Nina Vadiei

Interests

Teaching

Innovative teaching methods; Curriculum development

Research

Psychiatry; Geriatric Psychiatry; Medication Safety; Medication adherence

Courses

Scholarly Contributions

Chapters

• Vadiei, N. (2020). Substance-Related Disorders. In Pharmacotherapy Principles and Practice Study Guide: A Case Based Care Plan Approach, 5th ed.. New York: McGraw Hill Medical.

Journals/Publications

• Jeffers, T., Darling, B., Edwards, C., & Vadiei, N. (2022). Efficacy of Combination Haloperidol, Lorazepam, and Diphenhydramine vs. Combination Haloperidol and Lorazepam in the Treatment of Acute Agitation: A Multicenter Retrospective Cohort Study. The Journal of emergency medicine, 62(4), 516-523.
  More info

  Antipsychotic and sedative combinations are commonly used for treating agitation in the emergency department despite limited evidence regarding their comparative safety and efficacy.
• Vadiei, N., & Lee, J. K. (2022). An innovative approach to teaching depression and anxiety medication management: Virtual choose your own adventure, psychiatry edition. The mental health clinician, 12(4), 225-231.
  More info

  Rates of depression and anxiety continue to increase in the United States. It's important for pharmacy students to graduate knowledgeable and confident in treating these disorders. The purpose of this study was to evaluate whether a virtual active-learning exercise (choose your own adventure) is helpful in teaching students how to manage medications for depression and anxiety.
• Vadiei, N., El-Ali, J., Delaune, J., Wild, C., & Liu, Y. S. (2022). Patterns and predictors of oral antipsychotic prescribing in adult patients with schizophrenia. Exploratory research in clinical and social pharmacy, 6, 100148.
  More info

  Evidence increasingly suggests minimal differences in efficacy between oral antipsychotics for the pharmacologic treatment of schizophrenia. As a result, newer treatment guidelines avoid an algorithmic approach to antipsychotic selection and recommend treatment be determined on a case-by-case basis.
• Vadiei, N., Francis, R., & Staroschak, C. M. (2022). Prevalence of incomplete and inaccurate drug allergy documentation in an inpatient psychiatric hospital. General hospital psychiatry, 78, 145-147.
• Agley, J., Meyerson, B. E., Eldridge, L. A., Crosby, R. A., Bentele, K. G., Jun, M., Vadiei, N., Kennedy, A., & Anderson, K. (2021). Exploration of pharmacist comfort with harm reduction behaviors: Cross-sectional latent class analysis. Journal of the American Pharmacists Association : JAPhA.
  More info

  Pharmacists are positioned to play important roles in implementing evidence-based prevention and harm reduction approaches for opioid misuse and related health care outcomes such as human immunodeficiency virus (HIV) and hepatitis C. More research is needed to understand how best to facilitate harm reduction practices among pharmacists.
• Shangraw, A. M., Silvers, J., Warholak, T., & Vadiei, N. (2021). Prevalence of Anxiety and Depressive Symptoms Among Pharmacy Students. American journal of pharmaceutical education, 85(2), 8166.
  More info

  To explore and compare the prevalence of anxiety and depressive symptoms between first-, second-, and third-year pharmacy students. A repeated-measures study was conducted at two campuses (main and satellite) of the University of Arizona College of Pharmacy. A survey was administered in February 2019 and again in April 2019 during mandatory courses for first-, second-, and third-year Doctor of Pharmacy students to collect seven-item Generalized Anxiety Disorder (GAD-7) scores, nine-item Patient Health Questionnaire (PHQ-9) scores, and demographic information. A chi-square test with a Bonferroni correction was performed to compare the number of students in a class year with clinically significant symptoms, defined as scores of ≥10 for both the GAD-7 and PHQ-9. The survey response rate was 82%. Thirty percent of students self-reported having clinically significant anxiety symptoms and 22% of students self-reported having clinically significant depressive symptoms. More second-year pharmacy students self-reported anxiety and depressive symptoms as the semester progressed. About one in four pharmacy students self-reported clinically significant symptoms of anxiety and depression, and more second-year pharmacy students reported anxiety and depressive symptoms later in the semester. These findings support the need for optimizing the delivery of well-being resources to pharmacy students.
• Vadiei, N., Eldridge, L. A., Meyerson, B. E., & Agley, J. (2021). "The gatekeepers in prevention": Community pharmacist perceptions of their role in the opioid epidemic. Substance abuse, 1-9.
  More info

