Ernest R Vina

Interests

Research

Osteoarthritis, Systemic lupus erythematosus, Racial/ethnic disparities, Decision-making, Health services research, Rheumatology

Courses

No activities entered.

Scholarly Contributions

Chapters

• Vina, E. R., & Kwoh, C. K. (2016). Osteoarthritis. In Hazzard's Geriatric Medicine and Gerontology. McGraw Hill.

Journals/Publications

• Hakim, M., Vina, E., & White, D. (2024). Disparities in knee pain and disability among historically underserved individuals with knee osteoarthritis seeking physical therapy: An exploratory study. JOSPT Open, 2(2), 125-133. doi:10.2519/josptopen.2024.1131
• Patel, J., Yao, L., Vina, E., Fleece, D., Arundathi, J., Caricchio, R., & Wu, H. (2024). Phenotype Systemic Lupus Erythematosus Patients from EPIC Cosmos. Stud Health Technol Inform, 310, 159-163.
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  Systemic Lupus Erythematosus (SLE) is a widespread autoimmune disease for which early diagnosis is paramount in improving clinical outcomes. In this project, we used the de-identified patients from Epic Cosmos to retrieve the ICD code for SLE, checked data quality based on the EULAR/ACR classification systems, created an approach to determine the SLE patients, and performed statistical analyses on lab tests and clinical characteristics. Our preliminary results showed that clinical notes must be reviewed to improve the completeness, as structured EHR data fields provide limited information in determining if a patient meets the established classification criteria.
• Vina, E. R., Patel, P., Grest, C. V., Kwoh, C. K., Jakiela, J. T., Bye, T., & White, D. K. (2024). Does Physical Activity Confound Race Differences in Osteoarthritis-Related Functional Limitation?. Arthritis care & research, 76(2), 200-207.
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  This study sought to determine the extent to which physical activity confounds the relation between race and the incidence of osteoarthritis (OA)-related functional limitation.
• Hurst, C., Soto, M., Vina, E. R., & Rodgers, K. E. (2023). Renin-Angiotensin System-Modifying Antihypertensive Drugs Can Reduce the Risk of Cardiovascular Complications in Lupus: A Retrospective Cohort Study. The American journal of medicine, 136(3), 284-293.e4.
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  Patients with systemic lupus erythematosus have a higher incidence of cardiovascular disease than the general population. Antihypertensive drugs that modify the renin-angiotensin system (RAS) are used to protect renal function in lupus nephritis and may also have extrarenal effects that lower cardiovascular disease risk due to their anti-inflammatory properties. In this study, we compared the effects of RAS vs non-RAS antihypertensive drugs on cardiovascular disease incidence in patients with lupus.
• Vina, E. R., Tsoukas, P. H., Abdollahi, S., Mody, N., Roth, S. C., Redford, A. H., & Kwoh, C. K. (2022). Racial and ethnic differences in the pharmacologic management of osteoarthritis: rapid systematic review. Therapeutic advances in musculoskeletal disease, 14, 1759720X221105011.
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  Racial and ethnic disparities in osteoarthritis (OA) patients' disease experience may be related to marked differences in the utilization and prescription of pharmacologic treatments.
• Vina, E. R., & Quinones, C. (2021). Understanding the Role and Challenges of Patient Preferences in Disparities in Rheumatologic Disease Care. Rheumatic diseases clinics of North America, 47(1), 83-96.
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  Evidence suggests patient preferences, including values and perspectives, have affected clinical outcomes, such as compliance, patient well-being, and satisfaction with care. A literature review was conducted with the purpose of exploring the tools used to elicit patients' treatment preferences and their roles in clinical outcomes. This review revealed racial differences in treatment preferences among patients with rheumatic and musculoskeletal diseases. The use of decision aids is a proactive intervention with potential for reducing race disparities and improving clinical outcomes. The utilization of patient preferences and values can improve outcomes by complementing the shared decision-making approach between patients and rheumatologists.
• Vina, E. R., Hannon, M. J., Quinones, C., Hausmann, L. R., Ibrahim, S. A., Dagnino, J., & Kwoh, C. K. (2021). The Role of Knowledge and Attitudes About Nonsteroidal Anti-inflammatory Drugs in Determining Treatment Use. ACR open rheumatology, 3(3), 154-163.
