Kapildeo Lotun

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Scholarly Contributions

Chapters

• Lotun, K., Shah, P., & Losordo, D. (2005). GENE THERAPY FOR ANGIOGENESIS IN THE TREATMENT OF CARDIOVASCULAR AND PERIPHERAL ARTERIAL DISEASE. In IN ANGIOGENESIS AND DIRECT MYOCARDIAL REVASCULARIZATION(pp 215-244). Humana Press. doi:10.1007/978-1-59259-934-9_8

Journals/Publications

• Kapur, N. K., Alkhouli, M. A., DeMartini, T. J., Faraz, H., George, Z. H., Goodwin, M. J., Hernandez-Montfort, J. A., Iyer, V. S., Josephy, N., Kalra, S., Kaki, A., Karas, R. H., Kimmelstiel, C. D., Koenig, G. C., Lau, E., Lotun, K., Madder, R. D., Mannino, S. F., Meraj, P. M., , Moreland, J. A., et al. (2019). Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment-Elevation Myocardial Infarction. Circulation, 139(3), 337-346.
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  In ST-segment-elevation myocardial infarction (STEMI), infarct size correlates directly with heart failure and mortality. Preclinical testing has shown that, in comparison with reperfusion alone, mechanically unloading the left ventricle (LV) before reperfusion reduces infarct size and that 30 minutes of unloading activates a cardioprotective program that limits reperfusion injury. The DTU-STEMI pilot trial (Door-To-Unload in STEMI Pilot Trial) represents the first exploratory study testing whether LV unloading and delayed reperfusion in patients with STEMI without cardiogenic shock is safe and feasible.
• Kumar, K., Reddy, S., Acharya, D., & Lotun, K. (2019). Novel technique of performing multivessel PCI through an Impella sheath. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
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  A 69-year-old woman with diabetes was found to have multi-vessel coronary artery disease and underwent 5-vessel coronary artery bypass grafting. Patient had persistent cardiogenic shock postoperatively despite intra-aortic balloon pump and escalating pressor requirements. Electrocardiogram showed new ischemic changes and the patient was urgently taken to the catheterization lab for coronary angiography and placement of an Impella CP for higher degree of hemodynamic support via the left femoral artery. Due to limitations in vascular access the Impella CP sheath was utilized for vascular access for diagnostic angiography and coronary intervention concurrently with ongoing Impella CP support. The first obtuse marginal had severe proximal disease and was treated with percutaneous coronary intervention (PCI) with a drug eluting stent. To our knowledge, this case is the first in which successful diagnostic angiography as well as multi-vessel PCI was performed via an Impella sheath while concurrently using the percutaneous mechanical circulatory support system of the Impella CP. Multiple guide catheters and a pigtail catheter were successfully passed via the Impella CP sheath to perform PCI. This novel method of vascular access could be an important tool to use in high-risk patients with limitations in access sites and decrease potential bleeding complications by limiting the number of arterial punctures.
• Lotun, K., Truong, H. T., Cha, K. C., Alsakka, H., Gianotto-Oliveira, R., Smith, N., Rao, P., Bien, T., Chatelain, S., Kern, M. C., Hsu, C. H., Zuercher, M., & Kern, K. B. (2019). Cardiac Arrest in the Cardiac Catheterization Laboratory: Combining Mechanical Chest Compressions and Percutaneous LV Assistance. JACC. Cardiovascular interventions, 12(18), 1840-1849.
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  The aim of this study was to evaluate the optimal treatment approach for cardiac arrest (CA) occurring in the cardiac catheterization laboratory.
• Brilakis, E. S., Edson, R., Bhatt, D. L., Goldman, S., Holmes, D. R., Rao, S. V., Shunk, K., Rangan, B. V., Mavromatis, K., Ramanathan, K., Bavry, A. A., Garcia, S., Latif, F., Armstrong, E., Jneid, H., Conner, T. A., Wagner, T., Karacsonyi, J., Uyeda, L., , Ventura, B., et al. (2018). Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial. Lancet (London, England), 391(10134), 1997-2007.
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  Few studies have examined the efficacy of drug-eluting stents (DES) for reducing aortocoronary saphenous vein bypass graft (SVG) failure compared with bare-metal stents (BMS) in patients undergoing stenting of de-novo SVG lesions. We assessed the risks and benefits of the use of DES versus BMS in de-novo SVG lesions.
• Kumar, K., & Lotun, K. (2018). The Role of Coronary Catheterization Laboratory in Post-Resuscitation Care of Patients Without ST Elevation Myocardial Infarction. Current cardiology reviews, 14(2), 92-96.
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  Out of hospital cardiac arrest management of patients with non-ST myocardial infarction per current American Heart Association and European Resuscitation Council guidelines leave the decision in regard to early angiography up to the physician operators. Guidelines are clear on the positive impact of early intervention on survival and improvement on left ventricular function in patients presenting with cardiac arrest and ST elevation myocardial infarction on electrocardiogram. This review aims to analyze the data that current guidelines are based upon in regards to out of hospital cardiac arrest with electrocardiogram findings of non-ST elevation myocardial infarction as well as review of other clinical trials that support early angiography and reperfusion strategies.
• Schwartz, G. G., Steg, P. G., Szarek, M., Bhatt, D. L., Bittner, V. A., Diaz, R., Edelberg, J. M., Goodman, S. G., Hanotin, C., Harrington, R. A., Jukema, J. W., Lecorps, G., Mahaffey, K. W., Moryusef, A., Pordy, R., Quintero, K., Roe, M. T., Sasiela, W. J., Tamby, J. F., , Tricoci, P., et al. (2018). Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. The New England journal of medicine, 379(22), 2097-2107.
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  Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9), would improve cardiovascular outcomes after an acute coronary syndrome in patients receiving high-intensity statin therapy.
• Shanmugasundaram, M., & Lotun, K. (2018). Refractory Out of Hospital Cardiac Arrest. Current Cardiology Reviews. doi:10.2174/1573403X14666180507155622
• Shanmugasundaram, M., & Lotun, K. (2018). Refractory Out of Hospital Cardiac Arrest. Current cardiology reviews, 14(2), 109-114.
