- Associate Professor, Public Health
- Associate Professor, Genetics - GIDP
- Associate Professor, Statistics-GIDP
- Ph.D. Biomathematics
- University of California, Los Angeles
- M.S. Applied Mathematics
- Nankai University
- B.S. Mathematics
- Nanjing Normal University
- Harvard University, Boston, Massachusetts (2011 - 2013)
- Junior Faculty Travel Award
- Southern Regional Council on Statistics, Summer 2016
Statistical Genetics; Genetics Epidemiology; Mixed Effects Models; Public Health Informatics
Mixed Effects Models; Longitudinal Studies; Multivariate Analysis; Statistical Computing; Statistical Genetics
DissertationBIOS 920 (Fall 2020)
Gen Line+Mix Effect MdlBIOS 684 (Fall 2020)
Healthcare Data ScienceBIOS 511 (Fall 2020)
Independent StudyBIOS 699 (Fall 2020)
DissertationBIOS 920 (Summer I 2020)
ResearchBIOS 900 (Spring 2020)
Independent StudyEPID 699 (Fall 2019)
ResearchBIOS 900 (Fall 2019)
Special Topics: BiostatisticsBIOS 685 (Fall 2019)
DissertationBIOS 920 (Spring 2019)
ThesisBIOS 910 (Spring 2019)
DissertationBIOS 920 (Fall 2018)
ResearchBIOS 900 (Fall 2018)
Special Topics: BiostatisticsBIOS 685 (Fall 2018)
ResearchBIOS 900 (Spring 2018)
Gen Line+Mix Effect MdlBIOS 684 (Fall 2017)
ThesisCPH 910 (Spring 2017)
Gen Line+Mix Effect MdlCPH 684 (Fall 2016)
Gen Line+Mix Effect MdlEPID 684 (Fall 2016)
Independent StudyCPH 699 (Fall 2016)
ThesisCPH 910 (Spring 2016)
- Richt, C., Peate, W., Moore, P., Gulotta, J., Littau, S., Zhai, J., Dearmon-Moore, D., Jacobs, E. T., Griffin, S., Zhou, J., & Jeong, K. (2018). MicroRNA Changes in Firefighters. JOEM, 60(5), 469.
- Klimentidis, Y. C., Arora, A., Zhou, J., Kittles, R., & Allison, D. B. (2016). The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies. Frontiers in Genetics, 7.
- Twigg, H. L., Knox, K. S., Zhou, J., Crothers, K. A., Nelson, D. E., Toh, E., Day, R. B., Lin, H., Gao, X., Dong, Q., Mi, D., Katz, B. P., Sodergren, E., & Weinstock, G. M. (2016). Effect of Advanced HIV Infection on the Respiratory Microbiome. American journal of respiratory and critical care medicine, 194(2), 226-35.More infoPrevious work found the lung microbiome in healthy subjects infected with HIV was similar to that in uninfected subjects. We hypothesized the lung microbiome from subjects infected with HIV with more advanced disease would differ from that of an uninfected control population.
- Vina, E. R., Ran, D., Ashbeck, E. L., Ibrahim, S. A., Hannon, M. J., Zhou, J. J., & Kwoh, C. K. (2016). Patient preferences for total knee replacement surgery: Relationship to clinical outcomes and stability of patient preferences over 2 years. Seminars in arthritis and rheumatism, 46(1).
- Zhang, Y., Zhou, H., Zhou, J., & Sun, W. (2016). Regression models for multivariate count data. Journal of Computational and Graphical Statistics, 1--37.
- Zhou, J. J., Hu, T., Qiao, D., Cho, M. H., & Zhou, H. (2016). Boosting Gene Mapping Power and Efficiency with Efficient Exact Variance Component Tests of SNP Sets. Genetics, genetics--116.
- Zhou, J. J., Cho, M. H., Castaldi, P. J., Hersh, C. P., Silverman, E. K., & Laird, N. M. (2013). Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. American journal of respiratory and critical care medicine, 188(8).More infoPrevious studies of chronic obstructive pulmonary disease (COPD) have suggested that genetic factors play an important role in the development of disease. However, single-nucleotide polymorphisms that are associated with COPD in genome-wide association studies have been shown to account for only a small percentage of the genetic variance in phenotypes of COPD, such as spirometry and imaging variables. These phenotypes are highly predictive of disease, and family studies have shown that spirometric phenotypes are heritable.
- Tong, Y., Zheng, Y., Zhou, J. J., Oyesiku, N. M., Koeffler, H. P., & Melmed, S. (2012). Genomic characterization of human and rat prolactinomas. Endocrinology, 153(8), 3679-91.
