Katalin Scherer
- Professor, Neurology - (Clinical Scholar Track)
Contact
- (520) 626-4551
- Arizona Health Sciences Center, Rm. 6205
- Tucson, AZ 85724
- kscherer@arizona.edu
Biography
Peer Reviewed Journal Publications
- Park J, Flores B, Scherer K, Küpper H, et al, Haack TB: De novo variants in SLC12A6 cause early-onset progressive sensorimotor neuropathy [J Med Genet.2019;0:1-6]
- Gravbrot N, Scherer K, Sundararajan S: Safe transition to pembrolizumab following ipilimumab-induced Guillain-Barré syndrome: a case report and review of the literature [Case Rep Oncol Med. 2019:5490707]
- Kazi ZB, Desai AK, Troxler RB..... Scherer K.......et al: An immune tolerance approach using transient low-dose methotrexate in the ERT-naïve setting of patients treated with a therapeutic protein: experience in infantile-onset Pompe disease, Genetics in Medicine2019;21(4):887-895.
- Scherer, K., Day, W. A., Andrew, D. R., Montfort, W. R., Hammer, M. F., & Restifo, L. L. (2017). A sporadic case of severe peripheral neuropathy expands the phenotypic range of TUBB2A mutations. [manuscript in preparation]
- Zahedieh S, Andrews J, Klewer SE, Daines CL, Scherer K, Barber BJ, Seckeler MD. Regional and Racial Variation in Hospitalization Costs for Males with Muscular Dystrophies [submitted to Pediatrics, under peer review]
- Scherer K, Bedlack RS. Diaphragm pacing in amyotrophic lateral sclerosis: a literature review. Muscle Nerve 2012;46(1):1-8
- Davis MF, Scherer K, Miller TM, Meaney FJ. Measuring disease severity in Duchenne and Becker Muscular Dystrophy. J of Methods and Measurement in the Social Sciences 2010;1(1):8-18.
- Scherer K. Radial nerve palsy in Guillain-Barré syndrome. J Clin Neuromuscular Disease 2009;11(1):31-4.
- Scherer K, Skeen MS, Strine SA, Juel VC. Hanging leg syndrome: Combined bilateral femoral and sciatic neuropathies. Neurology 2006;66(7):1124-1125.
- Scherer K and Bedlack RS. Working through the challenges of neuropathic pain. Emergency Medicine 2005;37(10):37-43.
- Scherer K, Bedlack RS, Simel DL. Does This Patient Have Myasthenia Gravis? JAMA 2005;293(15):1906-14.
- Scherer K. Images in Clinical Medicine Neurologic Manifestations of Vitamin B12 Deficiency. NEJM 2003;348(22):2208.
- Wilson MG and Scherer K. Shigella sonnei enterocolitis and rhabdomyolysis. Medicine Online – The International Journal of Medicine 2001; http://www.priory.com/med/shigella.htm
Book chapters
- Scherer K, Bedlack RS, Simel DL. Does This Patient Have Myasthenia Gravis? In: Simel DL and Rennie D, eds. JAMA Rational Clinical Examination. New York, NY:McGraw-Hill; 2008.
Abstracts/Presentations
- Yogendran LV , Barcelo B, Mortel MD, Shane BS, Ibarra BL, Johnston CB , Horak H, Scherer K: Identifying Important Palliative Topics and Communication Preferences Among ALS Patients. American Academy of Hospice and Palliative Medicine Annual Assembly, San Diego, CA, March 2020
- Yogendran LV , Barcelo B, Mortel MD, Shane BS, Ibarra BL, Johnston CB , Horak H, Scherer K: Identifying Important Palliative Topics and Communication Preferences Among ALS Patients. Northeast ALS Consortiujm Annual Conference, Clearwater Beach, FL, Oct 2019
- Rossi M, Scherer K, Galindo M, RadtkeK, Park MS, Powis Z, Shinde DN: Heterozygous de novo alteration in SLC12A6 in a patient with progressive sensorimotor polyneuropathy and abnormal EEG, Poster, ASHG, Orlando, FL, October 2017
- Scherer K. The benefits and pitfalls of next generation sequencing: 3 illustrative cases of myasthenia, Poster, MGFA Annual meeting, Scottsdale, AZ, Sept 2017
- Tay J., Shwonka V., Scherer K. Novel dominant SYNE1 (nesprin 1) mutation causing a mild Muscular Dystrophy Phenotype, Poster, AANEM annual meeting, New Orleans, LA Sept 2016
- Bonsell KC, Galindo MK, Chacon M, Talwar D, Scherer K. Novel PMP22 mutation causing DEJERINE SOTTAS DISEASE, clinically indistinguishable from CIDP, Poster, AANEM annual meeting, New Orleans, LA Sept 2016.
