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Philip Rosen
- Assistant Clinical Professor, Surgery - (Clinical Series Track)
- (520) 626-7754
- Arizona Health Sciences Center, Rm. 245131
- philiprosen@arizona.edu
Biography
Philip L. Rosen, MD, FACS, joins the University of Arizona College of Medicine - Tucson Department of Surgery as a clinical assistant professor of colon and rectal surgery in the Division of Surgical Oncology.
Dr. Rosen has advanced training in minimally invasive colon and rectal surgery including robotic and laparoscopic surgery as well as screening colonoscopies and office-based procedures.
He received his Medical Degree from the University of Pennsylvania Perelman School of Medicine. He completed his training in general surgery at SUNY Downstate/Kings County Medical Center in Brooklyn, NY, and completed his colon and rectal surgery fellowship with a focus on robotic and minimally invasive surgery at the Colon & Rectal Clinic of Orlando. Prior to joining the University of Arizona, he practiced at the Optum Multispecialty Group in Long Island, NY.
Dr. Rosen is dual board certified in both general surgery and colorectal surgery. His research interests include minimally invasive surgery and cancer outcomes.
“I believe in treating colon, rectal and anal issues nonoperatively whenever possible," he said. "But when surgery is required, I use the latest technology and minimally invasive techniques including robotic and laparoscopic surgery to maximize safety, minimize scarring, and return patients to their healthy lives as quickly as possible."
Outside of medicine and surgery, Dr. Rosen enjoys tennis, cooking, and exploring Arizona with family and friends.
Degrees
- M.D. Medical Doctor
- University of Pennsylvania, Philadelphia, Pennsylvania, United States
- B.A. Economics and Mathematics
- University of Pennsylvania, Philadelphia, Pennsylvania, United States
Work Experience
- The University of Arizona, College of Medicine (2022 - Ongoing)
- ProHEALTH Multispecialty Group (2020 - 2022)
- School District of Philadelphia (2007 - 2008)
Awards
- Fellow, American College of Surgeons, (elected)
- American College of Surgeons, Fall 2022
Licensure & Certification
- Basic Life Support (BLS), American Heart Association (2013)
- Advanced Cardiovascular Life Support (ACLS), American Heart Association (2013)
- New York Medical License (294537), New York State Education Department (2018)
- Florida Medical License (ME138982), Florida Board of Medicine (2019)
- American Board of Colon and Rectal Surgery Certification, American Board of Colon and Rectal Surgery (2021)
- American Board of Surgery Certification, American Board of Surgery (2019)
- Advanced Trauma Life Support (ATLS), American Heart Association (2014)
- California Medical License (A 168114), Medical Board of California (2020)
- Arizona Medical License (67530), Arizona Medical Board (2022)
Interests
No activities entered.
Courses
No activities entered.
Scholarly Contributions
Journals/Publications
- Valentino, J. D., Rosen, P. L., Poggio, J. L., Tyler, K. M., & , H. E. (2021). The Impact of the Noncompete. Diseases of the colon and rectum, 64(12), 1452-1453.
- Noory, M., Renz, J. F., Rosen, P. L., Gross, D. J., & Gruessner, R. W. (2019). Kidney After Intestinal Transplantation Using Two Different Living Donors: A First Case Report. Transplantation proceedings, 51(9), 3178-3180.More infoWe describe a unique case of a 53-year-old woman who underwent a nonrelated living donor kidney transplant 9 years after a previous small bowel transplant from her sister. The patient had suffered from short bowel syndrome secondary to volvulus after undergoing bariatric surgery for morbid obesity. Her entire small bowel had to be resected emergently, but she also developed acute kidney failure at the time. This initial kidney injury associated with long-term exposure to calcineurin-inhibitor medication eventually led to end-stage renal disease. A successful kidney transplant from a different, nonrelated adult donor was performed. Of note, the unrelated kidney donor matched exactly the 2 HLA-A and HLA-B antigens that the recipient had not matched with her sister. We discuss the unique HLA configuration between the patient and her 2 living donors, the absence of posttransplant rejection and posttransplant immunosuppressive therapy. To our knowledge this is the first published report of a successful kidney after a previous bowel transplant using (2 different) living donors.
