Sejal V Jain
- Associate Professor, Neurology - (Clinical Scholar Track)
- B.J. Medical College, Ahmedabad, India
- University of Arizona, College of Medicine (2016 - Ongoing)
- Cincinnati Children's Hospital Medical Center (2015)
- Cincinnati Children's Hospital Medical Center (2014 - 2015)
- Cincinnati Children's Hospital Medical Center (2012 - 2015)
- Cincinnati Children's Hospital Medical Center (2012 - 2015)
- Cincinnati Children's Hospital Medical Center (2010 - 2015)
- Cincinnati Children's Hospital Medical Center (2008 - 2015)
Licensure & Certification
- Neurology with Special Qualification in Child Neurology, ABPN, ABPN (2008)
- Sleep Medicine, ABPN (2011)
- Clinical Neurophysiology, ABPN (2009)
- Epilepsy, ABPN (2014)
No activities entered.
Pediatric NeurologyNEUR 850G (Spring 2017)
- Jain, S. (2017). Disorders of excessive sleepiness. In Swaiman KF, et al. Swaiman’s Pediatric Neurology: Principles and Practice, 6th edition. Elsevier Health Sciences, London, UK.
- Jain, S. (2017). Nocturnal Paroxysmal Disorders. In Swaiman KF, et al. Swaiman’s Pediatric Neurology: Principles and Practice, 6th edition. Elsevier Health Sciences, London, UK.
- Jain, S. (2017). Epilepsy and Sleep in Adolescents. In Sleep Disorders in Adolescents: A Clinical Casebook. Springer Publishing.
- Jain, S. (2017). Epilepsy and Sleep. In Pediatric Epilepsy, Diagnosis and Treatment. Demos Medical Publishing, New York.
- Jain, S. (2017). Sleep and Epilepsy. In Sleep disorders in Children. Springer International Publishing Switzerland.
- Martin, L. F., Patwardhan, A. M., Jain, S. V., Salloum, M. M., Freeman, J., Khanna, R., Gannala, P., Goel, V., Jones-MacFarland, F. N., Killgore, W. D., Porreca, F., & Ibrahim, M. M. (2020). Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial. Cephalalgia : an international journal of headache, 333102420956711.More infoPharmacological management of migraine can be ineffective for some patients. We previously demonstrated that exposure to green light resulted in antinociception and reversal of thermal and mechanical hypersensitivity in rodent pain models. Given the safety of green light emitting diodes, we evaluated green light as a potential therapy in patients with episodic or chronic migraine.
- Martin, L., Porreca, F., Mata, E. I., Salloum, M., Goel, V., Gunnala, P., Killgore, W. D., Jain, S., Jones-MacFarland, F. N., Khanna, R., Patwardhan, A., & Ibrahim, M. M. (2020). Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial. Pain medicine (Malden, Mass.).More infoFibromyalgia is a functional pain disorder in which patients suffer from widespread pain and poor quality of life. Fibromyalgia pain and its impact on quality of life are not effectively managed with current therapeutics. Previously, in a preclinical rat study, we demonstrated that exposure to green light-emitting diodes (GLED) for 8 hours/day for 5 days resulted in antinociception and reversal of thermal and mechanical hypersensitivity associated with models of injury-related pain. Given the safety of GLED and the ease of its use, our objective is to administer GLED as a potential therapy to patients with fibromyalgia.
- Gurbani, N., Dye, T. J., Dougherty, K., Jain, S., Horn, P. S., & Simakajornboon, N. (2019). Improvement of Parasomnias After Treatment of Restless Leg Syndrome/ Periodic Limb Movement Disorder in Children. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 15(5), 743-748.More infoPrevious studies have shown that non-rapid eye movement (NREM) sleep parasomnias commonly coexist with restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) in children, leading to speculation that RLS/PLMD may precipitate or worsen parasomnias. However, there are limited data about the effect of the treatment of RLS/PLMD on parasomnias in children. Hence, we performed this study to determine whether the treatment of RLS/PLMD with oral iron therapy is associated with improvement of parasomnias in children.
