Rabail Chaudhry

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Scholarly Contributions

Journals/Publications

• Khan, M. S., Zarmer, L. F., Liang, J., Saroukhani, S., Lucas, A. R., McCartney, C. J., & Chaudhry, R. (2025). Evaluating multiplicity reporting in analgesic clinical trials: An analytical review. European journal of pain (London, England), 29(1), e4756.
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  Analgesia trials often demands multiple comparisons to assess various treatment arms, outcomes, or repeated assessments. These multiple comparisons risk inflating the false positive rate. Multiplicity correction in recent analgesic randomized controlled trials (RCTs) remains unclear despite statistical method advancements and regulatory guidelines. Our study aimed to identify reporting inadequacies in multiple analysis adjustments and explanations to understand these deficiencies.
• Chaudhry, R. A., Zarmer, L., West, K., & Chung, F. (2024). Obstructive Sleep Apnea and Risk of Postoperative Complications after Non-Cardiac Surgery. Journal of clinical medicine, 13(9).
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  Obstructive sleep apnea (OSA), a common sleep disorder, poses significant challenges in perioperative management due to its complexity and multifactorial nature. With a global prevalence of approximately 22.6%, OSA often remains undiagnosed, and increases the risk of cardiac and respiratory postoperative complications. Preoperative screening has become essential in many institutions to identify patients at increased risk, and experts recommend proceeding with surgery in the absence of severe symptoms, albeit with heightened postoperative monitoring. Anesthetic and sedative agents exacerbate upper airway collapsibility and depress central respiratory activity, complicating intraoperative management, especially with neuromuscular blockade use. Additionally, OSA patients are particularly prone to opioid-induced respiratory depression, given their increased sensitivity to opioids and heightened pain perception. Thus, regional anesthesia and multimodal analgesia are strongly advocated to reduce perioperative complication risks. Postoperative care for OSA patients necessitates vigilant monitoring and tailored management strategies, such as supplemental oxygen and Positive Airway Pressure therapy, to minimize cardiorespiratory complications. Health care institutions are increasingly focusing on enhanced monitoring and resource allocation for patient safety. However, the rising prevalence of OSA, heterogeneity in disease severity, and lack of evidence for the efficacy of costly perioperative measures pose challenges. The development of effective screening and monitoring algorithms, alongside reliable risk predictors, is crucial for identifying OSA patients needing extended postoperative care. This review emphasizes a multidimensional approach in managing OSA patients throughout the perioperative period, aiming to optimize patient outcomes and minimize adverse outcomes.
• Ford, P., Cheung, A. R., Khan, M. S., Rollo, G., Paidy, S., Hutchinson, M., & Chaudhry, R. (2024). Anesthetic Techniques for Ablation in Atrial Fibrillation: A Comparative Review. Journal of cardiothoracic and vascular anesthesia, 38(11), 2754-2760.
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  Atrial fibrillation, the most prevalent cardiac arrhythmia, has witnessed significant advancements in treatment modalities, transitioning from invasive procedures like the maze procedure to minimally invasive catheter ablation techniques. This review focuses on recent improvements in anesthetic approaches that enhance outcomes in catheter atrial fibrillation ablation. We highlight the efficacy of contact force sensing catheters with steerable introducer sheaths, which outperform traditional catheters by ensuring more effective contact time and lesion formation. Comparing general anesthesia with conscious sedation, we find that general anesthesia provides superior catheter stability due to reduced respiratory variability, resulting in more effective lesion formation, and reduced pulmonary vein reconnection. The use of high-frequency jet ventilation under general anesthesia, delivering low tidal volumes, effectively minimizes left atrial movement, decreasing catheter displacement and procedure time, and reducing recurrence in paroxysmal atrial fibrillation. An alternative, high-frequency low tidal volume ventilation using conventional ventilators, also shows improved catheter stability and lesion durability compared to traditional ventilation methods. However, a detailed comparative study of high-frequency jet ventilation, high-frequency low tidal volume ventilation, and conventional mechanical ventilation in catheter ablation for atrial fibrillation is lacking. This review emphasizes the need for such studies to identify optimal anesthetic techniques, potentially enhancing patient outcomes in atrial fibrillation treatment. Our findings suggest that careful selection of anesthetic methods, including ventilation strategies, plays a crucial role in the success of catheter ablation for atrial fibrillation, warranting further research for evidence-based practice.

Presentations

• Chaudhry, R., Anthony, L., Sehra, R., J, L., Gabrielle, B., & Sana, R. (2024, May). Evaluating Pain Management in Anterior Rib Fractures: A Retrospective Comparison of ESP and PVB Blocks. Western Anesthesia Resident Conference. Irvine, CA: Western Anesthesia Resident Conference.
• Chaudhry, R., M, K., T, M., H, H., S, S., & B, J. (2024, May). Racial Based Disparities in Timeliness of Life Saving Interventions and Discharge Disposition Among Severe Trauma Patients. International Anesthesia Research Society. Seattle, WA: IARS.