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  The objective of this study was to evaluate how patient knowledge and beliefs regarding nonsteroidal anti-inflammatory drugs (NSAIDs) may influence the use of NSAIDs for osteoarthritis (OA).
• Vina, E. R., Quinones, C., Hausmann, L. R., Ibrahim, S. A., & Kwoh, C. K. (2021). Association of Patients' Familiarity and Perceptions of Efficacy and Risks With the Use of Opioid Medications in the Management of Osteoarthritis. The Journal of rheumatology.
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  While opioids are known to cause unintended adverse effects, they are being utilized by a number of patients with osteoarthritis (OA). The aim of this study was to evaluate the association of patient familiarity and perceptions regarding efficacy and risks with opioid medication use for OA.
• Vina, E. R., Youk, A. O., Quinones, C., Kwoh, C. K., Ibrahim, S. A., & Hausmann, L. R. (2021). Use of Complementary and Alternative Therapy for Knee Osteoarthritis: Race and Gender Variations. ACR open rheumatology, 3(9), 660-667.
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  To evaluate race and gender variations in complementary and alternative medicine (CAM) use for knee osteoarthritis (OA) (unadjusted and adjusted for demographic and clinical factors).
• Weaver, J. S., Vina, E. R., Munk, P. L., Klauser, A. S., Elifritz, J. M., & Taljanovic, M. S. (2021). Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging. Journal of clinical medicine, 11(1).
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  Gout, a crystalline arthropathy caused by the deposition of monosodium urate crystals in the articular and periarticular soft tissues, is a frequent cause of painful arthropathy. Imaging has an important role in the initial evaluation as well as the treatment and follow up of gouty arthropathy. The imaging findings of gouty arthropathy on radiography, ultrasonography, computed tomography, dual energy computed tomography, and magnetic resonance imaging are described to include findings of the early, acute and chronic phases of gout. These findings include early monosodium urate deposits, osseous erosions, and tophi, which may involve periarticular tissues, tendons, and bursae. Treatment of gout includes non-steroidal anti-inflammatories, colchicine, glucocorticoids, interleukin-1 inhibitors, xanthine oxidase inhibitors, uricosuric drugs, and recombinant uricase. Imaging is critical in monitoring response to therapy; clinical management can be modulated based on imaging findings. This review article describes the current standard of care in imaging and treatment of gouty arthropathy.
• McClendon, J., Essien, U. R., Youk, A., Ibrahim, S. A., Vina, E., Kwoh, C. K., & Hausmann, L. R. (2020). Cumulative Disadvantage and Disparities in Depression and Pain among Veterans with Osteoarthritis: The Role of Perceived Discrimination. Arthritis care & research. doi:10.1002/acr.24481
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  Perceived discrimination is associated with chronic pain and depression and contributes to racial health disparities. In a cohort of older adult veterans with osteoarthritis (OA), we sought to examine how membership in multiple socially disadvantaged groups (cumulative disadvantage) was associated with perceived discrimination, pain, and depression. We also tested whether perceived discrimination mediated the association of cumulative disadvantage with depression and pain.
• Tighe, C. A., Youk, A., Ibrahim, S. A., Weiner, D. K., Vina, E. R., Kwoh, C. K., Gallagher, R. M., Bramoweth, A. D., & Hausmann, L. R. (2020). Pain Catastrophizing and Arthritis Self-Efficacy as Mediators of Sleep Disturbance and Osteoarthritis Symptom Severity. Pain medicine (Malden, Mass.), 21(3), 501-510. doi:10.1093/pm/pnz187
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  Sleep and pain-related experiences are consistently associated, but the pathways linking these experiences are not well understood. We evaluated whether pain catastrophizing and arthritis self-efficacy mediate the association between sleep disturbance and osteoarthritis (OA) symptom severity in patients with knee OA.
• Vina, E. R., Hannon, M. J., Masood, H. S., Hausmann, L. R., Ibrahim, S. A., Dagnino, J., Arellano, A., & Kwoh, C. K. (2020). Nonsteroidal Anti-Inflammatory Drug Use in Chronic Arthritis Pain: Variations by Ethnicity. The American journal of medicine, 133(6), 733-740. doi:10.1016/j.amjmed.2019.11.016
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  Our objective was to determine if there are ethnic differences in the use of over-the-counter (OTC) and prescription oral nonsteroidal anti-inflammatory drugs (NSAIDs) and if observed ethnic differences persist after adjustment for sociodemographic and clinical factors.