- Jain, S. V., Dye, T., & Kedia, P. (2018). Value of combined video EEG and polysomnography in clinical management of children with epilepsy and daytime or nocturnal spells. Seizure, 65, 1-5.More infoSleep disorders are common in epilepsy. Additionally, events of staring, jerking, or nocturnal behaviors are common presentations in neurology or sleep practice. Moreover, sleepiness and nocturnal awakenings are common symptoms in children with epilepsy and differentiation form ongoing seizures and sleep disorders is needed. However, limited data exist for the best evaluation methods. This study evaluated the usefulness of combined video electroencephalography (EEG) and polysomnography (PSG) studies (vEEG/PSG).
- Arya, R., Leach, J. L., Horn, P. S., Greiner, H. M., Gelfand, M., Byars, A. W., Arthur, T. M., Tenney, J. R., Jain, S. V., Rozhkov, L., Fujiwara, H., Rose, D. F., Mangano, F. T., & Holland, K. D. (2016). Clinical factors predict surgical outcomes in pediatric MRI-negative drug-resistant epilepsy. Seizure, 41, 56-61.More infoLack of a potentially epileptogenic lesion on brain magnetic resonance imaging (MRI) is a poor prognostic marker for epilepsy surgery. We present a single-center series of childhood-onset MRI-negative drug-resistant epilepsy (DRE) and analyze surgical outcomes and predictors.
- Dye, T. J., Jain, S. V., & Simakajornboon, N. (2016). Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD). Sleep medicine.More infoRestless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are thought to center around a genetically mediated sensitivity to iron insufficiency. Previous studies have shown the effectiveness of short-term iron therapy in children with low iron storage. Little is known, however, about long-term iron treatment in children with RLS and PLMD. Therefore, we performed this study to assess the long-term effect of iron therapy in children with RLS and PLMD.
- Greiner, H. M., Horn, P. S., Tenney, J. R., Arya, R., Jain, S. V., Holland, K. D., Leach, J. L., Miles, L., Rose, D. F., Fujiwara, H., & Mangano, F. T. (2016). Preresection intraoperative electrocorticography (ECoG) abnormalities predict seizure-onset zone and outcome in pediatric epilepsy surgery. Epilepsia, 57(4), 582-9.More infoThe predictive value of intraoperative electrocorticography (ECoG) in pediatric epilepsy surgery is unknown. In a population of children undergoing ECoG followed typically by invasive extraoperative monitoring (IEM) and resection, we aimed to determine the relationship between frequent ECoG abnormalities and the seizure onset zone and outcome after resection.
- Greiner, H. M., Horn, P. S., Tenney, J. R., Arya, R., Jain, S. V., Holland, K. D., Leach, J. L., Miles, L., Rose, D. F., Fujiwara, H., & Mangano, F. T. (2016). Should spikes on post-resection ECoG guide pediatric epilepsy surgery?. Epilepsy research, 122, 73-8.More infoThere is wide variation in clinical practice regarding the role of electrocorticography immediately after resection (post-resection ECoG) for pediatric epilepsy surgery. Results can guide further resection of potentially epileptogenic tissue. We hypothesized that post-resection ECoG spiking represents a biomarker of the epileptogenic zone and predicts seizure outcome in children undergoing epilepsy surgery.
- Dye, T. J., Jain, S. V., & Kothare, S. V. (2015). Central Hypersomnia. Seminars in pediatric neurology, 22(2), 93-104.More infoSleepiness is not uncommon in the pediatric population. Although the etiology can be multifactorial, sleepiness due to increased sleep drive, also called central hypersomnia, is a common cause. The third edition of the International Classification of Sleep Disorders updated the diagnostic criteria for several of the central disorders of hypersomnolence, most notably narcolepsy. Although the International Classification Of Sleep Disorders-3 is not specific to pediatric patients, the peak incidence for many of the included disorders occurs during childhood or adolescence. As a result, recognition of these lifelong and potentially debilitating disorders is imperative for providers who evaluate pediatric patients. This review provides an update on recent advances in the field and highlights some of the diagnostic dilemmas, unique clinical features, and variable presentations associated with central disorders of hypersomnolence within the pediatric population.
