Kaveh Laksari

Interests

Research

My research focus is on the field of biomechanics in general and injury biomechanics in particular. I have worked on modeling and preventing traumatic brain injury (TBI) in contact sports, and on modeling arteria wall tissue with a focus on high-rate loadings that could lead to loss of mechanical integrity and eventual dissection. I am also working on using high-performance computing to model patient-specific cerebral hemodynamics in stroke patients.

Teaching

Biomechanics, numerical methods, continuum mechanics, tissue biomechanics

Courses

Scholarly Contributions

Journals/Publications

• Laksari, K., Sarabian, M., & Babaee, H. (2022). Physics-Informed Neural Networks for Brain Hemodynamic Predictions Using Medical Imaging. IEEE Transactions on Medical Imaging, 41(9), 2285-2303. doi:10.1109/tmi.2022.3161653
• Laksari, K., Toosizadeh, N., Elliott, J., Deshpande, A., Kari, N., Jiang, B., Michel, P., Fahadan, P. T., Kidwell, C., & Wintermark, M. (2022). Novel imaging markers for altered cerebrovascular morphology in aging, stroke, and Alzheimer's disease. Journal of Neuroimaging, 32(5), 956-967. doi:10.1111/jon.13023
• Agah, M. R., Laksari, K., & Darvish, K. (2021). Hyperelastic Behavior of Porcine Aorta under Sub-Failure Inflation Loading.
• Eskandari, F., Shafieian, M., Aghdam, M. M., & Laksari, K. (2021). Mechanical Properties of Brain White Matter under Repetitive Loading Condition: Introducing a Mechanical Damage Function.
• Eskandari, F., Shafieian, M., Aghdam, M. M., & Laksari, K. (2021). Mind the gap: A mechanobiological hypothesis for the role of gap junctions in the mechanical properties of injured brain tissue. Journal of the mechanical behavior of biomedical materials, 115, 104240.
• Eskandari, F., Shafieian, M., Aghdam, M. M., & Laksari, K. (2021). Visco-hyperelastic Properties of White and Gray Matters under Tension: an Ex-vivo Study.
• Laksari, K. (2021). Automatic segmentation, feature extraction and comparison of healthy and stroke cerebral vasculature. NeuroImage: Clinical.
• Laksari, K. (2021). Mind the gap: A mechanobiological hypothesis for the role of gap junctions in the mechanical properties of injured brain tissue. Journal of the Mechanical Behavior of Biomedical Materials.
• Laksari, K., & Darvish, K. (2021). Nonlinear Shock Wave Propagation in Soft Tissues as a Mechanism of Injury.
• Laksari, K., Chou, Y., Grijalva, C., Toosizadeh, N., & Sindorf, J. (2021). Dual‐task performance is associated with brain MRI Morphometry in individuals with mild cognitive impairment. Journal of Neuroimaging, 31(3), 588-601. doi:10.1111/jon.12845
• Laksari, K., Witte, R., & Thurgood, H. (2021). 4D Reconstruction and Identification of Carotid Artery Stenosis Utilizing a Novel Pulsatile Ultrasound Phantom. Current Protocols, 1(10). doi:10.1002/cpz1.264
• Ozkaya, E., Fabris, G., Macruz, F., Suar, Z. M., Abderezaei, J., Su, B., Laksari, K., Wu, L., Camarillo, D. B., Pauly, K. B., & others, . (2021). Viscoelasticity of children and adolescent brains through MR elastography. Journal of the Mechanical Behavior of Biomedical Materials, 115, 104229.
• Arru'e, P., Toosizadeh, N., Babaee, H., & Laksari, K. (2020). Low-Rank Representation of Head Impact Kinematics: A Data-Driven Emulator. Frontiers in Bioengineering and Biotechnology, 8, 1049.
• Arrue, P., Toosizadeh, N., Babaee, H., & Laksari, K. (2020). Low-rank representation of head impact kinematics: A data-driven emulator. arXiv preprint arXiv:2004.12979.
• Deshpande, A., Jamilpour, N., Jiang, B., Kidwell, C., Wintermark, M., & Laksari, K. (2020). Automatic Segmentation, Feature Extraction and Comparison of Healthy and Stroke Cerebral Vasculature. arXiv preprint arXiv:2002.11208.
• Eskandari, F., Shafieian, M., Aghdam, M. M., & Laksari, K. (2020). A knowledge map analysis of brain biomechanics: Current evidence and future directions. Clinical Biomechanics, 75, 105000.