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  Refractory out of hospital cardiac arrest is a common problem that is associated with poor overall survival rates and neurological outcomes. There are various definitions that have been used but the most accepted one is cardiac arrest that requires more than 10 minutes of Cardiopulmonary Resuscitation (CPR) efforts or more than 3 defibrillation attempts. There have been different pharmacologic and non-pharmacologic therapies that were studied in these patients. None of the antiarrhythmic or vasopressor medications have been consistently shown to improve survival or neurological outcomes in this subset of patients. This has led to the introduction of various devices aimed at improving outcomes such as mechanical CPR devices, Extracorporeal Cardiopulmonary Resuscitation (ECPR), targeted temperature management and early invasive approach. There is accumulating evidence that there seems to be an improvement in outcomes when these devices are used in refractory cardiac arrest patients. But none of these devices have been shown to improve outcomes when used in isolation. This underscores the importance of systematic approach to these complex patients and using these therapies in combination. There has been a paradigm shift in the approach to these patients. Instead of repeated and prolonged CPR attempts in the field, it is suggested that these patients need to be moved to cardiac arrest centers with a mechanical CPR device in place, so a percutaneous Extracorporeal Membrane Oxygenator (ECMO) can be placed to "buy" time for other therapies such as therapeutic hypothermia and early coronary angiography followed by intervention as indicated. Careful selection of patients who might potentially benefit from this approach is critical to the success of these programs.
• Shanmugasundaram, M., Murugapandian, S., Truong, H. T., Lotun, K., & Banerjee, S. (2018). Drug coated balloon in peripheral artery disease. Cardiovascular revascularization medicine : including molecular interventions.
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  Peripheral artery disease (PAD) is highly prevalent but is often underdiagnosed and undertreated. Lower extremity PAD can often be life style limiting. Revascularization in carefully selected lower extremity PAD patients improves symptoms and functional status. Surgical revascularization used to be the only available strategy, but in the recent years, endovascular strategies have gained popularity due to faster recovery times with low morbidity and mortality rates. Endovascular procedures have increased significantly in the United States in the past few years. That being said, higher restenosis rates and low long-term patency rates have been the limiting factors for this strategy. Drug eluting stents have been introduced to help with lowering restenosis, however lower extremity PAD involves long segment where the outcomes of stents are suboptimal. Also, the disease often crosses joint line that makes it less ideal for the stents. Drug coated balloons (DCB) have been introduced to improve patency rates following endovascular intervention for lower extremity PAD. They have gained popularity among endovascular specialists due to its ease of use and the concept of "leave nothing behind". This is a review of scientific evidence supporting DCB use in PAD.
• Truong, H. T., Hunter, G., Lotun, K., Shetty, R., Shanmugasundaram, M., Kapoor, D., & Thai, H. M. (2018). Insertion of the Impella via the axillary artery for high-risk percutaneous coronary intervention. Cardiovascular revascularization medicine : including molecular interventions, 19(5 Pt A), 540-544.
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  Hemodynamic support with the Impella device is an important tool during high risk percutaneous coronary intervention. This device is usually inserted via the femoral artery. However, some patients have severe peripheral artery disease precluding the use of the femoral artery for this purpose. The axillary artery is a viable alternative in these cases. We reviewed the two access techniques for inserting the Impella via the axillary artery and also described 6 cases of successful implantation.
• Ferng, A. S., Connell, A. M., Marsh, K. M., Qu, N., Medina, A. O., Bajaj, N., Palomares, D., Iwanski, J., Tran, P. L., Lotun, K., Johnson, K., & Khalpey, Z. (2017). Acellular porcine heart matrices: whole organ decellularization with 3D-bioscaffold & vascular preservation. Journal of clinical and translational research, 3(2), 260-270.
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  Regenerative medicine, particularly decellularization-recellularization methods via whole-organ tissue engineering, has been increasingly studied due to the growing donor organ shortage. Though numerous decellularization protocols exist, the ideal decellularization protocol for optimal recellularization is unclear. This study was performed to optimize existing heart decellularization protocols and compare current methods using the detergents SDS (sodium dodecyl sulfate), Triton X-100, OGP (octyl β-D-glucopyranoside), and CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate) through retrograde aortic perfusion via aortic cannulation of a whole porcine heart. The goal of decellularization is to preserve extracellular matrix integrity and architecture, which was analyzed in this study through histology, microscopy, DNA analysis, hydroxyproline content analysis, materials analysis and angiography. Effective decellularization was determined by analyzing the tissue organization, geometry, and biological properties of the resultant extracellular matrix scaffold. Using these parameters, optimal decellularization was achieved between 90 and 120 mmHg pressure with 3% SDS as a detergent. This study provides important information about whole heart decellularization, which will ultimately contribute to heart bioengineering.
• Lotun, K., Soukas, P., Cho, S., O'Donnell, K., Griben, A., Irwin, W. T., & Schainfeld, R. M. (2017). Beta radiation in the treatment of in-stent restenosis of an in situ saphenous vein bypass graft A case report. Cardiovascular revascularization medicine : including molecular interventions, 6(2), 75-81.
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  We describe a case of instent restenosis in a femoral-distal saphenous vein bypass graft successfully treated with brachytherapy. A 45-year-old insulin-requiring diabetic woman underwent an in-situ femoral-anterior tibial bypass graft for a non-healing ischemic ulcer. Despite a technically successful percutaneous transluminal angioplasty and endovascular stenting of a retained valve within the threatened graft, the wound failed to heal. At the 1-month follow-up, instent restenosis was documented and successful cutting balloon angioplasty, complemented by adjunctive beta-irradiation was successfully performed. Clinical and hemodynamic success was achieved, with prompt ulcer healing and intermediate-term graft patency maintained on surveillance duplex ultrasound follow-up. We review the literature on radiation therapy in the management of peripheral arterial disease and discuss therapeutic options in the management of restenosis.
• Lincoff, A. M., Mehran, R., Povsic, T. J., Zelenkofske, S. L., Huang, Z., Armstrong, P. W., Steg, P. G., Bode, C., Cohen, M. G., Buller, C., Laanmets, P., Valgimigli, M., Marandi, T., Fridrich, V., Cantor, W. J., Merkely, B., Lopez-Sendon, J., Cornel, J. H., Kasprzak, J. D., , Aschermann, M., et al. (2016). Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial. Lancet (London, England), 387(10016), 349-56.
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  REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide. We tested the hypothesis that near complete inhibition of factor IXa with pegnivacogin during percutaneous coronary intervention, followed by partial reversal with anivamersen, would reduce ischaemic events compared with bivalirudin, without increasing bleeding.
