Tracy E Crane

Interests

Teaching

Health Promotion TheoryeHealth Solutions for ResearchDissemination and Implementation ScienceInterventions for improving Lifestyle Behaviors

Research

Lifestyle behavior modification, cancer survivors, symptom management, ehealth solutions, diet, physical activity, tobacco cessation, sleep, informal caregivers

Courses

Scholarly Contributions

Chapters

• Crane, T. E., & Thomson, C. A. (2017). Biomarkers of Diet and Nutritional Health. In Biological Measures of Human Experience. Springer.

Journals/Publications

• Skiba, M. B., McElfresh, J. J., Howe, C. L., Crane, T. E., Kopp, L. M., Jacobs, E. T., & Thomson, C. A. (2020). Dietary Interventions for Adult Survivors of Adolescent and Young Adult Cancers: A Systematic Review and Narrative Synthesis. Journal of adolescent and young adult oncology.
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  Adolescent and young adult (AYA) cancer survivors, here defined as individuals diagnosed with cancer between 15 and 39 years of age, are at high risk for adverse late-term metabolic effects of treatment through adulthood. Diet is a modifiable lifestyle behavior that may improve metabolic health outcomes in AYA cancer survivors. However, the details of dietary interventions for this unique population remain largely undescribed. In this systematic review, we aim to synthesize the results of dietary interventions for adult AYA cancer survivors. Seven databases and clinical trial registries were searched in March 2019 for interventions targeting dietary behaviors in AYA cancer survivors (PROPSERO systematic review number: CRD42019126376). Descriptive statistics and a narrative synthesis were completed to detail intervention participants and components. After full text review of 233 studies, four studies met all inclusion criteria. All studies were heterogeneous for participant age, cancer type, and duration, and were designed for feasibility and preliminary efficacy. Included studies followed different dietary guidance; however, each resulted in a significant change on a primary outcome of either dietary quality or body composition. Three of the four studies included a theoretical framework, where self-efficacy was a central construct. Counseling, in person, telephone, or electronic, provided behavioral support. Results of this systematic review suggest high potential to change dietary behaviors in AYA, but interventions remain limited. AYA cancer survivors demonstrate unique physiological and psychosocial needs, and future interventions designed to address this care gap should be targeted for this population with consideration of social support, delivery mode, and individual tailoring.
• Thomson, C. A., Sarto, G. E., Kroenke, C. H., Datta, M., Snetselaar, L., Hatsu, I. E., Santiago-Torres, M., Shivappa, N., Steck, S. E., Hebert, H. R., Kohler, L. N., Wertheim, B. C., Garcia, D. O., Crane, T. E., & Lopez-Pentecost, M. (2020). Role of dietary patterns and acculturation in cancer risk and mortality among postmenopausal Hispanic women: results from the Women’s Health Initiative (WHI). J Public Health. doi:https://doi.org/10.1007/s10389-020-01342-8
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  Lopez-Pentecost M, Crane TE, Garcia DO, Wertheim, BC, Kohler LN, Hebert HR, Steck SE, Shivappa N, Santiago-Torres M, Neuhouser ML, Hatsu IE, Snetselaar L, Datta M, Kroenke CH, Sarto GE, Thomson CA. Role of dietary patterns and acculturation in cancer risk and mortality among postmenopausal Hispanic women: results from the Women’s Health Initiative (WHI). J Public Health
• Bell, M. L., Collins, B. N., Krupski, L. A., Crane, T. E., Nair, U. S., & Yuan, N. P. (2019). Impact of Changes in Home Smoking Bans on Tobacco Cessation among Quitline Callers. Health Education Research.
• Brady, B. R., Crane, T. E., O'Connor, P. A., Nair, U. S., & Yuan, N. P. (2019). E-Cigarette Use and Smoking Cessation in a State-Based Quitline. Journal of Smoking Cessation.
• Brady, B. R., Crane, T. E., O'Connor, P. A., Nair, U. S., & Yuan, N. P. (2019). Electronic Cigarette Use and Smoking Cessation in a State-Based Quitline. Journal of Smoking Cessation, 14(3), 176-185. doi:https://doi.org/10.1017/jsc.2019.2
• Crane, T. E., Badger, T. A., Sikorskii, A., Segrin, C., Hsu, C. H., & Rosenfeld, A. G. (2019). Trajectories of Depression and Anxiety in Latina Breast Cancer Survivors. Oncology nursing forum, 46(2), 217-227.
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  To identify subgroups of Latina breast cancer survivors with unique trajectories of depression and anxiety and examine predictors associated with these subgroups.
• Crane, T. E., Latif, Y. A., Wertheim, B. C., Kohler, L. N., Garcia, D. O., Rhee, J. J., Seguin, R., Kazlauskaite, R., Shikany, J. M., & Thomson, C. A. (2019). Does Season of Reported Dietary Intake Influence Diet Quality? Analysis From the Women's Health Initiative. American journal of epidemiology, 188(7), 1304-1310.
