Khadijah Breathett

Interests

Research

Research interests include reducing racial/ethnic and gender disparities in advanced heart failure and preventing populations that experience disparities from developing advanced heart failure.

Courses

No activities entered.

Scholarly Contributions

Chapters

• Breathett, K. (2018). Color Atlas and Synopsis of Heart Failure. In Heart Failure in Minorities(pp 128-135). McGraw Hill.
• Breathett, K., Baliga, R., & Capers, Q. (2015). Management of Heart Failure. Chapter 14. Review of Heart Failure Management in African-Americans.. In Springer.
• Franco, V., Breathett, K., & Baliga, R. (2015). Management of Heart Failure. Chapter Therapy of Heart Failure.. In API Textbook of Medicine. Jaypee Brothers Medical Publishers Ltd.
• Breathett, K., & Gulati, M. (2014). Risk Factors for Cardiovascular Disease. In Color Atlas and Synopsis of Women's Cardiovascular Health.
• Capers, Q., Cummings, M., & Breathett, K. (2014). Endovascular Intervention. Case-Based Approach. In Upper Extremity Arterial Disease(pp 185-192).
• Breathett, K., & Newby, K. (2012). Short-stay Management of Acute Heart Failure.. In Outpatient Medication Titration in Acute Contemporary Cardiology(pp 217-230).