• O'Donoghue, M. L., Glaser, R., Cavender, M. A., Aylward, P. E., Bonaca, M. P., Budaj, A., Davies, R. Y., Dellborg, M., Fox, K. A., Gutierrez, J. A., Hamm, C., Kiss, R. G., Kovar, F., Kuder, J. F., Im, K. A., Lepore, J. J., Lopez-Sendon, J. L., Ophuis, T. O., Parkhomenko, A., , Shannon, J. B., et al. (2016). Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial. JAMA, 315(15), 1591-9.
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  p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI). Pilot data in a phase 2 trial in non-ST elevation MI indicated that the p38 MAPK inhibitor losmapimod attenuates inflammation and may improve outcomes.
• Kanakadandi, U., Abidov, A., Lotun, K., & Bhatt, D. (2015). ABNORMAL STRESS ANKLE BRACHIAL INDEX PREDICTS ALL-CAUSE MORTALITY. Journal of the American College of Cardiology. doi:10.1016/S0735-1097(15)62121-0
• Kannan, A., Jahan, K., Lotun, K., & Janardhanan, R. (2015). Prosthetic mitral valve obstruction: role of real-time three-dimensional transesophageal echocardiography in diagnosis. BMJ case reports, 2015.
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  Acute prosthetic valve thrombosis is a potentially serious complication with an incidence as high as 6% per patient-year for prostheses in the mitral position. Accurate diagnosis of the degree of obstruction and differentiation of pannus versus thrombus is critical in determination of the best mode of therapy. We discuss a case of a patient with multiple comorbidities who presented with mechanical mitral valve obstruction where both transthoracic and two-dimensional transesophageal echocardiography (TEE) were limited in making an accurate diagnosis regarding the mechanism of obstruction. Real-time 3D-TEE (RT-3DTEE) was critical in identifying a partial thrombus on the mechanical valve and guided the choice of thrombolysis as the most appropriate intervention, thus avoiding high-risk surgery in this patient with significant multiple comorbidities.
• Kannan, A., Jahan, K., Lotun, K., & Janardhanan, R. (2015). Prosthetic mitral valve obstruction: role of real-time three-dimensional transesophageal echocardiography in diagnosis.. BMJ Publishing Group Ltd..
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  Acute prosthetic valve thrombosis is a potentially serious complication with an incidence as high as 6% per patient-year for prostheses in the mitral position. Accurate diagnosis of the degree of obstruction and differentiation of pannus versus thrombus is critical in determination of the best mode of therapy. We discuss a case of a patient with multiple comorbidities who presented with mechanical mitral valve obstruction where both transthoracic and two-dimensional transesophageal echocardiography (TEE) were limited in making an accurate diagnosis regarding the mechanism of obstruction. Real-time 3D-TEE (RT-3DTEE) was critical in identifying a partial thrombus on the mechanical valve and guided the choice of thrombolysis as the most appropriate intervention, thus avoiding high-risk surgery in this patient with significant multiple comorbidities.
• Kern, K. B., Lotun, K., Patel, N., Mooney, M. R., Hollenbeck, R. D., McPherson, J. A., McMullan, P. W., Unger, B., Hsu, C. H., & Seder, D. B. (2015). Outcomes of Comatose Cardiac Arrest Survivors With and Without ST-Segment Elevation Myocardial Infarction: Importance of Coronary Angiography.. JACC Cardiovasc Interv. doi:10.1016/j.jcin.2015.02.021
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  The 2013 STEMI guidelines recommend performing immediate angiography in resuscitated patients whose initial electrocardiogram shows STEMI. The optimal approach for those without STEMI post-cardiac arrest is less clear.
• Kern, K. B., Lotun, K., Patel, N., Mooney, M. R., Hollenbeck, R. D., McPherson, J. A., McMullan, P. W., Unger, B., Hsu, C. H., Seder, D. B., & , I. R. (2015). Outcomes of Comatose Cardiac Arrest Survivors With and Without ST-Segment Elevation Myocardial Infarction: Importance of Coronary Angiography. JACC. Cardiovascular interventions, 8(8), 1031-1040.
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  The aim of this study was to compare outcomes and coronary angiographic findings in post-cardiac arrest patients with and without ST-segment elevation myocardial infarction (STEMI).
• Lee, J. Z., Tey, K. R., Mizyed, A., Hennemeyer, C. T., Janardhanan, R., & Lotun, K. (2015). Mitral valve replacement complicated by iatrogenic left ventricular outflow obstruction and paravalvular leak: case report and review of literature. BMC Cardiovasc Disord.. doi:10.1186/s12872-015-0108-z
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  Left ventricular outflow tract (LVOT) obstruction and paravalvular leak (PVL) are relatively uncommon, but are serious complications of prosthetic valve replacement.
• Lee, J. Z., Tey, K. R., Mizyed, A., Hennemeyer, C. T., Janardhanan, R., & Lotun, K. (2015). Mitral valve replacement complicated by iatrogenic left ventricular outflow obstruction and paravalvular leak: case report and review of literature. BMC cardiovascular disorders, 15, 119.
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  Left ventricular outflow tract (LVOT) obstruction and paravalvular leak (PVL) are relatively uncommon, but are serious complications of prosthetic valve replacement.
• Lee, J. Z., Tey, K. R., Mizyed, A., Hennemeyer, C. T., Janardhanan, R., & Lotun, K. (2015). Mitral valve replacement complicated by iatrogenic left ventricular outflow obstruction and paravalvular leak: case report and review of literature.. BMC Cardiovasc Disord.. doi:10.1186/s12872-015-0108-z
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  Left ventricular outflow tract (LVOT) obstruction and paravalvular leak (PVL) are relatively uncommon, but are serious complications of prosthetic valve replacement.
• Lotun, K., & Kern, K. B. (2015). How Much Is Enough… What More Is Needed?. Circ Cardiovasc Interv.. doi:10.1161/CIRCINTERVENTIONS.115.003075.
• Suryanarayana, P., Lee, J. Z., Abidov, A., & Lotun, K. (2015). Anomalous right coronary artery: case series and review of literature. Cardiovascular revascularization medicine : including molecular interventions, 16(6), 362-6.