• Eskandari, F., Shafieian, M., Aghdam, M. M., & Laksari, K. (2020). Structural Anisotropy vs. Mechanical Anisotropy: The Contribution of Axonal Fibers to the Material Properties of Brain White Matter. Annals of Biomedical Engineering, 1--9.
• Eskandari, F., Shafieian, M., Aghdam, M. M., & Laksari, K. (2020). Tension strain-softening and compression strain-stiffening behavior of brain white matter. Annals of Biomedical Engineering, 1--11.
• Eskandari, F., Shafieian, M., Aghdam, M. M., & Laksari, K. (2020). The importance of axonal directions in the brainstem injury during neurosurgical interventions. Injury.
• Kumar, D. P., Wendel, C., Mohler, J., Laksari, K., & Toosizadeh, N. (2020). Between-day repeatability of sensor-based in-home gait assessment among older adults: assessing the effect of frailty. Aging clinical and experimental research, 1--9.
• Laksari, K., Fanton, M., Wu, L. C., Nguyen, T. H., Kurt, M., Giordano, C., Kelly, E., O'Keeffe, E., Wallace, E., Doherty, C., & others, . (2020). Multi-directional dynamic model for traumatic brain injury detection. Journal of neurotrauma, 37(7), 982--993.
• Laksari, K., Toosizadeh, N., Kumar, D. P., Mohler, J., Ehsani, H., & Mannier, C. (2020). Sensor-based Characterization of Daily Walking: A New Paradigm in Pre-frailty/Frailty Assessment. BMC Geriatrics. doi:10.21203/rs.2.16000/v4
• Lv, H., Kurt, M., Zeng, N. a., Ozkaya, E., Marcuz, F., Wu, L., Laksari, K., Camarillo, D. B., Pauly, K. B., Wang, Z., & others, . (2020). MR elastography frequency--dependent and independent parameters demonstrate accelerated decrease of brain stiffness in elder subjects. European Radiology, 30(12), 6614--6623.
• Pradeep, K. D., Toosizadeh, N., Mohler, J., Ehsani, H., Mannier, C., & Laksari, K. (2020). Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment. BMC geriatrics, 20, 1--11.
• Abderezaei, J., Zhao, W., Grijalva, C. L., Fabris, G., Ji, S., Laksari, K., & Kurt, M. (2019). Nonlinear dynamical behavior of the deep white matter during head impact. Physical Review Applied, 12(1), 014058.
• Kumar, D. P., Toosizadeh, N., Mohler, J., & Laksari, K. (2019). FRAILTY ASSESSMENT BASED ON THE QUALITY OF DAILY WALKING. Innovation in Aging, 3(Suppl 1), S85.
• Kumar, D. P., Toosizadeh, N., Mohler, J., Ehsani, H., & Laksari, K. (2019). Sensor-based Characterization of Daily Walking: A New Paradigm in Frailty Assessment.
• Kurt, M., Wu, L., Laksari, K., Ozkaya, E., Suar, Z. M., Lv, H., Epperson, K., Epperson, K., Sawyer, A. M., Camarillo, D., & others, . (2019). Optimization of a multifrequency magnetic resonance elastography protocol for the human brain. Journal of Neuroimaging, 29(4), 440--446.
• Laksari, K., Toosizadeh, N., Kumar, D. P., & Mohler, J. (2019). FRAILTY ASSESSMENT BASED ON THE QUALITY OF DAILY WALKING. Innovation in Aging, 3(Supplement_1), S85-S85. doi:10.1093/geroni/igz038.328
• Chuan, Y. T., Mohler, J., Dohm, M., Laksari, K., Najafi, B., & Toosizadeh, N. (2018). The Effect of Pain Relief on Daily Physical Activity: In-Home Objective Physical Activity Assessment in Chronic Low Back Pain Patients after Paravertebral Spinal Block. Sensors, 18(9), 3048.
• Laksari, K., Fanton, M., Wu, L. C., Nguyen, T. H., Kurt, M., Giordano, C., Kelly, E., O'Keeffe, E., Wallace, E., Doherty, C., & others, . (2018). Multi-directional dynamic model for traumatic brain injury detection. arXiv preprint arXiv:1812.07731.
• Laksari, K., Kurt, M., Babaee, H., Kleiven, S., & Camarillo, D. (2018). Mechanistic insights into human brain impact dynamics through modal analysis. Physical review letters, 120(13), 138101.
• Ahuja, C., Khazaei, M., Baig, S., Merchant, J., Chan, P., Fehlings, M., Alshareef, A., Giudice, J. S., Forman, J., Panzer, M. B., & others, . (2017). Abstracts from The 35th Annual National Neurotrauma Symposium July 7--12, 2017 Snowbird, Utah. Journal of Neurotrauma, 34(13), A--1.
