Hong Seok Lee

Interests

Research

clinical trial big data analysisEcho QI PROJECT

Teaching

Fellow, resident, and medical student teaching

Courses

No activities entered.

Scholarly Contributions

Journals/Publications

• Lee, H. S. (2023). Association of Sustained Low or High Income and Income Changes With Risk of Incident Type 2 Diabetes Among Individuals Aged 30 to 64 Years . JAMA.
• Choi, J. Y., Lee, Y. J., Ko, J. H., Kim, S. H., Kim, H. J., Lee, H. W., Jeong, H., Kim, T. Y., Jang, Y. G., Hong, H. J., Kim, M. S., Lee, S. E., Kim, Y. G., Chung, E. J., Lim, H., Jang, S., Kim, K., Kim, S. S., Ahn, J. Y., , Choi, J. Y., et al. (2022). Neutralizing Activity Against SARS-CoV-2 Delta and Omicron Variants Following a Third BNT162b2 Booster Dose According to Three Homologous or Heterologous COVID-19 Vaccination Schedules. Frontiers in cellular and infection microbiology, 12, 948014.
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  With the emergence and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants, escaping vaccine-induced immunity is a concern. Three vaccination schedules, homologous or heterologous, have been initially applied due to an insufficient supply of vaccines in Korea. We investigated neutralizing activities against Omicron and Delta variants in each schedule. Three schedules using three doses of the BNT162b2 (BNT) or the ChAdOx1 (ChAd) vaccines include ChAd-ChAd-BNT, ChAd-BNT-BNT, and BNT-BNT-BNT. Neutralizing activities were evaluated using plaque-reduction neutralization test (PRNT) against wild type (WT) SARS-CoV-2, Delta variant, and Omicron variant. A total of 170 sera from 75 participants were tested, and the baseline characteristics of participants were not significantly different between groups. After the 2nd vaccine dose, geometric mean titers of PRNT ND against WT, Delta, and Omicron were highest after ChAd-BNT vaccination (2,463, 1,097, and 107) followed by BNT-BNT (2,364, 674, and 38) and ChAd-ChAd (449, 163, and 25). After the 3rd dose of BNT, the increase of PRNT ND against WT, Delta, and Omicron was most robust in ChAd-ChAd-BNT (4,632, 988, and 260), while the BNT-BNT-BNT group showed the most augmented neutralizing activity against Delta and Omicron variants (2,315 and 628). ChAd-BNT-BNT showed a slight increase of PRNT ND against WT, Delta, and Omicron (2,757, 1,279, and 230) compared to the 2nd dose. The results suggest that a 3rd BNT booster dose induced strengthened neutralizing activity against Delta and Omicron variants. The waning of cross-reactive neutralizing antibodies after the 3rd dose and the need for additional boosting should be further investigated.
• Lee, H., & Naqvi, T. Z. (2021). Late presentation of traumatic tricuspid valve regurgitation after motor vehicle accident managemed with valve replacement surgery: Role of 3D echocardiography. Echocardiography (Mount Kisco, N.Y.), 38(10), 1813-1816.
• Ashraf, H., Lee, H., Tran, K. H., Agasthi, P., Keddis, M. T., Unzek, S., Narayanasamy, H., & Wilansky, S. (2020). Prevalence and Outcomes of Pericardial Effusion in Kidney Transplant Candidates. The American journal of cardiology, 132, 140-146.
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  Pericardial disease is a recognized manifestation of cardiovascular disease in the end-stage renal disease (ESRD) population, and can manifest as pericardial effusion, though the prognosis of pericardial disease in ESRD patients is unclear. In the modern era of renal replacement therapy, little is known about the prevalence and the implications of pericardial effusion in ESRD patients, its echocardiographic characteristics, and risk factors. We conducted a retrospective chart review on subjects > than 18 years of age with known ESRD who were undergoing outpatient evaluation for renal transplantation at Mayo Clinic Arizona between January 2001 and December 2015 and had baseline echocardiogram completed within 3 months of their initial evaluation. Patients with moderate sized pericardial effusions or larger were identified. The pericardial effusion cohort was age and gender matched with a cohort of patients with ESRD without pericardial effusion in a 1:2 fashion. 54 patients with moderate or greater sized pericardial effusion out of 2,820 patients that fit our inclusion criteria, corresponding to a prevalence of 1.9%. A total of 41 patients or 75.9%, had a moderate sized effusion. A total of 13 patients, or 24.1% had a large sized effusion, 7 of whom had tamponade physiology on echocardiography. The presence and size of the effusion was not predictive for worse outcomes. Hemodialysis duration was protective, but no other factors were predictive or protective in the development of moderate sized or larger pericardial effusions, including echocardiographic parameters.
• Chao, C. J., DeValeria, P. A., Sen, A., Lee, H., Pedrotty, D. M., Patel, B., Arsanjani, R., & Naqvi, T. Z. (2020). Reversible cardiac dysfunction in severe COVID-19 infection, mechanisms and case report. Echocardiography (Mount Kisco, N.Y.), 37(9), 1465-1469.