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  We evaluated the role of seasonality in self-reported diet quality among postmenopausal women participating in the Women's Health Initiative (WHI). A total of 156,911 women completed a food frequency questionnaire (FFQ) at enrollment (1993-1998). FFQ responses reflected intake over the prior 3-month period, and seasons were defined as spring (March-May), summer (June-August), fall (September-November), and winter (December-February). FFQ data were used to calculate the Alternate Healthy Eating Index (AHEI), a measure of diet quality that has a score range of 2.5-87.5, with higher scores representing better diet quality. In multivariable linear regression models using winter as the reference season, AHEI scores were higher in spring, summer, and fall (all P values < 0.05); although significant, the variance was minimal (mean AHEI score: winter, 41.7 (standard deviation, 11.3); summer, 42.2 (standard deviation, 11.3)). Applying these findings to hypothesis-driven association analysis of diet quality and its relationship with chronic disease risk (cardiovascular disease) showed that controlling for season had no effect on the estimated hazard ratios. Although significant differences in diet quality across seasons can be detected in this population of US postmenopausal women, these differences are not substantial enough to warrant consideration in association studies of diet quality.
• Creasy, S. A., Crane, T. E., Garcia, D. O., Thomson, C. A., Kohler, L. N., Wertheim, B. C., Baker, L. D., Coday, M., Hale, L., Womack, C. R., Wright, K. P., & Melanson, E. L. (2019). Higher amounts of sedentary time are associated with short sleep duration and poor sleep quality in postmenopausal women. Sleep, 42(7).
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  To evaluate the associations between sedentary time, total (total-PA), light (light-PA), moderate (MOD-PA), and vigorous (VIG-PA) physical activity with indices of sleep in postmenopausal women.
• Pace, T. W., Dodds, S. E., Sikorskii, A., Badger, T. A., Segrin, C., Negi, L. T., Harrison, T., & Crane, T. E. (2019). Cognitively-Based Compassion Training versus cancer health education to improve health-related quality of life in survivors of solid tumor cancers and their informal caregivers: study protocol for a randomized controlled pilot trial. Trials, 20(1), 247.
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  Cancer survivors and their informal caregivers (family members, close friends) often experience significant impairments in health-related quality of life (HRQOL), including disruptions in psychological, physical, social, and spiritual well-being both during and after primary cancer treatment. The purpose of this in-progress pilot trial is to determine acceptability and preliminary efficacy (as reflected by effect sizes) of CBCT® (Cognitively-Based Compassion Training) compared with a cancer health education (CHE) attention control to improve the primary outcome of depressive symptoms and secondary outcomes of other HRQOL domains (e.g., anxiety, fatigue), biomarkers of inflammation and diurnal cortisol rhythm, and healthcare utilization-related outcomes in both cancer survivors and informal caregivers.
• Skiba, M. B., Kohler, L. N., Crane, T. E., Jacobs, E. T., Shadyab, A. H., Kato, I., Snetselaar, L., Qi, L., & Thomson, C. A. (2019). The Association between Prebiotic Fiber Supplement Use and Colorectal Cancer Risk and Mortality in the Women's Health Initiative. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 28(11), 1884-1890.
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  Fiber-based prebiotic supplements are marketed for maintaining bowel health and promoting beneficial gut bacteria. However, the association between prebiotic supplement use and colorectal cancer risk and mortality is unknown.
• Yuan, N. P., Nair, U. S., Crane, T. E., Krupski, L., Collins, B. N., & Bell, M. L. (2019). Impact of changes in home smoking bans on tobacco cessation among quitline callers. Health education research, 34(3), 345-355.