• Vina, E. R., Ran, D., Ashbeck, E. L., & Kwoh, C. K. (2020). Widespread Pain Is Associated with Increased Risk of No Clinical Improvement After TKA in Women. Clinical orthopaedics and related research, 478(7), 1453. doi:10.1097/CORR.0000000000001001
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  When conservative treatments do not work, TKA may be the best option for patients with knee osteoarthritis, although a relatively large proportion of individuals do not have clinically important improvement after TKA. Evidence also suggests that women are less likely to benefit from TKA than men, but the reasons are unclear. Widespread pain disproportionately affects women and has been associated with worse outcomes after joint arthroplasty, yet it is unknown if the effect of widespread pain on TKA outcomes differs by patient gender.
• Vina, E. R., Hannon, M. J., Hausmann, L. R., Ibrahim, S. A., Dagnino, J., Arellano, A., & Kwoh, C. K. (2019). Modifiable Determinants of Exercise Use in a Diverse Ethnic Population With Osteoarthritis. Arthritis care & research, 71(11), 1495-1503.
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  To determine the extent of ethnic differences in the use of exercise for therapy and identify relevant modifiable determinants of exercise use among patients with knee/hip osteoarthritis (OA).
• Vina, E. R., Hausmann, L. R., Obrosky, D. S., Youk, A., Ibrahim, S. A., Weiner, D. K., Gallagher, R. M., & Kwoh, C. K. (2019). Social & psychological factors associated with oral analgesic use in knee osteoarthritis management. Osteoarthritis and cartilage, 27(7), 1018-1025.
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  Determine modifiable social and psychological health factors that are associated with use of oral opioid and non-opioid medications for OA.
• Abbate, L. M., Jeffreys, A. S., Coffman, C. J., Schwartz, T. A., Arbeeva, L., Callahan, L. F., Negbenebor, N. A., Kohrt, W. M., Schwartz, R. S., Vina, E., & Allen, K. D. (2018). Demographic and Clinical Factors Associated with Non-Surgical Osteoarthritis Treatment Use Among Patients in Outpatient Clinics. Arthritis care & research, 70(8), 1141-1149. doi:10.1002/acr.23466
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  To identify patient demographic and clinical characteristics associated with osteoarthritis (OA) treatment use.
• Hausmann, L. R., Ibrahim, S. A., Kwoh, C. K., Youk, A., Obrosky, D. S., Weiner, D. K., Vina, E., Gallagher, R. M., Mauro, G. T., & Parks, A. (2018). Rationale and design of the Staying Positive with Arthritis (SPA) Study: A randomized controlled trial testing the impact of a positive psychology intervention on racial disparities in pain. Contemporary clinical trials, 64, 243-253. doi:10.1016/j.cct.2017.09.001
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  Knee osteoarthritis is a painful, disabling condition that disproportionately affects African Americans. Existing arthritis treatments yield small to moderate improvements in pain and have not been effective at reducing racial disparities in the management of pain. The biopsychosocial model of pain and evidence from the positive psychology literature suggest that increasing positive psychological skills (e.g., gratitude, kindness) could improve pain and functioning and reduce disparities in osteoarthritis pain management. Activities to cultivate positive psychological skills have been developed and validated; however, they have not been tested in patients with osteoarthritis, their effects on racial differences in health outcomes have not been examined, and evidence of their effects on health outcomes in patients with other chronic illnesses is of limited quality. In this article we describe the rationale and design of Staying Positive with Arthritis (SPA) study, a randomized controlled trial in which 180 African American and 180 White primary care patients with chronic pain from knee osteoarthritis will be randomized to a 6-week program of either positive skill-building activities or neutral control activities. The primary outcomes will be self-reported pain and functioning as measured by the WOMAC Osteoarthritis Index. We will assess these primary outcomes and potential, exploratory psychosocial mediating variables at an in-person baseline visit and by telephone at 1, 3, and 6months following completion of the assigned program. If effective, the SPA program would be a novel, theoretically-informed psychosocial intervention to improve quality and equity of care in the management of chronic pain from osteoarthritis.
• Hausmann, L. R., Youk, A., Kwoh, C. K., Gallagher, R. M., Weiner, D. K., Vina, E. R., Obrosky, D. S., Mauro, G. T., McInnes, S., & Ibrahim, S. A. (2018). Effect of a Positive Psychological Intervention on Pain and Functional Difficulty Among Adults With Osteoarthritis: A Randomized Clinical Trial. JAMA network open, 1(5), e182533.