- Scherer K. Dejerine Sottas Disease is clinically indistinguishable from CIDP. Case presentation, AAN Annual Meeting, Vancouver, BC, Canada, April 2016.
- Zahedieh S, Seckeler MD, Jennifer Andrews J, Scott E. Klewer SE, MD, Scherer K, Daines CL, Barber BJ. Regional and Racial Variation in Hospitalization Costs in Patients with Duchenne Muscular Dystrophy. Poster presented at the American Academy of Pediatrics National Conference and Exhibition, Washington DC, October 2015.
- Davis MF, Scherer K. (accepted, November, 2015). Estimating disease severity from electronic health records. A presentation to the annual meeting of the American Evaluation Association. Chicago, Il
- Arumaithurai K, Kapoor A, Horak H, Scherer K: Celiac Disease: Neurological Manifestations in 2 undiagnosed patients. Poster presented at the AANEM annual meeting, Savannah, GA, Oct 2014
- Patel K, Whiddon R, Scherer K: The bane of a pianist – median hand. Poster presented at the AANEM annual meeting, Orlando, FL, October 2012
- Whiddon R, Patel K, Scherer K: An elderly woman with scapular, paraspinal and hamstring weakness: an atypical presentation of FHSD. Poster presented at AANEM annual meeting, Orlando, FL, October 2012
Degrees
- M.D. Medicine
- Albert Szent Gyorgyi Medical University, Szeged, Hungary
- Capsaicin Sensitive Primary Sensory Neurons
Work Experience
- The University of Arizona, Arizona (2021 - Ongoing)
- Department Neurology (2005 - 2021)
Licensure & Certification
- Neurology - primary specialty, American Board of Psychiatry and Neurology (2005)
- Electrodiagnostic Medicine (EMG) - subspecialty, American Board of Electrodiagnostic Medicine (2006)
- Neuromuscular Medicine - subspecialty, APBN/Neuromuscular Medicine subspecialty (2009)
- Neuromuscular Ultrasound - Added Qualification, ABEM - Certificate of Added Qualification (2019)
Interests
Research
Neuromuscular Disorders
Teaching
Neurophysiology - EMG, IOMNeuromuscular DisordersNeuromuscular Ultrasound
Courses
2023-24 Courses
-
Neuromuscular Disorders
NEUR 850F (Spring 2024) -
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2023) -
Neuromuscular Disorders
NEUR 850F (Fall 2023)
2022-23 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2022)
2021-22 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2021)
2020-21 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Spring 2021) -
Neurology Clerkship Clinical
NEUR 813C2 (Spring 2021) -
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2020)
2019-20 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2019)
2018-19 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2018)
2017-18 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2017)
2016-17 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Spring 2017) -
Neurology Gen. Inpatient Svc.
NEUR 850A (Spring 2017) -
Pediatric Neurology
NEUR 850G (Spring 2017) -
Neuro+Rehab Med Clerkshp
NEUR 813C (Fall 2016)
2015-16 Courses
-
Neuro+Rehab Med Clerkshp
NEUR 813C (Spring 2016)
Scholarly Contributions
Chapters
- Scherer, K., Bedlack, R. R., & Simel, D. L. (2008). Does This Patient Have Myasthenia Gravis?. In JAMA Rational Clinical Examination. New York, NY: McGraw Hill.
