Oleh Haluszka

Interests

No activities entered.

Courses

No activities entered.

Scholarly Contributions

Journals/Publications

• Haluszka, O. (2019). Reducing the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis using 4-Fr pancreatic plastic stents placed with common-type guidewires: Results from a prospective multinational registry. Digestive Endoscopy.
• Haluszka, O., Tokar, J. L., & Greenwald, B. D. (2019). Endoscopic oncology. Current problems in cancer, 29(2), 37-112.
  More info

  Endoscopy plays a critical role in the management of patients with malignancies involving the gastrointestinal tract. Endoscopic ultrasound has provided essential staging information, made more complete by the ability to perform fine needle aspiration of suspicious lymph nodes. Novel endoscopic resection and ablative techniques are expanding therapeutic choices in premalignant and malignant conditions. Obstruction, virtually anywhere along the length of the gastrointestinal tract, can be relieved with new stents. All of these advances have made the therapeutic gastroenterologist a key member of the team managing patients with tumors of the gastrointestinal tract.
• Sahar, N., Ross, A., Lakhtakia, S., Coté, G. A., Neuhaus, H., Bruno, M. J., Haluszka, O., Kozarek, R., Ramchandani, M., Beyna, T., Poley, J. W., Maranki, J., Freeman, M., Kedia, P., Tarnasky, P., & , P. S. (2018). Reducing the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis using 4-Fr pancreatic plastic stents placed with common-type guidewires: Results from a prospective multinational registry. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society.
  More info

  Pancreatic plastic stents (PPS) can reduce the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). Prospective multicenter documentation of PEP rate after PPS placement is scarce. A new 4-Fr stent designed to be deployed over a 0.035-inch guidewire was used to assess the effectiveness of PEP prophylaxis.
• DiMaio, C. J., Kolb, J. M., Benias, P. C., Shah, H., Shah, S., Haluszka, O., Maranki, J., Sharzehi, K., Lam, E., Gordon, S. R., Hyder, S. M., Kaimakliotis, P. Z., Allaparthi, S. B., Gress, F. G., Sethi, A., Shah, A. R., Nieto, J., Kaul, V., Kothari, S., , Kothari, T. H., et al. (2016). Initial experience with a novel EUS-guided core biopsy needle (SharkCore): results of a large North American multicenter study. Endoscopy international open, 4(9), E974-9.
  More info

  The ability to safely and effectively obtain sufficient tissue for pathologic evaluation by using endoscopic ultrasound (EUS) guidance remains a challenge. Novel designs in EUS needles may provide for improved ability to obtain such core biopsies. The aim of this study was to evaluate the diagnostic yield of core biopsy specimens obtained using a novel EUS needle specifically designed to obtain core biopsies.
• Khashab, M. A., El Zein, M. H., Sharzehi, K., Marson, F. P., Haluszka, O., Small, A. J., Nakai, Y., Park, D. H., Kunda, R., Teoh, A. Y., Peñas, I., Perez-Miranda, M., Kumbhari, V., Van der Merwe, S., Artifon, E. L., & Ross, A. S. (2016). EUS-guided biliary drainage or enteroscopy-assisted ERCP in patients with surgical anatomy and biliary obstruction: an international comparative study. Endoscopy international open, 4(12), E1322-E1327.
  More info

  Background and study aims: How enteroscopy-assisted ERCP (e-ERCP) and endoscopic ultrasound-guided biliary drainage (EUS-BD) compare in patients with surgically altered upper gastrointestinal anatomy is currently unknown. The aims of this study were to compare efficacy and safety of both techniques and study predictors of these outcomes. Patients and methods: This was an international, multicenter comparative cohort study at 10 tertiary centers. Outcomes data included technical success (biliary access with cholangiography and stent placement [when indicated]), clinical success (resolution of biliary obstruction) and adverse events (AEs) (graded according to the ASGE lexicon). Results: A total of 98 patients underwent EUS-BD (n = 49) or e-ERCP (n = 49). Technical success was achieved in 48 (98 %) patients in the EUS-BD group as compared to 32 (65.3 %) patients in the e-ERCP group (OR 12.48, P = 0.001). Clinical success was attained in 88 % of patients in EUS-BD group as compared to 59.1 % in the e-ERCP group (OR 2.83, P = 0.03). Procedural time was significantly shorter in the EUS-BD group (55 min vs 95 min, P 
• Wang, K. K., Carr-Locke, D. L., Singh, S. K., Neumann, H., Bertani, H., Galmiche, J. P., Arsenescu, R. I., Caillol, F., Chang, K. J., Chaussade, S., Coron, E., Costamagna, G., Dlugosz, A., Ian Gan, S., Giovannini, M., Gress, F. G., Haluszka, O., Ho, K. Y., Kahaleh, M., , Konda, V. J., et al. (2015). Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence. United European gastroenterology journal, 3(3), 230-54.
  More info