Journals/Publications

• , W. C., Maddox, T. M., Januzzi, J. L., Allen, L. A., Breathett, K., Butler, J., Davis, L. L., Fonarow, G. C., Ibrahim, N. E., Lindenfeld, J., Masoudi, F. A., Motiwala, S. R., Oliveros, E., Patterson, J. H., Walsh, M. N., Wasserman, A., Yancy, C. W., & Youmans, Q. R. (2021). 2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee. Journal of the American College of Cardiology.
• Bellam, N., Denfeld, Q. E., Kamdar, F., Alexy, T., Breathett, K., Patel, P. A., Faulkenberg, K., Moyer, B., Psotka, M. A., & Ginwalla, M. (2021). Navigating Early Careers in Heart Failure in the Era of Novel Coronavirus Disease-2019. Journal of cardiac failure, 27(1), 97-99.
• Breathett, K. K., Knapp, S. M., Wightman, P., Desai, A., Mazimba, S., Calhoun, E., & Sweitzer, N. K. (2020). Is the Affordable Care Act Medicaid Expansion Linked to Change in Rate of Ventricular Assist Device Implantation for Blacks and Whites?. Circulation. Heart failure, 13(4), e006544.
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  The Affordable Care Act (ACA) has been associated with increased heart transplant listings among blacks, who are disproportionately uninsured. It is unclear whether the ACA is also associated with increased ventricular assist device implantation in blacks.
• Breathett, K., Kohler, L. N., Eaton, C. B., Franceschini, N., Garcia, L., Klein, L., Martin, L. W., Ochs-Balcom, H. M., Shadyab, A. H., & Cené, C. W. (2020). When the At-Risk Do Not Develop Heart Failure: Understanding Positive Deviance Among Postmenopausal African American and Hispanic Women. Journal of cardiac failure.
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  African American and Hispanic postmenopausal women have the highest risk for heart failure compared with other races, but heart failure prevalence is lower than expected in some national cohorts. It is unknown whether psychosocial factors are associated with lower risk of incident heart failure hospitalization among high-risk postmenopausal minority women.
• Breathett, K., Sims, M., Gross, M., Jackson, E. A., Jones, E. J., Navas-Acien, A., Taylor, H., Thomas, K. L., Howard, B. V., & , A. H. (2020). Cardiovascular Health in American Indians and Alaska Natives: A Scientific Statement From the American Heart Association. Circulation, 141(25), e948-e959.
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  Cardiovascular disease (CVD) is the leading cause of death among American Indians and Alaska Natives. Over the past 50 years, the prevalence of CVD has been rising among American Indians and Alaska Natives. The objective of this statement is to summarize population-level risk factors and management techniques tailored for the American Indian and Alaska Native populations.
• Breathett, K., Yee, E., Pool, N., Hebdon, M., Crist, J. D., Yee, R. H., Knapp, S. M., Solola, S., Luy, L., Herrera-Theut, K., Zabala, L., Stone, J., McEwen, M. M., Calhoun, E., & Sweitzer, N. K. (2020). Association of Gender and Race With Allocation of Advanced Heart Failure Therapies. JAMA network open, 3(7), e2011044.
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  Racial bias is associated with the allocation of advanced heart failure therapies, heart transplants, and ventricular assist devices. It is unknown whether gender and racial biases are associated with the allocation of advanced therapies among women.
• DeFilippis, E. M., Breathett, K., Donald, E. M., Nakagawa, S., Takeda, K., Takayama, H., Truby, L. K., Sayer, G., Colombo, P. C., Yuzefpolskaya, M., Uriel, N., Farr, M. A., & Topkara, V. K. (2020). Psychosocial Risk and Its Association With Outcomes in Continuous-Flow Left Ventricular Assist Device Patients. Circulation. Heart failure, 13(9), e006910.
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  Advanced heart failure therapies such as left ventricular assist device (LVAD) implantation require intricate follow-up and complex care. We sought to explore the burden of psychosocial risk factors among patients with LVAD and their impact on postimplant outcomes using the Interagency Registry for Mechanically Assisted Circulatory Support.
• Flint, K., Chaussee, E. L., Henderson, K., Breathett, K., Khazanie, P., Thompson, J. S., Mcilvennan, C. K., Larue, S. J., Matlock, D. D., & Allen, L. A. (2020). Social Determinants of Health and Rates of Implantation for Patients Considering Destination Therapy Left Ventricular Assist Device. Journal of cardiac failure.
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  A left ventricular assist device (LVAD) is a treatment option available to select patients with advanced heart failure. However, there are important social determinants of health that can play a role in determining patients' outcomes after device placement.
• Galaviz, K. I., Breland, J. Y., Sanders, M., Breathett, K., Cerezo, A., Gil, O., Hollier, J. M., Marshall, C., Wilson, J. D., & Essien, U. R. (2020). Implementation Science to Address Health Disparities During the Coronavirus Pandemic. Health equity, 4(1), 463-467.
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  The coronavirus disease 2019 (COVID-19) pandemic is disproportionally affecting racial and ethnic minorities. In the United States, data show African American, Hispanic, and Native American populations are overrepresented among COVID-19 cases and deaths. As we speed through the discovery and translation of approaches to fight COVID-19, these disparities are likely to increase. Implementation science can help address disparities by guiding the equitable development and deployment of preventive interventions, testing, and, eventually, treatment and vaccines. In this study, we discuss three ways in which implementation science can inform these efforts: (1) quantify and understand disparities; (2) design equitable interventions; and (3) test, refine, and retest interventions.
• Heidenreich, P. A., Fonarow, G. C., Breathett, K., Jurgens, C. Y., Pisani, B. A., Pozehl, B. J., Spertus, J. A., Taylor, K. G., Thibodeau, J. T., Yancy, C. W., & Ziaeian, B. (2020). 2020 ACC/AHA Clinical Performance and Quality Measures for Adults With Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Circulation. Cardiovascular quality and outcomes, 13(11), e000099.
• Heidenreich, P. A., Fonarow, G. C., Breathett, K., Jurgens, C. Y., Pisani, B. A., Pozehl, B. J., Spertus, J. A., Taylor, K. G., Thibodeau, J. T., Yancy, C. W., & Ziaeian, B. (2020). 2020 ACC/AHA Clinical Performance and Quality Measures for Adults With Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Journal of the American College of Cardiology, 76(21), 2527-2564.
• Sims, M., Kershaw, K. N., Breathett, K., Jackson, E. A., Lewis, L. M., Mujahid, M. S., Suglia, S. F., & , A. H. (2020). Importance of Housing and Cardiovascular Health and Well-Being: A Scientific Statement From the American Heart Association. Circulation. Cardiovascular quality and outcomes, 13(8), e000089.