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  A previously healthy 49-year-old male patient presented with COVID-19 infection and required mechanical ventilation and extracorporeal membrane oxygenation due to severe hypoxemia. Echocardiography showed cardiac dysfunction with an apical sparing strain pattern, which rapidly normalized within a week. Apical sparing myocardial strain in patients with COVID-19 infection may suggest reverse-type stress cardiomyopathy.
• Lee, H. S., & Sureddi, R. (2020). Accessory pathway-mediated cardiomyopathy: Left ventricular systolic dysfunction due to preexcitation. HeartRhythm case reports, 6(5), 272-274.
• Seok Lee, H., Park, Y. M., Han, K., Yang, J. H., Lee, S., Lee, S. S., Yoo, S., & Kim, S. R. (2020). Obesity-related hypertension: Findings from The Korea National Health and Nutrition Examination Survey 2008-2010. PloS one, 15(4), e0230616.
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  We aimed to investigate the association of various obesity parameters and phenotypes with hypertension in nationally representative Korean adults. Among adults aged 19 years and older who participated in the Korea National Health and Nutrition Examination Survey in 2008-2010, a total of 16,363 subjects (8,184 men and 8,179 women) were analyzed. Hypertension was defined as blood pressure of 140/90 mm Hg or higher or taking antihypertensive medication. Multiple logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Higher obesity parameters [body mass index (BMI) representing general obesity, waist circumference (WC) representing central obesity, and percentage body fat (PBF) representing elevated body fat] were consistently associated with increased odds of prevalent hypertension (OR, 7.54; 95% CI, 5.89-9.65 for BMI ≥30 vs. 18.5-23; OR, 3.97; 95% CI, 3.41-4.63 for WC ≥95 cm in males and ≥90 cm in females vs.
• Lee, H. S., Pai, R., Nazzal, S., & Mukherjee, A. (2019). STEMI mimicker in a 26-year-old man. BMJ case reports, 12(2).
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  We herein describe a case of acute myocarditis which may mimic myocardial infarction, since affected patients experience 'typical' chest pain, the ECG changes are identical to those observed in acute coronary syndromes, and serum markers are increased. This case emphasises the importance of performing appropriate cardiac MRI to help in the differential and definitive diagnosis as well as the extent of myocardial involvement. ST elevation myocardial infarction is rare in young adults and when it is encountered, it should raise the differential diagnosis of its mimickers.
• Lee, H. S., Park, Y. M., Han, K., Pekler, G., Lee, S. S., Yoo, S., & Kim, S. R. (2017). Sex-specific association between asthma and hypertension in nationally representative young Korean adults. Scientific reports, 7(1), 15667.
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  It has been reported that people with asthma have an increased risk of hypertension. However, little is known about the specific relationship between asthma and hypertension in young adults. Among subjects who participated in the Korea National Health and Nutrition Examination Survey conducted in 2008-2013, a total of 10,138 young adults (4,226 men and 5,912 women) aged 19-39 years were analyzed. Multiple logistic regression analysis was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). The prevalence of ever asthma was 11.1% in men and 8.4% in women. The mean diastolic blood pressure (DBP) was lower in men with asthma than in men without asthma (p = 0.03), whereas the mean DBP was higher in women with asthma than in women without asthma (p = 0.04). Having asthma was inversely associated with hypertension in men (OR: 0.62, 95% CI: 0.41-0.91). In contrast, having asthma was positively associated with hypertension in women (OR: 2.19, 95% CI: 1.19-4.02). Our results suggest that asthma pathophysiology might be differentially associated with hypertension in young adults depending on sex.
• Lee, H. S., Lim, C. H., Park, E. Y., Lee, W. H., No, J. H., Jun, B. Y., Moon, S. J., Kim, J. S., Cho, Y. K., Park, J. M., Lee, I. S., Kim, S. W., Choi, M. G., & Choi, K. Y. (2014). Usefulness of the introducer method for percutaneous endoscopic gastrostomy using ultrathin transnasal endoscopy. Surgical endoscopy, 28(2), 603-6.
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  The introducer method of percutaneous endoscopic gastrostomy (PEG) minimizes procedure-related peristomal infection. Ultrathin transnasal endoscopy (UTE) allows comfortable endoscopic examination of patients with fewer adverse effects and passage of the endoscope through a narrow esophagus or oropharynx. This study aimed to investigate the clinical outcomes for the introducer method of PEG with UTE.