  Probe-based confocal laser endomicroscopy (pCLE) provides microscopic imaging during an endoscopic procedure. Its introduction as a standard modality in gastroenterology has brought significant progress in management strategies, affecting many aspects of clinical care and requiring standardisation of practice and training.
• Lewis, A., Partridge, B., & Haluszka, O. (2014). The role of endoscopy in the management of pancreatic necrosis. Current gastroenterology reports, 16(9), 406.
  More info

  The management of acute pancreatitis has seen many advances over the past three decades. Attempts to improve care have led to new definitions, classification systems, and treatment strategies. Despite those efforts, considerable morbidity and mortality result from complications of severe acute pancreatitis. Much attention has been given to new ways to treat these complications, including inflammatory pancreatic fluid collections and associated infections. Endoscopy has become one of the established modalities for the treatment of these complications in many expert centers. This chapter will specifically address the role of endoscopy in the management of pancreatic necrosis.
• Makipour, K., Modiri, A. N., Ehrlich, A., Friedenberg, F. K., Maranki, J., Enestvedt, B. K., Heller, S., Tokar, J., & Haluszka, O. (2014). Double balloon enteroscopy: effective and minimally invasive method for removal of retained video capsules. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 26(5), 646-9.
  More info

  Prior case series document removal of retained video capsules predominantly via surgical intervention. Data on endoscopic removal of retained capsules are limited. Our aim was to describe an endoscopic method of retrieval using double balloon enteroscopy (DBE).
• Siddiqui, A. A., Chaaya, A., Shelton, C., Marmion, J., Kowalski, T. E., Loren, D. E., Heller, S. J., Haluszka, O., Adler, D. G., & Tokar, J. L. (2013). Utility of the short double-balloon enteroscope to perform pancreaticobiliary interventions in patients with surgically altered anatomy in a US multicenter study. Digestive diseases and sciences, 58(3), 858-64.
  More info

  Double-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreaticography (DBE-ERCP) is an effective method for interventions in the pancreaticobiliary system in the post-surgical patient. However, use of currently available endoscopic accessories during this procedure is limited due of the length of the conventional instrument (200 cm). The aim of this study was to explore the utility of the short DBE (152 cm) for the management of pancreaticobiliary disorders in patients with surgically altered anatomies.
• Keller, D., Jaffe, J., Philp, M. M., Haluszka, O., & Khanna, A. (2012). Should all endoscopically excised rectal polyps be tattooed? A plea for localization. Surgical endoscopy, 26(11), 3101-5.
  More info

  More than 5-8 % of endoscopically removed rectal polyps presumed to be benign contain invasive carcinoma. Tattooing has been advocated for follow-up localization of the resection site. Despite proven benefits, the authors propose that tattooing is not routinely performed when benign-appearing rectal polyps are endoscopically excised, thereby confounding management when invasive cancer is found. The secondary goal of the study was to determine the frequency of localization, polyp characteristics, and accuracy of predicting malignant potential at the authors' institution.
• Konski, A., Li, T., Christensen, M., Cheng, J. D., Yu, J. Q., Crawford, K., Haluszka, O., Tokar, J., Scott, W., Meropol, N. J., Cohen, S. J., Maurer, A., & Freedman, G. M. (2012). Symptomatic cardiac toxicity is predicted by dosimetric and patient factors rather than changes in 18F-FDG PET determination of myocardial activity after chemoradiotherapy for esophageal cancer. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 104(1), 72-7.
  More info