Journals/Publications
- Gravbrot, N., Scherer, K., & Sundararajan, S. (2019). Safe Transition to Pembrolizumab following Ipilimumab-Induced Guillain-Barré Syndrome: A Case Report and Review of the Literature. Case reports in oncological medicine, 2019, 5490707.More infoImmune checkpoint inhibitors are novel therapies with indications for treating several solid cancers. They are associated with immune-related adverse events, which are generally well tolerated. Though rare, severe side effects may be life-threatening. One such adverse event is Guillain-Barré syndrome, which requires cessation of the immunotherapy and intravenous immunoglobulin and/or high-dose steroids to treat. No recommendations have been published regarding restarting cancer treatment after development of immunotherapy-induced Guillain-Barré syndrome.
- Park, J., Flores, B. R., Scherer, K., Kuepper, H., Rossi, M., Rupprich, K., Rautenberg, M., Deininger, N., Weichselbaum, A., Grimm, A., Sturm, M., Grasshoff, U., Delpire, E., & Haack, T. B. (2019). variants in cause sporadic early-onset progressive sensorimotor neuropathy. Journal of medical genetics.More infoCharcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous disorder of the peripheral nervous system. Biallelic variants in have been associated with autosomal-recessive hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC). We identified heterozygous de novo variants in in three unrelated patients with intermediate CMT.
- Richards, S. M., Troxler, R. B., Tanpaiboon, P., Sung, C., Sherry, L., Segel, R., Scherer, K., Sabbadini, M., Rizzo, W. B., Richards, S., Packman, S., Niyazov, D. M., Nampoothiri, S., Mcvie-wylie, A., Kronn, D., Kishnani, P. S., Kazi, Z. B., Joseph, A. M., Gupta, N., , Feigenbaum, A., et al. (2019). An immune tolerance approach using transient low-dose methotrexate in the ERT-naïve setting of patients treated with a therapeutic protein: experience in infantile-onset Pompe disease.. Genetics in medicine : official journal of the American College of Medical Genetics, 21(4), 887-895. doi:10.1038/s41436-018-0270-7More infoTo investigate immune tolerance induction with transient low-dose methotrexate (TLD-MTX) initiated with recombinant human acid α-glucosidase (rhGAA), in treatment-naïve cross-reactive immunologic material (CRIM)-positive infantile-onset Pompe disease (IOPD) patients..Newly diagnosed IOPD patients received subcutaneous or oral 0.4 mg/kg TLD-MTX for 3 cycles (3 doses/cycle) with the first 3 rhGAA infusions. Anti-rhGAA IgG titers, classified as high-sustained (HSAT; ≥51,200, ≥2 times after 6 months), sustained intermediate (SIT; ≥12,800 and
- Kazi, Z. B., Desai, A. K., Troxler, R. B., Kronn, D., Packman, S., Sabbadini, M., Rizzo, W. B., Scherer, K., Abdul-Rahman, O., Tanpaiboon, P., Nampoothiri, S., Gupta, N., Feigenbaum, A., Niyazov, D. M., Sherry, L., Segel, R., McVie-Wylie, A., Sung, C., Joseph, A. M., , Richards, S., et al. (2018). An immune tolerance approach using transient low-dose methotrexate in the ERT-naïve setting of patients treated with a therapeutic protein: experience in infantile-onset Pompe disease. Genetics in medicine : official journal of the American College of Medical Genetics.More infoTo investigate immune tolerance induction with transient low-dose methotrexate (TLD-MTX) initiated with recombinant human acid α-glucosidase (rhGAA), in treatment-naïve cross-reactive immunologic material (CRIM)-positive infantile-onset Pompe disease (IOPD) patients.
- Seckeler, M. D., Zahedieh, S., Seckeler, M. D., Scherer, K., Klewer, S. E., Daines, C. L., Barber, B. J., & Andrews, J. (2016). Regional and Racial Variation in Hospitalization Costs in Patients with Duchenne Muscular Dystrophy. Pediatrics, 140, 28-28. doi:10.1542/peds.140.1_meetingabstract.28More infoAdvances in management for Duchenne muscular dystrophy (DMD) have improved survival. The purpose of this study was to describe hospital outcomes and costs for DMD patients and to identify regional and racial variation. Retrospective review of University Health System Consortium Clinical Data Base/Resource Manager, a …
- Scherer, K., & Bedlack, R. S. (2012). Diaphragm pacing in amyotrophic lateral sclerosis: a literature review. Muscle & nerve, 46(1), 1-8.More infoAmyotrophic lateral sclerosis (ALS) remains a rapidly progressive fatal degenerative disease of motor neurons for which there are few interventions to slow disease progression or improve quality of life. A diaphragm pacing system was approved by the U.S. Food and Drug Administration in September 2011 for ALS under a Humanitarian Device Exemption. News of this approval has been met with a combination of excitement and uncertainty by members of the ALS community. We review the currently available data on the diaphragm pacing system and its use in ALS. Diaphragm pacing appears to be reasonably safe in carefully selected patients, but flaws in the reporting on it thus far preclude conclusions regarding efficacy. Further study is needed.
