Patricia Thompson

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Scholarly Contributions

Journals/Publications

• Gemmill, J. A., Thompson, P., Batiste, R., Vacchi-Suzzi, C., Preece, C., Cohen, J., Baer, L., Mies, C., Turner, M., Russell, C. A., & Stopeck, A. (2025). Metastatic breast cancer through the Oncotype DX Breast Recurrence Score®: insights from a small cohort study. Breast cancer research and treatment, 212(2), 407-413.
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  To evaluate the feasibility of obtaining a 21-gene Oncotype DX Breast Recurrence Score® (RS) result from metastatic biopsies in newly diagnosed hormone receptor positive, HER2- metastatic breast cancer patients and correlate RS results with matched primary samples.
• Hagio, T., Galons, J. P., Roe, D., Marron, M. T., Thomson, C., Thompson, P., Stopeck, A. T., Bilgin, A., Altbach, M. I., & Chiang, J. A. (2025). Concurrent water T and fat fraction mapping of the breast using the radial gradient and spin echo (RADGRASE) pulse sequence. Magnetic resonance imaging, 118, 110355.
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  This work describes and evaluates an efficient radial gradient- and spin-echo (RADGRASE) pulse sequence and reconstruction algorithm for concurrent measurement of proton-density weighted fat fraction (FF) and water component T (T) within breast tissues. The ability to estimate T in breast tissues, where fat can be highly abundant, is demonstrated using oil/gel phantoms across a wide range of FF values (0.1-0.7). Successful T mapping of breast tissues is also demonstrated in vivo by comparison with fat suppressed T values. The sensitivity of RADGRASE to detect changes in the breast was assessed by tracking T in 3 healthy volunteers through their menstrual cycle, demonstrating T values in the late luteal phase to be 18-29 ms higher than in the follicular phase. The technique is also applied to a cohort of 68 patients taking tamoxifen for breast cancer risk reduction, where significant positive correlation between the FF parameter Frac50 and T (p = 0.035) was observed in premenopausal subjects (n = 20). Our findings demonstrate the ability and efficacy of RADGRASE for simultaneously mapping FF and T within breast tissues, and the potential utility of the technique in studying breast tissue changes in clinical applications.
• Mastrogiacomo, C. N., Courtepatte, A., Moyer, A., Preece, C., Thompson, P., & Stopeck, A. (2025). Willingness of Women at Increased Risk of Breast Cancer to Participate in Prevention Trials. JCO oncology practice, 21(5), 647-653.
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  The factors affecting women's willingness to participate (WTP) in breast cancer (BC) prevention trials are poorly understood. This study aimed to identify the characteristics of interventions associated with a higher WTP among high BC risk women.
• Schmit, S. L., Loroña, N. C., Sobieski, D., Matejcic, M., Nguyen, N. T., Hoehn, H. J., Diaz, D. B., Shankar, K., Cockman, E. M., Jean-Baptiste, E., Tsai, Y. Y., Buchalter, R. B., Brito, K., Wilson, R., Coppola, D., Fulmer, C., Saglam, O., Tassielli, A. F., Beato, F., , Dai, R., et al. (2025). Building research infrastructure to advance precision medicine in colorectal cancer. JNCI cancer spectrum, 9(3).
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  Addressing critical gaps in precision medicine initiatives in colorectal cancer (CRC) requires building larger collaborative studies.

Poster Presentations

• Hagio, T., Galons, J., Thompson-Carino, P. A., Stopeck, A. T., Thomson, C. A., Chalasani, P., Squire, S. W., Marron, M. T., & Altbach, M. I. (2016, Spring). T2w mapping in breast density for differentiating tissue composition. International Society for Magnetic Resonance in Medicine. Singapore.