Mohammad Khreiss

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Scholarly Contributions

Chapters

• Khreiss, M., & Hoballah, J. J. (2014). Illustrated Glossary of Surgical Instruments. In Illustrated Glossary of Surgical Instruments. Springer, New York, NY. doi:10.1007/978-1-4614-1393-6_11
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  This chapter shows both open and laparoscopic instruments and the common names which they are given. It is provided as a guide to new surgeons.
• Khreiss, M., & Tsikitis, V. L. (2012). Laparoscopic Abdominoperineal Resection. In Laparoscopic Abdominoperineal Resection. Springer, New York, NY. doi:10.1007/978-1-4614-0451-4_47
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  Low rectal adenocarcinoma; location precludes adequate 1 cm distal margin for a sphincter preserving procedure. Melanoma of the anorectum involving the sphincters. Anal carcinoma recurrence after Nigro protocol.
• Khreiss, M., & Tsikitis, V. L. (2012). Laparoscopic Low Anterior Resection. In Laparoscopic Low Anterior Resection. Springer, New York, NY. doi:10.1007/978-1-4614-0451-4_45
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  ESSENTIAL STEPS 1. Place the patient in the lithotomy position, with both arms tucked and well padded. Secure the patient carefully to the table to avoid movement when the table is tilter. Place a Foley catheter and an orogastric tube. 2. Perform rigid proctosigmoidoscopy to identify and mark the distal margin from the anal verge. 3. We perform a diverting loop ileostomy for all anastomosis less than 5 cm from the anal verge. 4. Placement of four trocars: Three 5-mm trocars in the supraumbilical, left lower abdomen and one suprapubic, one 12-mm trocar in the right lower abdomen (use the site that was marked by the enterostomy nurse for this trocar; this will be the site of the future diverting ileostomy if needed). 5. Explore the abdomen for the evidence of metastatic disease. 6. Place the patient in steep Trendelenburg position. 7. Mobilize the left colon from medial to lateral and identify the vascular pedicle. Have the assistant elevate this pedicle at the level of the sacral promontory. 8. Create and enlarge an opening in the peritoneum. Sweep the retroperitoneum downwards while the mesentery
• Khreiss, M., Khreiss, M., & Joseph, B. A. (2012). Packing of Liver Injury with Damage Control Laparotomy. In Packing of Liver Injury with Damage Control Laparotomy. Springer, New York, NY. doi:10.1007/978-1-4614-0451-4_83
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  Packing of liver injury is performed during damage control laparotomy for major trauma. This chapter lists the indications, essential steps, common technical variations, and complications of the procedure. A detailed operative note dictation template is included.

Journals/Publications

• Galouzis, N., Khawam, M., Alexander, E. V., Khreiss, M. R., Luu, C., Mesropyan, L., Riall, T. S., Kwass, W. K., & Dull, R. O. (2024). Pilot Study to Optimize Goal-directed Hemodynamic Management During Pancreatectomy. The Journal of surgical research, 300, 173-182.
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  Intraoperative goal-directed hemodynamic therapy (GDHT) is a cornerstone of enhanced recovery protocols. We hypothesized that use of an advanced noninvasive intraoperative hemodynamic monitoring system to guide GDHT may decrease intraoperative hypotension (IOH) and improve perfusion during pancreatic resection.
• Galouzis, N., Khawam, M., Alexander, E. V., Yallourakis, M. D., Mesropyan, L., Luu, C., Khreiss, M. R., & Riall, T. S. (2024). Decision regret and satisfaction with shared decision-making in pancreatic surgery. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 101870.
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  Pancreatic surgery often does not provide long-term survival in patients with cancer or consistently improve symptoms in benign disease. This study aimed to assess decision regret and satisfaction with the decision-making process among patients who underwent pancreatectomy.
• Jehan, F. S., Alizai, Q., Powers, M. T., Khreiss, M., Joseph, B., & Aziz, H. (2024). Feeble, fallen, and forgetting: association of cognitive impairment and falls on outcomes of major intra-abdominal surgeries in older adults. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 28(9), 1505-1511.