- Davis, M. F., Scherer, K., Miller, T. M., & Meaney, F. J. (2010). Measuring disease severity in Duchenne and Becker Muscular Dystrophy. Journal of Methods and Measurement in the Social Sciences, 1(1), 8-18.
- Scherer, K. (2009). Radial nerve palsy in Guillain-Barré syndrome.. Journal of clinical neuromuscular disease, 11(1), 31-4. doi:10.1097/cnd.0b013e3181adcdd0More infoThe risk of focal compression neuropathy in the setting of an underlying inflammatory polyneuropathy is unknown. A man developed ascending weakness and severe sensory ataxia and could not walk. Electromyography was diagnostic of Guillain-Barré syndrome. He improved with gammaglobulin and was released home 1 month later. Shortly after discharge, he developed severe left arm pain followed by wrist and finger drop. He was readmitted for another round of gamma-globulin without improvement. Subsequent electromyography showed severe radial neuropathy. Only then did he disclose that he usually slept with his wife's head on his arm at home. Two years later, he had recovered from Guillain-Barré syndrome with minimal gait imbalance, but wrist and finger extension remained weak. Reduced awareness of warning paresthesias coupled with the underlying polyneuropathy may account for this case of severe radial nerve compression. Potential mechanisms underlying increased nerve susceptibility to compression in the setting of polyneuropathy are reviewed.
- Strine, S. A., Skeen, M. B., Scherer, K., & Juel, V. C. (2006). Hanging leg syndrome: combined bilateral femoral and sciatic neuropathies.. Neurology, 66(7), 1124-5. doi:10.1212/01.wnl.0000204192.09346.c2More infoFocal nerve injuries may occur in the setting of depressed consciousness via compression or traction. Such nerve injuries may follow general anesthesia or may develop in the context of hypnotic drug or alcohol intoxication. We report a case of severe, combined, bilateral femoral and sciatic neuropathies in the context of alcohol intoxication. A 43-year-old man with chronic low back pain lost consciousness after a night of heavy alcohol consumption. He lay supine with both legs hanging over the end of his bed. His hips were hyperextended and a wooden footboard impressed into the posterior thighs near the gluteal sulci. He awoke 12 hours later unable to move or feel his legs. Bowel, bladder, and sexual function remained normal. Two months later, he was evaluated for persistent paraparesis and abnormal lower extremity sensation. His examination showed linear violaceous skin impressions at the gluteal sulci corresponding to the points of contact with the footboard (figure). There was severe bilateral …
- Scherer, K., Bedlack, R. S., & Simel, D. L. (2005). Does this patient have myasthenia gravis?. JAMA, 293(15), 1906-14.More infoClinicians must be able to diagnose myasthenia gravis, since delays in establishing the diagnosis may put patients at risk for complications from this treatable disease.
- Scherer, K. (2003). Images in clinical medicine. Neurologic manifestations of vitamin B12 deficiency.. The New England journal of medicine, 348(22), 2208. doi:10.1056/nejmicm020588More infoA 56-year-old woman presented with a four-month history of progressive cognitive decline, weakness, incoordination, and gait disturbance. She had a score of 12 of 28 on the Mini–Mental State Examination, moderate weakness, and severe ataxia; reflexes, vibratory sensation, and the sense of position were absent throughout her arms and legs. T2-weighted magnetic resonance imaging (MRI) of the brain demonstrated extensive areas of high-intensity signal in the periventricular white matter (Panel A, arrow). MRI of the spine showed a hyperintense signal along the posterior columns in all segments, including the lower portion of the cervical cord (Panel B, arrow). . . .