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  Anomalous right coronary arteries (ARCA) are extremely rare in general population. Although mostly asymptomatic and recognized incidentally on cardiac catheterizations, they can be catastrophic and can cause sudden cardiac death. Sudden cardiac deaths are more common when the anomalous vessel runs an inter-arterial course between the aorta and the pulmonary artery. Asymptomatic patients with malignant course of anomalous coronaries can pose clinical dilemmas. Based on prior experience, management of asymptomatic ARCA with malignant course should be subjected to a risk-benefit analysis. This case series begins with a brief description of four separate cases of ARCA. They had their origin in the left coronary sinus or off left anterior descending artery (LAD). Three of them had anterior course between aorta and pulmonary trunk, confirmed by coronary CT angiography (CTA). Whereas two of our patients presented with chronic symptoms, two presented as acute cases with electrocardiographically proven STEMI. These cases were managed differently; by conservative, surgical or interventional approaches. All four cases had good final outcomes. This goes to show how different treatment options can be employed in management of complications associated with anomalous coronary arteries. It is also interesting to note that the radial access provides better guide support that is needed to tackle complex lesions. Many operators have been using radial approach for anomalous coronary interventions. We have successfully employed radial technique after failed trans-femoral attempts and also in STEMI situations. Based on our experience, right radial approach appears to be safer and quicker.
• Suryanarayana, P., Lee, J. Z., Abidov, A., & Lotun, K. (2015). Anomalous right coronary artery: case series and review of literature.. Cardiovasc Revasc Med.. doi:10.1016/j.carrev.2015.03.006
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  Anomalous right coronary arteries (ARCA) are extremely rare in general population. Although mostly asymptomatic and recognized incidentally on cardiac catheterizations, they can be catastrophic and can cause sudden cardiac death. Sudden cardiac deaths are more common when the anomalous vessel runs an inter-arterial course between the aorta and the pulmonary artery. Asymptomatic patients with malignant course of anomalous coronaries can pose clinical dilemmas. Based on prior experience, management of asymptomatic ARCA with malignant course should be subjected to a risk-benefit analysis. This case series begins with a brief description of four separate cases of ARCA. They had their origin in the left coronary sinus or off left anterior descending artery (LAD). Three of them had anterior course between aorta and pulmonary trunk, confirmed by coronary CT angiography (CTA). Whereas two of our patients presented with chronic symptoms, two presented as acute cases with electrocardiographically proven STEMI. These cases were managed differently; by conservative, surgical or interventional approaches. All four cases had good final outcomes. This goes to show how different treatment options can be employed in management of complications associated with anomalous coronary arteries. It is also interesting to note that the radial access provides better guide support that is needed to tackle complex lesions. Many operators have been using radial approach for anomalous coronary interventions. We have successfully employed radial technique after failed trans-femoral attempts and also in STEMI situations. Based on our experience, right radial approach appears to be safer and quicker.
• Lee, J. Z., Lee, K. S., Abidov, A., Samson, R. A., & Lotun, K. (2014). Endovascular stenting of suture line supravalvular pulmonic stenosis after orthotopic heart transplantation using rapid pacing stabilization. JACC. Cardiovascular interventions, 7(8), e91-3.
• Riaz, I. B., Dhoble, A., Mizyed, A., Hsu, C. H., Husnain, M., Lee, J. Z., Lotun, K., & Lee, K. S. (2013). Transcatheter patent foramen ovale closure versus medical therapy for cryptogenic stroke: a meta-analysis of randomized clinical trials. BMC cardiovascular disorders, 13, 116.
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  There is an association between cryptogenic stroke and patent foramen ovale (PFO). The optimal treatment strategy for secondary prevention remains unclear. The purpose of this study was to analyze aggregate data examining the safety and efficacy of transcatheter device closure versus standard medical therapy in patients with PFO and cryptogenic stroke.
• Shetty, R., & Lotun, K. (2013). Treatment of an iatrogenic femoral artery pseudoaneurysm with concomitant arteriovenous fistula with percutaneous implantation of an Amplatzer vascular plug. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(1), E53-7.
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  Iatrogenic pseudoaneurysms can occur following percutaneous cardiac and peripheral procedures. There are multiple modalities available for the treatment of pseudoaneurysms including ultrasound guided compression repair, ultrasound guided thrombin injection, or endovascular repair with covered stent placement. If these methods are not indicated or unsuccessful, patients typically require open surgical repair. We report a case of a woman with a post-procedural pseudoaneurysm with concomitant arteriovenous fistula who was treated percutaneously with the implantation of an Amplatzer vascular plug. This novel technique was safe and effective and allowed our patient to avoid the morbidity and mortality associated with surgical repair.
• Lotun, K., Shetty, R., & Topaz, O. (2012). Atherosclerotic inferior mesenteric artery stenosis resulting in large intestinal hypoperfusion: a paradigm shift in the diagnosis and management of symptomatic chronic mesenteric ischemia. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 80(5), 877-82.
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  Symptomatic chronic mesenteric ischemia results from intestinal hypoperfusion and is classically thought to result from involvement of two or more mesenteric arteries. The celiac artery and superior mesenteric artery are most frequently implicated in this disease process, and their involvement usually results in symptoms of small intestinal ischemia. Symptomatic chronic mesenteric ischemia resulting predominantly from inferior mesenteric artery involvement has largely been overlooked but does gives rise to its own, unique clinical presentation with symptoms resulting from large intestinal ischemia. We present four patients with atherosclerotic inferior mesenteric artery stenosis with symptomatic chronic mesenteric ischemia that have unique clinical presentations consistent with large intestinal ischemia that resolved following percutaneous endovascular treatment of the inferior mesenteric artery stenosis. These cases represent a novel approach to the diagnosis and management of this disease process and may warrant a further subclassification of chronic mesenteric ischemia into chronic small intestinal ischemia and chronic large intestinal ischemia.
• Lotun, K., Shetty, R., Patel, M., & Arain, S. A. (2012). Percutaneous left axillary artery approach for Impella 2.5 liter circulatory support for patients with severe aortoiliac arterial disease undergoing high-risk percutaneous coronary intervention. Journal of interventional cardiology, 25(2), 210-3.
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  The use of the Impella 2.5 liter (L) device for hemodynamic support has been well described. The typical access site for the Impella 2.5 L device is the femoral artery. The use of the axillary and subclavian artery has been described via surgical cut down for the Impella 5 L device when femoral artery access is not possible. In patients with severe aortoiliac disease and difficult anatomy the femoral artery access for the Impella 2.5 L device is not feasible. We describe the successful percutaneous use of the Impella 2.5 L device for hemodynamic support via the left axillary artery in 2 patients undergoing high-risk PCI with concomitant severe aortoiliac disease.
• Lotun, K. (2011). APPROPRIATE USE CRITERIA FOR ECHOCARDIOGRAPHY. J Am Soc Echocardiogr, 229-67.
