzales DA, Szivek JA. Patient Specific Scaffolds for Treatment of Scaphoid Fractures and Nonunions with Significant Bone Loss. Annual Meeting of the American Association for Hand Surgery. Palm Desert, California, January 2019
• Margolis, D. S. (2019, July). Peer Reviewed Abstract: Sensate Long Segment Regeneration Scaffolds Can Document Load Changes Following Dynamization. Orthopaedic Research Society 48th International Musculoskeletal Biology Workshop. Sun Valley, Idaho: ORS.
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  Szivek JA, Gonzales DA, Barron E, Margolis DS. Sensate Long Segment Regeneration Scaffolds Can Document Load Changes Following Dynamization. Orthopaedic Research Society 48th International Musculoskeletal Biology Workshop. Sun Valley, Idaho, July 2019.
• Margolis, D. S. (2019, July). Sensate Long Segment Regeneration Scaffolds Can Document Load Changes Following Dynamization. ORS 48th International Musculoskeletal Biology Workshop. Sun Valley, Idaho: Orthopaedic Research Society.
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  Szivek JA, Gonzales DA, Barron E, Margolis DS. Sensate Long Segment Regeneration Scaffolds Can Document Load Changes Following Dynamization. Orthopaedic Research Society 48th International Musculoskeletal Biology Workshop. Sun Valley, Idaho, July 2019.
• Margolis, D. S. (2019, May). Dynamic Bioreactor for Engineered Cartilage Tissue. Statewide Symposium in Regenerative Medicine. Scottsdale, Arizona.
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  Villalobos EB, Altamirano DE, Freitas SS, Gu X, Larson D, Tat T, Gonzales DA, Margolis DS. Dynamic Bioreactor for Engineered Cartilage Tissue. Statewide Symposium in Regenerative Medicine. Scottsdale, Arizona, May 2019.
• Margolis, D. S. (2019, May). Peer Reviewed Abstract: Dynamic Bioreactor for Engineered Cartilage Tissue. Statewide Symposium in Regenerative Medicine. Statewide Symposium in Regenerative Medicine.
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  Villalobos EB, Altamirano DE, Freitas SS, Gu X, Larson D, Tat T, Gonzales DA, Margolis DS. Dynamic Bioreactor for Engineered Cartilage Tissue. Statewide Symposium in Regenerative Medicine. Scottsdale, Arizona, May 2019.
• Margolis, D. S. (2019, May). Peer Reviewed Abstract: Treatment of Scaphoid Fractures with Significant Bone Loss using Patient Specific 3D Polymer Scaffolds.. Statewide Symposium in Regenerative Medicine. Scottsdale, Arizona: AZ State University.
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  Margolis DS, Larson DN, Gonzales DA, Szivek JA. Treatment of Scaphoid Fractures with Significant Bone Loss using Patient Specific 3D Polymer Scaffolds. Statewide Symposium in Regenerative Medicine. Scottsdale, Arizona, May 2019
• Margolis, D. S. (2019, May). Treatment of Scaphoid Fractures with Significant Bone Loss using Patient Specific 3D Polymer Scaffolds. Statewide Symposium in Regenerative Medicine. Scottsdale, Arizona.
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  Margolis DS, Larson DN, Gonzales DA, Szivek JA. Treatment of Scaphoid Fractures with Significant Bone Loss using Patient Specific 3D Polymer Scaffolds. Statewide Symposium in Regenerative Medicine. Scottsdale, Arizona, May 2019.
• Margolis, D. S. (2019, Oct). Efficacy and Long-Term Stability of a High-Density Intramuscular Electrode System for Functional Electrical Stimulation.. Annual Meeting of the Society for Neuroscience.. Chicago, Illinois: Society for Neuroscience.
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  Holly NL, Hasse BA, Cox L, Margolis DS, Gothard KM, Fuglevand AJ. Efficacy and Long-Term Stability of a High-Density Intramuscular Electrode System for Functional Electrical Stimulation. Annual Meeting of the Society for Neuroscience. Chicago, Illinois, October 2019.
• Margolis, D. S. (2019, Oct). Implantable sensors to monitor and treat skeletal pathology. Innovations and Inventions (Annual Fall event). UA Health Sciences Innovation Building.
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  This event focuses on the people behind the cutting-edge research at the College. The purpose of the event is to provide a networking platform for researchers from the College of Medicine – Tucson and around the UA.
• Margolis, D. S. (2019, Oct). Peer Reviewed Abstract: Efficacy and Long-Term Stability of a High-Density Intramuscular Electrode System for Functional Electrical Stimulation.. Annual Meeting of the Society for Neuroscience. Chicago, IL: Society for Neuroscience.
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  Holly NL, Hasse BA, Cox L, Margolis DS, Gothard KM, Fuglevand AJ. Efficacy and Long-Term Stability of a High-Density Intramuscular Electrode System for Functional Electrical Stimulation. Annual Meeting of the Society for Neuroscience. Chicago, Illinois, October 2019
• Margolis, D. S. (2019, Oct). Peer Reviewed Abstract: Polymer Ceramic Hybrid Scaffolds for Bone Tissue Regeneration. Society of Hispanic Professional Engineers National Convention. Phoenix, Arizona: Society of Hispanic Professional Engineers.
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  Arciniaga LF, Rajendran V, Loy DA, Barron E, Gonzales DA, Szivek JA, Margolis DS. Polymer Ceramic Hybrid Scaffolds for Bone Tissue Regeneration. Society of Hispanic Professional Engineers National Convention. Phoenix, Arizona, October 2019.
• Margolis, D. S. (2019, Sept). Development of a Porcine Model to Treat Scaphoid Nonunion with 3D Printed Scaffolds.. Annual ASSH Meeting. Las Vegas, Nevada: ASSH.
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  iPoster: Margolis DS, Larson DN, Villalobos EB, Gonzales DA, Szivek JA. Development of a Porcine Model to Treat Scaphoid Nonunion with 3D Printed Scaffolds. 74th Annual Meeting of the American Society for Surgery of the Hand. Las Vegas, Nevada, September, 2019.
• Margolis, D. S. (2019, Sept). Peer Reviewed Abstract: Development of a Porcine Model to Treat Scaphoid Nonunion with 3D Printed Scaffolds. 74th Annual Meeting of the American Society for Surgery of the Hand. Las Vegas, Nevada: ASSH.
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  Margolis DS, Larson DN, Villalobos EB, Gonzales DA, Szivek JA. Development of a Porcine Model to Treat Scaphoid Nonunion with 3D Printed Scaffolds. 74th Annual Meeting of the American Society for Surgery of the Hand. Las Vegas, Nevada, September, 2019.
• Margolis, D. S., Szivek, J. A., Buchak, J., Wojtanowski, A. M., Gonzales, D. A., Barreda, A., & Smith, J. L. (2017, June). Development and Testing of a Long Bone Segment Regenerating Scaffold for Patients.. Summer Biomechanics, Bioengineering and Biotransport Conference. Tucson, Arizona: SB3C.