- Wilson, M. G., & Scherer, K. (2001). Shigella sonnei enterocolitis and rhabdomyolysis. Medicine Online – The International Journal of Medicine;.
Poster Presentations
- Rossi, M., Scherer, K., Kelly, M. E., Radtke, K., Powis, Z., & Shinde, D. N. (2017, October). Heterozygous de novo alteration in SLC12A6 in a patient with progressive sensorimotor polyneuropathy and abnormal EEG. ASHG annual meeting. Orlando, FL: American Society of Human Genetics.
- Scherer, K. (2017, September). The benefits and pitfalls of next generation sequencing: 3 illustrative cases of myasthenia. MGFA Annual meeting. Scottsdale, Arizona: MGFA, AANEM.
- Bonsell, K., Kelly, M. E., Chacon, M., Talwar, D., & Scherer, K. (2016, Sept). Novel PMP22 mutation causing DEJERINE SOTTAS DISEASE, clinically indistinguishable from CIDP. AANEM annual meeting. New Orleans, LA.
- Scherer, K. (2016, April). Dejerine Sottas Disease is clinically indistinguishable from CIDP. AAN annual meeting. Vancouver, BC, Canada.
- Tay, J., Shwonka, V., & Scherer, K. (2016, 09/16). Novel dominant SYNE1 (nesprin 1) mutation causing a mild Muscular Dystrophy Phenotype. AANEM annual meeting. New Orleans, LA.
- Zahedieh, S., Seckeler, M., Andrews, J., Klewer, S. E., Scherer, K., Daines, C. L., & Barber, B. J. (2015, Fall). Regional and Racial Variation in Hospitalization Costs in Patients with Duchenne Muscular Dystrophy. American Academy of Pediatrics National Conference and Exhibition. Washington, DC: AAP.
- Arumaithurai, K., Kapoor, A., Horak, H. A., & Scherer, K. (2014, October). Celiac Disease: Neurological Manifestations in 2 undiagnosed patients. AANEM Annual Meeting. Savannah, Georgia: AANEM.
- Patel, R., Khan, M., & Scherer, K. (2014, November). Oddities – Unusual Non-motor Symptoms in 3 ALS Patients. ALSA National Conference. Phoenix/Scottsdale.
- Patel, K., Whiddon, R., & Scherer, K. (2012, Fall). THE BANE OF A PIANIST – MEDIAN HAND. AANEM Annual meeting. Orlando, FL.
- Whiddon, R., Patel, K., & Scherer, K. (2012, Fall). AN ELDERLY WOMAN WITH SCAPULAR, PARASPINAL, AND HAMSTRING WEAKNESS: AN ATYPICAL PRESENTATION OF FSHD. AANEM Annual Meeting. Orlando, FL.
Case Studies
- Scherer, K. (2009. Radial nerve palsy in Guillain-Barré syndrome(pp 31-4).More infoThe risk of focal compression neuropathy in the setting of an underlying inflammatory polyneuropathy is unknown. A man developed ascending weakness and severe sensory ataxia and could not walk. Electromyography was diagnostic of Guillain-Barré syndrome. He improved with gammaglobulin and was released home 1 month later. Shortly after discharge, he developed severe left arm pain followed by wrist and finger drop. He was readmitted for another round of gamma-globulin without improvement. Subsequent electromyography showed severe radial neuropathy. Only then did he disclose that he usually slept with his wife's head on his arm at home. Two years later, he had recovered from Guillain-Barré syndrome with minimal gait imbalance, but wrist and finger extension remained weak. Reduced awareness of warning paresthesias coupled with the underlying polyneuropathy may account for this case of severe radial nerve compression. Potential mechanisms underlying increased nerve susceptibility to compression in the setting of polyneuropathy are reviewed.
- Scherer, K., Skeen, M. B., Strine, S. A., & Juel, V. C. (2006. Hanging leg syndrome: combined bilateral femoral and sciatic neuropathies(pp 1124-5).
- Scherer, K. (2003. Images in clinical medicine. Neurologic manifestations of vitamin B12 deficiency(p. 2208).