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  ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 APPROPRIATE USE CRITERIA FOR ECHOCARDIOGRAPHY. A REPORT OF THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION APPROPRIATE USE CRITERIA TASK FORCE, AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, AMERICAN HEART ASSOCIATION, AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY, HEART FAILURE SOCIETY OF AMERICA, HEART RHYTHM SOCIETY, SOCIETY FOR CARDIOVASCULAR ANGIOGRAPHY AND INTERVENTIONS, SOCIETY OF CRITICAL CARE MEDICINE, SOCIETY OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE AMERICAN COLLEGE OF CHEST PHYSICIANS; J Am Soc Echocardiogr. 2011 Mar; 24(3):229-67
• Lotun, K. (2011). APPROPRIATE USE CRITERIA FOR ECHOCARDIOGRAPHY.. J Am Coll Cardiol, 1126-66.
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  ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 APPROPRIATE USE CRITERIA FOR ECHOCARDIOGRAPHY. A REPORT OF THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION APPROPRIATE USE CRITERIA TASK FORCE, AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, AMERICAN HEART ASSOCIATION, AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY, HEART FAILURE SOCIETY OF AMERICA, HEART RHYTHM SOCIETY, SOCIETY FOR CARDIOVASCULAR ANGIOGRAPHY AND INTERVENTIONS, SOCIETY OF CRITICAL CARE MEDICINE, SOCIETY OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, AND SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE ENDORSED BY THE AMERICAN COLLEGE OF CHEST PHYSICIANS; J Am Coll Cardiol. 2011 Mar 1; 57(9):1126-66
• Lotun, K. (2011). ARTERIAL THORACIC OUTLET SYNDROME WITH INTERMITTENT SUBCLAVIAN ARTERY OCCLUSION. Interventional Cardiology, 165-170.
• Shetty, R., & Lotun, K. (2011). A unique case of renal artery fibromuscular dysplasia. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 78(1), 78-83.
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  Fibromuscular dysplasia (FMD) is a noninflammatory, nonatherosclerotic disorder resulting in arterial stenosis. Here, a unique case of renal artery FMD (RA FMD) is presented. With the use of angiograpic and intravascular ultrasound (IVUS) imaging modalities, a patient was diagnosed with two distinct types of FMD. Until now, the prevalence of FMD has been underestimated due to limitations in diagnostic modalities. Clinically, the correct identification of RA FMD is essential because these patients have been shown to respond to revascularization therapy with significant improvement in blood pressure whereas renal artery lesions secondary to other etiologies such as atherosclerosis have yet to show the same consistent response. Further, the presence of two subtypes of FMD in a single patient may suggest the possibility of genetic factors that predispose certain vessels to certain subtypes of FMD.
• Stribling, W. K., Kontos, M. C., Abbate, A., Cooke, R., Vetrovec, G. W., & Lotun, K. (2011). Clinical outcomes in patients with acute left circumflex/obtuse marginal occlusion presenting with myocardial infarction. Journal of interventional cardiology, 24(1), 27-33.
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   Acute occlusion of left circumflex (LCx) or obtuse marginal (OM) arteries can present as ST elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI). NSTEMI patients (pts) with occlusions have worse outcomes than those without occlusions, but no studies specifically examine outcomes in acute myocardial infarction (AMI) pts with LCx/OM occlusion. This study aims to define the incidence of NSTEMI in pts presenting with LCx/OM occlusion and analyzes clinical characteristics and outcomes in those presenting with NSTEMI compared to STEMI.
• Stribling, W. K., Kontos, M. C., Abbate, A., Cooke, R., Vetrovec, G. W., Dai, D., Honeycutt, E., Wang, T. Y., & Lotun, K. (2011). Left circumflex occlusion in acute myocardial infarction (from the National Cardiovascular Data Registry). The American journal of cardiology, 108(7), 959-63.
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  Compared to occlusions of other major coronary arteries, patients presenting with acute left circumflex (LCx) occlusion usually have ST-segment elevation on the electrocardiogram
• Abbate, A., Kontos, M. C., Grizzard, J. D., Biondi-Zoccai, G. G., Van Tassell, B. W., Robati, R., Roach, L. M., Arena, R. A., Roberts, C. S., Varma, A., Gelwix, C. C., Salloum, F. N., Hastillo, A., Dinarello, C. A., Vetrovec, G. W., & , V. I. (2010). Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). The American journal of cardiology, 105(10), 1371-1377.e1.
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  Acute myocardial infarction (AMI) initiates an intense inflammatory response in which interleukin-1 (IL-1) plays a central role. The IL-1 receptor antagonist is a naturally occurring antagonist, and anakinra is the recombinant form used to treat inflammatory diseases. The aim of the present pilot study was to test the safety and effects of IL-1 blockade with anakinra on left ventricular (LV) remodeling after AMI. Ten patients with ST-segment elevation AMI were randomized to either anakinra 100 mg/day subcutaneously for 14 days or placebo in a double-blind fashion. Two cardiac magnetic resonance (CMR) imaging and echocardiographic studies were performed during a 10- to 14-week period. The primary end point was the difference in the interval change in the LV end-systolic volume index (LVESVi) between the 2 groups on CMR imaging. The secondary end points included differences in the interval changes in the LV end-diastolic volume index, and C-reactive protein levels. A +2.0 ml/m(2) median increase (interquartile range +1.0, +11.5) in the LVESVi on CMR imaging was seen in the placebo group and a -3.2 ml/m(2) median decrease (interquartile range -4.5, -1.6) was seen in the anakinra group (p = 0.033). The median difference was 5.2 ml/m(2). On echocardiography, the median difference in the LVESVi change was 13.4 ml/m(2) (p = 0.006). Similar differences were observed in the LV end-diastolic volume index on CMR imaging (7.6 ml/m(2), p = 0.033) and echocardiography (9.4 ml/m(2), p = 0.008). The change in C-reactive protein levels between admission and 72 hours after admission correlated with the change in the LVESVi (R = +0.71, p = 0.022). In conclusion, in the present pilot study of patients with ST-segment elevation AMI, IL-1 blockade with anakinra was safe and favorably affected by LV remodeling. If confirmed in larger trials, IL-1 blockade might represent a novel therapeutic strategy to prevent heart failure after AMI.
• Al-Husami, W., Yturralde, F., Mohanty, G., Pastore, C., Lotun, K., Venesy, D., Waxman, S., Pyne, C., Gossman, D., Nesto, R., & Piemonte, T. (2008). Single-center experience with the TandemHeart percutaneous ventricular assist device to support patients undergoing high-risk percutaneous coronary intervention. The Journal of invasive cardiology, 20(6), 319-22.