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  Cardiovascular disease disparities are shaped by differences in risk factors across racial and ethnic groups. Housing remains an important social determinant of health. The objective of this statement is to review and summarize research that has examined the associations of housing status with cardiovascular health and overall health. PubMed/Medline, Centers for Disease Control and Prevention data, US Census data, Cochrane Library reviews, and the annual Heart Disease and Stroke Statistics report from the American Heart Association were used to identify empirical research studies that examined associations of housing with cardiovascular health and overall well-being. Health is affected by 4 prominent dimensions of housing: stability, quality and safety, affordability and accessibility, and neighborhood environment. Vulnerable and underserved populations are adversely affected by housing insecurity and homelessness, are at risk for lower-quality and unsafe housing conditions, confront structural barriers that limit access to affordable housing, and are at risk for living in areas with substandard built environment features that are linked to cardiovascular disease. Research linking select pathways to cardiovascular health is relatively strong, but research gaps in other housing pathways and cardiovascular health remain. Efforts to eliminate cardiovascular disease disparities have recently emphasized the importance of social determinants of health. Housing is a prominent social determinant of cardiovascular health and well-being and should be considered in the evaluation of prevention efforts to reduce and eliminate racial/ethnic and socioeconomic disparities.
• Solola, S., Luy, L., Herrera-Theut, K., Zabala, L., Torabzadeh, E., Bedrick, E. J., Yee, E., Larsen, A., Stone, J., McEwen, M., Calhoun, E., Crist, J. D., Hebdon, M., Pool, N., Carnes, M., Sweitzer, N., & Breathett, K. (2020). Race and Gender-Based Perceptions of Older Adults: Will the Youth Lead the Way?. Journal of racial and ethnic health disparities.
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  Older individuals encounter the greatest racial/gender biases. It is unknown whether younger generations, who often lead culture shifts, have racial and gender biases against older populations.
• Whitelaw, S., Thabane, L., Mamas, M. A., Reza, N., Breathett, K., Douglas, P. S., & Van Spall, H. G. (2020). Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors. Journal of the American College of Cardiology, 76(17), 1919-1930.
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  Clinical trials change practice in cardiology, and leading them requires research training, mentorship, sponsorship, and networking. Women report challenges in obtaining these opportunities.
• Zhuo, D. X., Bilchick, K. C., Shah, K. P., Mehta, N. K., Mwansa, H., Nkanza-Kabaso, K., Kwon, Y., Breathett, K. K., Hilton-Buchholz, E. J., & Mazimba, S. (2020). MAGGIC, STS, and EuroSCORE II Risk Score Comparison After Aortic and Mitral Valve Surgery. Journal of cardiothoracic and vascular anesthesia.
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  To compare the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score with the established Society of Thoracic Surgeons (STS) and EuroSCORE II risk prediction models regarding mortality discrimination after aortic and mitral valve surgery.
• Breathett, K. (2019). Dare to Achieve Health Equity. JACC. Heart failure, 7(6), 516-517.
• Breathett, K. (2019). One for All and All for One: Moving Toward a Single Payer for Heart Transplant. JACC. Heart failure, 7(1), 63-64.
• Breathett, K., Yee, E., Pool, N., Hebdon, M., Crist, J. D., Knapp, S., Larsen, A., Solola, S., Luy, L., Herrera-Theut, K., Zabala, L., Stone, J., McEwen, M. M., Calhoun, E., & Sweitzer, N. K. (2019). Does Race Influence Decision Making for Advanced Heart Failure Therapies?. Journal of the American Heart Association, 8(22), e013592.
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  Background Race influences medical decision making, but its impact on advanced heart failure therapy allocation is unknown. We sought to determine whether patient race influences allocation of advanced heart failure therapies. Methods and Results Members of a national heart failure organization were randomized to clinical vignettes that varied by patient race (black or white man) and were blinded to study objectives. Participants (N=422) completed Likert scale surveys rating factors for advanced therapy allocation and think-aloud interviews (n=44). Survey results were analyzed by least absolute shrinkage and selection operator and multivariable regression to identify factors influencing advanced therapy allocation, including interactions with vignette race and participant demographics. Interviews were analyzed using grounded theory. Surveys revealed no differences in overall racial ratings for advanced therapies. Least absolute shrinkage and selection operator regression selected no interactions between vignette race and clinical factors as important in allocation. However, interactions between participants aged ≥40 years and black vignette negatively influenced heart transplant allocation modestly (-0.58; 95% CI, -1.15 to -0.0002), with adherence and social history the most influential factors. Interviews revealed sequential decision making: forming overall impression, identifying urgency, evaluating prior care appropriateness, anticipating challenges, and evaluating trust while making recommendations. Race influenced each step: avoiding discussing race, believing photographs may contribute to racial bias, believing the black man was sicker compared with the white man, developing greater concern for trust and adherence with the black man, and ultimately offering the white man transplantation and the black man ventricular assist device implantation. Conclusions Black race modestly influenced decision making for heart transplant, particularly during conversations. Because advanced therapy selection meetings are conversations rather than surveys, allocation may be vulnerable to racial bias.
• Callister, C., Jones, J., Schroeder, S., Breathett, K., Dollar, B., Sanghvi, U. J., Harnke, B., Lum, H. D., & Jones, C. D. (2019). Caregiver Experiences of Care Coordination for Recently Discharged Patients: A Qualitative Metasynthesis. Western journal of nursing research, 193945919880183.
