Le Yu

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Courses

Scholarly Contributions

Books

• Yu, L. (2015). Eye Diseases Associated with Sleep Disorders. New York: Nova Science Publishers.

Journals/Publications

• Hsiao, J. L., Shi, V. Y., Thompson, A. M., & Yu, L. (2021).

  Dermatology-ophthalmology collaborations are needed in dupilumab-associated ocular events.

  . Journal of the American Academy of Dermatology, 84(6), e279-e280. doi:10.1016/j.jaad.2021.01.043
• Thompson, A. M., Yu, L., Hsiao, J. L., & Shi, V. Y. (2021). Dermatology-ophthalmology collaborations are needed in dupilumab-associated ocular events. Journal of the American Academy of Dermatology, 84(6), e279-e280.
• Yu, L. (2015). Large Dehisced Senile Calcific Plaque Associated with Necrotizing Scleritis and Perforation. Herald Scholarly Open Access Journal of Ophthalmology and Clinical Research, 2(2), 1-3.
• Yu, L., Tsui, I., & Hubschman, J. (2012). Macular hole associated with sarcoidosis. Retinal cases & brief reports, 6(4), 412-4.
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  To describe an interventional case report of macular hole associated with sarcoidosis.
• Yu, L., Aldave, A. J., & Glasgow, B. J. (2009). Epstein-Barr virus-associated smooth muscle tumor of the iris in a patient with transplant: a case report and review of the literature. Archives of pathology & laboratory medicine, 133(8), 1238-41.
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  Epstein-Barr virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr virus infection was confirmed by in situ hybridization for Epstein-Barr virus-encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr virus-associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.
• Leveque, T. K., Yu, L., Musch, D. C., Chervin, R. D., & Zacks, D. N. (2007). Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep & breathing = Schlaf & Atmung, 11(4), 253-7.
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  Patients with obstructive sleep apnea (OSA), in comparison to controls, have increased levels of circulating epinephrine and norepinephrine, both of which are risk factors for the development of central serous chorioretinopathy (CSCR). The aim of this pilot study was to investigate the frequency of symptoms that suggest OSA in CSCR patients and normal controls. The Berlin Questionnaire, a validated research tool to assess risk for OSA, was administered to 29 patients who met the criteria for active, acute, non-steroid-induced CSCR and 29 controls matched for age and sex. In this retrospective case-controlled study, the main outcome measure was increased risk for OSA. The mean age of the patients was 47.8 years (range 29-72) and the mean age of controls was 47.3 years (range 25-70). Seventy-six percent (22) of both groups were men. Survey scores showed 58.6% (17) of patients with CSCR to be at an increased risk for OSA compared to 31.0% (nine) of controls. A conditional logistic regression analysis showed that the CSCR group had a higher proportion with an increased risk for OSA compared to the control group (odds ratio=3.67; 95% CI: 1.02, 13.14; P = 0.046). Patients with CSCR may be more likely than other adults to have OSA, and screening for this sleep disorder should be considered in this population. Further research is warranted to determine whether sleep apnea may contribute to the development of CSCR, and to assess whether treatment of sleep apnea might offer a new therapeutic option for some patients with CSCR.