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  Positive psychological interventions for improving health have received increasing attention recently. Evidence on the impact of such interventions on pain, and racial disparities in pain, is limited.
• Kabadi, S., Yeaw, J., Bacani, A. K., Tafesse, E., Bos, K., Karkare, S., DeKoven, M., & Vina, E. R. (2018). Healthcare resource utilization and costs associated with long-term corticosteroid exposure in patients with systemic lupus erythematosus. Lupus, 27(11), 1799-1809.
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  Objective To evaluate the association between exposure to oral corticosteroids and future healthcare resource utilization and costs for patients with systemic lupus erythematosus. Methods Adults diagnosed with systemic lupus erythematosus (index date) between 1 January 2008 and 30 June 2013 and naive to oral corticosteroids with continuous health plan enrollment for ≥6 months pre- and ≥5 years post-index were identified from a large health plan claims database. Per-patient monthly average daily dose of oral corticosteroids (prednisone or its equivalent) was calculated for the first 2 years post-index to categorize patients into four steroid exposure cohorts: low (≤5 mg/day), medium (6-20 mg/day), high (>20 mg/day) and no steroids. Differences in healthcare resource utilization and total healthcare costs during the third year post-index across corticosteroid exposure cohorts were modeled with adjustment for baseline characteristics. Results The study included 18,618 systemic lupus erythematosus patients (163 high dose, 1127 medium dose, 6717 low dose and 10,611 no steroids). Compared to low-dose corticosteroid users, high-dose corticosteroid users were more likely to have emergency room visits (39.3% vs. 29.7%; p = 0.0085) and to be hospitalized (21.5% vs. 12.3%; p = 0.0005). After adjustment for baseline characteristics, they also had significantly greater average annual total healthcare costs (US$60,366 vs. US$18,777; p 
• Vina, E. R., & Kwoh, C. K. (2018). Epidemiology of osteoarthritis: literature update. Current opinion in rheumatology, 30(2), 160-167. doi:10.1097/BOR.0000000000000479
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  The purpose of this review is to highlight recent studies of osteoarthritis epidemiology, including research on prevalence, disease impact, and potential risk factors.
• Vina, E. R., Ran, D., Ashbeck, E. L., & Kwoh, C. K. (2018). Natural history of pain and disability among African-Americans and Whites with or at risk for knee osteoarthritis: A longitudinal study. Osteoarthritis and cartilage, 26(4), 471-479.
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  Compare knee pain and disability between African Americans (AAs) and Whites (WHs), with or at risk of knee osteoarthritis (KOA), over 9 years, and evaluate racial disparities in KOA-related symptoms across socioeconomic and clinical characteristics.
• Vina, E. R., Ran, D., Ashbeck, E. L., Ratzlaff, C., & Kwoh, C. K. (2018). Race, sex, and risk factors in radiographic worsening of knee osteoarthritis. Seminars in arthritis and rheumatism, 47(4), 464-471. doi:10.1016/j.semarthrit.2017.08.008
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  Characterize radiographic worsening in knee osteoarthritis (KOA) by race and sex over 4 years and evaluate the role of established risk factors in observed race/sex differences.
• Vina, E. R., Kallan, M. J., Collier, A., Nelson, C. L., & Ibrahim, S. A. (2017). Race and Rehabilitation Destination After Elective Total Hip Arthroplasty: Analysis of a Large Regional Data Set. Geriatric orthopaedic surgery & rehabilitation, 8(4), 192-201.
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  Three-quarters of patients who undergo total hip replacement (THR) receive postsurgical rehabilitation care in an inpatient rehabilitation facility (IRF), a skilled nursing facility (SNF), or through a home health agency. The objectives of this study are to examine racial differences where THR recipients receive postsurgical rehabilitation care and determine whether discharge destination is associated with hospital readmission.
• Vina, E. R., Hannon, M. J., & Kwoh, C. K. (2016). Improvement following total knee replacement surgery: Exploring preoperative symptoms and change in preoperative symptoms. Seminars in arthritis and rheumatism, 45(5), 547-55. doi:10.1016/j.semarthrit.2015.10.002
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  To determine whether changes in preoperative osteoarthritis (OA) symptoms are associated with improvement after total knee replacement (TKR) and to identify predictors of clinically significant improvement.