  Community pharmacists are at the frontline of patient care, yet their role in the opioid epidemic remains unclear. This qualitative study examines the perception of community pharmacists about their role in the opioid epidemic and challenges to fulfilling this role. A secondary analysis of cross-sectional survey data from an Indiana census of community managing pharmacists was conducted. Qualitative data were coded using and emergent themes. categories included the perceived role of pharmacists in the opioid epidemic and perception of practice barriers. A total of 215 Indiana community managing pharmacists participated in this study. Pharmacists understood themselves as gatekeepers in preventing opioid misuse and overdose. Reported pharmacy practices included providing patient education and communicating with prescribers. Challenges to fulfilling this role included pharmacy structure and operation, lack of patient and provider clarity about pharmacist scope of practice, and pharmacist perception that that there is no available discretionary time to support additional services. Pharmacists believe they have a vital role in combatting opioid misuse and overdose but are hampered by structural aspects of pharmacy practice and lack of recognition of their role. Pharmacy associations and policy partners are encouraged to identify opportunities to address these barriers.
• Bhattacharjee, S., Naeem, S., Knapp, S. M., Lee, J. K., Patanwala, A. E., Vadiei, N., Malone, D. C., Lo-Ciganic, W. H., & Burke, W. J. (2020). Health Outcomes Associated with Adherence to Antidepressant Use during Acute and Continuation Phases of Depression Treatment among Older Adults with Dementia and Major Depressive Disorder. Journal of clinical medicine, 9(10).
  More info

  To examine health outcomes associated with adherence to Healthcare Effectiveness Data and Information Set (HEDIS) antidepressant medication management (AMM) during acute and continuation phases of depression treatment among older adults with dementia and major depressive disorder (MDD).
• Vadiei, N. (2020). Effect of Depression on Health Behavior among Myocardial Infarction Survivors in the United States. Mental Health Clinician.
• Vadiei, N. (2020). Evaluating antipsychotic titration patterns at an acute care psychiatric hospital: do rapid titrations result in rapid improvement?. Mental Health Clinician.
• Vadiei, N. (2020). Extent and Factors Associated with Adherence to Antidepressant Treatment during Acute and Continuation Phase Depression Treatment among Older Adults with Dementia and Major Depressive Disorder. Neuropsychiatric Disease and Treatment.
• Vadiei, N. (2020). Impact of Recent Methamphetamine Use on Vancomycin Clearance. Psychopharmacology Bulletin.
• Vadiei, N., & Bhattacharjee, S. (2020). Concurrent Opioid and Benzodiazepine Utilization Patterns and Predictors among Community-Dwelling Adults in the United States. Psychiatric Services.
• Vadiei, N., Howe, C. L., Zerr, B., Ladziak, N. A., Fain, M. J., & Lee, J. K. (2020). Psychotropic medication use patterns in home-based primary care: a scoping review. Mental Health Clinician.
• Meyerson, B. E., Agley, J. D., Jayawardene, W., Eldridge, L. A., Arora, P., Smith, C., Vadiei, N., Kennedy, A. K., & Moehling, T. (2019). Feasibility of a pharmacy-based harm reduction intervention to reduce opioid overdose, HIV and hepatitis C – Indiana, 2019. Res Soc Admin Pharm, 13, 644-652. doi:https://doi.org/10.1016/j.sapharm.2019.08.026
  More info