- Noory, M., Renz, J. F., Rosen, P. L., Patel, H., Schwartzman, A., & Gruessner, R. W. (2019). Real-Time, Intraoperative Doppler/Ultrasound Monitoring of Islet Infusion During Total Pancreatectomy With Islet Autotransplant: A First Report. Transplantation proceedings, 51(10), 3428-3430.More infoChronic pancreatitis (CP), secondary to a wide variety of etiologies, is a progressive and irreversible disease. Initially, CP is managed with endoscopic interventions, long-term analgesia for its associated chronic abdominal pain syndrome and pancreatic enzyme replacement for exocrine dysfunction. As the disease advances, pancreatic drainage procedures and partial resections are considered, but they leave diseased tissue behind and usually result in short-term relief only. Total pancreatectomy alone is widely viewed as a last resort treatment option because it causes brittle diabetes mellitus. However, total pancreatectomy with islet autotransplantation (TPIAT) can prevent the development of diabetes and cure the chronic pain syndrome. One serious, albeit rare, complication of TPIAT is (partial) portal vein thrombosis. Its incidence is probably about 5%. To prevent the occurrence of portal vein thrombosis, we propose herein, and have successfully performed, continuous real-time Doppler ultrasonography during the islet infusion to study portal vein and intrahepatic flow patterns, as well as changes in Doppler signals. Flow and signal changes may allow for timely adjustment of the infusion rate, before a marked increase in portal vein pressure is noted and decrease the risk of portal vein thrombosis.
- Rosen, P., Gross, D. J., Ighalo, F., Rubinshteyn, V., & Chendrasekhar, A. (2019). Delayed traumatic intracranial bleeding and herniation after initial negative computed tomography scan
. ACS Case Reviews in Surgery, 2(3), 12-14. - Gross, D. J., Chang, E. H., Rosen, P. L., Roudnitsky, V., Muthusamy, M., Sugiyama, G., & Chung, P. J. (2018). Outcomes in video-assisted thoracoscopic surgery lobectomies: challenging preconceived notions. The Journal of surgical research, 231, 161-166.More infoMost thoracic surgical procedures in the United States are being performed by general surgeons (GSs) without any advanced training. With the recent approval of computed tomography screening for lung malignancy in high-risk populations, the number of thoracic oncologic resections is expected to rise. Previous literature has demonstrated consistently worsened outcomes for patients undergoing thoracic surgical procedure when done by nonthoracic fellowship-trained surgeons. Using the American College of Surgeons National Surgical Quality Improvement Project database, we examined short-term outcomes in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for malignancy.
- Lee, R. J., Workman, A. D., Carey, R. M., Chen, B., Rosen, P. L., Doghramji, L., Adappa, N. D., Palmer, J. N., Kennedy, D. W., & Cohen, N. A. (2016). Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function. Scientific reports, 6, 33221.More infoAflatoxins are mycotoxins secreted by Aspergillus flavus, which can colonize the respiratory tract and cause fungal rhinosinusitis or bronchopulmonary aspergillosis. A. flavus is the second leading cause of invasive aspergillosis worldwide. Because many respiratory pathogens secrete toxins to impair mucociliary immunity, we examined the effects of acute exposure to aflatoxins on airway cell physiology. Using air-liquid interface cultures of primary human sinonasal and bronchial cells, we imaged ciliary beat frequency (CBF), intracellular calcium, and nitric oxide (NO). Exposure to aflatoxins (0.1 to 10 μM; 5 to 10 minutes) reduced baseline (~6-12%) and agonist-stimulated CBF. Conditioned media (CM) from A. fumigatus, A. niger, and A. flavus cultures also reduced CBF by ~10% after 60 min exposure, but effects were blocked by an anti-aflatoxin antibody only with A. flavus CM. CBF reduction required protein kinase C but was not associated with changes in calcium or NO. However, AFB2 reduced NO production by ~50% during stimulation of the ciliary-localized T2R38 receptor. Using a fluorescent reporter construct expressed in A549 cells, we directly observed activation of PKC activity by AFB2. Aflatoxins secreted by respiratory A. flavus may impair motile and chemosensory functions of airway cilia, contributing to pathogenesis of fungal airway diseases.