• Vina, E. R., Ran, D., Ashbeck, E. L., Ibrahim, S. A., Hannon, M. J., Zhou, J. J., & Kwoh, C. K. (2016). Patient preferences for total knee replacement surgery: Relationship to clinical outcomes and stability of patient preferences over 2 years. Seminars in arthritis and rheumatism, 46(1), 27-33. doi:10.1016/j.semarthrit.2016.03.012
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  Evaluate the relationship between patient preferences for total knee replacement (TKR) with receipt of TKR, and assess participant characteristics that may influence change in willingness to undergo TKR.
• Vina, E. R., Ran, D., Ashbeck, E. L., Kaur, M., & Kwoh, C. K. (2017). Relationship Between Knee Pain and Patient Preferences for Joint Replacement: Health Care Access Matters. Arthritis care & research, 69(1), 95-103.
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  To determine if severity of osteoarthritis-related knee pain is associated with a willingness to undergo total knee replacement (TKR) and whether this association is confounded or modified by components of socioeconomic status and health care coverage.
• Vina, E. R., Richardson, D., Medvedeva, E., Kent Kwoh, C., Collier, A., & Ibrahim, S. A. (2016). Does a Patient-centered Educational Intervention Affect African-American Access to Knee Replacement? A Randomized Trial. Clinical orthopaedics and related research, 474(8), 1755-64. doi:10.1007/s11999-016-4834-z
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  A TKA is the most effective and cost-effective surgical option for moderate to severe osteoarthritis (OA) of the knee. Yet, black patients are less willing to undergo knee replacement surgery than white patients. Decision aids help people understand treatment options and consider the personal importance of possible benefits and harms of treatments, including TKA.
• Kwoh, C. K., Vina, E. R., Cloonan, Y. K., Hannon, M. J., Boudreau, R. M., & Ibrahim, S. A. (2015). Determinants of patient preferences for total knee replacement: African-Americans and whites. Arthritis research & therapy, 17, 348.
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  Patient preferences contribute to marked racial disparities in the utilization of total knee replacement (TKR). The objectives of this study were to identify the determinants of knee osteoarthritis (OA) patients' preferences regarding TKR by race and to identify the variables that may mediate racial differences in willingness to undergo TKR.
• Vina, E. R., Hausmann, L. R., Utset, T. O., Masi, C. M., Liang, K. P., & Kwoh, C. K. (2015). Perceptions of racism in healthcare among patients with systemic lupus erythematosus: a cross-sectional study. Lupus science & medicine, 2(1), e000110.
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  Racial disparities in the clinical outcomes of systemic lupus erythematosus (SLE) exist. Perceived racial discrimination may contribute to disparities in health.
• Vina, E. R., Utset, T. O., Hannon, M. J., Masi, C. M., Roberts, N., & Kwoh, C. K. (2015). Racial differences in treatment preferences among lupus patients: a two-site study. Clinical and experimental rheumatology, 32(5), 680-8.
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  To identify the demographic, clinical and psychosocial characteristics associated with racial differences in willingness to receive cyclophosphamide (CYC) or participate in a research clinical trial (RCT) among patients with systemic lupus erythematosus (SLE).
• Vina, E. R., Cloonan, Y. K., Ibrahim, S. A., Hannon, M. J., Boudreau, R. M., & Kwoh, C. K. (2013). Race, sex, and total knee replacement consideration: role of social support. Arthritis care & research, 65(7), 1103-11.
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  To determine whether there are racial differences in social support among patients with knee osteoarthritis (OA) and whether the impact of social support on patient preferences for total knee replacement (TKR) varies by race and sex.
• Vina, E. R., Green, S. L., Trivedi, T., Kwoh, C. K., & Utset, T. O. (2013). Correlates of sleep abnormalities in systemic lupus: a cross-sectional survey in an urban, academic center. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 19(1), 7-13.
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  Systemic lupus erythematosus (SLE) is a complex autoimmune disease that is associated with poor health-related quality-of-life outcomes.
• McBurney, C. A., & Vina, E. R. (2012). Racial and ethnic disparities in rheumatoid arthritis. Current rheumatology reports, 14(5), 463-71.