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  Caregivers of patients often provide key support for patients after hospitalization. This qualitative metasynthesis describes caregiver perspectives about care coordination for patients discharged from the hospital. A literature search of Ovid Medline and CINAHL completed on May 23, 2018, identified 1,546 studies. Twelve articles were included in the final metasynthesis. Caregiver perspectives about care coordination were compiled into overall themes. A subanalysis of studies in which patients were discharged with home health services was completed. Five main themes emerged related to caregiver perspectives on care coordination after hospitalization: (a) Suboptimal access to clinicians after discharge, (b) Feeling disregarded by clinicians, (c) Need for information and training at discharge, (d) Overwhelming responsibilities to manage appointments and medications, and (e) Need for emotional support. Findings from this metasynthesis suggest the need for clinicians to engage with caregivers to provide support, training, and communication after hospital discharge.
• Ebong, I., & Breathett, K. (2019). The Cardiovascular Disease Epidemic in African American Women: Recognizing and Tackling a Persistent Problem. Journal of women's health (2002).
• Ebong, I., Mazimba, S., & Breathett, K. (2019). Cardiac Biomarkers in Advanced Heart Failure: How Can They Impact Our Pre-transplant or Pre-LVAD Decision-making. Current heart failure reports, 16(6), 274-284.
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  Decision-making in advanced heart failure (HF) is a complex process that involves careful consideration of competing tradeoffs of risks and benefits in regard to heart transplantation (HT) or left ventricular assist device (LVAD) placement. The purpose of this review is to discuss how biomarkers may affect decision-making for HT or LVAD implantation.
• Felix, A. S., Lehman, A., Nolan, T. S., Sealy-Jefferson, S., Breathett, K., Hood, D. B., Addison, D., Anderson, C. M., Cené, C. W., Warren, B. J., Jackson, R. D., & Williams, K. P. (2019). Stress, Resilience, and Cardiovascular Disease Risk Among Black Women. Circulation. Cardiovascular quality and outcomes, 12(4), e005284.
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  Empirical data on the link between stress and cardiovascular disease (CVD) risk among black women is limited. We examined associations of stressful life events and social strain with incident CVD among black women and tested for effect modification by resilience.
• Peters, A. E., Smith, L. A., Ababio, P., Breathett, K., McMurry, T. L., Kennedy, J. L., Abuannadi, M., Bergin, J., & Mazimba, S. (2019). Comparative Analysis of Established Risk Scores and Novel Hemodynamic Metrics in Predicting Right Ventricular Failure in Left Ventricular Assist Device Patients. Journal of cardiac failure, 25(8), 620-628.
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  Right ventricular failure (RVF) portends poor outcomes after left ventricular assist device (LVAD) implantation. Although numerous RVF predictive models have been developed, there are few independent comparative analyses of these risk models.
• Breathett, K. (2018). Health Status Equity: A Right Not a Privilege. JACC. Heart failure, 6(6), 474-475.
• Breathett, K. (2018). Same Story, Different Disease: It Is Time to Change the Storyline for Racial Minorities and Patients of Lower Socioeconomic Status. Circulation. Heart failure, 11(3), e004931.
• Breathett, K., Allen, L. A., Helmkamp, L., Colborn, K., Daugherty, S. L., Blair, I. V., Jones, J., Khazanie, P., Mazimba, S., McEwen, M., Stone, J., Calhoun, E., Sweitzer, N. K., & Peterson, P. N. (2018). Temporal Trends in Contemporary Use of Ventricular Assist Devices by Race and Ethnicity. Circulation. Heart failure, 11(8), e005008.
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  The proportion of racial/ethnic minorities receiving ventricular assist devices (VADs) has previously been less than expected. It is unclear if trends have changed since the broadening of access to insurance in 2014 and the rapid adoption of VAD technology.
• Breathett, K., Jones, J., Lum, H. D., Koonkongsatian, D., Jones, C. D., Sanghvi, U., Hoffecker, L., McEwen, M., Daugherty, S. L., Blair, I. V., Calhoun, E., de Groot, E., Sweitzer, N. K., & Peterson, P. N. (2018). Factors Related to Physician Clinical Decision-Making for African-American and Hispanic Patients: a Qualitative Meta-Synthesis. Journal of racial and ethnic health disparities, 5(6), 1215-1229.
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  Clinical decision-making may have a role in racial and ethnic disparities in healthcare but has not been evaluated systematically. The purpose of this study was to synthesize qualitative studies that explore various aspects of how a patient's African-American race or Hispanic ethnicity may factor into physician clinical decision-making. Using Ovid MEDLINE, Embase, and Cochrane Library, we identified 13 manuscripts that met inclusion criteria of usage of qualitative methods; addressed US physician clinical decision-making factors when caring for African-American, Hispanic, or Caucasian patients; and published between 2000 and 2017. We derived six fundamental themes that detail the role of patient race and ethnicity on physician decision-making, including importance of race, patient-level issues, system-level issues, bias and racism, patient values, and communication. In conclusion, a non-hierarchical system of intertwining themes influenced clinical decision-making among racial and ethnic minority patients. Future study should systematically intervene upon each theme in order to promote equitable clinical decision-making among diverse racial/ethnic patients.
• Breathett, K., Leng, I., Foraker, R. E., Abraham, W. T., Coker, L., Whitfield, K. E., Shumaker, S., Manson, J. E., Eaton, C. B., Howard, B. V., Ijioma, N., Cené, C. W., Martin, L. W., Johnson, K. C., & Klein, L. (2018). Risk Factor Burden, Heart Failure, and Survival in Women of Different Ethnic Groups: Insights From the Women's Health Initiative. Circulation. Heart failure, 11(5), e004642.
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  The higher risk of heart failure (HF) in African-American and Hispanic women compared with white women is related to the higher burden of risk factors (RFs) in minorities. However, it is unclear if there are differences in the association between the number of RFs for HF and the risk of development of HF and death within racial/ethnic groups.
• Breathett, K., Liu, W. G., Allen, L. A., Daugherty, S. L., Blair, I. V., Jones, J., Grunwald, G. K., Moss, M., Kiser, T. H., Burnham, E., Vandivier, R. W., Clark, B. J., Lewis, E. F., Mazimba, S., Battaglia, C., Ho, P. M., & Peterson, P. N. (2018). African Americans Are Less Likely to Receive Care by a Cardiologist During an Intensive Care Unit Admission for Heart Failure. JACC. Heart failure, 6(5), 413-420.