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  We describe our experience of patients, from December 2005 through May 2007 who underwent percutaneous coronary intervention (PCI) with severely depressed left ventricle systolic function and complex coronary lesions. The complex coronary lesions included multiple vessel coronary artery disease, left main (LM) coronary artery disease, calcified coronary lesions and bypass graft disease. All patients were clinically assessed to be at too high of a risk for circulatory collapse without maximal hemodynamic support while they underwent high-risk PCI. The TandemHeart percutaneous ventricular assist device (THpVAD) may be able to provide the necessary circulatory support required to enhance procedural success and patient safety during high-risk PCI.
• Lotun, K., Schainfeld, R. M., Razvi, S., Cho, S., Irwin, W. T., Gribben, A., & Chong, F. K. (2006). An unusual late complication of axillobifemoral bypass graft: a case report. Annals of vascular surgery, 20(6), 830-3.
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  Axillobifemoral bypass is a well-established surgical procedure performed in conditions that preclude direct arterial reconstruction due to aortic sepsis, aortoenteric fistula, or other hostile abdominal pathology or prohibitive surgical risk. The choice of prosthetic graft used is either knitted Dacron(R) or polytetrafluoroethylene, with equally good results. Although externally supported grafts reportedly yielded improvement in primary patency compared to historical controls, no consensus exists as to which demonstrates superiority over the other despite several retrospective studies. Complications are usually limited to the perioperative period, although late anastomotic disruption, graft thrombosis, axillary thromboembolism, pseudoaneurysm formation due to seat belt trauma, and hemorrhage or graft rupture have all been described. In addition to the above complications responsible for graft failure, perigraft infection, intimal hyperplasia, poor distal runoff, anastomotic fibrosis, and comorbid conditions may contribute to graft failure. We describe an unusual late complication of an axillobifemoral bypass graft whereby an organized thrombus within the layers of the bypass graft led to luminal compromise and, hence, attenuation of flow and resultant "failing graft."
• Plaugher, G., Long, C. R., Alcantara, J., Silveus, A. D., Wood, H., Lotun, K., Menke, J. M., Meeker, W. C., & Rowe, S. H. (2002). Practice-based randomized controlled-comparison clinical trial of chiropractic adjustments and brief massage treatment at sites of subluxation in subjects with essential hypertension: pilot study. Journal of manipulative and physiological therapeutics, 25(4), 221-39.
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  To determine the feasibility of conducting a randomized clinical trial in the private practice setting examining short- and long-term effects of chiropractic adjustments for subjects with essential hypertension compared with a brief soft tissue massage, as well as a nontreatment control group.
• Tomanek, R. J., Lotun, K., Clark, E. B., Suvarna, P. R., & Hu, N. (1998). VEGF and bFGF stimulate myocardial vascularization in embryonic chick. The American journal of physiology, 274(5 Pt 2), H1620-6.
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  We tested the hypothesis that early vascularization of the embryonic heart is enhanced after bolus injections of vascular, endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) into the vitelline vein before the onset of myocardial vasculogenesis (3.5 days, stage 21). Electron and light microscopy were utilized to obtain morphometric data. At stages 29 and 31, myocardial vessel volume or numerical density were higher in embryos injected with 50 ng bFGF than in the saline-injected controls. A VEGF injection increased vascular volume density at stage 29 and both volume and numerical, density at stage 31, bFGF, but not VEGF, was associated with an enhancement of the sinusoidal system (spongy layer of the ventricle) at stage 29. This effect disappeared by stage 31. In conclusion, 1) enhancement of bFGF or VEGF before myocardial vascularization increases vascular growth, but the initial effect of bFGF is greater; 2) the effects of these growth factors on vascular volume and numerical density are temporally dependent; and 3) bFGF, in addition to its effects on the coronary vasculature, influences ventricular modeling by apparently acting on myocytes as well as endothelial cells.
• Lotun, K., & Tomanek, R. J. (1997). MYOCARDIAL VASCULARIZATION IS STIMULATED BY BASIC FIBROBLASTS GROWTH FACTOR AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN EMBRYOGENIC CHICK HEART. FASEB J, 1138.

Presentations

• Lotun, K., & Truong, H. (2016, August). Uncommon Path to the Chronic Total Occlusion.. Cardiovascular Innovation Conference. Denver, CO.
• 84. Kanakadandi, U., Abidov, A., Lotun, K., & D, B. (2015, March). Abnormal Stress Ankle Brachial Index Predicts All-Cause Mortality. ACC 2015 Annual Scientific Sessions. San Diego, CA..
• Janardhanan, R., Lotun, K., Thompson, J., & Shetty, R. (2015, June). Closure of Aortic Paravalvular Leak Resulting in Resolution of Transvalvular Leak: Is it a Venturi Effect?. ASE. Boston: American Society of Echocardiography.

Poster Presentations

• Kumar, K., Reddy, S., Hashim, T., Kazui, T., Lee, K. S., Shetty, R., & Lotun, K. (2018, Sep). Feasibility of performing multivessel PCI through an Impella sheath. Transcatheter Therapeutics (TCT). San Diego, CA.
• Lee, K. S., Koester, S., Dhakal, B., Lee, J. Z., Desai, R., Lotun, K., Shetty, R., & Kumar, G. (2018, Sep). Optical coherence tomography strut coverage temporal trend differences in STEMI vs stable patients within 1-year of implantation: Meta-analysis of current generation drug eluting stents. Transcatheter Therapeutics (TCT). San Diego, CA.
• Truong, H., Kern, K. B., Hsu, C., Lotun, K., Tran, T., Smith, N., Talwar, S., Rao, P., Done, A., Gianotto-Oliveira, R., Rivera-Zotigh, J., Rivera-Zotigh, J., Gianotto-Oliveira, R., Done, A., Rao, P., Talwar, S., Smith, N., Tran, T., Hsu, C., , Lotun, K., et al. (2017, November). Combining Mechanical Chest Compressions With a Percutaneous Left Ventricular Assist Device Improves Favorable Neurological Function After Cardiac Arrest in a Large Animal Catheterization Laboratory.. Circulation.
• Lotun, K., & Enakpene, E. (2016, March). Coronary Aneurysm Treatment with Coiling and Stenting. CRT. Washington, DC.
• Lotun, K., Lassar, T., Lee, K. S., Kannan, A., Poongkunran, M., & Sundararajan, S. (2016, March). Comparison Of Drug Coated Balloons And Drug Eluting Stents In In-stent Restenosis- A Meta Analysis.. American College of Cardiology Scientific Sessions.