- Shaknovsky, T. J., Sabido, F., Shaikh, D., & Rosen, P. (2016). Robotic repair of Amyand’s hernia: A case report. Journal of Case Reports and Images in Surgery, 2, 92-96.
- Lee, R. J., Kofonow, J. M., Rosen, P. L., Siebert, A. P., Chen, B., Doghramji, L., Xiong, G., Adappa, N. D., Palmer, J. N., Kennedy, D. W., Kreindler, J. L., Margolskee, R. F., & Cohen, N. A. (2014). Bitter and sweet taste receptors regulate human upper respiratory innate immunity. The Journal of clinical investigation, 124(3), 1393-405.More infoBitter taste receptors (T2Rs) in the human airway detect harmful compounds, including secreted bacterial products. Here, using human primary sinonasal air-liquid interface cultures and tissue explants, we determined that activation of a subset of airway T2Rs expressed in nasal solitary chemosensory cells activates a calcium wave that propagates through gap junctions to the surrounding respiratory epithelial cells. The T2R-dependent calcium wave stimulated robust secretion of antimicrobial peptides into the mucus that was capable of killing a variety of respiratory pathogens. Furthermore, sweet taste receptor (T1R2/3) activation suppressed T2R-mediated antimicrobial peptide secretion, suggesting that T1R2/3-mediated inhibition of T2Rs prevents full antimicrobial peptide release during times of relative health. In contrast, during acute bacterial infection, T1R2/3 is likely deactivated in response to bacterial consumption of airway surface liquid glucose, alleviating T2R inhibition and resulting in antimicrobial peptide secretion. We found that patients with chronic rhinosinusitis have elevated glucose concentrations in their nasal secretions, and other reports have shown that patients with hyperglycemia likewise have elevated nasal glucose levels. These data suggest that increased glucose in respiratory secretions in pathologic states, such as chronic rhinosinusitis or hyperglycemia, promotes tonic activation of T1R2/3 and suppresses T2R-mediated innate defense. Furthermore, targeting T1R2/3-dependent suppression of T2Rs may have therapeutic potential for upper respiratory tract infections.
- Rosen, P. L., Palmer, J. N., O'Malley, B. W., & Cohen, N. A. (2013). Surfactants in the management of rhinopathologies. American journal of rhinology & allergy, 27(3), 177-80.More infoSurfactants are a class of amphiphilic surface active compounds that show several unique physical properties at liquid-liquid or liquid-solid surface interfaces including the ability to increase the solubility of substances, lower the surface tension of a liquid, and decrease friction between two mediums. Because of these unique physical properties several in vitro, ex vivo, and human trials have examined the role of surfactants as stand-alone or adjunct therapy in recalcitrant chronic rhinosinusitis (CRS).
Presentations
- Gross, D. J., Zangbar, B., Chang, K., Chang, E. H., Rosen, P., Boudourakis, L., Muthusamy, M., Roudnitsky, V., & Schwartz, T. (2019, Spring). The challenge of enteroatmospheric fistulas. 14th Annual Academic Surgical Congress. Houston, TX: Association for Academic Surgery (AAS) and The Society of University Surgeons (SUS).
- Rosen, P. (2019, Fall). Updates in the treatment of Clostridium difficile colitis. Surgical Grand Rounds. Orlando, FL: Orlando Health.
- Shraga, S., Zayko, O., Silverstein, B., Rosen, P., Gruessner, A., & Schwartz, T. (2019, Spring). Perianal abscess: When should surgeons get involved?. 14th Annual Academic Surgical Congress. Houston, TX: Association for Academic Surgery (AAS) and The Society of University Surgeons (SUS).