  To determine factors associated with symptomatic cardiac toxicity in patients with esophageal cancer treated with chemoradiotherapy.
• Chen, Y. K., Parsi, M. A., Binmoeller, K. F., Hawes, R. H., Pleskow, D. K., Slivka, A., Haluszka, O., Petersen, B. T., Sherman, S., Devière, J., Meisner, S., Stevens, P. D., Costamagna, G., Ponchon, T., Peetermans, J. A., & Neuhaus, H. (2011). Single-operator cholangioscopy in patients requiring evaluation of bile duct disease or therapy of biliary stones (with videos). Gastrointestinal endoscopy, 74(4), 805-14.
  More info

  The feasibility of single-operator cholangioscopy (SOC) for biliary diagnostic and therapeutic procedures was previously reported.
• Partridge, B. J., Tokar, J. L., Haluszka, O., & Heller, S. J. (2011). Small bowel cancers diagnosed by device-assisted enteroscopy at a U.S. referral center: a five-year experience. Digestive diseases and sciences, 56(9), 2701-5.
  More info

  Primary malignant neoplasms of the small bowel comprise only 1-3% of all gastrointestinal malignancies. Small bowel cancers pose a significant diagnostic challenge. The recent development of video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE) have greatly facilitated evaluation of the small bowel.
• Sharma, N. K., Silverman, J. S., Li, T., Cheng, J., Yu, J. Q., Haluszka, O., Scott, W., Meropol, N. J., Cohen, S. J., Freedman, G. M., & Konski, A. A. (2011). Decreased Posttreatment SUV on PET Scan Is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer. Gastrointestinal cancer research : GCR, 4(3), 84-9.
  More info

  The relationship between local, regional, or distant disease control (LC, RC, DC) and maximal posttreatment standardized uptake value (SUV(max)) in patients with esophageal cancer has not been elucidated. This study was initiated to explore whether a decrease in SUV on positron emission tomography-computed tomography (PET-CT) scan is associated with LC, RC, or DC in patients with esophageal carcinoma treated with definitive chemoradiotherapy.
• Chun, Y. S., Milestone, B. N., Watson, J. C., Cohen, S. J., Burtness, B., Engstrom, P. F., Haluszka, O., Tokar, J. L., Hall, M. J., Denlinger, C. S., Astsaturov, I., & Hoffman, J. P. (2010). Defining venous involvement in borderline resectable pancreatic cancer. Annals of surgical oncology, 17(11), 2832-8.
  More info

  Pancreatic adenocarcinoma impinging the portal and/or superior mesenteric vein (PV-SMV) is classified as borderline resectable, and preoperative chemoradiation is recommended to increase the margin-negative resection rate. There is no consensus about what degree of venous impingement constitutes borderline resectability.
• Hegde, S. R., Iffrig, K., Li, T., Downey, S., Heller, S. J., Tokar, J. L., & Haluszka, O. (2010). Double-balloon enteroscopy in the elderly: safety, findings, and diagnostic and therapeutic success. Gastrointestinal endoscopy, 71(6), 983-9.
  More info

  Double-balloon enteroscopy (DBE) is an important tool in the evaluation and management of small-bowel disease. Limited data are available on the safety, findings, and outcomes of DBE in elderly patients.
• Heller, S. J., Tokar, J. L., Nguyen, M. T., Haluszka, O., & Weinberg, D. S. (2010). Management of bleeding GI tumors. Gastrointestinal endoscopy, 72(4), 817-24.
• Morgan, D., Upchurch, B., Draganov, P., Binmoeller, K. F., Haluszka, O., Jonnalagadda, S., Okolo, P., Grimm, I., Judah, J., Tokar, J., & Chiorean, M. (2010). Spiral enteroscopy: prospective U.S. multicenter study in patients with small-bowel disorders. Gastrointestinal endoscopy, 72(5), 992-8.
  More info

  The performance characteristics of spiral enteroscopy have not been well-described.
• Gerson, L. B., Tokar, J., Chiorean, M., Lo, S., Decker, G. A., Cave, D., Bouhaidar, D., Mishkin, D., Dye, C., Haluszka, O., Leighton, J. A., Zfass, A., & Semrad, C. (2009). Complications associated with double balloon enteroscopy at nine US centers. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 7(11), 1177-82, 1182.e1-3.
  More info

