Katri V Typpo

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Courses

Scholarly Contributions

Chapters

• Typpo, K. V., & Akcan-Arikan, A. (2019). Chapter 12: Fluids, Nutrition, and Acute Kidney Injury in Pediatric Acute Respiratory Distress Syndrome. In Pediatric Acute Respiratory Distress Syndrome: A Clinical Guide(pp 141-157). Cham, Switzerland: Springer. doi:10.1007/978-3-030-21840-9
• Typpo, K. V. (2011). Chapter 9 - Critical Care. In Texas Childrens Hospital Handbook of Pediatrics and Neonatology. Texas: McGraw Hill.
• Typpo, K. V., & Mariscalco, M. (2007). Multiple Organ Dysfunstion Syndrome. In Pediatric Critical Care Medicine: Basic Science & Clinical Evidence. London: Springer Verlag.

Journals/Publications

• Shein, S. L., Karam, O., Beardsley, A., Karsies, T., Prentice, E., Tarquinio, K. M., Willson, D. F., Carroll, C. L., Chima, R. S., Davila, S., Demartini, T., Flori, H., Fontela, P., Gedeit, R., Goodman, D., Hassinger, A. B., Jeyapalan, A., Jouvet, P., Khemani, R., , Kirby, A., et al. (2019). Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections*. PEDIATRIC CRITICAL CARE MEDICINE, 20(8), 697-706.
• Spinella, P. C., Tucci, M., Fergusson, D. A., Lacroix, J., Hebert, P. C., Leteurtre, S., Schechtman, K. B., Doctor, A., Berg, R. A., Bockelmann, T., Caro, J. J., Chiusolo, F., Clayton, L., Cholette, J. M., Guerra, G. G., Josephson, C. D., Menon, K., Muszynski, J. A., Nellis, M. E., , Sarpal, A., et al. (2019). Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 322(22), 2179-2190.
• Srinivasan, V., Hasbani, N. R., Mehta, N. M., Irving, S. Y., Kandil, S. B., Allen, H. C., Typpo, K. V., Cvijanovich, N. Z., Faustino, E. V., Wypij, D., Agus, M. S., Nadkarni, V. M., & , H. a. (2019). Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
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  The impact of early enteral nutrition on clinical outcomes in critically ill children has not been adequately described. We hypothesized that early enteral nutrition is associated with improved clinical outcomes in critically ill children.
• Typpo, K., Watson, R. S., Bennett, T. D., Farris, R. W., Spaeder, M. C., Petersen, N. J., & , P. E. (2019). Outcomes of Day 1 Multiple Organ Dysfunction Syndrome in the PICU. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 20(10), 914-922.
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  We sought to describe current outcomes of Multiple Organ Dysfunction Syndrome present on day 1 of PICU admission.
• Irving, S. Y., Daly, B., Verger, J., Typpo, K. V., Brown, A. M., Hanlon, A., Weiss, S. L., Fitzgerald, J. C., Nadkarni, V. M., Thomas, N. J., Srinivasan, V., & , S. P. (2018). The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study. Critical care medicine, 46(11), e1029-e1039.
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  The impact of nutrition status on outcomes in pediatric severe sepsis is unclear. We studied the association of nutrition status (expressed as body mass index z score) with outcomes in pediatric severe sepsis.
• Doctor, A., Zimmerman, J., Agus, M., Rajasekaran, S., Bubeck Wardenburg, J., Fortenberry, J., Zajicek, A., Mairson, E., & Typpo, K. (2017). Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 18(3_suppl Suppl 1), S67-S82.
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  To describe the state of the science, identify knowledge gaps, and offer potential future research questions regarding promising therapies for children with multiple organ dysfunction syndrome presented during the Eunice Kennedy Shriver National Institute of Child Health and Human Development Workshop on Pediatric Multiple Organ Dysfunction Syndrome (March 26-27, 2015).
• Hartman, M. E., Saeed, M. J., Bennett, T., Typpo, K., Matos, R., & Olsen, M. A. (2017). Readmission and Late Mortality After Critical Illness in Childhood. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
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  Little is known about the ongoing mortality risk and healthcare utilization among U.S. children after discharge from a hospitalization involving ICU care. We sought to understand risks for hospital readmission and trends in mortality during the year following ICU discharge.
• Khemani, R. G., Ross, P. A., & Typpo, K. (2017). The authors reply. Critical care medicine, 45(12), e1304-e1305.
• Seckeler, M. D., Typpo, K., Deschenes, J., Higgins, R., Samson, R., & Lichtenthal, P. (2017). Inaccuracy of a continuous arterial pressure waveform monitor when used for congenital cardiac catheterization. Congenital heart disease, 12(6), 815-819.
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  To determine the accuracy of a continuous cardiac output monitor (FloTrac sensor) for measuring cardiac index in children with congenital heart disease undergoing cardiac catheterization. Cardiac index is a critical hemodynamic parameter measured during catheterizations in children with congenital heart disease. This has been challenging to measure accurately and many clinicians rely on predictive equations for calculating cardiac index.
• Typpo, K. V., & Lacroix, J. R. (2017). Monitoring Severity of Multiple Organ Dysfunction Syndrome: New and Progressive Multiple Organ Dysfunction Syndrome, Scoring Systems. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 18(3_suppl Suppl 1), S17-S23.
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  To describe the diagnostic criteria of new and progressive multiple organ dysfunction syndrome and scoring systems that might be used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children presented as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015).
• Typpo, K. V., Wong, H. R., Finley, S. D., Daniels, R. C., Seely, A. J., & Lacroix, J. (2017). Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 18(3_suppl Suppl 1), S24-S31.
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  To describe new technologies (biomarkers and tests) used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children as discussed as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015).
• Typpo, K., & Doctor, A. (2017). The authors reply. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 18(7), 731-732.
• Typpo, K. V., & Mendelson, J. S. (2016). After the Fairytale Ending: Functional Impairment After Pediatric Critical Illness. Pediatric Critical Care Medicine, 15(5), 473-4.
• Gaspers, M., Deschenes, J., & Typpo, K. (2015). 272: INCREASED FEEDING INTOLERANCE IN PICU PATIENTS IS SEEN WITH DELAYED INITIATION OF ENTERAL NUTRITION. Critical care medicine, 43(12 Suppl 1), 69-70.
• Typpo, K. V., Larmonier, C. B., Deschenes, J., Redford, D., Kiela, P. R., & Ghishan, F. K. (2015). Clinical characteristics associated with postoperative intestinal epithelial barrier dysfunction in children with congenital heart disease. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 16(1), 37-44.