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  Home smoking bans may be an effective way to promote tobacco cessation among treatment seeking smokers. Few studies have examined this relationship in a quitline setting. Data were obtained from 14,296 adults who were enrolled in a state quitline between January 2011 and July 2016. This study investigated whether cessation rates varied by changes in home smoking ban implementation between enrollment and 7-month follow-up. The impact of changes in home smoking bans on cessation at follow-up was significantly modified by having other smokers living in the home at follow-up (P < 0.0001). Among callers who did not live with other smokers in the home, the highest odds ratio of 30-day cessation was for callers who reported bans at follow-up only (OR = 10.50, 95%CI: 8.00, 13.70), followed by callers who reported bans at both enrollment and follow-up (OR = 8.02, 95%CI: 6.27, 10.30) and callers who reported bans at enrollment only (OR = 2.06, 95% CI: 1.47, 2.89) compared with callers with no home smoking bans. When callers reported that they lived with other smokers in the home, the effect of home smoking bans on cessation was much smaller. Quitlines should support the implementation of home smoking bans as a part of callers' goal setting activities to achieve tobacco cessation.
• Yuan, N. P., Nair, U. S., O'Connor, P. A., Crane, T. E., & Brady, B. R. (2019). E-Cigarette Use and Smoking Cessation in a State-Based Quitline. Journal of Smoking Cessation. doi:https://doi.org/10.1017/jsc.2019.2
• Arthur, R., Brasky, T. M., Crane, T. E., Felix, A. S., Kaunitz, A., Shadyab, A. H., Qi, L., Wassertheil-Smoller, S., & Rohan, T. E. (2018). A Healthy Lifestyle Index in Relation to Risk of Endometrial and Ovarian Cancer Among Women in the Women's Health Initiative Study. American journal of epidemiology.
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  Lifestyle-related factors influence risk of endometrial and ovarian cancers, but few studies have examined their joint associations with risk of these cancers. Using multivariable Cox regression models, we assessed the association of a healthy lifestyle index ((HLI) - a composite score (range 0-20) involving diet, alcohol consumption, physical activity, body mass index and smoking; higher scores represent healthier behavior) - with risk of endometrial and ovarian cancers among 108,136 postmenopausal women who were recruited in the Women's Health Initiative study between 1993 and 1998. After a median follow-up of 17.9 years, 1,435 endometrial cancer cases and 904 ovarian cancer cases had been ascertained. Women in the highest quintile of the HLI score had a lower risk of overall, Type I, well-differentiated, moderately differentiated, poorly differentiated, and localized endometrial cancer than those in the lowest quintile (HR≥q5 vs q1: 0.61 (95% CI: 0.51,0.72), 0.60 (0.49.0.72), 0.66 (0.46, 0.96), 0.69 (0.52,0.90), 0.49 (0.34,0.72) and 0.61 (0.50,0.74), respectively). The HLI score had a weak positive association with risk of serous ovarian cancer. Our findings underscore the potential importance of a healthy lifestyle in lowering endometrial cancer risk among postmenopausal women.
• Beverly, C. M., Naughton, M. J., Pennell, M. L., Foraker, R. E., Young, G., Hale, L., Feliciano, E. M., Pan, K., Crane, T. E., Danhauer, S. C., & Paskett, E. D. (2018). Change in longitudinal trends in sleep quality and duration following breast cancer diagnosis: results from the Women's Health Initiative. Nature Practice Journal breast cancer, 4, 15.
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  Breast cancer survivors frequently report sleep problems, but little research has studied sleep patterns longitudinally. We examined trends in sleep quality and duration up to 15 years before and 20 years after a diagnosis of breast cancer, over time among postmenopausal women participating in the Women's Health Initiative (WHI). We included 12,098 participants who developed invasive breast cancer after study enrollment. A linear mixed-effects model was used to determine whether the time trend in sleep quality, as measured by the WHI Insomnia Rating Scale (WHIIRS), a measure of perceived insomnia symptoms from the past 4 weeks, changed following a cancer diagnosis. To examine sleep duration, we fit a logistic regression model with random effects for both short (
• Kaplan, D. M., Palitsky, R., Carey, A. L., Crane, T. E., Havens, C. M., Medrano, M. R., Reznik, S. J., Sbarra, D. A., & O'Connor, M. F. (2018). Maladaptive repetitive thought as a transdiagnostic phenomenon and treatment target: An integrative review. Journal of clinical psychology.
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  Maladaptive repetitive thought (RT), the frequent and repetitive revisiting of thoughts or internal experiences, is associated with a range of psychopathological processes and disorders. We present a synthesis of prior research on maladaptive RT and develop a framework for elucidating and distinguishing between five forms of maladaptive RT.
• LoConte, N. K., Gershenwald, J. E., Thomson, C. A., Crane, T. E., Harmon, G. E., & Rechis, R. (2018). Lifestyle Modifications and Policy Implications for Primary and Secondary Cancer Prevention: Diet, Exercise, Sun Safety, and Alcohol Reduction. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 88-100.