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  Both cognitive impairment/dementia (CID) and falls occur more commonly in older adults than in younger patients. This study aimed to analyze the association of a history of CID or falls with the postoperative outcomes of older adults undergoing major intra-abdominal surgeries on a national level.
• Jehan, F. S., Khreiss, M., Seth, A., & Aziz, H. (2024). Trends and disparities in access to minimally invasive distal pancreatectomy (midp): an eight-year analysis from the national cancer database. Journal of robotic surgery, 18(1), 52.
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  Laparoscopic and robotic approaches to distal pancreatectomy are becoming the standard of care. The aim of our study was to evaluate the trends of utilization and disparities in access to minimally invasive approaches in distal pancreatectomy. We queried the National Cancer Database (NCDB) and analyzed all the patients who underwent distal pancreatectomy from 2010 to 2017. Patients were divided into groups of those with open distal pancreatectomy (ODP) and those with laparoscopic or robotic distal pancreatectomy (MIDP = minimally invasive distal pancreatectomy). Our outcome measures were trends of MIDP and disparities in access to MIDP. Cochran Armitage trend analysis and multivariate regression analysis were used to evaluate outcomes. A total of 13,537 patients with distal pancreatectomy were identified in the NCDB from 2010 to 2017. 7548 (55.8%) underwent ODP, while 5989 (44.2%) underwent MIDP. The MIDP rates increased from 25% in 2010 to 52% in 2017 (p 
• Rao, A., Rao, R., Taylor, M. K., Khreiss, M., & Arshad, J. (2024). Concurrent Stage III Unresectable Duodenal Adenocarcinoma and Metastatic Gastrointestinal Stromal Tumor Treated With Combination of Imatinib and mFOLFIRI. Cureus, 16(4), e58248.
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  Cases of concurrent duodenal adenocarcinoma and gastrointestinal stromal tumors (GISTs) are rare, and only a few have been reported. While some cases of other synchronous primary tumors with GIST have been reported, no shared mutations have been consistently found, creating challenges in selecting chemotherapy in cases of inoperable tumors. Here, we presented a case of a stage IIIA locally advanced/unresectable duodenal adenocarcinoma with concurrent metastatic small bowel GIST successfully being treated with combined imatinib and modified folinic acid, 5-fluorouracil, and irinotecan (mFOLFIRI) regimen.
• Aziz, H., Nordan, T., Feng, L. R., Kwon, Y. K., Khreiss, M., Karagozian, R., & Schnelldorfer, T. (2023). Association Between Preoperative Angioembolization and Bleeding Complications in Patients With Benign Liver Tumors: Analysis of a National Database. The Journal of surgical research, 291, 536-545.
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  The role of angioembolization (AE) in patients with benign liver diseases is an area of active research. This study aims to assess any difference in liver resection outcomes in patients with benign tumors dependent on utilization of preoperative AE.
• Young, S., Hannallah, J., Goldberg, D., Khreiss, M., Shroff, R., Arshad, J., Scott, A., & Woodhead, G. (2023). Liver-Directed Therapy Combined with Systemic Therapy: Current Status and Future Directions. Seminars in interventional radiology, 40(6), 515-523.
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  In the past several decades, major advances in both systemic and locoregional therapies have been made for many cancer patients. This has led to modern cancer treatment algorithms frequently calling for active interventions by multiple subspecialists at the same time. One of the areas where this can be clearly seen is the concomitant use of locoregional and systemic therapies in patients with primary or secondary cancers of the liver. These combined algorithms have gained favor over the last decade and are largely focused on the allure of the combined ability to control systemic disease while at the same time addressing refractory/resistant clonal populations. While the general concept has gained favor and is likely to only increase in popularity with the continued establishment of viable immunotherapy treatments, for many patients questions remain. Lingering concerns over the increase in toxicity when combining treatment methods, patient selection, and sequencing remain for multiple cancer patient populations. While further work remains, some of these questions have been addressed in the literature. This article reviews the available data on three commonly treated primary and secondary cancers of the liver, namely, hepatocellular carcinoma, cholangiocarcinoma, and metastatic colorectal cancer. Furthermore, strengths and weaknesses are reviewed and future directions are discussed.