  Double balloon enteroscopy (DBE) was introduced into the US in 2004. Potential complications include perforation, pancreatitis, and gastrointestinal bleeding. Prevalence and risk factors for complications have not been described in a US population.
• Haley, M., Konski, A., Li, T., Cheng, J. D., Maurer, A., Haluszka, O., Scott, W., Meropol, N. J., Cohen, S. J., & Freedman, G. (2009). Influence of Diabetes on the Interpretation of PET Scans in Patients With Esophageal Cancer. Gastrointestinal cancer research : GCR, 3(4), 149-52.
  More info

  Patients with diabetes mellitus (DM) can have altered sugar transport into cells, potentially affecting the results of 18-FDG PET scans. The specific aim of this study was to determine the effect of DM on pre- and post-treatment standard uptake value (SUV) scores in patients undergoing chemoradiotherapy for esophageal cancer.
• Ke, E., Patel, B. B., Liu, T., Li, X. M., Haluszka, O., Hoffman, J. P., Ehya, H., Young, N. A., Watson, J. C., Weinberg, D. S., Nguyen, M. T., Cohen, S. J., Meropol, N. J., Litwin, S., Tokar, J. L., & Yeung, A. T. (2009). Proteomic analyses of pancreatic cyst fluids. Pancreas, 38(2), e33-42.
  More info

  There are currently no diagnostic indicators that are consistently reliable, obtainable, and conclusive for diagnosing and risk-stratifying pancreatic cysts. Proteomic analyses were performed to explore pancreatic cyst fluids to yield effective diagnostic biomarkers.
• Ross, A., Mehdizadeh, S., Tokar, J., Leighton, J. A., Kamal, A., Chen, A., Schembre, D., Chen, G., Binmoeller, K., Kozarek, R., Waxman, I., Dye, C., Gerson, L., Harrison, M. E., Haluszka, O., Lo, S., & Semrad, C. (2008). Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy. Digestive diseases and sciences, 53(8), 2140-3.
  More info

  Small bowel mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB). Their detection has been limited by the inability to endoscopically examine the entire small intestine. This has changed with the introduction of capsule endoscopy (CE) and double balloon enteroscopy (DBE) into clinical practice.
• Konski, A. A., Cheng, J. D., Goldberg, M., Li, T., Maurer, A., Yu, J. Q., Haluszka, O., Scott, W., Meropol, N. J., Cohen, S. J., Freedman, G., & Weiner, L. M. (2007). Correlation of molecular response as measured by 18-FDG positron emission tomography with outcome after chemoradiotherapy in patients with esophageal carcinoma. International journal of radiation oncology, biology, physics, 69(2), 358-63.
  More info

  To determine whether 18-fluorodeoxyglucose positron emission tomography (PET) computed tomography scans predict the pathologic complete response and disease-free and overall survival in patients with esophageal carcinoma undergoing definitive or preoperative chemoradiotherapy.
• Tokar, J. L., Haluszka, O., & Weinberg, D. S. (2007). Endoscopic therapy of dysplasia and early-stage cancers of the esophagus. Seminars in radiation oncology, 17(1), 10-21.
  More info

  Endoscopic treatments have become a viable alternative for some patients with early-stage esophageal neoplasia. Although esophagectomy remains the standard of care for high-grade dysplasia and superficial cancers, surgical morbidity and mortality may deter patients who are medically unfit or reluctant to undergo surgery. Photodynamic therapy (PDT) and endoscopic mucosal resection (EMR) are the best-studied nonsurgical approaches at present. PDT has been reported to eradicate high-grade dysplasia (HGD) and early Barrett's cancers at rates ranging from 75% to 100% and 17% to 100%, respectively, and a recent randomized controlled trial confirmed that PDT may prevent progression of HGD to cancer. Complete remission rates greater than 90% have also been reported with EMR and other mucosa-ablating interventions, although recurrence rates necessitate close endoscopic surveillance and retreatment in some patients. In addition to PDT and EMR, several emerging endoscopic treatment options for superficial esophageal neoplasia may provide attractive alternatives to surgery.
• Goldberg, E., Titus, M., Haluszka, O., & Darwin, P. (2005). Pancreatic-duct stent placement facilitates difficult common bile duct cannulation. Gastrointestinal endoscopy, 62(4), 592-6.
  More info

  Cannulation of the common bile duct can be difficult in certain instances. Difficult cannulation has been demonstrated to be a risk factor for post-ERCP pancreatitis. We report a technique to facilitate difficult cannulation that uses a pancreatic-duct stent to guide biliary cannulation.
• Haluszka, O. (2005). Palliative gastroenterology. Seminars in oncology, 32(2), 174-8.
  More info