• Lotun, K., Truong, H., Kern, K. B., Cha, K., Oliveira, R., Smith, N., Bien, T., Rao, P., Chatelain, S., & Kern, M. (2016, Fall). Mechanical Chest Compression or Percutaneous Left Ventricular Assist Devices Improve Survival In Cardiac Arrest in the Cath Lab. American Heart Association Scientific Sessions. New Orleans, LA.
• Doraiswamy, V. A., Trinidad, M., Subramanian, K., Szerlip, M., Abidov, A., & Lotun, K. (2015, Summer). USE OF CONDUITS IN PATIENTS WITH PROHIBITIVE ILIO-FEMORAL ARTERY ANATOMY FOR TRANSCATHETER AORTIC VALVE REPLACEMENT. INTERNATIONAL ACADEMY OF CARDIOLOGY, 20TH WORLD CONGRESS ON HEART DISEASE, ANNUAL SCIENTIFIC SESSIONS. Vancouver, Canada: International Academy of Cardiology.
• Lotun, K., & Kandala, J. (2015, Spring). RED BLOOD CELL TRANSFUSION IS ASSOCIATED WITH INCREASED RISK OF ADVERSE EVENTS IN PATIENTS UNDERGOING TAVR. SCAI MEETING. San Diego, CA: SCAI.
• Lotun, K., & Kandala, J. (2015, Spring). SEVERE PULMONARY HYPERTENSION IS ASSOCIATED INCREASED RISK OF DEATH IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT. SCAI MEETING. San Diego, CA: SCAI.
• Lotun, K., Kanakadandi, U. B., Abidov, A., & Bhatt, D. (2015, March). PROGNOSTIC VALUE OF ABNORMAL STRESS ANKLE BRACHIAL INDEX. ACC MEETING. San Diego, CA.
• Lotun, K., Shetty, R., Ellingson, C., & Kern, K. B. (2015, Nov). Optimal hemodynamic support for emergency coronary intervention during refractory cardiac arrest. AHA Annual Scientific Sessions 2015. Orlando, FL: AHA.
• Enkapene, E., Kanakadandi, U., & Lotun, K. (2014, March). LOCALIZED CARDIAC TAMPONADE IN AN ANTICOAGULATED PATIENT POST ROBOTIC CARDIAC BYPASS. ACC. Washington, D.C..
• Lotun, K., & Nguyen, T. (2014, September). MAINTAINING PERFUSION PRESSURE DURING ASYSTOLE WITH IMPELLA 2.5. TCT MEETING. Washington, D.C..
• Rou Tey, K., Boyella, R., Kalra, N., Lee, J., Lee, K. S., & Lotun, K. (2014, January). CASE REPORT OF ILIOFEMORAL THROMBOSIS SECONDARY TO ILIAC COMPRESSION SYNDROME IN DOUBLE INFERIOR VENA CAVA. ISET Meeting. Miami, FL.
• Balachandran, M., Lotun, K., Thompson, J., & Janardhanan, R. (2013, October). A CHALLENGING CASE OF MITRAL PARAVALVULAR LEAKS: SUCCESSFUL 3D-TEE GUIDED TRANSCATHETER CLOSURE. 13. 2ND WORLD ECHOCARDIOGRAPHY SUMMIT. NEW DELHI, INDIA.
• Bhatnagar, S., Szerlip, M., Lotun, K., Abidov, A., Subramanian, S., Sethi, G., Paidy, S., & Poston, R. (2013, May). IMPROVING TEAM PERFORMANCE AND PATIENT OUTCOMES DURING TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR) THROUGH SIMULATION. SCAI ANNUAL MEETING. Orlando, FL.
• Irbaz Bin Riaz, F., Dhoble, A., Mizyed, A., Hsu, P., Husnain, M., Lotun, K., & Lee, K. S. (2013, May). TRANSCATHETER CLOSURE VS MEDICAL THERAPY FOR CRYPTOGENIC STROKE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Euro PCR. Paris, France.
• Janardhanan, R., Lotun, K., Khalpey, Z. I., Smith, M. C., Rutter, T., Nemanova, D., & Friedman, M. (2013, June). MITRAL VALVE OBSTRUCTION: ACCURATE DIAGNOSIS BY 3D-TRANSESOPHAGEAL ECHOCARDIOGRAPHY. AMERICAN SOCIETY OF ECHOCARDIOGRAPHY. Minneapolis, MN.
• Lee, K. S., Lee, J., Irbaz Bin Riaz, F., Husnain, M., Riaz, H., Lotun, K., & Kern, K. B. (2013, October). STRUT LEVEL OPTICAL COHERENCE TOMOGRAPHY EVALUATION OF CORONARY STENT STRUT COVERAGE TEMPORAL TRENDS: A SYSTEMATIC REVIEW. TCT MEETING. San Francisco, CA.
• Lotun, K., & Janardhanan, R. (2013, March). A CASE OF TWIST AND TURNS. AMERICAN COLLEGE OF CARDIOLOGY – SUB MEETING 29TH INTERNATIONAL CONF. OF RECENT ADVANCES IN ECHOCARDIOGRAPHY AND ALLIED TECHNIQUES. San Francisco, CA.
• Habibzadeh, R., Kern, K. B., & Lotun, K. (2012, October). CHALLENGING CASE SERIES - FLOATING CORONARY STENT. TCT Meeting. Miami, FL.
• Abbate, A., Kontos, M., Grizzard, J. D., Biondi-Zoccai, G. G., Van Tassell, B. W., Robati, R., & Lotun, K. (2010, March). INTERLEUKIN-1 BLOCKADE WITH ANAKINRA TO PREVENT ADVERSE COMMONWEALTH UNIVERSITY ANAKINRA REMODELING TRIAL {VCU-ART} PILOT STUDY). 22. AMERICAN COLLEGE OF CARDIOLOGY MEETING. Atlanta, GA.
• Lotun, K., Igbokidi, I., Luu, J. T., Cowley, M. J., Goudreau, E., Marwaha, V., & Vetrovec, G. W. (2010, May). RADIAL ACCESS IS ASSOCIATED WITH LOWER VASCULAR COMPLICATIONS AND DECREASED HOSPITALIZATION IN PATIENTS WITH END STAGE LIVER DISEASE REQUIRING CARDIAC CATHETERIZATION. SCAI Annual Meeting. San Diego, CA.