- Jain, S. V., & Kothare, S. V. (2015). Sleep and Epilepsy. Seminars in pediatric neurology, 22(2), 86-92.More infoSleep and epilepsy are common bedfellows. Sleep can affect frequency and occurrence of interictal spikes and occurrence, timing, and threshold of seizure. Epilepsy can worsen sleep architecture and severity of sleep disorders. Thus, a vicious cycle is set. Certain epilepsy syndromes are so intertwined with sleep that they are considered sleep-related epilepsies. Poor sleep in epilepsy is multifactorial and is worsened by poorly controlled seizures. On the contrary, poor sleep is associated with worsened quality of life, psychological function, and memory. Improving sleep has been noted to improve seizure frequency and an overall well-being in patients with epilepsy. Hence, an emphasis should be given to address sleep in patients with epilepsy. These interactions are discussed in detail in this review.
- Jain, S. V., Horn, P. S., Simakajornboon, N., Beebe, D. W., Holland, K., Byars, A. W., & Glauser, T. A. (2015). Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study. Sleep medicine, 16(5), 637-44.More infoInsomnia, especially maintenance insomnia, is widely prevalent in epilepsy. Although melatonin is commonly used, limited data address its efficacy. We performed a randomized, double-blind, placebo-controlled, crossover study to identify the effects of melatonin on sleep and seizure control in children with epilepsy.
- Jain, S. V., & Glauser, T. A. (2014). Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia, 55(1), 26-37.More infoSleep is considered restorative, and good quantity and quality sleep is required for memory consolidation and synaptic plasticity. Sleep disorders are common in patients with epilepsy. Poor sleep quality or quantity may worsen seizure control. On the other end, seizures and epilepsy may worsen the sleep quality and set a vicious cycle. In addition, antiepileptic drugs have an effect on sleep architecture. We performed a systemic literature review with a goal to evaluate the effect of antiepileptic drugs and nondrug treatments for epilepsy on sleep architecture to help better understand treatment effects, especially in patients with epilepsy and sleep problems.
- Jain, S. V., & Glauser, T. A. (2014). In response: Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia, 55(5), 778.
- Jain, S. V., Simakajornboon, N., & Arthur, T. M. (2014). Central sleep apnea: does stabilizing sleep improve it?. Journal of child neurology, 29(1), 96-8.More infoCentral sleep apnea is not uncommon in children with neurologic disorders. The mechanisms include increased ventilatory chemosensitivity to carbon dioxide level. Conventional treatments include oxygen, noninvasive ventilation, and in patients with heart failure, improving cardiac output. Here, we present a case of a 9-year-old male with Angelman syndrome, epilepsy, insomnia, and central sleep apnea. The patient was initially evaluated for nighttime awakenings and pauses in breathing. Sustained-release melatonin was used to improve his nighttime awakenings. A polysomnography confirmed central sleep apnea. We saw a reduction in arousals and improvement in insomnia with sustained-release melatonin. On a repeat study, central sleep apnea was improved. We hypothesize that sustained-release melatonin, by improving sleep continuity and reducing arousals, might improve central sleep apnea. Studies are needed to test the hypothesis.