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  Improved cancer treatments and cancer detection methods are not likely to completely eradicate the burden of cancer. Primary prevention of cancer is a logical strategy to use to control cancer while also seeking novel treatments and earlier detection. Lifestyle modification strategies to improve primary prevention and risk reduction for the development of cancer include choosing a healthy diet with an emphasis on plant sources, maintaining a healthy weight throughout life, being physically active, regularly using sunscreen and wearing protective clothing, limiting sun exposure during the hours of 10 AM to 2 PM, avoiding indoor tanning, and reducing or eliminating alcohol use. In addition to continued use of ongoing education of the public, health care providers, and cancer support communities, other policy and public health efforts should be pursued as well. Examples of supported and successful policy approaches are included in this article, including efforts to limit indoor tanning and improve community-wide interventions to reduce ultraviolet radiation exposure as well as to formally support various alcohol policy strategies including increasing alcohol taxes, reducing alcohol outlet density, improving clinical screening for alcohol use disorders, and limiting youth exposure to alcohol marketing and advertising. These prevention strategies are expected to have the largest impact on the development of melanoma as well as breast, colorectal, head and neck, liver, and esophageal cancers. The impact of these strategies as secondary prevention is less well understood. Areas of additional needed research and implementation are also highlighted. Future areas of needed research are the effects of these modifications after the diagnosis of cancer (as secondary prevention).
• Sikorskii, A., Wyatt, G. K., Victorson, D. E., O'Connor, P., Hankin, V., Safikhani, A., Crane, T. E., & Badger, T. A. (2017). Performance of PROMIS and legacy measures among advanced breast cancer patients and their cargivers. Medical Care.
• Sun, V., Crane, T. E., Slack, S. D., Yung, A., Wright, S., Sentovich, S., Melstrom, K., Fakih, M., Krouse, R. S., & Thomson, C. A. (2018). Rationale, development, and design of the Altering Intake, Managing Symptoms (AIMS) dietary intervention for bowel dysfunction in rectal cancer survivors. Contemporary clinical trials, 68, 61-66.
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  Bowel dysfunction is a common, persistent long-term effect of treatment for rectal cancer survivors. Survivors often use dietary modifications to maintain bowel control. There are few evidence-based interventions to guide survivors on appropriate diet modifications for bowel symptom management. The purpose of this paper is to describe the development and design of the Altering Intake, Managing Symptoms (AIMS) intervention to support bowel dysfunction management in rectal cancer survivors.
• Qi, L., Chlebowski, R., Leblanc, E., Rohan, T., Datta, M., Snetsellar, L., Hingle, M. D., Wertheim, B. C., Garcia, D. O., Crane, T. E., & Thomson, C. A. (2017). Association between dietary energy density and obesity-associated cancer: Results from the Women's Health Initiative. Journal of the Academy of Nutrition and Dietetics.
• Segrin, C., Badger, T. A., Sikorskii, A., Crane, T. E., & Pace, T. W. (2017). A dyadic analysis of stress processes in Latinas with breast cancer and their family caregivers. Psycho-oncology.
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  Breast cancer diagnosis and treatment negatively affect quality of life for survivors and their family caregivers. The stress process model has been useful for describing the cascade of social and psychological experiences that culminate in degraded quality of life for both survivors and their family caregivers. This study is designed to test theoretically specified predictors of negative psychosocial outcomes in a dyadic context.
• Thomson, C. A., Crane, T. E., Garcia, D. O., Wertheim, B. C., Hingle, M., Snetselaar, L., Datta, M., Rohan, T., LeBlanc, E., Chlebowski, R. T., & Qi, L. (2017). Association between Dietary Energy Density and Obesity-Associated Cancer: Results from the Women's Health Initiative. Journal of the Academy of Nutrition and Dietetics.
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  Dietary energy density (DED) is the ratio of energy (kilocalories or kilojoules) intake to food weight (grams) and is a measure of diet quality. Consumption of foods high in DED has been associated with weight gain in adults.
• Crane, T. E., & Thomson, C. A. (2016). Commentary on Trends in Obesity Prevalence in Adults With a History of Cancer: Results From the US National Health Interview Survey, 1997 to 2014. HemOnc Today.