• Stribling, W. K., Abbate, A., Kontos, M., Cooke, R., Vetrovec, G., & Lotun, K. (2010, May). CLINICAL OUTCOMES IN PATIENTS WITH ACUTE LEFT CIRCUMFLEX/OBTUSE MARGINAL OCCLUSION PRESENTING WITH MYOCARDIAL INFARCTION. SCAI Annual Meeting. San Diego, CA.
• Stribling, W. K., Kontos, M. C., Abbate, A., Cooke, R., Vetrovec, G. W., Dai, D., Honeycutt, E., & Lotun, K. (2010, September). TOTAL LEFT CIRCUMFLEX OCCLUSION IN MYOCARDIAL INFARCTION: FINDINGS FROM THE NATIONAL CARDIOVASCULAR REGISTRY (NCDR®) CATHPCI REGISTRY®.. TCT Meeting. Washington, D.C..
• Lotun, K., Jaff, M. R., Sevestre, M., Soukas, P., Kenney, L., Ingram, S., & Schainfeld, R. (2004, June). RENAL RESISTIVE INDEX DECREASES IN THE CONTRALATERAL NON-STENTED KIDNEY IN PATIENTS UNDERGOING UNILATERAL RENAL ARTERY STENTING: A NEW INDICATION FOR RENAL ARTERY STENTING?. SVMB Meeting. Anaheim, CA.
• Lotun, K., Pieczek, A., Isner, J. M., Schainfeld, R., & Losordo, D. (2004, June). PHYSICAL EXAMINATION AND ROUTINE TESTING IS AN ADEQUATE STRATEGY TO SCREEN PATIENTS FOR PARTICIPATION IN ANGIOGENIC GENE THERAPY TRIALS. SVMB Meeting. Anaheim, CA.
• Lotun, K., Cho, S. S., Soukas, P. A., Irwin, W., & Schainfeld, R. (2003, July). CAROTID ARTERY STENTING WITH NORMAL FINAL COMPLETION ANGIOGRAM: IS THERE A ROLE FOR EARLY DUPLEX SCAN?. SVMB Meeting. Chicago, IL.
• Lotun, K., Schainfeld, R., Pieczek, A., Curry, C., Irwin, W. T., Isner, J. M., & Losordo, D. W. (2003, July). PREEMPTIVE TREATMENT OF EDEMA MAY LEAD TO BENEFICIAL EFFECT IN PATIENTS UNDERGOING INTRAMUSCULAR GENE TRANSFER FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASES. SVMB Meeting. Chicago, IL.
• Lotun, K., Schainfeld, R., Pieczek, A., Isner, J. M., & Losordo, D. W. (2003, July). INTRAMUSCULAR GENE TRANSFER IS SAFE AND EFFICACIOUS IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASES: A DOSE ESCALATION TRIAL. SVMB Meeting. Chicago, IL.
• Lotun, K., Pieczek, A., Schainfeld, R., Curry, C., Irwin, W. T., Isner, J. M., & Losordo, D. W. (2002, November). INTRAMUSCULAR GENE TRANSFER FOR THE TREATMENT OF PERIPHERAL VASCULAR DISEASES: A RANDOMIZED DOUBLE BLINDED STUDY. AMERICAN HEART ASSOCIATION MEETING. Chicago, IL.
• Tomanek, R. J., & Lotun, K. (1996, April). ROLE OF BFGF AND VEGF IN CORONARY VASCULOGENESIS AND ANGIOGENESIS. WEINSTEIN CARDIOVASCULAR MEET. Philadelphia, PA.

Case Studies

• Low, S. W., Lotun, K., & Lee, K. (2015. Iliofemoral Thrombosis Secondary to Iliac(pp E54-E61).
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  Duplication of the inferior vena cava (D-IVC) joined by a pelvic connector is a rarecongenital anomaly. May-Thurner syndrome (MTS), also known as iliac compression syndrome, iscaused by a localized stricture at the point where the left common iliac vein is crossed by the rightcommon iliac artery resulting in left common femoral deep venous thrombosis. The combinationpathology of D-IVC and MTS is rarely described. We describe a case of a patient with iliofemoralthrombosis precipitated by MTS with D-IVC, heterozygous mutation of factor V Leiden, and describeour successful treatment approach. Iliofemoral Thrombosis Secondary to Iliac Compression Syndrome in Double Inferior Vena Cava (PDF Download Available). Available from: https://www.researchgate.net/publication/275973427_Iliofemoral_Thrombosis_Secondary_to_Iliac_Compression_Syndrome_in_Double_Inferior_Vena_Cava [accessed Dec 31, 2015].

Others

• Kern, K. B., Truong, H., Lotun, K., Smith, N., Rao, P., Gianotto-Oliveira, R., RIvera-Zotigh, J. M., Talwar, S., Tran, T., & Hsu, C. (2017, Spring). Combining mechanical chest compressions with a percutaneous left ventricular assist device improves favorable neurological outcome after cardiac arrest in a large animal catheterization laboratory.. Circulation.
• Reddy, S., Lotun, K., Shetty, R., Lee, K. S., & Kazui, T. (2017, October). Successful Treatment of Staphylococcus Aureus 28 X 11 mm Mycotic Aneurysm of the Proximal Left Anterior Descending Artery with Endovascular Coiling in High Risk Surgical Patient.. TCT 2017.
• Reddy, S., Lotun, K., Shetty, R., Lee, K. S., & Kazui, T. (2017, October). Transcutaneous Aortic Valve Replacement Within a Previously Placed Surgical and Transcutaneous Prosthetic Valves Under Peripheral Extracorporeal Membrane Oxygenation Support (TandemLife) Hemodynamic Support in a High Risk Patient.. TCT 2017.
• Verma, D. R., Pershad, A., Morse, M., & Lotun, K. (2017, October). TCT-464 Percutaneous Transcatheter Mitral Valve Replacement via Transseptal or Transapical Approach in Patients who are Prohibitive Risk for Surgery: US Multicenter Registry.. TCT 2017.
• Verma, D. R., Pershad, A., Morse, M., & Lotun, K. (2017, October). TCT-465 A US Multicenter Registry for Percutaneous Transcatheter Mitral Valve Replacement Using Balloon Expandable Valve in Patients who are at Prohibitive Risk for Surgery.. TCT 2017.
• Kern, M., Chatelain, S., Rao, P., Bien, T., Smith, N., Oliveira, R., Cha, K., Kern, K. B., Lotun, K., & Truong, H. (2016, January). Mechanical Chest Compression or Percutaneous Left Ventricular Assist Devices Improve Survival In Cardiac Arrest in the Cath Lab..