Jacob Douglas Negrey

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• Negrey, J. D., Frye, B. M., Johnson, C. S., Kim, J., Barcus, R. A., Lockhart, S. N., Whitlow, C. T., Sutphen, C., Chiou, K. L., Snyder-Mackler, N., Montine, T. J., Craft, S., Shively, C. A., & Register, T. C. (2023). Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety. bioRxiv : the preprint server for biology.
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  Mediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets, however the underlying biology is poorly understood.
• Trumble, B. C., Negrey, J., Koebele, S. V., Thompson, R. C., Samuel Wann, L., Allam, A. H., Beheim, B., Linda Sutherland, M., Sutherland, J. D., Eid Rodriguez, D., Michalik, D. E., Rowan, C. J., Lombardi, G. P., Garcia, A. R., Cummings, D. K., Seabright, E., Alami, S., Kraft, T. S., Hooper, P., , Buetow, K., et al. (2023). Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population. Evolution, medicine, and public health, 11(1), 472-484.
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  In industrialized populations, low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here, we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk and low coronary artery calcium scores.
• Wood, B. M., Negrey, J. D., Brown, J. L., Deschner, T., Thompson, M. E., Gunter, S., Mitani, J. C., Watts, D. P., & Langergraber, K. E. (2023). Demographic and hormonal evidence for menopause in wild chimpanzees. Science (New York, N.Y.), 382(6669), eadd5473.
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  Among mammals, post-reproductive life spans are currently documented only in humans and a few species of toothed whales. Here we show that a post-reproductive life span exists among wild chimpanzees in the Ngogo community of Kibale National Park, Uganda. Post-reproductive representation was 0.195, indicating that a female who reached adulthood could expect to live about one-fifth of her adult life in a post-reproductive state, around half as long as human hunter-gatherers. Post-reproductive females exhibited hormonal signatures of menopause, including sharply increasing gonadotropins after age 50. We discuss whether post-reproductive life spans in wild chimpanzees occur only rarely, as a short-term response to favorable ecological conditions, or instead are an evolved species-typical trait as well as the implications of these alternatives for our understanding of the evolution of post-reproductive life spans.