Thomas Ardiles

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Journals/Publications

• Ardiles, T., & Dark, D. (2007). Pulmonary complications of sickle cell disease in adults. Missouri medicine, 104(3), 250-4.
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  Acute and chronic pulmonary complications are a very important cause of morbidity and mortality in sickle cell disease. The Acute Chest Syndrome (ACS) is the most common form of acute pulmonary disease and will be reviewed in this article. Early recognition and aggressive treatment of ACS are important for successful management. The development of pulmonary hypertension is a very important cause of chronic pulmonary disease and contributes to mortality. Because of the increased numbers of sickle cell patients living to adulthood, it is important for primary care providers to become familiar with these complications.
• Wilke, E., Ardiles, T., & Carlson, R. W. (2005). A case of coccidioidal fungemia initially diagnosed as rhinosporidiosis. Heart & lung : the journal of critical care, 34(3), 217-21.
• Wu, Y., Chhaya, S., Hurowitz, B., Ardiles, T., & Carlson, R. (2015). Clinically Amyopathic Dermatomyositis Complicated by Pleural Effusion Case Report, Literature Review, and Proposed Mechanism. Bulletin of the Hospital for Joint Disease (2013), 73(3), 217-20.
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  Polymyositis-dermatomyositis (PM-DM) is a chronic inflammatory disorder that mainly involves muscles and skin. Clinically amyopathic dermatomyositis (CADM) is a unique subset of PM-DM with typical skin manifestations but little or no evidence of musculoskeletal involvement. Many cases of dermatomyositis and CADM are associated with internal malignancy, but pulmonary manifestations can also been seen; the most common of which is interstitial lung disease. Pleural effusion is a rare complication and may be difficult to differentiate from other causes, such as infections, heart failure, or malignancy. We report a patient with CADM complicated by rapidly progressive pleural effusions. Based on findings of this patient, as well as literature review, we suggest that the etiology of massive pleural effusion in this setting is most likely related to local immune pleuritis associated with underlying interstitial lung disease due to dermatomyositis. Optimal management should be individualized and may include immunosuppressive agents, as well as antimicrobials, and potentially other agents.
• Kashani, K., Al-Khafaji, A., Ardiles, T., Artigas, A., Bagshaw, S. M., Bell, M., Bihorac, A., Birkhahn, R., Cely, C. M., Chawla, L. S., Davison, D. L., Feldkamp, T., Forni, L. G., Gong, M. N., Gunnerson, K. J., Haase, M., Hackett, J., Honore, P. M., Hoste, E. A., , Joannes-Boyau, O., et al. (2013). Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Critical care (London, England), 17(1), R25.
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  Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying early markers of kidney damage has been difficult due to the complex nature of human AKI, in which multiple etiologies exist. The objective of this study was to identify and validate novel biomarkers of AKI.