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  This study sought to determine whether the likelihood of receiving primary intensive care unit (ICU) care by a cardiologist versus a noncardiologist was greater for Caucasians than for African Americans admitted to an ICU for heart failure (HF). The authors further evaluated whether primary ICU care by a cardiologist is associated with higher in-hospital survival, irrespective of race.
• Breathett, K., Maffett, S., Foraker, R. E., Sturdivant, R., Moon, K., Hasan, A., Franco, V., Smith, S., Lampert, B. C., Emani, S., Haas, G., Kahwash, R., Hershberger, R. E., Binkley, P. F., Helmkamp, L., Colborn, K., Peterson, P. N., Sweitzer, N., & Abraham, W. T. (2018). Pilot Randomized Controlled Trial to Reduce Readmission for Heart Failure Using Novel Tablet and Nurse Practitioner Education. The American journal of medicine, 131(8), 974-978.
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  Heart failure education programs are not standardized. The best form of education is unclear. We evaluated whether addition of a novel tablet application to nurse practitioner (NP) education was superior to NP education alone in reducing 30-day readmission after heart failure hospitalization.
• Ebong, I., & Breathett, K. (2018). The Time Is Now: Reducing Racial Risk of Hypertension with Postpregnancy Follow-Up. Journal of women's health (2002).
• Mazimba, S., Welch, T. S., Mwansa, H., Breathett, K. K., Kennedy, J. L., Mihalek, A. D., Harding, W. C., Mysore, M. M., Zhuo, D. X., & Bilchick, K. C. (2018). Haemodynamically Derived Pulmonary Artery Pulsatility Index Predicts Mortality in Pulmonary Arterial Hypertension. Heart, lung & circulation.
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  Pulmonary artery (PA) pulsitility index (PAPi) is a novel haemodynamic index shown to predict right ventricular failure in acute inferior myocardial infarction and post left ventricular assist device surgery. We hypothesised that PAPi calculated as [PA systolic pressure - PA diastolic pressure]/right atrial pressure (RAP) would be associated with mortality in the National Institutes of Health Registry for Primary Pulmonary Hypertension (NIH-RPPH).
• Mysore, M. M., Bilchick, K. C., Ababio, P., Ruth, B. K., Harding, W. C., Breathett, K., Chadwell, K., Patterson, B., Mwansa, H., Jeukeng, C. M., Kwon, Y., Kennedy, J. L., Mihalek, A. D., & Mazimba, S. (2018). Right atrial to left atrial volume index ratio is associated with increased mortality in patients with pulmonary hypertension. Echocardiography (Mount Kisco, N.Y.), 35(11), 1729-1735.
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  Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance leading to right heart failure. Elevated right atrial (RA) pressure reflects right ventricular (RV) pressure overload and is an established risk factor for mortality in PH. We hypothesized that PH patients with an increased ratio of RA to LA volume index (RAVI/LAVI), would have increased mortality.
• Somes, E., Dukes, J., Brungardt, A., Jordan, S., DeSanto, K., Jones, C. D., Sanghvi, U. J., Breathett, K., Jones, J., & Lum, H. D. (2018). Perceptions of trained laypersons in end-of-life or advance care planning conversations: a qualitative meta-synthesis. BMC palliative care, 17(1), 98.
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  Laypersons including volunteers, community health navigators, or peer educators provide important support to individuals with serious illnesses in community or healthcare settings. The experiences of laypersons in communication with seriously ill peers is unknown.
• Bilchick, K. C., Mejia-Lopez, E., McCullough, P., Breathett, K., Kennedy, J. L., Tallaj, J., Bergin, J., Pamboukian, S., Abuannadi, M., & Mazimba, S. (2017). Clinical Impact of Changes in Hemodynamic Indices of Contractile Function During Treatment of Acute Decompensated Heart Failure. Journal of cardiac failure.
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  The objective of this work was to determine the impact of improving right ventricular versus left ventricular stroke work indexes (RVSWI vs LVSWI) during therapy for acute decompensated heart failure (ADHF).
• Breathett, K., Allen, L. A., Helmkamp, L., Colborn, K., Daugherty, S. L., Khazanie, P., Lindrooth, R., & Peterson, P. N. (2017). The Affordable Care Act Medicaid Expansion Correlated With Increased Heart Transplant Listings in African-Americans But Not Hispanics or Caucasians. JACC. Heart failure, 5(2), 136-147.
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  The aim of this study was to determine if the Affordable Care Act (ACA) Medicaid Expansion was associated with increased census-adjusted heart transplant listing rates for racial/ethnic minorities.
• Breathett, K., D'Amico, R., Adesanya, T. M., Hatfield, S., Willis, S., Sturdivant, R. X., Foraker, R. E., Smith, S., Binkley, P., Abraham, W. T., & Peterson, P. N. (2017). Patient Perceptions on Facilitating Follow-Up After Heart Failure Hospitalization. Circulation. Heart failure, 10(6).
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  Timely follow-up after hospitalization for heart failure (HF) is recommended. However, follow-up is suboptimal, especially in lower socioeconomic groups. Patient-centered solutions for facilitating follow-up post-HF hospitalization have not been extensively evaluated.
• Breathett, K., Filley, J., Pandey, M., Rai, N., & Peterson, P. N. (2017). Trends in Early Prenatal Care Among Women with Pre-Existing Diabetes: Have Income Disparities Changed?. Journal of women's health (2002).
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  Women with pre-existing diabetes are at high maternal risk for comorbidities and death, particularly when early prenatal care is not received. Low income is a known barrier to early prenatal care. It is unknown whether recent policies to expand access to prenatal care have reduced income disparities. We hypothesized that income disparities would be minimized and that the odds of receipt of first trimester prenatal care among women with pre-existing diabetes would become similar across income strata over time.
• Breathett, K., Willis, S., Foraker, R. E., & Smith, S. (2017). Impact of Insurance Type on Initial Rejection Post Heart Transplant. Heart, lung & circulation, 26(2), 164-171.
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  Heart transplantation allocation is often restricted from patients with low socioeconomic status (SES) due to concern for worse outcomes. We hypothesised that comorbidities would have a greater impact on risk of severe rejection post-orthotopic heart transplant than would Medicaid insurance and Median Household Income (MHI).
• Bristow, M. R., Kao, D. P., Breathett, K. K., Altman, N. L., Gorcsan, J., Gill, E. A., Lowes, B. D., Gilbert, E. M., Quaife, R. A., & Mann, D. L. (2017). Structural and Functional Phenotyping of the Failing Heart: Is the Left Ventricular Ejection Fraction Obsolete?. JACC. Heart failure, 5(11), 772-781.