• AlMasri, S., Hammad, A. Y., & Zureikat, A. H. (2022). Robotic Cyst Gastrostomy and Roux-en-Y Cyst Jejunostomy for a Bilobed Walled-Off Pancreatic Necroma. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(4), 989-990.
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  Walled-off pancreatic necrosis (WON) represents delayed sequelae of necrotizing pancreatitis, generally developing in 5-15% of cases 4 weeks after the initial attack (Boškoski and Costamagna Ann Gastroenterol 27(2):93-94, 2014). They are characterized by a well-circumscribed, encapsulated collection of necrotic parenchyma with variable degree of gland liquefaction (Boškoski and Costamagna Ann Gastroenterol 27(2):93-94, 2014, Khreiss et al. J Gastrointest Surg 19(8):1441-1448, 2015). Although a significant number of WONs are asymptomatic and resolve spontaneously, some will ultimately require endoscopic or surgical intervention (Costa et al. Br J Surg 101(1):e65-e79, 2014). In this video, we demonstrate a robotic cyst gastrostomy and Roux-en-Y cyst jejunostomy performed for two simultaneous and complex WONs.
• Jehan, F. S., Pandit, V., Khreiss, M., Joseph, B., & Aziz, H. (2022). Frailty Predicts Loss of Independence After Liver Surgery. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(12), 2496-2502.
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  Loss of independence (LOI) is a significant concern in patients undergoing liver surgery. Although the risks of morbidity and mortality have been well studied, there is a dearth of data regarding the risk of LOI. Therefore, this study aimed to assess predictors of LOI after liver surgery.
• Ollerton, M. T., Folkvord, J. M., Peachman, K. K., Shashikumar, S., Morrison, E. B., Jagodzinski, L. L., Peel, S. A., Khreiss, M., D'Aquila, R. T., Casares, S., Rao, M., & Connick, E. (2022). HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues. Frontiers in immunology, 13, 1047277.
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  A major barrier in the use of humanized mice as models of HIV-1 (HIV) infection is the inadequate generation of virus-specific antibody responses. Humanized DRAGA (hDRAGA) mice generate antigen-specific class switched antibodies to several pathogens, but whether they do so in HIV infection and the extent to which their secondary lymphoid tissues (sLT) support germinal center responses is unknown. hDRAGA mice were evaluated for their ability to support HIV replication, generate virus-specific antibody responses, develop splenocyte subsets, and organize sLT architecture. hDRAGA mice supported persistent HIV replication and developed modest levels of gp41-specific human IgM and IgG. Spleens from uninfected and HIV infected hDRAGA mice contained differentiated B and CD4 T cell subsets including germinal center (GC) B cells and T follicular helper cells (TFH); relative expansions of TFH and CD8 T cells, but not GC B cells, occurred in HIV-infected hDRAGA mice compared to uninfected animals. Immunofluorescent staining of spleen and mesenteric lymph node sections demonstrated atypical morphology. Most CD4 and CD8 T cells resided within CD20 areas. CD20 areas lacked canonical germinal centers, as defined by staining for IgDKi67cells. No human follicular dendritic cells (FDC) were detected. Mouse FDC were distributed broadly throughout both CD20 and CD20 regions of sLT. HIV RNA particles were detected by hybridization within CD20 areas and some co-localized with mouse FDC. Viral RNA cells were more concentrated within CD20 compared to CD20 areas of sLT, but differences were diminished in spleen and eliminated in mesenteric lymph nodes when adjusted for CD4 cell frequency. Thus, hDRAGA mice recapitulated multiple aspects of HIV pathogenesis including HIV replication, relative expansions in TFH and CD8 T cells, and modest HIV-specific antibody production. Nevertheless, classical germinal center morphology in sLT was not observed, which may account for the inefficient expansion of GC B cells and generation of low titer human antibody responses to HIV-1 in this model.
• Succar, B., Abuhakmeh, Y., Khreiss, M., & Zhou, W. (2022). Mobile primary renal vein lipoma with an accelerated growth pattern. Journal of vascular surgery cases and innovative techniques, 8(4), 670-673.
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  Primary intravascular lipoma is a rare proliferation of adipose tissue originating from the wall of blood vessels. We have described an unusual case of a benign, but fast-growing, primary intravascular lipoma of the left renal vein with the mobile edge extending to the cavoatrial junction within just a few months. We have discussed the surgical indications, management, and technical considerations and highlighted the importance of surgical planning for similar cases.