- Tenney, J. R., & Jain, S. V. (2014). Absence Epilepsy: Older vs Newer AEDs. Current treatment options in neurology, 16(5), 290.More infoOver the last one to two decades, several new antiepileptic drugs (AEDs) have become available. These medications have different mechanisms of action, metabolism, efficacy, and side effect profiles. Hence, it has become possible to customize medications for a particular patient. It has also become possible to use various combinations of treatments for refractory epilepsies. As medication options have increased, our goal has shifted to not only to maximize seizure control but also to minimize side effects. However, the older AEDs are still widely used. So the question arises-are newer medications better than older AEDs for the treatment of absence epilepsy? Based on a large multicenter class I study, older AEDs-ethosuximide and valproic acid-are more efficacious than newer AEDs. Due to reduced side effects, ethosuximide remains the first line treatment for childhood absence epilepsy.
- Jain, S. V., Horn, P. S., Simakajornboon, N., & Glauser, T. A. (2013). Obstructive sleep apnea and primary snoring in children with epilepsy. Journal of child neurology, 28(1), 77-82.More infoSleep-related breathing disruptions in children with epilepsy are common and can range from primary snoring to obstructive sleep apnea. Untreated obstructive sleep apnea can lead to significant morbidity. This study aimed to identify factors associated with its occurrence and severity in children with epilepsy. Children with epilepsy and sleep disruption were evaluated with polysomnography and diagnosed with obstructive sleep apnea or primary snoring. Statistical analyses were done to identify differences within both the groups and among the subjects in the obstructive sleep apnea group. Uncontrolled epilepsy was a risk factor for obstructive sleep apnea (80%) compared with primary snoring (47%, P = .02). Obstructive index increased with increasing number of antiepileptic drugs. In children with epilepsy and disturbed sleep, obstructive sleep apnea is associated with uncontrolled epilepsy and is more severe with polytherapy use. Children with uncontrolled seizures on antiepileptic polytherapy should be routinely screened for obstructive sleep apnea.
- Jain, S. V., Simakajornboon, N., & Glauser, T. A. (2013). Provider practices impact adequate diagnosis of sleep disorders in children with epilepsy. Journal of child neurology, 28(5), 589-95.More infoSleep disorders significantly affect the lives of children with epilepsy. Limited data exist about provider practices concerning detection and correct diagnosis of sleep problems in epilepsy. The authors conducted this study to identify and correlate sleep screening methods, referral practices, referral reasons and final sleep diagnoses. They identified that 94% of the providers who had referred patients to the sleep center of a major children's hospital used routine screening and 70% of them used 2 to 3 screening questions. This method, however, underidentified the patients at risk for sleep disorders. Moreover, in 40% of the children, sleep disorder was incorrectly anticipated, based on the initial symptoms. Of these children, 10% had no sleep disorder and 30% had unexpected sleep disorder. The authors conclude that better screening methods should be used for sleep disorders. Once identified, these patients should have formal sleep evaluation and management. Further studies are needed to develop screening questionnaires.
- Natarajan, N., Jain, S. V., Chaudhry, H., Hallinan, B. E., & Simakajornboon, N. (2013). Narcolepsy-cataplexy: is streptococcal infection a trigger?. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 9(3), 269-70.More infoNarcolepsy-cataplexy is an uncommon sleep disorder which may present in childhood. We report a case of an 8-year-old presenting with narcolepsy-cataplexy following a streptococcal infection. Autoimmune etiology for narcolepsy has been suggested. In our patient increased anti-streptolysin O and anti-DNAse B titers were noted. As suggested by recent cases, the streptococcal infection was likely a trigger for narcolepsy onset in this genetically predisposed child. The patient was initially diagnosed as having Sydenham chorea due to motor movements. However, these transient movements may be due to the narcolepsy onset. Narcolepsy in childhood may present with atypical symptoms; it might be difficult to obtain accurate history and can be misdiagnosed as in the reported case. A high index of clinical suspicion is needed to diagnose these patients.