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  Racial and ethnic health disparities are a national health issue. They are well described in other chronic diseases, but in rheumatoid arthritis (RA), research into their causes, outcomes, and elimination is in its early stages. Health disparities occur in a complex milieu, with system-level, provider-level, and individual-level factors playing roles. Dissecting the overlapping aspects of race/ethnicity, socioeconomic variables, and how their individual components combine to explain the magnitude of disparities in RA can be challenging. Recent research has focused on the extent to which treatment preferences, adherence, trust in physicians, patient-physician communication, health literacy, and depression have contributed to observed disparities in RA. Practicing evidence-based medicine, improving patient-physician communication skills, reducing language and literacy barriers, improving adherence to therapies, raising awareness of racial/ethnic disparities, and recognizing comorbidities such as depression are steps clinicians may take to help eliminate racial/ethnic disparities in RA.
• Vina, E. R., Masi, C. M., Green, S. L., & Utset, T. O. (2012). A study of racial/ethnic differences in treatment preferences among lupus patients. Rheumatology (Oxford, England), 51(9), 1697-706.
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  To determine whether there are racial/ethnic differences in the willingness of SLE patients to receive CYC or participate in clinical trials, and whether demographic, psychosocial and clinical characteristics contribute to these differences.
• Vina, E. R., Rhew, D. C., Weingarten, S. R., Weingarten, J. B., & Chang, J. T. (2009). Relationship between organizational factors and performance among pay-for-performance hospitals. Journal of general internal medicine, 24(7), 833-40.
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  The Centers for Medicare & Medicaid Services (CMS)/Premier Hospital Quality Incentive Demonstration (HQID) project aims to improve clinical performance through a pay-for-performance program. We conducted this study to identify the key organizational factors associated with higher performance.
• Vina, E. R., Dang, S., Trinh, N., & Arkfeld, D. G. (2005). Rheumatology quiz, systemic lupus erythematosus and coining. Resident and Staff Physician, 51(5), 16, 20.
• Vina, E. R., Fang, A. J., Wallace, D. J., & Weisman, M. H. (2005). Chronic inflammatory demyelinating polyneuropathy in patients with systemic lupus erythematosus: prognosis and outcome. Seminars in arthritis and rheumatism, 35(3), 175-84.
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  To identify clinical characteristics, laboratory features, approaches to management, and predictors of outcome of chronic inflammatory demyelinating polyneuropathy (CIDP) in patients with systemic lupus erythematosus (SLE).
• Yamamoto, T., Kakar, N. R., Vina, E. R., Johnson, P. E., & Bing, R. J. (2001). Effect of cyclooxygenase-2 inhibitor (celecoxib) on the infarcted heart in situ. Pharmacology, 63(1), 28-33.
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  Several attempts have been made to replace aspirin with compounds without gastric toxicity; a cyclooxygenase-2 (COX-2) inhibitor, celecoxib, and a nitric oxide-aspirin, NCX-4016, have been developed for this purpose. This paper compares effects of celecoxib, NCX-4016 and aspirin on production of prostacyclin (PGI2) and thromboxane A2 (TXA2) and activation of the inducible form of nitric oxide synthase (iNOS) in infarcted heart in situ. Aspirin was most effective in reducing myocardial PGI2 synthesis and formation of TXA2. Myocardial effects of celecoxib resemble those of NCX-4016, although the two compounds have different modes of action.
• Yamamoto, T., Kakar, N. R., Vina, E. R., Johnson, P. E., & Bing, R. J. (2000). The effect of aspirin and two nitric oxide donors on the infarcted heart in situ. Life sciences, 67(7), 839-46.
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  Nitric oxide (NO) donors are heterogeneous substances which release NO, a biologically active compound. NO released by nitric oxide donors has important effects on the circulation by causing vasodilation, diminishing myocardial contractile force, inhibiting platelet aggregation, and counteracting the effects of thromboxane A2. In the infarcted heart, activation of the inducible form of nitric oxide synthase (iNOS) and the formation of prostacyclin and thromboxane A2 by cyclooxygenase (COX) were increased. Myocardial infarction also resulted in increased myocardial NO production. Aspirin (acetylsalicylic acid. ASA) at low concentration (35 mg/kg/day) fails to change iNOS production, in contrast to higher dose (150 mg/kg/day) which, as previously shown, inhibits iNOS activity. ASA at all doses also suppresses myocardial prostanoid formation because of inhibition of COX. Recently, two NO donors have been synthesized: NCX 4016 and Diethylenetriamine/NO (DETA/NO). NCX 4016 combines an NO-releasing moiety with a carboxylic residue via an esteric bond. We describe here that NCX 4016 (65 mg/kg/day) increased prostacyclin and thromboxane A2 production in the infarcted heart muscle, overcoming the inhibitory effects of ASA. As a result of nitric oxide release, oxidation products of NO (NO2- and NO3-; NOx) in arterial blood rose following administration of NCX 4016. On oral administration, NCX 4016 did not change systemic arterial pressure. The effects of a single NO donor, DETA/NO (1.0 mg/kg/day) on the infarcted heart were also investigated On intravenous administration, the compound increased NO concentration in arterial blood slightly but to a lesser degree than NCX 4016. Like NCX 4016, it raised myocardial production of prostacyclin and thromboxane A2 in the infarcted heart. However, it caused a severe fall in blood pressure. These findings demonstrate that newly-synthesized NO donors release nitric oxide in situ and increase myocardial production of prostanoids. NCX 4016 has therapeutic potential because it can be orally administered, lacks hypotensive effects, increases blood levels of nitric oxide and myocardial prostacyclin production.