• Arrington, A. K., Hsu, C. H., Schaefer, K. L., O'Grady, C. L., Khreiss, M., & Riall, T. S. (2021). Survival after Margin-Positive Resection in the Era of Modern Chemotherapy for Pancreatic Cancer: Do Patients Still Benefit?. Journal of the American College of Surgeons, 233(1), 100-109.
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  R0 resection for pancreatic cancer is considered standard of care, but is not always achieved. This study looks at R1/R2 resection outcomes compared with chemotherapy alone. Our hypothesis is that patients with margin-positive disease have better outcomes than those receiving chemotherapy alone.
• Dauch, J., Hamidi, M., Arrington, A. K., O'Grady, C. L., Hsu, C. H., Joseph, B., Riall, T. S., & Khreiss, M. (2021). The Impact of Frailty on Patients Undergoing Liver Resection for Colorectal Liver Metastasis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
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  The aim of this study is to assess the impact of frailty on short-term outcomes after hepatectomy for colorectal liver metastasis (CRLM).
• Hamidi, M., O'Grady, C. L., Brown, S. D., Arrington, A. K., Morris-Wiseman, L., Riall, T. S., & Khreiss, M. (2021). Does Preoperative Estimated Glomerular Filtration Rate (eGFR) Predict Short-Term Surgical Outcomes in Patients Undergoing Pancreatic Resections?. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
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  Preoperative eGFR has been found to be a reliable predictor of post-operative outcomes in patients with normal creatinine levels who undergo surgery. The aim of our study was to evaluate the impact of preoperative eGFR levels on short-term post-operative outcomes in patients undergoing pancreatectomy.
• Sadovnikov, I., Anthony, M., Mushtaq, R., Khreiss, M., Gavini, H., & Arif-Tiwari, H. (2021). Role of magnetic resonance imaging in Bouveret's syndrome: A case report with review of the literature. Clinical imaging, 77, 43-47.
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  Bouveret's syndrome is a rare form of gallstone ileus occurring due to obstructing gallstone into the proximal duodenum through a cholecystoduodenal fistula. We report the case of a 72-year-old female presenting with abdominal pain secondary to a large gallstone in the region of the duodenal bulb, causing the upstream gastric obstruction. Here we discuss the clinical features, imaging technologies, and surgical management of Bouveret's syndrome.
• Arrington, A. K., O'Grady, C., Schaefer, K., Khreiss, M., & Riall, T. S. (2020). Significance of Lymph Node Resection After Neoadjuvant Therapy in Pancreatic, Gastric, and Rectal Cancers. Annals of surgery.
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  Gastrointestinal cancers are increasingly being treated with NAT before surgical resection. Currently, quality metrics are linked to the number of LNs resected to determine subsequent treatment and prognosis. We hypothesize that NAT decreases LN metastasis, downstages patients, and decreases overall lymph node yields (LNY) compared to initial surgical resection. With increasing use of NAT, this brings into question the validity of quality metrics.
• Hamidi, M., Dauch, J., Watson, R., O'Grady, C., Hsu, P., Arrington, A., Riall, T. S., & Khreiss, M. (2020). Outcomes with Preoperative Biliary Stenting After Pancreaticoduodenectomy In the Modern Era. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
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  Previous studies have documented increased complications following pancreaticoduodenectomy in patients who undergo preoperative biliary stenting (PBS). However, in the modern era, the vast majority of patients with jaundice are stented. We hypothesized that there is no difference in short-term postoperative outcomes between PBS and no PBS in patient with obstructive jaundice undergoing pancreaticoduodenectomy.
• Holokai, L., Chakrabarti, J., Lundy, J., Croagh, D., Adhikary, P., Richards, S. S., Woodson, C., Steele, N., Kuester, R., Scott, A., Khreiss, M., Frankel, T., Merchant, J., Jenkins, B. J., Wang, J., Shroff, R. T., Ahmad, S. A., & Zavros, Y. (2020). Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma. Cancers, 12(12).