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  Diagnosis, prognosis, treatment, and development of new therapies for diseases or syndromes depend on a reliable means of identifying phenotypes associated with distinct predictive probabilities for these various objectives. Left ventricular ejection fraction (LVEF) provides the current basis for combined functional and structural phenotyping in heart failure by classifying patients as those with heart failure with reduced ejection fraction (HFrEF) and those with heart failure with preserved ejection fraction (HFpEF). Recently the utility of LVEF as the major phenotypic determinant of heart failure has been challenged based on its load dependency and measurement variability. We review the history of the development and adoption of LVEF as a critical measurement of LV function and structure and demonstrate that, in chronic heart failure, load dependency is not an important practical issue, and we provide hemodynamic and molecular biomarker evidence that LVEF is superior or equal to more unwieldy methods of identifying phenotypes of ventricular remodeling. We conclude that, because it reliably measures both left ventricular function and structure, LVEF remains the best current method of assessing pathologic remodeling in heart failure in both individual clinical and multicenter group settings. Because of the present and future importance of left ventricular phenotyping in heart failure, LVEF should be measured by using the most accurate technology and methodologic refinements available, and improved characterization methods should continue to be sought.
• Breathett, K., Allen, L. A., & Ambardekar, A. V. (2016). Patient-centered care for left ventricular assist device therapy: current challenges and future directions. Current opinion in cardiology, 31(3), 313-20.
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  Discuss the current status and obstacles that need to be overcome in the future to provide patient-centered care with left ventricular assist device (LVAD) therapy.
• Breathett, K., Allen, L. A., Udelson, J., Davis, G., & Bristow, M. (2016). Changes in Left Ventricular Ejection Fraction Predict Survival and Hospitalization in Heart Failure With Reduced Ejection Fraction. Circulation. Heart failure, 9(10).
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  Left ventricular remodeling, as commonly measured by left ventricular ejection fraction (LVEF), is associated with clinical outcomes. Although change in LVEF over time should reflect response to therapy and clinical course, serial measurement of LVEF is inconsistently performed in observational settings, and the incremental prognostic value of change in LVEF has not been well characterized.
• Breathett, K., Mehta, N., Yildiz, V., Abel, E., & Husa, R. (2016). The impact of body mass index on patient survival after therapeutic hypothermia after resuscitation. The American journal of emergency medicine, 34(4), 722-5.
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  Therapeutic hypothermia improves survival in patients after cardiac arrest, yet the impact of body mass index (BMI) on survival is lesser known. We hypothesized that nonobese patients would have greater survival post-therapeutic hypothermia than obese patients.
• Eaton, C. B., Pettinger, M., Rossouw, J., Martin, L. W., Foraker, R., Quddus, A., Liu, S., Wampler, N. S., Hank Wu, W. C., Manson, J. E., Margolis, K., Johnson, K. C., Allison, M., Corbie-Smith, G., Rosamond, W., Breathett, K., & Klein, L. (2016). Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women. Circulation. Heart failure, 9(10).
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  Heart failure is an important and growing public health problem in women. Risk factors for incident hospitalized heart failure with preserved ejection fraction (HFpEF) compared with heart failure with reduced ejection fraction (HFrEF) in women and differences by race/ethnicity are not well characterized.
• Oza, N. M., & Breathett, K. (2015). Women in cardiology: fellows' perspective. Journal of the American College of Cardiology, 65(9), 951-3.
• Breathett, K., Muhlestein, D., Foraker, R., & Gulati, M. (2014). Differences in preeclampsia rates between African American and Caucasian women: trends from the National Hospital Discharge Survey. Journal of women's health (2002), 23(11), 886-93.
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  African Americans are at higher risk for preeclampsia compared with Caucasians, but longitudinal changes are unknown. We hypothesized that preeclampsia rates among African Americans would be higher than that of Caucasians and over time would maintain a consistent divergence.
• Esber, C., Breathett, K., Sachak, T., Moore, S., & Lilly, S. M. (2014). Acute Myocardial Infarction in Patient With Triple Negative Breast Cancer After Paclitaxel Infusion: A Case Report. Cardiology research, 5(3-4), 108-111.
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  A 47-year-old woman with breast cancer suffered progressive chest pain and flushing within 5 minutes of her second exposure to paclitaxel. Her symptoms progressed and she became pulseless. Advanced cardiac life support (ACLS) was initiated, and after a series of chest compressions the cardiac monitor revealed ventricular fibrillation. With ongoing ACLS she was transferred to the emergency department where she regained a pulse. Review of electrocardiogram revealed prominent ST elevation in leads V1, V2 and V3 with reciprocal ST depression. She was transferred urgently to the catheterization laboratory. Angiography revealed a high-grade stenosis in the proximal left anterior descending artery (LAD), and drug-eluting stents were placed without complications. She was then transferred to the floor and shortly thereafter suffered pulseless electrical activity and died despite prolonged attempts at resuscitation. Herein, we describe the development of acute myocardial infarction after paclitaxel administration, discuss potential etiologies and review evidence for an allergic component.
• Thomas, K. L., Shah, B. R., Elliot-Bynum, S., Thomas, K. D., Damon, K., Allen LaPointe, N. M., Calhoun, S., Thomas, L., Breathett, K., Mathews, R., Anderson, M., Califf, R. M., & Peterson, E. D. (2014). Check it, change it: a community-based, multifaceted intervention to improve blood pressure control. Circulation. Cardiovascular quality and outcomes, 7(6), 828-34.
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  Although home blood pressure (BP) monitoring interventions have shown potential in selected populations, it is unclear whether such strategies can be generalized. We sought to determine whether a multifaceted BP control program that uses a web-based health portal (Heart360), community health coaches, and physician assistant guidance could improve hypertension control in a diverse community setting.