- Chang, E. H., Rosen, P., Gross, D. J., Roudnitsky, V., Muthusamy, M., Coppa, G. F., Sugiyama, G., & Chung, P. J. (2018, Sporing). The effects of morbid obesity on outcomes following pancreaticoduodenectomy for pancreatic cancer. 13th Annual Academic Surgical Congress. Jacksonville, FL: Association for Academic Surgery (AAS) and The Society of University Surgeons (SUS).
- Gross, D. J., Rosen, P., Roudnitsky, V., Muthusamy, M., Sugiyama, G., & Chung, P. J. (2018, Spring). Outcomes in VATS lobectomies: Challenging preconceived notions. 13th Annual Academic Surgical Congress. Jacksonville, FL: Association for Academic Surgery (AAS) and The Society of University Surgeons (SUS).
- Rosen, P. (2018, Spring). Penetrating neck trauma: There’s nothing magical about zone II. Surgical Grand Rounds. Brooklyn, NY: SUNY Downstate.
- Rosen, P., Gross, D. J., Talus, H., Roudnitsky, V., Muthusamy, M., Sugiyama, G., & Chung, P. J. (2018, Spring). Laparoscopic surgery for rectal prolapse: short-term outcomes should not dictate the approach. 13th Annual Academic Surgical Congress. Jacksonville, FL: Association for Academic Surgery (AAS) and The Society of University Surgeons (SUS).More infoQuickshot Presentation
- Rosen, P. (2017, April). Updates in the treatment of Clostridium difficile colitis. Surgical Grand Rounds. Brooklyn, NY: SUNY Downstate.
- Rosen, P. (2009, Fall). Hypertonic saline resuscitation of surgical ICU patients.. Agnew Surgical Society Fall Presentation. Philadelphia, PA.
Poster Presentations
- Rosen, P. L., Shraga, S., Silverstein, B., Gross, D., Zayko, O., & Schwartz, T. (2019, Summer). Lowering the threat level on perianal abscesses in the safety-net hospital ED: Do we actually need to cover for MRSA?. 2019 American Society of Colon and Rectal Surgeons Annual Scientific Meeting. Cleveland, OH: The American Society of Colon and Rectal Surgeons,.
- Rosen, P. L., Gross, D., Biggs, C., Chung, P., & Talus, H. (2018, Spring). Opioids and intussusception: A case report of mega intussusception (160 cm) twelve years after a laparoscopic Roux-en-Y gastric bypass in a methadone user. The American Society of Colon and Rectal Surgeons, 2018 ASCRS Annual Scientific Meeting. Nashville, TN: The American Society of Colon and Rectal Surgeons,.
- Rosen, P. L., Shraga, S., Silverstein, B., Gross, D. J., Zayko, O., & Schwartz, T. (2018, Spring). Perianal abscesses in the inner city safety net hospital: Should we anticipate methicillin-resistant Staphylococcus aureus (MRSA)?. SUNY Downstate Annual Research Day. Brooklyn, NY.
- Pfeil, D., Plaut, J., Dabski, M., Rosen, P., & Worah, S. (2017, Fall). Asynchronous independent lung ventilation in a patient with tracheoesophageal fistula. NY State Conference for Anesthesiology Residents and Fellows. New York, NY.
- Rosen, P. (2017, Fall). Laparoscopic surgery for rectal prolapse: Short-term outcomes should not dictate the approach. New York Surgical Society, Scientific Session and Dinner. New York, NY.
- Gallesio, J., Rosen, P. L., Holena, D., Sarani, B., Sims, C., Enberg, J., & Pascual, J. (2012, Spring). Damage control ICU resuscitation: Concrete advantages in using hypertonic saline. 13th European Congress of Trauma & Emergency Surgery. Basel, Switzerland.
- Pascual, J., Rosen, P. L., Horan, A., Sarani, B., Sims, C., & Schwab, C. (2010, Summer). Hypertonic fluids in SICU shock patients reduces fluid and oxygen requirements. 33rd Annual Conference on Shock. Portland, OR: Shock Society.