  Background: Evidence-based harm reduction intervention components which might benefit pharmacy patients have not been integrated and studied.Objective: To investigate the feasibility and acceptability of a proposed pharmacy-based harm reduction intervention to reduce opioid overdose, HIV and hepatitis C called PharmNet.Methods: Indiana managing pharmacists were surveyed in 2018 to assess the feasibility and acceptability of an intervention for opioid misuse screening, brief intervention, syringe and naloxone dispensing, and referrals provision. The Consolidated Framework for Implementation Research informed the survey development and analysis.Results: The sample included 303 (30.8%) pharmacists; 215 (70.9%) provided detailed written comments. Intervention Characteristics: 83.3% believed PharmNet would benefit patients, and that staff could deliver the intervention with adequate training (70.0%). Inner Setting: While 77.2% believed their pharmacy culture supported practice change, 57.5% of chain pharmacists believed their pharmacies would not have time for PharmNet. Outer Setting: 73.3% believed additional addiction and overdose screening is needed in their community, and pharmacies should offer new services to help reduce opioid overdose and addiction among their patients (79.5%). A vast majority (97.7%) were asked by patients in the past 2 years about syringe related issues;67.7% were asked about syringes for non-prescription injection drug use. Individuals Involved: While 62.4% believed PharmNet was within pharmacy scope of practice and 90.1% were comfortable consulting about syringe use, pharmacists reported that they had limited control over the implementation environment. Process: 38.0% of pharmacists indicated interest in advising the development of PharmNet.Conclusions: An implementation trial of a modified version of PharmNet is likely feasible; yet will be challenged by structural pressures particularly in chain pharmacies. Successful implementation will involve the development of resources and policy components to manage outer and inner setting characteristics and align the intervention to the implementation environment.
• Meyerson, B. E., Lawrence, C. A., Cope, S. D., Levin, S., Thomas, C., Eldridge, L. A., Coles, H. B., Vadiei, N., & Kennedy, A. K. (2019). I could take the judgement if you could just provide the service: non-prescription syringe purchase experience in Arizona pharmacies. BMC Harm Reduction, 16(57), 1-9. doi:doi: https://doi.org/10.1186/s12954-019-0327-1
• Vadiei, N. (2019). Decreasing Polypharmacy: The Art of Deprescribing. Elder Care.
• Vadiei, N. (2019). Extent and Predictors of Potentially Inappropriate Antidepressant Use Among Older Adults with Dementia and Major Depressive Disorder. American Journal of Geriatric Psychiatry.
• Vadiei, N. (2019). Impact of Gabapentin adjunct use with benzodiazepines for the treatment of alcohol withdrawal in an inpatient psychiatric hospital. Psychopharmacology Bulletin.
• Vadiei, N. (2018). Anxiety in Older Adults - Pharmacotherapy. Elder Care.
• Vadiei, N. (2018). Comparison of phenobarbital-adjunct versus benzodiazepine-only approach for alcohol withdrawal syndrome in the emergency department.. American Journal of Emergency Medicine.
• Vadiei, N. (2018). Depression Screening among Older Adults without Depression in Ambulatory Settings in the United States. Psychiatric Services.
• Vadiei, N. (2018). Development of oral candidiasis following initiation and re-challenge of extended-release bupropion in a geriatric patient. Mental Health Clinician.
• Vadiei, N. (2018). Patterns and Predictors of Depression Treatment among Adults with Chronic Kidney Disease and Depression in Ambulatory Care Settings in the United States. International Urology and Nephrology.
• Vadiei, N. (2018). Patterns and Predictors of Depression Treatment among Older Adults with Parkinson’s disease and Depression in Ambulatory Care Settings in the United States. Parkinson's Disease.
• Vadiei, N. (2018). Psychosis in Older Adults with Dementia - Pharmacotherapy. Elder Care.
• Ali, J. T., Daley, M. J., Vadiei, N., Enright, Z., Nguyen, J., Ali, S., Aydelotte, J. D., Teixeira, P. G., Coopwood, T. B., & Brown, C. V. (2017). Thromboelastogram does not detect pre-injury anticoagulation in acute trauma patients. The American journal of emergency medicine, 35(4), 632-636.
  More info