Proceedings Publications

• Mazimba, S., Baafi, P., David, S., Mysore, M., Sawch, D., Benjamin, C., Mehta, N., Butler, J., Tallaj, J., Kennedy, J., Mihalek, A., Hossack, J., Breathett, K., Chadwell, K., & Bilchick, K. (2019, MAR 12). PULMONARY DIASTOLIC DECAY TIME IS A NOVEL INDEX ASSOCIATED WITH SEVERE HEMODYNAMIC IMPAIRMENTS IN PATIENTS WITH PULMONARY HYPERTENSION. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 73, 1946-1946.
• Mazimba, S., Stafford, P., David, S., Barber, A., Abeya, F., Aktan, I., Noutong, S. N., Chadwell, K., Kwon, Y., Kabwe, L., Okello, S., Mehta, N., Breathett, K., & Bilchick, K. C. (2019, AUG). Ventricular Dyssynchrony is Associated with Worse Left Ventricular Ejection Fraction Trajectories in Severe Decompensated Systolic Heart Failure. In JOURNAL OF CARDIAC FAILURE, 25, S44-S44.
• Tertulien, T., Breathett, K., Cene, C. W., Corbie-Smith, G., Nassir, R., Allison, M., Roberts, M. B., Manson, J., & Eaton, C. B. (2018, MAR 20). Association of Race and SES with the Treatment of STEMI and NSTEMI and the Rate of Coronary Revascularization among Post-Menopausal Women: The Women Health Initiative. In CIRCULATION, 137.
• Mazimba, S., Parker, A., Breathett, K., Kennedy, J., Bergin, J., Welch, T., Abuannadi, M., & Bilchick, K. C. (2017, AUG). Increased Left Atrial Size in Chronic Systolic Heart Failure is Associated with Adverse Events: Insights From the HF-ACTION Trial. In JOURNAL OF CARDIAC FAILURE, 23, S40-S40.
• Mazimba, S., Schubert, S., Solanki, J., Mwansa, H., Parker, A., Kennedy, J. L., Bergin, J., Mubanga, M., Breathett, K., Mejia-Lopez, E., Abuannadi, M., & Bilchick, K. C. (2017, NOV 14). Increased Pulmonary-Systemic Pressure Ratio is Associated With Adverse Events in Advanced Heart Failure. In CIRCULATION, 136.
• Mazimba, S., Welch, T., McCullough, P., Breathett, K., Tallaj, J., Bergin, J., Kennedy, J., Smith, L., Abuannadi, M., & Bilchick, K. (2017, MAR 21). SYSTEMIC ARTERIAL PULSATILITY INDEX (SAPI) PREDICTS ADVERSE OUTCOMES IN ADVANCED HEART FAILURE PATIENTS. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 69, 856-856.
• Ruth, B., Bilchick, K., Mysore, M., Harding, W. C., Breathett, K., Parker, A., Bergin, J., Kennedy, J., Kemeyou, L., Abuannadil, M., & Mazimba, S. (2017, AUG). Increased Pulmonary to Systemic Pulse Pressure Ratio is Associated with Adverse Clinical Outcomes in Advanced Heart Failure. In JOURNAL OF CARDIAC FAILURE, 23, S56-S56.
• Breathett, K., Allen, L. A., Helmkamp, L., Colborn, K., Daugherty, S. L., Khazanie, P., LIndrooth, R., & Peterson, P. (2016, AUG). The Affordable Care Act-Medicaid Expansion is Associated with Increased Heart Transplant Listings in African-Americans. In JOURNAL OF CARDIAC FAILURE, 22, S4-S4.
• Tison, G. H., Nah, G., Olgin, J. E., Vittinghoff, E., Howard, B. V., Foraker, R., Allison, M. A., Casanova, R. L., Blair, R. H., Breathett, K. K., Klein, L., & Parikh, N. I. (2016, NOV 11). Identifying Novel Predictors for Incident Heart Failure Using Statistical Learning Techniques in the Women's Health Initiative (WHI) Cohort. In CIRCULATION, 134.
• Breathett, K., Sturdivant, R., Carpenter, D., Foraker, R., Binkley, P., & Abraham, W. T. (2014, NOV 25). High Dose Guideline-Directed Medical Therapy for Heart Failure at Discharge Improves 1-Year Mortality in African-Americans but Not Hypertensive Patients. In CIRCULATION, 130.
• Quddus, A., Klein, L., Rossouw, J. E., Wu, W., Liu, S., Wampler, N. S., Martin, L. W., Margolis, K., Johnson, K., Foraker, R., Corbie-Smith, G., Breathett, K., Allison, M., Manson, J. E., & Eaton, C. B. (2014, NOV 25). Racial and Ethnic Differences in Preserved Ejection Fraction and Reduced Ejection Fraction Incident Heart Failure in a Multiracial Cohort of Post-Menopausal Women. In CIRCULATION, 130.
• Thomas, K. L., Shah, B. R., Elliott-Bynum, S., Thomas, K. D., Damon, K., Lapointe, N. A., Calhoun, S., Thomas, L., Breathett, K., Mathews, R., Anderson, M., Califf, R. M., & Peterson, E. D. (2012, NOV 20). Check It Change It: A Community Based Hypertension Program. In CIRCULATION, 126.