• Phipps, A. I., Bhatti, P., Neuhouser, M. L., Chen, C., Crane, T. E., Kroenke, C. H., Ochs-Balcom, H., Rissling, M., Snively, B. M., Stefanick, M. L., Treggiari, M. M., & Watson, N. F. (2016). Pre-diagnostic Sleep Duration and Sleep Quality in Relation to Subsequent Cancer Survival. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 12(4), 495-503.
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  Poor sleep quality and short sleep duration have been associated with elevated risk for several cancer types; however, the relationship between sleep and cancer outcomes has not been well characterized. We assessed the association between pre-diagnostic sleep attributes and subsequent cancer survival within the Women's Health Initiative (WHI).
• Reeves, K. W., Tehranifar, P., Crane, T. E., Ko, L. K., Cameron, C., Hamilton, J. G., Lavigne, J. A., Reiter, P. L., & Thomson, C. A. (2016). Job Talks and Interviews: How to Stand Out and Fit In: A Report from the American Society of Preventive Oncology Junior Members Interest Group. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 25(1), 224-5.
• Thomson, C. A., Crane, T. E., Miller, A., Garcia, D. O., Basen-Engquist, K., & Alberts, D. S. (2016). A randomized trial of diet and physical activity in women treated for stage II-IV ovarian cancer: Rationale and design of the Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES): An NRG Oncology/Gynecologic Oncology Group (GOG-225) Study. Contemporary clinical trials, 49, 181-9.
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  Ovarian cancer is the most common cause of gynecological cancer death in United States women. Efforts to improve progression free survival (PFS) and quality of life (QoL) after treatment for ovarian cancer are necessary. Observational studies suggest that lifestyle behaviors, including diet and physical activity, are associated with lower mortality in this population. The Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES) NRG 0225 study is a randomized, controlled trial designed to test the hypothesis that a 24month lifestyle intervention will significantly increase PFS after oncological therapy for stage II-IV ovarian cancer. Women are randomized 1:1 to a high vegetable and fiber, low-fat diet with daily physical activity goals or an attention control group. Secondary outcomes to be evaluated include QoL and gastrointestinal health. Moreover an a priori lifestyle adherence score will be used to evaluate relationships between adoption of the diet and activity goals and PFS. Blood specimens are collected at baseline, 6, 12 and 24months for analysis of dietary adherence (carotenoids) in addition to mechanistic biomarkers (lipids, insulin, telomere length). Women are enrolled at NRG clinic sites nationally and the telephone based lifestyle intervention is delivered from The University of Arizona call center by trained health coaches. A study specific multi-modal telephone, email, and SMS behavior change software platform is utilized for information delivery, coaching and data capture. When completed, LIVES will be the largest behavior-based lifestyle intervention trial conducted among ovarian cancer survivors.
• George, S. M., Ballard, R., Shikany, J. M., Crane, T. E., & Neuhouser, M. L. (2015). A prospective analysis of diet quality and endometrial cancer among 84,415 postmenopausal women in the Women's Health Initiative. Annals of epidemiology, 25(10), 788-93.
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  Endometrial cancer is the most commonly diagnosed gynecologic cancer, but no convincing dietary risk factors for this cancer have been identified. Among postmenopausal women, we examined how four key a priori diet quality indices--the Healthy Eating Index-2010, Alternative Healthy Eating Index-2010, alternate Mediterranean Diet, and Dietary Approaches to Stop Hypertension are related to the risk of endometrial cancer in the Women's Health Initiative Clinical Trials and Observational Study.
• Crane, T. E., Khulpateea, B. R., Alberts, D. S., Basen-Engquist, K., & Thomson, C. A. (2014). Dietary intake and ovarian cancer risk: a systematic review. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23(2), 255-73.
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  Ovarian cancer is a leading cause of gynecological cancer death. There is a need to identify modifiable dietary risk factors for this disease. To evaluate the role of diet in ovarian cancer risk, we performed a PRISMA-directed systematic review that included prospective cohort studies with >200 cases (n = 24). Higher risk for ovarian cancer was shown for total, animal, and dairy fat (five of nine studies), as well as total nitrate and possibly total vitamin C. No associations were demonstrated for red meat, fiber, vitamin A, vitamin E, β-carotene, or folate. Vegetables were associated with lower risk in one of three studies; fruit showed no association, although risk estimates were all greater than 1.0. Isoflavones and flavonoids were associated with modestly lower risk in two studies and tea intake was associated with lower risk in one of two studies. This review suggests that no specific dietary factors are consistently associated with ovarian cancer risk. Data by tumor subtypes are limited, but suggest that differential associations by tumor subtype may exist and should be evaluated. Studies of ample sample size, varied exposure, which can better control for dietary measurement error, are needed to fully define dietary recommendations for ovarian cancer prevention.