- Zhou, J. J., Ghazalpour, A., Sobel, E. M., Sinsheimer, J. S., & Lange, K. (2012). Quantitative trait Loci association mapping by imputation of strain origins in multifounder crosses. Genetics, 190(2).More infoAlthough mapping quantitative traits in inbred strains is simpler than mapping the analogous traits in humans, classical inbred crosses suffer from reduced genetic diversity compared to experimental designs involving outbred animal populations. Multiple crosses, for example the Complex Trait Consortium's eight-way cross, circumvent these difficulties. However, complex mating schemes and systematic inbreeding raise substantial computational difficulties. Here we present a method for locally imputing the strain origins of each genotyped animal along its genome. Imputed origins then serve as mean effects in a multivariate Gaussian model for testing association between trait levels and local genomic variation. Imputation is a combinatorial process that assigns the maternal and paternal strain origin of each animal on the basis of observed genotypes and prior pedigree information. Without smoothing, imputation is likely to be ill-defined or jump erratically from one strain to another as an animal's genome is traversed. In practice, one expects to see long stretches where strain origins are invariant. Smoothing can be achieved by penalizing strain changes from one marker to the next. A dynamic programming algorithm then solves the strain imputation process in one quick pass through the genome of an animal. Imputation accuracy exceeds 99% in practical examples and leads to high-resolution mapping in simulated and real data. The previous fastest quantitative trait loci (QTL) mapping software for dense genome scans reduced compute times to hours. Our implementation further reduces compute times from hours to minutes with no loss in statistical power. Indeed, power is enhanced for full pedigree data.
- Tong, Y., Zhou, J. J., Mizutani, J., Fukuoka, H., Ren, S. G., Gutierrez-Hartmann, A., Koeffler, P. H., & Melmed, S. (2011). CEBPD suppresses prolactin expression and prolactinoma cell proliferation. Molecular Endocrinology, 25(11), 1880-91.
- Zhou, J. J., Pelka, S., Lange, K., Palmer, C. G., & Sinsheimer, J. S. (2011). Dissecting prenatal, postnatal, and inherited effects: ART and design. Genetic Epidemiology, 35(6), 437-46.
- Boudreault, P., Baldwin, E. E., Fox, M., Dutton, L., Tullis, L., Linden, J., Kobayashi, Y., Zhou, J. J., Sinsheimer, J. S., Sininger, Y., Grody, W. W., & Palmer, C. G. (2010). Deaf adults' reasons for genetic testing depend on cultural affiliation: results from a prospective, longitudinal genetic counseling and testing study. Journal of Deaf Studies and Deaf Education, 15(3), 209-27.
- Palmer, C. G., Lueddeke, J. T., & Zhou, J. J. (2009). Factors influencing parental decision about genetics evaluation for their deaf or hard-of-hearing child. Genetics in Medicine, 11(4), 248-55.
- Palmer, C. G., Martinez, A., Fox, M., Zhou, J. J., Shapiro, N., Sininger, Y., Grody, W. W., & Schimmenti, L. A. (2009). A prospective, longitudinal study of the impact of GJB2/GJB6 genetic testing on the beliefs and attitudes of parents of deaf and hard-of-hearing infants. American Journal of Medical Genetics, 149A(6), 1169-82.
- Zhou, J. J., Zhou, J. J., Lange, K., Lange, K., Papp, J. C., Papp, J. C., Sinsheimer, J. S., & Sinsheimer, J. S. (2009). A heterozygote-homozygote test of Hardy-Weinberg equilibrium. European Journal of Human Genetics, 178(11), 1495-1500.
- Zeng, J., & Zhou, J. J. (2006). A it q-analog of the Seidel generation of Genocchi numbers. European Journal of Combinatorics, 27(3), 364-381.
- Zeng, J., & Zhou, J. J. (2006). Applications of Waring's formula to some identities of Chebyshev polynomials. Fibonacci Quarterly, 44(2), 117--120.
- Klimentidis, Y. C., Zhou, J., Kittles, R. A., Allison, D. B., & Arora, A. (2016, Summer). West-African genetic ancestry is associated with a more favorable cardiometabolic profile among men: a phenomenon partly explained by a variant near COL3A1 and DIRC1. American Diabetes Association Scientific Sessions. New Orleans, LA: American Diabetes Association.More infoI presented this poster at the annual national meeting of the American Diabetes Association.
- Vina, E. R., Ran, D., Ashbeck, E., Ibrahim, S., Hannon, M., Zhou, J., & Kwoh, C. K. (2015, November). Patient preferences for total knee replacement surgery: two year follow-up.. American College of Rheumatology Annual Meeting. San Francisco, CA.