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  : Pancreatic ductal adenocarcinoma (PDAC) has the lowest five-year survival rate of all cancers in the United States. Programmed death 1 receptor (PD-1)-programmed death ligand 1 (PD-L1) immune checkpoint inhibition has been unsuccessful in clinical trials. Myeloid-derived suppressor cells (MDSCs) are known to block anti-tumor CD8+ T cell immune responses in various cancers including pancreas. This has led us to our objective that was to develop a clinically relevant in vitro organoid model to specifically target mechanisms that deplete MDSCs as a therapeutic strategy for PDAC. : Murine and human pancreatic ductal adenocarcinoma (PDAC) autologous organoid/immune cell co-cultures were used to test whether PDAC can be effectively treated with combinatorial therapy involving PD-1 inhibition and MDSC depletion. : Murine in vivo orthotopic and in vitro organoid/immune cell co-culture models demonstrated that polymorphonuclear (PMN)-MDSCs promoted tumor growth and suppressed cytotoxic T lymphocyte (CTL) proliferation, leading to diminished efficacy of checkpoint inhibition. Mouse- and human-derived organoid/immune cell co-cultures revealed that PD-L1-expressing organoids were unresponsive to nivolumab in vitro in the presence of PMN-MDSCs. Depletion of arginase 1-expressing PMN-MDSCs within these co-cultures rendered the organoids susceptible to anti-PD-1/PD-L1-induced cancer cell death. : Here we use mouse- and human-derived autologous pancreatic cancer organoid/immune cell co-cultures to demonstrate that elevated infiltration of polymorphonuclear (PMN)-MDSCs within the PDAC tumor microenvironment inhibit T cell effector function, regardless of PD-1/PD-L1 inhibition. We present a pre-clinical model that may predict the efficacy of targeted therapies to improve the outcome of patients with this aggressive and otherwise unpredictable malignancy.
• Khreiss, M. (2020). A Tale of Two Cancers: Do Lymph Node Resections Truly Mean the Same in Colon and Rectal Cancers? Gastroenterology; Volume 158, Issue 6, Supplement 1: S-1539-S-1540. [Presented at 61st Annual Meeting, Society for Surgery of the Alimentary Tract (SSAT); May 2-5, 2020; Chicago, IL]. Gastroenterology, Volume 158, Volume 158, Issue 6, Supplement 1: S-1539-S-1540.
• Jehan, F., Khan, M., Sakran, J. V., Khreiss, M., O'Keeffe, T., Chi, A., Kulvatunyou, N., Jain, A., Zakaria, E. R., & Joseph, B. (2018). Perioperative glycemic control and postoperative complications in patients undergoing emergency general surgery: What is the role of Plasma Hemoglobin A1c?. The journal of trauma and acute care surgery, 84(1), 112-117.
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  Plasma hemoglobin A1c (HbA1c) reflects quality of glucose control in diabetic patients. Literature reports that patients undergoing surgery with an elevated HbA1c level are associated with increased postoperative morbidity and mortality. The aim of our study was to evaluate the impact of HbA1c level on outcomes after emergency general surgery (EGS).
• Geller, D. A., & Khreiss, M. (2015). Laparoscopic liver resection. Clinical liver disease, 5(1), 1-4.
• Joseph, B., Haider, A. A., Pandit, V., Kulvatunyou, N., Orouji, T., Khreiss, M., Tang, A., O'Keeffe, T., Friese, R., & Rhee, P. (2015). Impact of Hemorrhagic Shock on Pituitary Function. Journal of the American College of Surgeons, 221(2), 502-8.
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  Hypopituitarism after hypovolemic shock is well established in certain patient cohorts. However; the effects of hemorrhagic shock on pituitary function in trauma patients remains unknown. The aim of this study was to assess pituitary hormone variations in trauma patients with hemorrhagic shock.
• Khreiss, M., & Geller, D. A. (2015). Reply to Letter: "Laparoscopic Retroperitoneal Hepatectomy: What Are the Indications?". Annals of surgery, 262(2), e78.
• Khreiss, M., Zenati, M., Clifford, A., Lee, K. K., Hogg, M. E., Slivka, A., Chennat, J., Gelrud, A., Zeh, H. J., Papachristou, G. I., & Zureikat, A. H. (2015). Cyst Gastrostomy and Necrosectomy for the Management of Sterile Walled-Off Pancreatic Necrosis: a Comparison of Minimally Invasive Surgical and Endoscopic Outcomes at a High-Volume Pancreatic Center. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 19(8), 1441-8.