• Kuo, C., Wu, L. C., Ye, P. P., Laksari, K., Camarillo, D. B., & Kuhl, E. (2017). Pilot findings of brain displacements and deformations during roller coaster rides. Journal of neurotrauma, 34(22), 3198--3205.
• Kurt, M., Laksari, K., Kuo, C., Grant, G. A., & Camarillo, D. B. (2017). Modeling and optimization of airbag helmets for preventing head injuries in bicycling. Annals of biomedical engineering, 45(4), 1148--1160.
• Laksari, K. (2017). Dissertation Details.
• Rastgar, A. M., Laksari, K., Assari, S., & Darvish, K. (2017). Mechanical behavior of porcine thoracic aorta in physiological and supra-physiological intraluminal pressures. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 231(4), 326--336.
• Shafieian, M., Laksari, K., Darvish, K., & Crandall, J. (2017). Material Properties of Brain Tissue under Complex Shear and Compression Loading.
• Wu, L. C., Kuo, C., Loza, J., Kurt, M., Laksari, K., Yanez, L. Z., Senif, D., Anderson, S. C., Miller, L. E., Urban, J. E., & others, . (2017). Detection of American football head impacts using biomechanical features and support vector machine classification. Scientific reports, 8(1), 1--14.
• Wu, L. C., Kuo, C., Loza, J., Kurt, M., Laksari, K., Yanez, L. Z., Senif, D., Anderson, S. C., Miller, L. E., Urban, J. E., & others, . (2017). Detection of American football head impacts using biomechanical features and support vector machine classification. Scientific reports, 8(1), 855.
• Laksari, K., Shahmirzadi, D., Acosta, C. J., & Konofagou, E. (2016). Energy-based constitutive modelling of local material properties of canine aortas. Royal Society open science, 3(9), 160365.
• Rastgar-Agah, M., Laksari, K., Assari, S., & Darvish, K. (2016). Mechanical instability of aorta due to intraluminal pressure. International Journal of Applied Mechanics, 8(01), 1650002.
• Wu, L. C., Laksari, K., Kuo, C., Luck, J. F., & Kleiven, S. (2016). Dale. Bass CR, Camarillo DB. Bandwidth and sample rate requirements for wearable head impact sensors. J Biomech. 2016a, 49, 2918--2924.
• Wu, L. C., Laksari, K., Kuo, C., Luck, J. F., Kleiven, S., Cameron, R., & Camarillo, D. B. (2016). Bandwidth and sample rate requirements for wearable head impact sensors. Journal of biomechanics, 49(13), 2918--2924.
• Hernandez, F., Wu, L. C., Yip, M. C., Laksari, K., Hoffman, A. R., Lopez, J. R., Grant, G. A., Kleiven, S., & Camarillo, D. B. (2015). Six degree-of-freedom measurements of human mild traumatic brain injury. Annals of biomedical engineering, 43(8), 1918--1934.
• Laksari, K., Assari, S., Seibold, B., Sadeghipour, K., & Darvish, K. (2015). Computational simulation of the mechanical response of brain tissue under blast loading. Biomechanics and modeling in mechanobiology, 14(3), 459--472.
• Laksari, K., Wu, L. C., Kurt, M., Kuo, C., & Camarillo, D. C. (2015). Resonance of human brain under head acceleration. Journal of The Royal Society Interface, 12(108), 20150331.
• Laksari, K., Sadeghipour, K., & Darvish, K. (2014). Mechanical response of brain tissue under blast loading. Journal of the mechanical behavior of biomedical materials, 32, 132--144.
• Laksari, K., Shafieian, M., & Darvish, K. (2012). Constitutive model for brain tissue under finite compression. Journal of biomechanics, 45(4), 642--646.
• Darvish, K., Shafieian, M., Laksari, K., Barabadi, B., & Parenti, C. (2008). Experimental and Computational Analysis of Brain Deformations in Linear Head Impact. IMECE2008-69296.
• Vay, J. L. (2007). General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.-Noninvariance of Space-and Time-Scale Ranges under a Lorentz Transformation and the Implications for the Study of. Physical Review Letters, 98(13), 130405--130500.