Poster Presentations

• Breathett, K. (2018, April/Spring). A Pilot Randomized Controlled Trial to Reduce Readmission For Heart Failure Using Novel Tablet and Nurse Practitioner Education Methods.. International Society of Heart and Lung Transplantation..
• Breathett, K. (2017, April). Racial Differences in Receipt of Care by a Cardiologist During a Critical Heart Failure Admission. International Society of Heart and Lung Transplantation.
• Breathett, K. (2017, April). Racial and Ethnic Differences in Contemporary Use of Left Ventricular Assist Device.. American Heart Association Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke.
• Breathett, K. (2016, May/Spring). Safe and shorter length of stay with reduction of time in bed after electrophysiology studies.. Heart Rhythm Society Annual Scientific Sessions..
• Breathett, K. (2016, November/Fall). Identifying Novel Predictors for Incident Heart Failure Using Statistical Learning Techniques in the Women’s Health Initiative Cohort.. American Heart Association Scientific Sessions.
• Breathett, K. (2016, November/Fall). Patient Perceptions On Improving Follow-up After Heart Failure Hospitalization.. American Heart Association Scientific Sessions..
• Breathett, K. (2015, May/Spring). Racial and Ethnic Differences in Heart Failure Stage Progression in PostMenopausal Women: The Women’s Health Initiative.. The Women’s Health Initiative Scientific Sessions..
• Breathett, K. (2015, May/Spring). Unexpected Differences In Traditional Etiologies of Readmission and Mortality Post Left Ventricular Assist Device After Adjusting For Socioeconomic Status.. American Heart Association Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke..
• Breathett, K. (2015, November/Fall). Impact of Insurance Type On Initial Rejection Requiring Hospitalization Post Orthotopic Heart Transplant.. American Heart Association Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke.. American Heart Association.
• Breathett, K. (2015, November/Fall). The Impact of Body Mass Index and Gender On Patient Survival After Therapeutic Hypothermia Following Resuscitation.. American Heart Association Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. American Heart Association.
• Breathett, K. (2013, December/Winter). The Impact of Insurance and Socioeconomic Status on Outcomes for Patients with Left Ventricular Access Devices.. Heart Failure Holiday Symposium.. The Bluhm Cardiovascular Institute of Northwestern Memorial Hospital and Heart Failure Society of America..
• Breathett, K. (2012, November/Fall). Check It Change It: A Community Based Hypertension Program. American Heart Association Scientific Sessions Abstract Presentation..
• Breathett, K. (2011, October/Fall). Community-Based Care Model for Hypertension: Phase 1, Community Identification of Solutions. Ohio American College of Cardiology Poster Presentation.

Others

• Breathett, K. (2020, October). Latest Evidence on Racial Inequities and Biases in Advanced Heart Failure. Expert Analysis.. American College of Cardiology. Heart Failure and Cardiomyopathies Clinical Topic Collection. https://www.acc.org/latestin- cardiology/articles/2020/10/01/11/39/latest-evidence-on-racial-inequities-and-biases-inadvanced- hf
• Breathett, K. (2018, Fall). Reducing Cardiovascular Disparities Among Minority Women: Prevention.. Sarver Heart Center Diversity Newsletter..
• Breathett, K. (2018, May). Helping Your Doctor Overcome Medical Bias of Minority Patients.. The Healthy Dose.
• Ebong, I., & Breathett, K. (2018, 04). Cardiovascular Health in African-Americans CME for acc.org..
• Breathett, K. (2017, 09). A Greater Awareness of Health Disparities in Heart Failure Across Race/Ethnicity and Sex. Sarver Heart Center Diversity Newsletter.
• Mehta Oza, N., Patel, D., Taylor, M., Breathett, K., & Pleister, A. (2015, 01). Recognizing Obesity Hypoventilation Syndrome.. http://apnea.cardiosource.org.