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  Walled-off pancreatic necrosis (WON) is a sequela of acute necrotizing pancreatitis in 15-40% of cases. We sought to compare the outcomes of minimally invasive surgical and endoscopic cyst gastrostomy (CG) and necrosectomy for the management for sterile WON at a tertiary care high-volume pancreas center.
• Khreiss, M., Daouadi, M., Hogg, M. E., Slivka, A., Chennat, J., Gelrud, A., Zureikat, A. H., Zenati, M. S., Zeh, H. J., Papachristou, G. I., & Lee, K. K. (2014). Tu1626 Minimally Invasive Surgical Cystgastrostomy and Necrosectomy for the Management of Walled Off Pancreatic Necrosis; Comparison With Endoscopic Approach At a High Volume Pancreatic Center. Gastroenterology, 146(5), S-1091. doi:10.1016/s0016-5085(14)63980-9
• Joseph, B., Pandit, V., Khreiss, M., Aziz, H., Kulvatunyou, N., Tang, A., Wynne, J., O'Keeffe, T., Friese, R. S., Weinstein, R. S., & Rhee, P. (2013). Improving communication in level 1 trauma centers: replacing pagers with smartphones. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 19(3), 150-4.
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  Communication among healthcare providers continues to change, and 90% of healthcare providers are now carrying cellular phones. Compared with pagers, the rate and amount of information immediately available via cellular phones are far superior. Wireless devices such as smartphones are ideal in acute trauma settings as they can transfer patient information quickly in a coordinate manner to all the team members responsible for patient care.
• Khreiss, M., Zeh, H. J., Boone, B. A., & Zureikat, A. H. (2013). Robotic-Assisted Pancreatoduodenectomy. Current Surgery Reports, 1(2), 98-105. doi:10.1007/s40137-013-0017-y
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  Pancreatoduodenectomy remains one of the most complex and technically challenging procedures of the upper gastrointestinal tract with a mortality rate of 5 % and morbidity of 40 %. In an attempt to refine the Whipple procedure and taking into consideration the success of minimally invasive surgery in other organ systems, some have popularized the laparoscopic pancreatoduodenectomy (LPD). However, laparoscopic surgery carries several limitations that can make the LPD difficult to implement. Use of the robotic platform offers multiple advantages that may allow robotic assisted pancreatoduodenctomy to be readily adopted. As the robotic platform becomes increasingly popular, this report will provide an up to date review on the robotic pancreatoduodenectomy.
• Hussein, M., Khreiss, M., Al-Helou, G., Alaeddine, M., Elias, E., & Abi Saad, G. S. (2012). Laparoscopic repair of a left paraduodenal hernia presenting with acute bowel obstruction: report of a case. Surgical laparoscopy, endoscopy & percutaneous techniques, 22(1), e28-30.
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  An internal hernia is any protrusion of a solid organ or a hollow viscus through a defect within the abdominal cavity. Paraduodenal hernias (PDHs) are rare; however, they are the most common form of internal hernias. We present a case of a left PDH in a 59-year-old healthy woman who presented with acute bowel obstruction. The PDH was diagnosed preoperatively using computed tomography scan. Laparoscopic exploration of the abdomen was then performed for reduction of the hernia. Using this approach, we managed to close the defect with intracorporeal continuous suturing with the aim of avoiding future incarceration. The patient was discharged 60 hours postoperation in a good condition, compared with 3 to 28 days postoperation reported in most of the literature. Our search of the english language literature revealed only 16 reported cases of laparoscopic repair of PDH. We believe that laparoscopic treatment of PDH in experienced hands is recommended in selected cases as it decreases the morbidity and significantly shortens the hospital stay.
• Soweid, A., Yaghi, S., Kobeissy, A., El Majzoub, N., Khreiss, M., Alaeddine, M., Ayoub, C., Seoud, M., Matar, G., & Jamali, F. (2012). Natural orifice transluminal endoscopic surgery (NOTES): assessment of peritoneal bacterial load after intraperitoneal antimicrobial wash and evaluation of hemodynamic changes in a porcine model. Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy, 21(4), 265-70.