  Thromboelastography (TEG) has been recommended to characterize post-traumatic coagulopathy, yet no study has evaluated the impact of pre-injury anticoagulation (AC) on TEG variables. We hypothesized patients on pre-injury AC have a greater incidence of coagulopathy on TEG compared to those without AC.
• Vadiei, N., Daley, M. J., Murthy, M. S., & Shuman, C. S. (2017). Impact of Norepinephrine Weight-Based Dosing Compared With Non-Weight-Based Dosing in Achieving Time to Goal Mean Arterial Pressure in Obese Patients With Septic Shock. The Annals of pharmacotherapy, 51(3), 194-202.
  More info

  Currently, a lack of standardization exists in norepinephrine dosing units, the first-line vasopressor for septic shock. Timely achievement of goal mean arterial pressure (MAP) is dependent on optimal vasopressor dosing.
• Vadiei, N., Shuman, C. A., Murthy, M. S., & Daley, M. J. (2017). Optimization of intelligent infusion pump technology to minimize vasopressor pump programming errors. Expert opinion on drug safety, 16(8), 891-895.
  More info

  There is a lack of data evaluating the impact of hard limit implementation into intelligent infusion pump technology (IIPT). The purpose of this study was to determine if incorporation of vasopressor upper hard limits (UHL) into IIPT increases efficacy of alerts by preventing pump programming errors.

Proceedings Publications

• Bhattacharjee, S., Knapp, S., Malone, D. C., Lee, J. K., Patanwala, A., Vadiei, N., Lo Ciganic, W., & Burke, W. J. (2019, November). Healthcare Expenditure Associated with Adherence to Antidepressant Medication Management Measures During Acute and Continuous Phases of Depression Treatment among Older Adults with Dementia and Depressive Disorder.. In ISPOR, 11, S740.
• Bhattacharjee, S., Lee, J. K., Patanwala, A., Vadiei, N., Knapp, S., Lo Ciganic, W., & Burke, W. J. (2019, May). Extent and Factors Associated with Adherence to Appropriate Antidepressant Treatment during Acute and Continuation Phase Depression Treatment among Older Adults with Dementia and Major Depressive Disorder.. In ISPOR, A287, Supplement 2.

Presentations

• Vadiei, N. (2021, April). Less is More: Approaches to Deprescribing in a Variety of Practice Settings. American Psychiatric Association. Virtual.
• Vadiei, N. (2021, June). Less is More: Approaches to Deprescribing in a Variety of Practice Settings. American Association of Geriatric Psychiatry. Virtual.
• Vadiei, N. (2020, Fall 2020). Gatekeepers in Prevention: Arizona Community Pharmacist’s Perception of Their Role in the Opioid Epidemic. Arizona Pharmacy Association.
• Vadiei, N. (2020, Spring 2020). Less is More: Approaches to Deprescribing in a Variety of Geriatric Practice Settings. American Association of Geriatric Psychiatry.
• Vadiei, N. (2019, Fall). Common issues, limited options: Challenges Faced and Lessons Learned in the Outpatient and Inpatient Management of Psychotic Disorders. American Association of Geriatric Psychiatry.
• Vadiei, N. (2018, March). The Marriage Between Clinical Pharmacy & Psychiatry: A Novel Geriatric Training Experience. American Association of Geriatric Psychiatry.

Poster Presentations

• Vadiei, N. (2021). Predictors of Inappropriate Antibiotic Initiation for Suspected Urinary Tract Infection: A Focus on Psychiatric vs. Non-psychiatric Patients. American Society of Health Systems Pharmacists.
• Vadiei, N. (2021). True Allergy to Antipsychotic Medications Within an Inpatient Psychiatric hospital: A Retrospective Chart Review. Arizona Psychiatry Association.
• Vadiei, N. (2019, December). Impact of CNS-active polypharmacy on readmission rates in geriatric patients admitted for acute psychiatric hospitalization: a retrospective, multicenter study. American Society of Health-System Pharmacists.
• Vadiei, N. (2019, Fall). Prevalence of depressive and anxiety symptoms among pharmacy students: Evidence to support the need for optimizing delivery of mental health resources. American Society of Health System Pharmacists.
• Vadiei, N. (2019, March). Psychotropic medication use patterns in home-based primary care: a scoping review. American Association of Geriatric Psychiatry 2019 Annual Meeting.