Proceedings Publications

• Kamali, A., Dieckhaus, L. A., Peters, E., Hutchinson, E. B., Laksari, K., & Pires, P. (2021, Oct.). The Golden Hour: Early outcomes of traumatic brain injury and stroke. In Biomedical Engineering Society.
• Agah, M. R., Laksari, K., & Darvish, K. (2012, June). Hyperelastic Behavior of Porcine Aorta under Sub-Failure Inflation Loading. In Summer Bioengineering Conference.
• Laksari, K., Darvish, K., & Sadeghipour, K. (2012, May). Nonlinear Shock Wave Propagation in Soft Tissues as a Mechanism of Injury. In Injury Biomechanics Symposium.
• Laksari, K., Wu, L., Nguyen, T., Kurt, M., Fanton, M., Ruan, J., Barbat, S., & Camarillo, D. (2017). MULTI-DIRECTIONAL DYNAMIC INJURY METRIC FOR MILD BRAIN TRAUMA DETECTION. In JOURNAL OF NEUROTRAUMA, 34.
• Assari, S., Laksari, K., Barbe, M., & Darvish, K. (2013). Cerebral blood pressure rise during blast exposure in a rat model of blast-induced traumatic brain injury. In ASME 2013 International Mechanical Engineering Congress and Exposition.
• Assari, S., Laksari, K., Barbe, M., & Darvish, K. (2013). Cerebral blood pressure rise during blast exposure in a rat model of blast-induced traumatic brain injury. In From the ASME 2013 International Mechanical Engineering Congress and Exposition, 3.
• Kermani, G., Laksari, K., & Darvish, K. (2013). Biomechanical Properties of Human Aorta from Dynamic Biaxial Loading. In Bioengineering Conference (NEBEC), 2013 39th Annual Northeast.
• Laksari, K., Assari, S., & Darvish, K. (2013). COMPUTATIONAL COMPARISON OF SHOCK WAVE PROPOAGATION IN EXPLOSIVE BLAST AND SHOCK TUBE EXPERIMENTS. In ASME 2013 International Mechanical Engineering Congress and Exposition.
• Laksari, K., Assari, S., & Darvish, K. (2013). Computational Comparison of Shock Wave Propagation in Explosive Blast and Shock Tube Experiments. In ASME International Mechanical Engineering Congress and Exposition, 56215.
• Laksari, K., Assari, S., & Darvish, K. (2013). Computational Simulation of Shock Tube and the Effect of Shock Thickness on Strain-Rates. In Bioengineering Conference (NEBEC), 2013 39th Annual Northeast.
• Agah, M. R., Laksari, K., & Darvish, K. (2012). Investigating the hyperelasticity of porcine aorta under sub-failure loading. In Bioengineering Conference (NEBEC), 2012 38th Annual Northeast.
• Agah, M. R., Laksari, K., Darvish, K., & Rachev, A. (2012). Buckling of Porcine Aorta under Static and Dynamic Loading. In American Society of Mechanical Engineering Summer Bioengineering Conference.
• Laksari, K., Agah, M. R., & Darvish, K. (2012). Hyperelastic Behavior of Porcine Aorta in Sub-Injury Pressures. In American Society of Mechanical Engineering Summer Bioengineering Conference.
• Laksari, K., Agah, M. R., Rachev, A., & Darvish, K. (2012). Investigating the effects of dynamic and static loading on the stability of porcine aorta. In Bioengineering Conference (NEBEC), 2012 38th Annual Northeast.
• Shafieian, M., Laksari, K., Darvish, K., & Crandall, J. (2012). Development of a constitutive model for brain tissue under multiaxial loading. In Proceedings of the 2012 International IRCOBI Conference on the Biomechanics of Injury.