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  Children with congenital heart disease have loss of intestinal epithelial barrier function, which increases their risk for postoperative sepsis and organ dysfunction. We do not understand how postoperative cardiopulmonary support or the inflammatory response to cardiopulmonary bypass might alter intestinal epithelial barrier function. We examined variation in a panel of plasma biomarkers to reflect intestinal epithelial barrier function (cellular and paracellular) after cardiopulmonary bypass and in response to routine ICU care.
• Typpo, K., Larmonier, C., Deschenes, J., Kiela, P., & Ghishan, F. (2015). 258: EARLY PARENTERAL NUTRITION IMPROVES INTESTINAL BARRIER FUNCTION: RESULTS FROM A PILOT RCT. Critical care medicine, 43(12 Suppl 1), 66.
• Bennett, T. D., Spaeder, M. C., Matos, R. I., Watson, R. S., Typpo, K. V., Khemani, R. G., Crow, S., Benneyworth, B. D., Thiagarajan, R. R., Dean, J. M., Markovitz, B. P., & , P. A. (2014). Existing data analysis in pediatric critical care research. Frontiers in pediatrics, 2, 79.
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  Our objectives were to review and categorize the existing data sources that are important to pediatric critical care medicine (PCCM) investigators and the types of questions that have been or could be studied with each data source. We conducted a narrative review of the medical literature, categorized the data sources available to PCCM investigators, and created an online data source registry. We found that many data sources are available for research in PCCM. To date, PCCM investigators have most often relied on pediatric critical care registries and treatment- or disease-specific registries. The available data sources vary widely in the level of clinical detail and the types of questions they can reliably answer. Linkage of data sources can expand the types of questions that a data source can be used to study. Careful matching of the scientific question to the best available data source or linked data sources is necessary. In addition, rigorous application of the best available analysis techniques and reporting consistent with observational research standards will maximize the quality of research using existing data in PCCM.
• Typpo, K. V., Tcharmtchi, M. H., Thomas, E. J., Kelly, P. A., Castillo, L. D., & Singh, H. (2012). Impact of resident duty hour limits on safety in the intensive care unit: a national survey of pediatric and neonatal intensivists. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 13(5), 578-82.
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  Resident duty-hour regulations potentially shift the workload from resident to attending physicians. We sought to understand how current or future regulatory changes might impact safety in academic pediatric and neonatal intensive care units.
• Profit, J., Typpo, K. V., Hysong, S. J., Woodard, L. D., Kallen, M. A., & Petersen, L. A. (2010). Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care. Implementation science : IS, 5, 13.
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  The measurement of healthcare provider performance is becoming more widespread. Physicians have been guarded about performance measurement, in part because the methodology for comparative measurement of care quality is underdeveloped. Comprehensive quality improvement will require comprehensive measurement, implying the aggregation of multiple quality metrics into composite indicators.
• Typpo, K. V., Petersen, N. J., Petersen, L. A., & Mariscalco, M. M. (2010). Children with chronic illness return to their baseline functional status after organ dysfunction on the first day of admission in the pediatric intensive care unit. The Journal of pediatrics, 157(1), 108-113.e1.
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  To determine chronic illness outcomes after admission with multiple organ dysfunction syndrome (MODS) for patients in the pediatric intensive care unit (PICU).
• Typpo, K. V., Petersen, N. J., Hallman, D. M., Markovitz, B. P., & Mariscalco, M. M. (2009). Day 1 multiple organ dysfunction syndrome is associated with poor functional outcome and mortality in the pediatric intensive care unit. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 10(5), 562-70.
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  The epidemiology and outcomes of multiple organ dysfunction syndrome (MODS) are incompletely characterized in the pediatric population due to small sample size and conflicting diagnoses of organ failure. We sought to describe the epidemiology and outcomes of early MODS in a large clinical database of pediatric intensive care unit (PICU) patients based on consensus definitions of organ failure.
• Simmons, D. D., Bertolotto, C., Typpo, K., Clay, A., & Wu, M. (1999). Differential development of cholinergic-like neurons in the superior olive: a light microscopic study. Anatomy and embryology, 200(6), 585-95.
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  To better understand the development of cholinergic-like neurons within the superior olivary complex, we investigated the onset and distribution of two well-known markers of cholinergic-like neurons in hamsters: choline acetyltransferase (ChAT) and acetylcholinesterase (AChE). From embryonic day (E) 14 through postnatal day (P) 0, olivary cells immunopositive for ChAT were restricted to the rostral periolivary (RPO) area. Between P0 and P3, ChAT-positive cells are found in progressively more caudal and ventral periolivary locations. Although rostral and ventral periolivary cells exhibited an early onset of ChAT expression, stable numbers were not reached until P4. In contrast, ChAT expression within the lateral superior olive (LSO) is not visible until after P0 and higher numbers of ChAT-positive cells are obtained by P5. The AChE expression lags several days but follows roughly the same pattern of onset as for ChAT. Additionally in rostral and ventral periolivary regions as well as in the LSO, there were fewer AChE-labeled cells than ChAT-labeled cells. The observed temporal relationships in cholinergic-like expression within olivary cells suggest that different cholinergic-like populations may be defined on the basis of the onset of neurotransmitter-related enzymes: RPO cells are first, cells in ventral periolivary regions are second, and cells associated with the LSO are last. The differences observed in the onset of ChAT and AChE expression may reflect differences in the timing of target innervation as well as differences in synaptogenesis.