• Thomson, C. A., E Crane, T., Wertheim, B. C., Neuhouser, M. L., Li, W., Snetselaar, L. G., Basen-Engquist, K. M., Zhou, Y., & Irwin, M. L. (2014). Diet quality and survival after ovarian cancer: results from the Women's Health Initiative. Journal of the National Cancer Institute, 106(11).
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  Survival after an ovarian cancer diagnosis is poor. Given the high mortality in these patients, efforts to identify modifiable lifestyle behaviors that could influence survival are needed. Earlier evidence suggests a protective role for vegetables, but no prior studies have evaluated overall dietary quality and ovarian cancer survival. The purpose of this analysis was to evaluate the role of prediagnosis diet quality in ovarian cancer survival.
• Butalla, A. C., Crane, T. E., Patil, B., Wertheim, B. C., Thompson, P., & Thomson, C. A. (2012). Effects of a carrot juice intervention on plasma carotenoids, oxidative stress, and inflammation in overweight breast cancer survivors. Nutrition and cancer, 64(2), 331-41.
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  Evidence suggests that higher plasma carotenoid concentrations are protective in relation to breast cancer recurrence. This simple randomized carrot juice intervention study was designed to test the hypothesis that daily intake of 8 ounces of fresh BetaSweet (anthocyanin-rich) or Balero orange carrot juice would increase plasma total carotenoid concentrations to levels previously shown to be associated with reduced breast cancer recurrence. It was hypothesized that regular carrot juice intake would be associated with reductions in oxidative stress (8-iso-PGF2α) and inflammation (thromboxane B2, prostaglandin E2 metabolites, and hsC-reactive protein). Sixty-nine overweight breast cancer survivors consumed fresh carrot juice made from study-provided carrots for 3 wk. Total plasma carotenoids increased by 1.65 and 1.38 umol/L for the BetaSweet and Balero carrot juice, respectively. Rise in total plasma carotenoids for the overall sample was inversely associated with 8-iso-PGFα (OR: 0.13; 95% CI: 0.20 to 0.75; no differences were shown by carrot variety. These results suggest daily intake of fresh carrot juice is a simple and effective approach to increasing plasma total carotenoids and in turn reducing oxidative stress, but not inflammatory markers, in women previously treated for breast cancer.
• Crane, T. E., Kubota, C., West, J. L., Kroggel, M. A., Wertheim, B. C., & Thomson, C. A. (2011). Increasing the vegetable intake dose is associated with a rise in plasma carotenoids without modifying oxidative stress or inflammation in overweight or obese postmenopausal women. The Journal of nutrition, 141(10), 1827-33.
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  The optimal amount of vegetable consumption required to reduce chronic disease risk is widely debated. Intervention trials evaluating biological activity of vegetables at various doses are limited. We conducted a 3-dose, crossover feeding trial to test the hypothesis that vegetable intake is associated in a dose-dependent manner with increased plasma carotenoids and subsequently reduced oxidative stress and inflammation in 49 overweight, postmenopausal women. Participants were assigned in random order to 2 (130 g), 5 (287 g), and 10 (614 g) daily servings of fresh, greenhouse-grown vegetables for 3-wk intervals with a 4-wk washout period between treatments. Plasma total carotenoids significantly increased from 1.63 to 2.07 μmol/L with a dose of 2 vegetable servings, from 1.49 to 2.84 μmol/L with a dose of 5 vegetable servings, and from 1.40 to 4.42 μmol/L with a dose of 10 vegetable servings (pre-post paired ttests, all P < 0.001). The change during each feeding period increased with each dose level (P < 0.001). Urine concentrations of 8-isoprostane F2α, hexanoyl lysine, and serum high sensitivity C-reactive protein were not affected by any administered vegetable dose. In this variable-dose vegetable study, a dose-response for plasma carotenoids was demonstrated without significant change in oxidative stress and inflammation in overweight, postmenopausal women.