• Laksari, K., Darvish, K., & Sadeghipour, K. (2011). Shock Wave as a Mechanism of Injury in Soft Tissues. In ASME 2011 Summer Bioengineering Conference.
• Laksari, K., Darvish, K., & Sadeghipour, K. (2011). Shock Wave as a Mechanism of Injury in Soft Tissues. In Summer Bioengineering Conference, 54587.
• Laksari, K., Shafieian, M., Darvish, K., & Sadeghipour, K. (2011). Shock wave propagation as a mechanism of injury in nonlinear viscoelastic soft tissues. In ASME 2011 International Mechanical Engineering Congress and Exposition.
• Laksari, K., Shafieian, M., Darvish, K., & Sadeghipour, K. (2011). Shock wave propagation as a mechanism of injury in nonlinear viscoelastic soft tissues. In ASME International Mechanical Engineering Congress and Exposition, 54884.
• Laksari, K., Assari, S., & Darvish, K. (2010). Modeling Linear Head Impact and the Effect of Brain-Skull Interface. In 26th Southern Biomedical Engineering Conference SBEC 2010, April 30-May 2, 2010, College Park, Maryland, USA.
• Romanov, V., Assari, S., Laksari, K., & Darvish, K. (2010). Pressure Oscillation Tests of Porcine Aorta. In American Society of Mechanical Engineering Summer Bioengineering Conference.
• Laksari, K., & Darvish, K. (2009). Brain Deformation in Linear Head Impact. In ASME 2009 International Mechanical Engineering Congress and Exposition.
• Laksari, K., & Darvish, K. (2009). Brain Deformation in Linear Head Impact. In ASME International Mechanical Engineering Congress and Exposition, 43864.
• Laksari, K., Assari, S., & Darvis, K. (2009). Brain Deformations in Linear Head Impact. In American Society of Mechanical Engineering International Mechanical Engineering Exposition and Conference.
• Laksari, K., Shafieian, M., Parenti, C., & Darvish, K. (2009). Finite element analysis and validation of brain deformation in linear head impact. In ASME 2009 Summer Bioengineering Conference.
• Laksari, K., Shafieian, M., Parenti, C., & Darvish, K. (2009). Finite element analysis and validation of brain deformation in linear head impact. In Summer Bioengineering Conference, 48913.
• Parenti, C., Laksari, K., Shafieian, M., & Darvish, K. (2009). Multilayer properties of aorta. In Bioengineering Conference, 2009 IEEE 35th Annual Northeast.
• Shafieian, M., Laksari, K., & Darvish, K. (2009). Characterization of the material properties of rat brain stem from indentation tests. In Bioengineering Conference, 2009 IEEE 35th Annual Northeast.
• Darvish, K., Shafieian, M., Laksari, K., Barabadi, B., & Parenti, C. (2008). Experimental and computational analysis of brain deformations in linear head impact. In ASME International Mechanical Engineering Congress and Exposition, 48784.

Others

• Kuo, C., Wu, L. C., Laksari, K., & Camarillo, D. B. (2017). Oral appliance for measuring head motions by isolating sensors from jaw perturbance.
• Hernandez, F., Laksari, K., & Camarillo, D. B. (2015). System for redirecting head impact force.
• Laksari, K. (2013). Nonlinear viscoelastic wave propagation in brain tissue.
• Laksari, K. (2009). Experimental and Computational Analysis of Brain Surrogate Material Under Linear Impact.