Holli A Horak

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Scholarly Contributions

Books

• Horak, H. A. (2016). Practical Neurology, 5th Edition. Chapter 31: Lippincott.
• Horak, H. A., & Mandler, R. (2016). Practical Neurology, 5th Edition. Chapter 52: Lippincott.

Chapters

• Tiryaki, E., & Horak, H. A. (2014).

  ALS and Other Motor Neuron Diseases

  . In ALS Handbook. doi:10.1212/01.con.0000455886.14298.a4
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Journals/Publications

• Patel, K., & Horak, H. A. (2021). Electrodiagnosis of Common Mononeuropathies: Median, Ulnar, and Fibular (Peroneal) Neuropathies.. Neurologic clinics, 39(4), 939-955. doi:10.1016/j.ncl.2021.06.004
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  This article addresses common mononeuropathies seen in the electrodiagnostic laboratory. The most common mononeuropathies-median neuropathy at the wrist (carpal tunnel syndrome), ulnar neuropathy at the elbow, and fibular (peroneal) neuropathy at the fibular head-are reviewed. The causes, clinical presentations, approached to the electrodiagnostic studies (including nerve conduction studies and needle electromyography), and the typical findings are discussed.
• Horak, H. A., Johnston, C. B., Scherer, K., Ibarra, B., Shane, B., Mortel, D., Barcelo, B., & Yogendran, L. (2020). When the Timing is Right: Is There an Association Between Willingness to Discuss Palliative Care and the Severity of ALS? (2788). Neurology.
• Horak, H., Patel, K., & Tiryaki, E. (2020). Diabetic neuropathies. Muscle & Nerve, 63(1), 22-30. doi:10.1002/mus.27014
• Johnston, C. B., Horak, H. A., Scherer, K., Ibarra, B., Shane, B., Mortel, M. D., Barcelo, B., & Yogendran, L. (2020). Identifying Important Palliative Topics and Communication Preferences Among ALS Patients (QI618). Journal of Pain and Symptom Management. doi:10.1016/j.jpainsymman.2019.12.227
• Horak, H. A. (2018). Entrustable Professional Activities. Neurology, 90(7), 326-332. doi:10.1212/WNL.0000000000004947
• Horak, H. A., Tiryaki, E., Soni, M., Kraakevik, J. A., Barratt, D., & Englander, R. (2018). Entrustable professional activities. Neurology. doi:10.1212/wnl.0000000000004947
• Horak, H. A., & Tiryaki, E. (2014). ALS and Other Motor Neuron Diseases. Continuum. doi:10.1212/01.con.0000455886.14298.a4
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  This review describes the most common motor neuron disease, ALS. It discusses the diagnosis and evaluation of ALS and the current understanding of its pathophysiology, including new genetic underpinnings of the disease. This article also covers other motor neuron diseases, reviews how to distinguish them from ALS, and discusses their pathophysiology.In this article, the spectrum of cognitive involvement in ALS, new concepts about protein synthesis pathology in the etiology of ALS, and new genetic associations will be covered. This concept has changed over the past 3 to 4 years with the discovery of new genes and genetic processes that may trigger the disease. As of 2014, two-thirds of familial ALS and 10% of sporadic ALS can be explained by genetics. TAR DNA binding protein 43 kDa (TDP-43), for instance, has been shown to cause frontotemporal dementia as well as some cases of familial ALS, and is associated with frontotemporal dysfunction in ALS.The anterior horn cells control all voluntary movement: motor activity, respiratory, speech, and swallowing functions are dependent upon signals from the anterior horn cells. Diseases that damage the anterior horn cells, therefore, have a profound impact. Symptoms of anterior horn cell loss (weakness, falling, choking) lead patients to seek medical attention. Neurologists are the most likely practitioners to recognize and diagnose damage or loss of anterior horn cells. ALS, the prototypical motor neuron disease, demonstrates the impact of this class of disorders. ALS and other motor neuron diseases can represent diagnostic challenges. Neurologists are often called upon to serve as a "medical home" for these patients: coordinating care, arranging for durable medical equipment, and leading discussions about end-of-life care with patients and caregivers. It is important for neurologists to be able to identify motor neuron diseases and to evaluate and treat patients affected by them.
• Merlin, L. R., Horak, H. A., Milligan, T. A., Kraakevik, J. A., & Ali, I. I. (2014). A competency-based longitudinal core curriculum in medical neuroscience. Neurology, 83(5), 456-62.
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  Current medical educational theory encourages the development of competency-based curricula. The Accreditation Council for Graduate Medical Education's 6 core competencies for resident education (medical knowledge, patient care, professionalism, interpersonal and communication skills, practice-based learning, and systems-based practice) have been embraced by medical schools as the building blocks necessary for becoming a competent licensed physician. Many medical schools are therefore changing their educational approach to an integrated model in which students demonstrate incremental acquisition and mastery of all competencies as they progress through medical school. Challenges to medical schools include integration of preclinical and clinical studies as well as development of learning objectives and assessment measures for each competency. The Undergraduate Education Subcommittee (UES) of the American Academy of Neurology (AAN) assembled a group of neuroscience educators to outline a longitudinal competency-based curriculum in medical neuroscience encompassing both preclinical and clinical coursework. In development of this curriculum, the committee reviewed United States Medical Licensing Examination content outlines, Liaison Committee on Medical Education requirements, prior AAN-mandated core curricula for basic neuroscience and clinical neurology, and survey responses from educators in US medical schools. The newly recommended curriculum provides an outline of learning objectives for each of the 6 competencies, listing each learning objective in active terms. Documentation of experiences is emphasized, and assessment measures are suggested to demonstrate adequate achievement in each competency. These guidelines, widely vetted and approved by the UES membership, aspire to be both useful as a stand-alone curriculum and also provide a framework for neuroscience educators who wish to develop a more detailed focus in certain areas of study.
• Tiryaki, E., & Horak, H. A. (2014). ALS and other motor neuron diseases. Continuum (Minneapolis, Minn.), 20(5 Peripheral Nervous System Disorders), 1185-207.
  More info

  This review describes the most common motor neuron disease, ALS. It discusses the diagnosis and evaluation of ALS and the current understanding of its pathophysiology, including new genetic underpinnings of the disease. This article also covers other motor neuron diseases, reviews how to distinguish them from ALS, and discusses their pathophysiology.

Presentations

• Meka, J., Ditillo, M., Horak, H. A., & Corral, J. (2021, April). Workplace-Based Assessment in Clinical Education: An Adoption Cycle of Experience. AAMC GEA 2021. Virtual: AAMC.
• Horak, H. A. (2015, April). CNCD Directors Workshop. AAN Annual Meeting.

Poster Presentations

• Arumaithurai, K., Kapoor, A., Horak, H. A., Scherer, K., Arumaithurai, K., Kapoor, A., Horak, H. A., Scherer, K., Arumaithurai, K., Kapoor, A., Horak, H. A., Scherer, K., Arumaithurai, K., Kapoor, A., Horak, H. A., Scherer, K., Arumaithurai, K., Kapoor, A., Horak, H. A., & Scherer, K. (2014, October). Celiac Disease: Neurological Manifestations in 2 undiagnosed patients. AANEM Annual Meeting. Savannah, Georgia: AANEM.

Other Teaching Materials

• Horak, H. A., & Tiryaki, E. (2016. AAN EMG workshop. American Academy of Neurology.
• Horak, H. A., & Tiryaki, E. (2016. Living with ALS Resource Guide. ALS Association.
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  Manual Written by ALS physicians/ care providers for patients living with ALS and their caregivers. Edited and reviewed for content.