Sunil K Sinha

Interests

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Courses

Scholarly Contributions

Chapters

• Sinha, S. (2020). Diabetes Mellitus in Children and Adolescents. In Chronic Disease and Disability: The Pediatric Liver(pp 33-49). Nova Science Publishers, Inc.

Journals/Publications

• Raissouni, N., Kolesnikov, A., Purushothaman, R., Sinha, S., Bhandari, S., Bhangoo, A., Malik, S., Baillargeon, J., Hernandez, M. I., Rosenbaum, M., Ten, S., Mathew, R. P., & Geller, D. H. (2012). Altered glucose disposition and insulin sensitivity in peri-pubertal first-degree relatives of women with polycystic ovary syndrome.. International journal of pediatric endocrinology, 2012(1), 14. doi:10.1186/1687-9856-2012-14
  More info

  First-degree relatives (FDRs) of women with PCOS are at increased risk for impaired insulin sensitivity and diabetes mellitus. Glucose tolerant FDR have evidence of insulin resistance and hyperinsulinemia prior to emergence of frank PCOS..To study insulin dynamics parameters in the early adolescent FDR of women with PCOS..This is a cross-sectional study involving 18 adolescents whose mothers or sisters had been diagnosed with PCOS and 21 healthy, age-matched control adolescents without FDR. Subjects underwent anthropometric measurements, steroid profiling and frequently sampled Intravenous Glucose Tolerance Test (IVGTT), Homeostasis Model Assessment (HOMA) index, Glucose Disposal Index (GDI), Acute Insulin Response (AIR) and Quantitative insulin sensitivity check index (QUICKI) were derived from IVGTT results..FDRs showed significantly higher mean HOMA and lower GDI. There were no differences in mean age or BMI Z-score between the cohorts. No differences in sex steroids or AIR were identified between groups..Female adolescent FDR of women with PCOS have higher HOMA index and lower QUICKI, reflecting altered insulin sensitivity and lower GDI reflecting poorer beta-cell function. The presence of multiple risk factors for type 2 diabetes suggests that aggressive screening of the early adolescent FDR of women with PCOS is indicated.

Poster Presentations

• Sinha, S. (2019, October). Continuous glucose monitoring and continuous insulin infusion via pump decrease diabetes related distress (DRD) and depression screening score in adolescents with type 1 diabetes.. 45th Annual ISPAD Conference. Boston, USA: ISPAD.