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  Natural orifice transluminal endoscopic surgery (NOTES) is a promising newly developed procedure; however, it is associated with many complications. The main aim of our study is to assess whether peritoneal wash with antibiotics decreases the bacterial load contamination related to the transgastric approach.
• Musallam, K. M., Tamim, H. M., Richards, T., Spahn, D. R., Rosendaal, F. R., Habbal, A., Khreiss, M., Dahdaleh, F. S., Khavandi, K., Sfeir, P. M., Soweid, A., Hoballah, J. J., Taher, A. T., & Jamali, F. R. (2011). Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet (London, England), 378(9800), 1396-407.
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  Preoperative anaemia is associated with adverse outcomes after cardiac surgery but outcomes after non-cardiac surgery are not well established. We aimed to assess the effect of preoperative anaemia on 30-day postoperative morbidity and mortality in patients undergoing major non-cardiac surgery.
• Karam, J., Khreiss, M., Musallam, K. M., Alaeddine, M. H., Al-Kutoubi, A., & Abi Saad, G. S. (2009). Small bowel intussusception following blunt abdominal trauma in an adult patient. Emergency medicine journal : EMJ, 26(10), 752-3.
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  Blunt abdominal trauma is a rare cause of small bowel intussusception in adults. A patient is described who presented with signs and symptoms of intestinal obstruction following a fall from a ladder. A CT scan revealed evidence of ileo-ileal intussusception. Exploratory laparotomy and resection of a necrotic bowel segment were performed. Rare occurrences like intussusception should be kept in mind in similar presentations with careful examination of the pathognomonic CT findings, as early detection and surgical intervention with manual reduction could preclude the need for small bowel resection and its untoward possible complications.
• Khreiss, M., Haddad, F. F., Musallam, K. M., Medawar, W., Daouk, M., & Khalil, I. (2009). High-output cardiac failure secondary to a large arteriovenous fistula: a persistent threat to the dialysis and kidney transplant patient. NDT plus, 2(2), 147-8.
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  High-output cardiac failure secondary to a surgically constructed arteriovenous fistula (AVF) is a rare entity that is usually under-diagnosed in the dialysis population. We herein present a case of a 35-year-old female who was diagnosed with high-output cardiac failure secondary to an AVF and later managed with surgical division of the fistula. Risk factors associated with this entity are discussed, and preventive screening strategies are recommended.
• Khreiss, M., Karam, J., Musallam, K. M., Al Harakeh, A. B., Nasr, V. G., & Abi Saad, G. S. (2009). Distinctive presentation of a diaphragmatic hernia 15 years after a traumatic insult. The Annals of thoracic surgery, 88(2), 651-3.
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  Diaphragmatic hernias are well-known sequelae of abdominal and chest wall trauma. However, they may go undiagnosed in the acute setting but present later due to gastrointestinal or respiratory complications. A distinctive presentation of a diaphragmatic hernia 15 years after a traumatic insult is herein described. Management strategies are also discussed.
• Khreiss, M., Musallam, K. M., Soweid, A., Zaatari, G., Yakan, A. S., & Jamali, F. R. (2009). Epigastric pain and elevated pancreatic enzymes. Heterotopic pancreas. Gut, 58(9), 1176, 1199.

Presentations

• Khreiss, M. (2020, May). Disparities in Receipt of Neoadjuvant Therapy for Gastric and Pancreatic Cancers: The Selection Bias is Real. 61st Annual Meeting, Society for Surgery of the Alimentary Tract (SSAT).
• Khreiss, M. (2020, May). Outcomes with Preoperative Biliary Stenting After Pancreaticoduodenectomy in the Modern Era. 61st Annual Meeting, Society for Surgery of the Alimentary Tract (SSAT.

Others

• Khreiss, M. (2023, July). "Early Cancer Detection is the Key to Saving Lives.". The Buckmaster Show KVOI AM 1030.
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  Associate Professor of Surgery Mohammad Khreiss, MD, FACS, FSSO, was featured in the July 26, 2023 talk, "Early Cancer Detection is the Key to Saving Lives."