Presentations

• Kaur, M., Zhou, L., Ashbeck, E., Vina, E. R., Roemer, F., Guermazi, A., Hunter, D. J., & Kwoh, C. K. (2018, October). Evaluating MRI-Detected Knee Inflammation Prior to Total Knee Replacement As a Predictive Biomarker of Clinically Important Pain Reduction Two Years Later. American College of Rheumatology Annual Meeting. Chicago, IL.
• Vina, E. R., Hausmann, L., Obrsosky, D. S., Youk, A., Weiner, D., Ibrahim, S. A., & Kwoh, C. K. (2018, June). Examining Modifiable Psychological & Social Health Factors Associated with Use of Osteoarthritis Oral Analgesic Treatment.. European League Against Rheumatism Annual Meeting. Amsterdam, Netherlands.
• Vina, E. R. (2017, October). Gender and Race Disparities in Osteoarthritis. Department of Medicine Research Seminar Series. Tucson, AZ.
• Vina, E. R., Ran, D., Ashbeck, E., & Kwoh, C. K. (2017, November). Widespread Pain Prior to Total Knee Replacement (TKR) Is Associated with Increased Risk of No Clinical Improvement in Pain Among Women. American College of Rheumatology Annual Meeting. San Diego, CA.
• Vina, E. R., Hannon, M., & Kwoh, C. K. (2014, November). Improvement following total knee replacement (TKR) surgery: exploring preoperative symptoms and change in preoperative symptoms. American College of Rheumatology Annual Meeting. Boston, MA.
• Vina, E. R., Rhew, D., Weingarten, S., Weingarten, J., & Chang, J. (2008, June). The relationship between organizational factors and high performance among hospitals participating in the CMS, Premier Hospital Quality Incentive Demonstration Project. 25th Annual Academy Health Research Meeting. Washington, DC.

Poster Presentations

• Vina, E. R., Dagnino, J., & Kwoh, C. K. (2019, November). Attitudes and Beliefs About Opioid Medications: Determining Treatment Use in Osteoarthritis. American College of Rheumatology Annual Meeting. Atlanta, GA.
• Vina, E. R., Hannon, M. J., Dagnino, J., & Kwoh, C. K. (2019, June). Understanding ethnic differences in the utilization of nonsteroidal anti-inflammatory drugs for osteoarthritis. European League Against Rheumatism Annual Meeting. Madrid, Spain.
• Masood, H., Hannon, M. J., Kwoh, C. K., Dagnino, J., & Vina, E. R. (2018, October). Examining Ethnic Differences in Osteoarthritis (OA) Patients’ Knowledge and Attitudes Regarding Prescription Nonsteroidal Anti-Inflammatory Drugs. American College of Rheumatology Annual Meeting. Chicago, IL.
• Masood, H., Hannon, M., Dagnino, J., Kwoh, C. K., & Vina, E. R. (2019, January). Examining Ethnic Differences in Osteoarthritis (OA) Patients’ Knowledge and Attitudes Regarding Prescription Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). University of Arizona Principal Investigator Poster Session. Tucson, AZ.
• Tighe, C., Ibrahim, S. A., Youk, A., Vina, E. R., Parks, A., Weiner, D., Kwoh, C. K., & Hausmann, L. (2018, June). Examining pain catastrophizing and self-efficacy as cross-sectional mediators of sleep disturbance and pain in a sample of Veterans with arthritis. Annual Meeting of the Associated Professional Sleep Societies, LLC. Baltimore, MD.
