Murali Kodali

Interests

Teaching

Hematology,Stem cell transplantation,Immune Biology

Research

Malignant Hematology,Engineered cell therapies,Stem cell transplantation

Courses

No activities entered.

Scholarly Contributions

Journals/Publications

• Raza, S., Shortridge, J. R., Kodali, M. K., Nistala, P., Kale, G., & Doll, D. C. (2014). Severe haemolytic anaemia with erythrophagocytosis following the bite of a brown recluse spider. British journal of haematology, 167(1), 1.
• Tello-Montoliu, A., Ferreiro, J. L., Kodali, M. K., Ueno, M., Tomasello, S. D., Rollini, F., Capodanno, D., Darlington, A., Patel, R., Desai, B., Guzman, L. A., Bass, T. A., & Angiolillo, D. J. (2013). Impact of renal function on clopidogrel-induced antiplatelet effects in coronary artery disease patients without diabetes mellitus. Journal of thrombosis and thrombolysis, 36(1), 14-7.
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  Diabetes mellitus (DM) is the most important predictor of chronic kidney disease (CKD), and pharmacodynamic (PD) studies have shown that DM patients with impaired renal function are characterized by reduced clopidogrel response. However, post-hoc PD studies conducted in unselected cohorts, composed of both DM and non-DM patients, have reached controversial findings on the effects of CKD on clopidogrel response, likely attributed to patient heterogeneity. The impact of renal function on clopidogrel response in non-DM patients remains unexplored and represented the aim of this prospective investigation. We conducted a prospective PD investigation in non-DM patients with and without CKD defined as an estimated glomerular filtration rate (eGFR) below or above 60 mL/min, respectively. All patients had known coronary artery disease and were on maintenance aspirin therapy. PD assessments were assessed at baseline and 2 and 24 h after a 600 mg loading dose of clopidogrel. PD assays included light transmission aggregometry (LTA) using 5 and 20 μmol ADP with and without PGE1 and flow cytometric assessment of the phosphorylation status of the vasodilator-stimulated phosphoprotein (VASP) to determine the platelet reactivity index. A total of 60 patients were studied (n = 30 eGFR ≥60 mL/min; n = 30 eGFR
• Tello-Montoliu, A., Tomasello, S. D., Ferreiro, J. L., Ueno, M., Seecheran, N., Desai, B., Kodali, M., Charlton, R. K., Box, L. C., Zenni, M. M., Guzman, L. A., Bass, T. A., & Angiolillo, D. J. (2012). Pharmacodynamic Effects of Prasugrel Dosing Regimens in Patients on Maintenance Prasugrel Therapy Results of a Prospective Randomized Study. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(19), 1681-1687.
• Ueno, M., Ferreiro, J. L., Desai, B., Tomasello, S. D., Tello-Montoliu, A., Capodanno, D., Capranzano, P., Kodali, M., Dharmashankar, K., Charlton, R. K., Bass, T. A., & Angiolillo, D. J. (2012). Cigarette Smoking Is Associated With a Dose-Response Effect in Clopidogrel-Treated Patients With Diabetes Mellitus and Coronary Artery Disease Results of a Pharmacodynamic Study. JACC-CARDIOVASCULAR INTERVENTIONS, 5(3), 293-300.
• Capodanno, D., Patel, A., Dharmashankar, K., Ferreiro, J. L., Ueno, M., Kodali, M., Tomasello, S. D., Capranzano, P., Seecheran, N., Darlington, A., Tello-Montoliu, A., Desai, B., Bass, T. A., & Angiolillo, D. J. (2011). Pharmacodynamic Effects of Different Aspirin Dosing Regimens in Type 2 Diabetes Mellitus Patients With Coronary Artery Disease. CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 4(2), 180-187.
• Ferreiro, J. L., Ueno, M., Tomasello, S. D., Capodanno, D., Desai, B., Dharmashankar, K., Seecheran, N., Kodali, M. K., Darlington, A., Pham, J. P., Tello-Montoliu, A., Charlton, R. K., Bass, T. A., & Angiolillo, D. J. (2011). Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: results of a prospective, randomized, crossover study. Circulation. Cardiovascular interventions, 4(3), 273-9.
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  Safety concerns have recently emerged based on a drug interaction between clopidogrel and proton pump inhibitors leading to reduced pharmacodynamic effects. However, whether such drug interaction is a class effect or a drug effect and if this can be modulated by timing of drug administration remains a matter of debate. The aim of this study was to assess the impact of high-dose pantoprazole therapy, a proton pump inhibitor with low potential to interfere with clopidogrel metabolism, administered concomitantly or staggered, on clopidogrel-mediated pharmacodynamic effects.
• Pham, J., Ueno, M., Tello-Montoliu, A., Ferreiro, J. L., Tomasello, S. D., Dharmashankar, K., Kodali, M., Seecheran, N., Capodanno, D., Desai, B., Bass, T. A., & Angiolillo, D. J. (2011). Impact of Gastric Acid-Suppressing Therapies on Platelet Reactivity in Patients With Coronary Artery Disease Treated With Clopidogrel Results of a Pharmacodynamic Study. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(13), 1396-1398.
• Ueno, M., Ferreiro, J. L., Dharmashankar, K., Tomasello, S. D., Tello-Montoliu, A., Capodanno, D., Kodali, M., Seecheran, N., Darlington, A., Capranzano, P., Desai, B., Charlton, R. K., Bass, T. A., & Angiolillo, D. J. (2011). SERUM COTININE LEVELS ARE ASSOCIATED WITH INCREASED CLOPIDOGREL-INDUCED ANTIPLATELET EFFECTS IN PATIENTS WITH DIABETES MELLITUS AND CORONARY ARTERY DISEASE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14), E1919-E1919.
• Ueno, M., Ferreiro, J. L., Tomasello, S. D., Capodanno, D., Tello-Montoliu, A., Kodali, M., Seecheran, N., Dharmashankar, K., Alissa, R., Capranzano, P., Desai, B., Charlton, R. K., Bass, T. A., & Anglolillo, D. J. (2011). Functional profile of the platelet P2Y(12) receptor signalling pathway in patients with type 2 diabetes mellitus and coronary artery disease. THROMBOSIS AND HAEMOSTASIS, 105(4), 730-732.
• Ueno, M., Ferreiro, J. L., Tomasello, S. D., Tello-Montoliu, A., Capodanno, D., Seecheran, N., Kodali, M., Dharmashankar, K., Desai, B., Charlton, R. K., Bass, T. A., & Angiolillo, D. J. (2011). Impact of Pentoxifylline on Platelet Function Profiles in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease on Dual Antiplatelet Therapy With Aspirin and Clopidogrel. JACC-CARDIOVASCULAR INTERVENTIONS, 4(8), 905-912.
• Ueno, M., Kodali, M., Tello-Montoliu, A., & Angiolillo, D. J. (2011). Role of Platelets and Antiplatelet Therapy in Cardiovascular Disease. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 18(6), 431-442.