Jacob Douglas Negrey

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• Frye, B. M., Negrey, J. D., Johnson, C. S., Kim, J., Barcus, R. A., Lockhart, S. N., Whitlow, C. T., Chiou, K. L., Snyder-Mackler, N., Montine, T. J., Craft, S., Shively, C. A., & Register, T. C. (2024). Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis). Brain, behavior, and immunity, 119, 681-692.
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  Mediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets; however, the underlying biology is poorly understood. We assessed the effects of Western versus Mediterranean-like diets on RNAseq-generated transcriptional profiles in lateral temporal cortex and their relationships with longitudinal changes in neuroanatomy, circulating monocyte gene expression, and observations of social isolation and anxiety in 38 socially-housed, middle-aged female cynomolgus macaques (Macaca fascicularis). Diet resulted in differential expression of seven transcripts (FDR 
• Negrey, J. D., Frye, B. M., Johnson, C. S., Kim, J., Barcus, R. A., Lockhart, S. N., Whitlow, C. T., Sutphen, C., Chiou, K. L., Snyder-Mackler, N., Montine, T. J., Craft, S., Shively, C. A., & Register, T. C. (2023). Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety. bioRxiv : the preprint server for biology.
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  Mediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets, however the underlying biology is poorly understood.
• Trumble, B. C., Negrey, J., Koebele, S. V., Thompson, R. C., Samuel Wann, L., Allam, A. H., Beheim, B., Linda Sutherland, M., Sutherland, J. D., Eid Rodriguez, D., Michalik, D. E., Rowan, C. J., Lombardi, G. P., Garcia, A. R., Cummings, D. K., Seabright, E., Alami, S., Kraft, T. S., Hooper, P., , Buetow, K., et al. (2023). Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population. Evolution, medicine, and public health, 11(1), 472-484.
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  In industrialized populations, low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here, we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk and low coronary artery calcium scores.
• Wood, B. M., Negrey, J. D., Brown, J. L., Deschner, T., Thompson, M. E., Gunter, S., Mitani, J. C., Watts, D. P., & Langergraber, K. E. (2023). Demographic and hormonal evidence for menopause in wild chimpanzees. Science (New York, N.Y.), 382(6669), eadd5473.
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  Among mammals, post-reproductive life spans are currently documented only in humans and a few species of toothed whales. Here we show that a post-reproductive life span exists among wild chimpanzees in the Ngogo community of Kibale National Park, Uganda. Post-reproductive representation was 0.195, indicating that a female who reached adulthood could expect to live about one-fifth of her adult life in a post-reproductive state, around half as long as human hunter-gatherers. Post-reproductive females exhibited hormonal signatures of menopause, including sharply increasing gonadotropins after age 50. We discuss whether post-reproductive life spans in wild chimpanzees occur only rarely, as a short-term response to favorable ecological conditions, or instead are an evolved species-typical trait as well as the implications of these alternatives for our understanding of the evolution of post-reproductive life spans.
• Negrey, J., & Langergraber, K. (2020). Corpse-directed play parenting by a sterile adult female chimpanzee. Primates, 61(1). doi:10.1007/s10329-019-00734-z
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  The study of representational play in nonhuman primates, including chimpanzees (Pan troglodytes), provides interspecific perspectives on human cognitive development and evolution. A notable form of representational play in chimpanzees is play parenting, wherein parental behavior is directed at inanimate objects. Though observed in captivity, unambiguous examples of play parenting by wild chimpanzees are rare. Here, we report two cases from Ngogo in Kibale National Park, Uganda, in which a wild adult female chimpanzee (P. t. schweinfurthii) directed parental behaviors at corpses. Both cases involved the same adult female chimpanzee, aged 20–21 years. The first case was observed on 5 March 2016, and the play object was the corpse of a bushbaby (Galago thomasi); in the second case, observed on 6 May 2017, the play object was a recently deceased chimpanzee infant postmortally stolen from the mother. The chimpanzee possessed the first and second play objects for approximately 5.5 h and 1.8 h, respectively. In both cases, she performed a variety of maternal behaviors, including co-nesting, grooming, and dorsally carrying the play objects. In contrast to previous observations of play parenting in captivity, the play parent was a presumably sterile adult female, well beyond the average age of first birth. These observations contribute to the expanding literature on chimpanzee interactions with the corpses of both conspecifics and heterospecifics.