• Vina, E. R., Ran, D., Ashbeck, E., & Kwoh, C. K. (2018, January). Widespread Pain Prior to Total Knee Replacement (TKR) Is Associated with Increased Risk of No Clinical Improvement in Pain Among Women. University of Arizona Principal Investigator Poster Session. Tucson, AZ.
• Vina, E. R., Ran, D., Hannon, M. J., & Kwoh, C. K. (2018, June). Understanding ethnic differences in the utilization of exercise for osteoarthritis. American College of Rheumatology Research Workshop. San Francisco, CA.
• Vina, E. R., Ran, D., Hannon, M. J., & Kwoh, C. K. (2018, June). Understanding ethnic differences in the utilization of exercise for osteoarthritis. European League Against Rheumatism Annual Meeting. Amsterdam, Netherlands.
• Vina, E. R. (2017, November). Widespread Pain Prior to Total Knee Replacement (TKR) Is Associated with Increased Risk of No Clinical Improvement in Pain Among Women. University of Arizona College of Medicine Junior Investigator Poster Forum. Tucson, AZ.
• Vina, E. R., Kallan, M. J., Collier, A., Nelson, C. L., & Ibrahim, S. A. (2017, June). Race and Rehabilitation Destination After Elective Total Hip Arthroplasty: Analysis of a Large Regional Data Set. European League Against Rheumatism Annual Meeting. Madrid, Spain.
• Vina, E. R., Ashbeck, E. L., Ran, D., & Kwoh, C. K. (2016, June). Race and sex differences in radiographic progression of knee osteoarthritis. European League Against Rheumatism Annual Meeting. London, England.
• Vina, E. R., Ran, D., Ashbeck, E., & Kwoh, C. K. (2016, November). Racial Differences in Self-Reported Pain and Disability: A Longitudinal Study of Knee Osteoarthritis. American College of Rheumatology Annual Meeting. Washington, DC.
• Vina, E. R., Ran, D., Ashbeck, E., Kaur, M., & Kwoh, C. K. (2016, November). Relationship Between Knee Pain and Patient Preferences for Joint Replacement: Health Care Access Matters. American College of Rheumatology Annual Meeting. Washington, DC.
• Vina, E. R., Ran, D., Ashbeck, E., & Kwoh, C. K. (2017, January). Racial Differences in Self-Reported Pain and Disability: A Longitudinal Study of Knee Osteoarthritis. Department of Medicine Principal Investigator Poster Session. Tucson, Arizona.
• Vina, E. R., Ran, D., Ashbeck, E., Ibrahim, S., Hannon, M., Zhou, J., & Kwoh, C. K. (2015, November). Patient preferences for total knee replacement surgery: two year follow-up.. American College of Rheumatology Annual Meeting. San Francisco, CA.
• Vina, E. R., Utset, T., Hannon, M., Masi, C., & Kwoh, C. K. (2013, October). Racial differences in lupus patients’ treatment preferences: a two-site study. American College of Rheumatology Annual Meeting. San Diego, CA.
• Vina, E. R., Cloonan, Y., Ibrahim, S., Hannon, M., Boudreau, R., & Kwoh, C. K. (2012, November). Race, gender and total knee replacement consideration: the role of social support. American College of Rheumatology Annual Meeting. Washington, DC.
• Vina, E. R., Cloonan, Y., Ibrahim, S., Hannon, M., Boudreau, R., & Kwoh, C. K. (2012, October). Race and total joint replacement consideration: the role of social support. Society for Medical Decision-Making Annual Meeting. Phoenix, AZ.
• Vina, E. R., Masi, C., Green, S., & Utset, T. (2012, July). Racial differences in treatment preferences among lupus patients in an urban academic center. Health Services Research & Development Service/Quality Enhancement Research Initiative Meeting. National Harbor, MD.
• Vina, E. R., Masi, C., Green, S., & Utset, T. (2011, November). Racial disparities in treatment preferences among lupus patients in an urban academic center. American College of Rheumatology Annual Meeting. Chicago, IL.
• Vina, E. R., Green, S., & Utset, T. (2010, June). The medical outcomes study (MOS) sleep scale in lupus patients. 9th International Congress on Systemic Lupus Erythematosus. Vancouver, Canada.
• Vina, E. R., Masi, C., Green, S., & Utset, T. (2010, November). Racial disparities in treatment preferences among lupus patients. American College of Rheumatology Annual Meeting. Atlanta, GA.