- Fujiwara, H., Greiner, H. M., Hemasilpin, N., Lee, K. H., Holland-Bouley, K., Arthur, T., Morita, D., Jain, S. V., Mangano, F. T., Degrauw, T., & Rose, D. F. (2012). Ictal MEG onset source localization compared to intracranial EEG and outcome: improved epilepsy presurgical evaluation in pediatrics. Epilepsy research, 99(3), 214-24.More infoMagnetoencephalography (MEG) has been shown a useful diagnostic tool for presurgical evaluation of pediatric medically intractable partial epilepsy as MEG source localization has been shown to improve the likelihood of seizure onset zone (SOZ) sampling during subsequent evaluation with intracranial EEG (ICEEG). We investigated whether ictal MEG onset source localization further improves results of interictal MEG in defining the SOZ.
- Jain, S. V., Simakajornboon, S., Shapiro, S. M., Morton, L. D., Leszczyszyn, D. J., & Simakajornboon, N. (2012). Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta neurologica Scandinavica, 125(1), e3-6.More infoObstructive sleep apnea (OSA) is prevalent in adults with epilepsy, especially refractory, but limited data exist in children with epilepsy.
- Jain, S. V., & Morton, L. D. (2008). Ischemic stroke and excellent recovery after administration of intravenous tissue plasminogen activator. Pediatric neurology, 38(2), 126-9.More infoIntravenous tissue plasminogen activator has become a mainstream treatment for ischemic hyperacute stroke in the adult population. Its safety and efficacy remain undetermined in the pediatric population. We present a teenager who was hospitalized with left-sided paralysis, and with decreased sensations on the left side. Head computed tomography indicated hyperdensity in the middle cerebral artery region, which confirmed the diagnosis of acute ischemic stroke. Her score on the National Institutes of Health stroke scale was 11. She received intravenous tissue plasminogen activator without any complications. At a follow-up visit 5 months after the stroke, the patient manifested mild apraxia in her left hand and mild expressive amusia. This case underscores the need for emergency head imaging in the pediatric population to establish a diagnosis. The excellent recovery in our patient indicates the need to establish thrombolytic treatment as an option for acute stroke in pediatric populations. It also suggests that tissue plasminogen activator can be used safely and effectively, even in pediatric populations. However, further studies are needed to establish the adequate dosage and adverse-effect profile in pediatric populations.
- Moskowitz, A., Kondapalli, K., Parthasarathy, S., Combs, D. A., & Jain, S. (2020, August). Sleep Education Improves Screening for Sleep Disorders among Physicians and Residents in Primary Care and Neurology Specialties. 2020 meeting of the Associated Professional Sleep Societies.
- Vo, A., & Jain, S. V. (2019, april). Screening for sleep disorders improves outcomes in children with epilepsy.. American Academy of neurology annual meeting, Philadelphia 2019.More infoPoster presentation
- yang, y., & Jain, S. V. (2018, april). Treatment of obstructive sleep apnea improves pain perception.. American Society of Regional Anesthesia and Pain Medicine, Annual Meeting, April 2018.
- Jain, S. (2017, Feb). Source Localization of Ictal Onset with Dense Array EEG in Presurgical Pediatric Epilepsy. American Clinical Neurophysiology Society (ACNS) Annual Meeting, Phoenix, AZ. Feb 2017.
- Rose, D., H, F., H, G. M., J, T., K, H., F, M. T., & Jain, S. V. (2017, Feb). Source Localization of Ictal Onset with Dense Array EEG in Presurgical Pediatric Epilepsy.. American Clinical Neurophysiology Society (ACNS) Annual Meeting, Phoenix, AZ..
- Jain, S. V. (2016, Feb). Usefulness of sleep evaluation and combined video EEG and polysomnography in children with presentation of events or epilepsy.. American Clinical Neurophysiology Society (ACNS) Annual Meeting. Orlando, FL. Feb 2016.
- Jain, S. V., & Vannest, j. (2016, Feb). EEG spikes are associated with sleep architecture in children with epilepsy.. American Clinical Neurophysiology Society (ACNS) Annual Meeting, Orlando, FL. Feb 2016.