Presentations

• Typpo, K. V. (2016, Winter 2016). Early Parenteral Nutrition Does Not Worsen Intestinal Barrier Dysfunction. American Society for Parenteral and Enteral Nutrition Clinical Nutrition Week. Austin, TX: ASPEN.

Poster Presentations

• Typpo, K. V., Berg, M., Patel, P., Stout, J., Wheeler, M. D., & Chin, C. (2018, May). Updated DKA Guideline Shortens Duration of Insulin Infusion and Hospital Length of Stay for Patients with Severe DKA. Pediatric Academic Societies Meeting. Toronto: Pediatric Academic Societies.
• Typpo, K. V., Laubitz, D., Kiela, P., Loftis, L., & Ghishan, F. K. (2018, Spring). Post-Operative Organ Dysfunction in Children with CHD is Associated with Dramatic Changes in Fecal Microbial Community Structure and Function. Pediatric Academic Society Annual Congress. Toronto, CA: Pediatric Academic Society.
• Gaspers, M., Meyer, R., Typpo, K. V., King, C., & Berg, M. D. (2016, October). EN Guidelines Reduce PN Utilization. SCCM Annual Conference.

Reviews

• Wilson, B., & Typpo, K. (2016. Nutrition: A Primary Therapy in Pediatric Acute Respiratory Distress Syndrome(p. 108).
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  Appropriate nutrition is an essential component of intensive care management of children with acute respiratory distress syndrome (ARDS) and is linked to patient outcomes. One out of every two children in the pediatric intensive care unit (PICU) will develop malnutrition or have worsening of baseline malnutrition and present with specific micronutrient deficiencies. Early and adequate enteral nutrition (EN) is associated with improved 60-day survival after pediatric critical illness, and, yet, despite early EN guidelines, critically ill children receive on average only 55% of goal calories by PICU day 10. Inadequate delivery of EN is due to perceived feeding intolerance, reluctance to enterally feed children with hemodynamic instability, and fluid restriction. Underlying each of these factors is large practice variation between providers and across institutions for initiation, advancement, and maintenance of EN. Strategies to improve early initiation and advancement and to maintain delivery of EN are needed to improve morbidity and mortality from pediatric ARDS. Both, over and underfeeding, prolong duration of mechanical ventilation in children and worsen other organ function such that precise calorie goals are needed. The gut is thought to act as a "motor" of organ dysfunction, and emerging data regarding the role of intestinal barrier functions and the intestinal microbiome on organ dysfunction and outcomes of critical illness present exciting opportunities to improve patient outcomes. Nutrition should be considered a primary rather than supportive therapy for pediatric ARDS. Precise nutritional therapies, which are titrated and targeted to preservation of intestinal barrier function, prevention of intestinal dysbiosis, preservation of lean body mass, and blunting of the systemic inflammatory response, offer great potential for improving outcomes of pediatric ARDS. In this review, we examine the current evidence regarding dose, route, and timing of nutrition, current recommendations for provision of nutrition to children with ARDS, and the current literature for immune-modulating diets for pediatric ARDS. We will examine emerging data regarding the role of the intestinal microbiome in modulating the response to critical illness.