  Continuous improvements in endoscopic imaging and accessories have opened up a field of interventional endoscopy. This highly technical offshoot of gastroenterology uses not just standard endoscopic techniques but also newer endoscopic ultrasound (EUS) imaging or fluoroscopic monitoring to facilitate procedures that were once performed either surgically or percutaneously, if at all. This review will update the role of these novel procedures that can be used to assist in the palliative care of patients whose malignancies involve the gastrointestinal tract. The emphasis will be on those palliative interventions that are used to overcome intestinal obstruction in the gastrointestinal tract and restore luminal patency. The role of EUS-guided celiac plexus neurolysis to assist in pain control, especially in patients with pancreatic malignancies, will also be detailed.
• Konski, A., Doss, M., Milestone, B., Haluszka, O., Hanlon, A., Freedman, G., & Adler, L. (2005). The integration of 18-fluoro-deoxy-glucose positron emission tomography and endoscopic ultrasound in the treatment-planning process for esophageal carcinoma. International journal of radiation oncology, biology, physics, 61(4), 1123-8.
  More info

  Accurate delineation of the gross tumor volume (GTV) is important in radiation therapy treatment planning. We evaluated the impact of PET and endoscopic ultrasound (EUS) compared with CT simulation in the planning of radiation fields for patients with esophageal carcinoma.
• Konski, A., Hoffman, J., Sigurdson, E., Haluszka, O., Engstrom, P., Cheng, J. D., Cohen, S. J., Watson, J. C., Eisenberg, D., McGarrity, E., Freedman, G., & Meropol, N. J. (2005). Can molecular imaging predict response to preoperative chemoradiation in patients with rectal cancer? A Fox Chase Cancer Center prospective experience. Seminars in oncology, 32(6 Suppl 9), S63-7.
  More info

  This study was undertaken to correlate change in fluorine-18 fluorodeoxyglucose positron emission tomography ((18)FDG-PET) uptake with response to combined-modality neoadjuvant therapy in patients with locally advanced rectal cancer. Twenty patients (13 male; 7 female) underwent (18)FDG-PET scans before and 3 to 4 weeks after completion of chemoradiation before surgery. Staging by endoscopic ultrasound was T3/T4 (17/1); two patients were unable to undergo endorectal ultrasound. Fifteen patients had perirectal lymphadenopathy. Median radiation dose was 5,040 cGy (range, 4,500 to 5,500 cGy). All patients received continuous infusion 5-fluorouracil (or capecitabine) with radiation. Median pre- and post-chemoradiation standard uptake values were 9.4 (range, 3.6 to 37.0) and 3.05 (range, 0.5 to 8.2), respectively. Median percent standard uptake value decrease observed in the postchemoradiation PET scans was 71% (range, 7% to 95%). Six patients (30%) had pathologic complete response. Only two of six patients with postchemoradiation standard uptake values
• Greenwald, B. D., Caldwell, S. H., Hespenheide, E. E., Patrie, J. T., Williams, J., Binmoeller, K. F., Woodall, L., & Haluszka, O. (2003). N-2-butyl-cyanoacrylate for bleeding gastric varices: a United States pilot study and cost analysis. The American journal of gastroenterology, 98(9), 1982-8.
  More info

  N-butyl-2-cyanoacrylate has been reported to be effective for bleeding varices but is not available in the United States. We report the initial US experience with cyanoacrylate in this prospective trial and evaluate its safety, efficacy, and relative costs.
• Haluszka, O., Campbell, A., & Horvath, K. (2002). Endoscopic management of pancreatic pseudocyst in children. Gastrointestinal endoscopy, 55(1), 128-31.
• Osei-Boateng, K., Ravendhran, N., Haluszka, O., & Darwin, P. E. (2002). Endoscopic treatment of a post-traumatic biliary stricture mimicking a Klatskin tumor. Gastrointestinal endoscopy, 55(2), 274-6.

Presentations

• Haluszka, O. (2023, October). Southwest Regional Advances in Foregut Diseases. Conference. Tucson, Arizona: The University of Arizona Gastroenterology.
  More info

  Southwest Regional Advances in Foregut Diseases 2023A half-day continuing medical education conference highlighting the latest developments in gastroenterology and foregut surgery.