Presentations

• Crane, T. E. (2020, January). Using SMS to Enhance Community Outreach and Engagement.. Four Corners Cancer Collborative. Tucson, AZ: National Cancer Institute.
• Crane, T. E. (2019, April). Does Season of Reported Dietary Intake Influence Diet Quality? Analysis from the Women’s Health Initiative.. Women's Health Initiative Nutrition Special Interest Group. Podcast.
• Crane, T. E. (2019, December). Lifestyle Interventions in the Digital Health Era: Making the Most of ehealth and mhealth Technologies. National Obesity Research Center. University of Alabama Birmingham.
• Crane, T. E. (2019, February). An Integrated Symptom Management and Lifestyle Intervention for Latinas with Cancer and their Informal Caregivers. American Psychosocial Oncology Society. Atlanta, Ga.
• Crane, T. E. (2019, March). Lifestyle for Intervention for Ovarian Cancer Enhanced Survival (LIVES) Study – Lessons learned; Lifestyle Modifications and Cancer Prevention for your Patients Symposium. Society of Gynecologic Oncology. Honolulu, Hawaii.
• Crane, T. E. (2019, November). Responsive Engagement and Cessation in Cancer Health (REACCH) Program. American Cancer Society - Cancer Summit. Scottsdale, AZ.
• Crane, T. E. (2019, October). Learning from the Lifestyle Intervention for Ovarian cancer Enhanced Survival. (LIVES). Society of Integrative Oncology. New York, NY.
• Crane, T. E., Harrison, T., Negi, L. T., Segrin, C. G., Badger, T. A., Pahlitzsc, K. H., Sikorskii, A., Dodds, S., & Pace, T. W. (2019, February). Feasibility and Acceptability of Cognitively-Based Compassion Training to Improve Indicators of Distress in Solid Tumor Cancer Survivors and Their Informal Caregivers. American Psychosocial Oncology Society. Atlanta, GA.
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  Background: Cancer survivors and their informal caregivers (ICs)(family members or friends) often experience higher depression, anxiety, and fatigue both during and after primary cancer treatment. Our prior work suggests these impairments are interdependent between survivors and ICs. The goal of this trial is to promote well-being in dyads consisting of solid tumor cancer survivors and ICs with an 8-week compassion meditation-based intervention called CBCT® (Cognitively-Based Compassion Training). We expect that CBCT® will leverage emotional contagion to promote sharing of positive affect and well-being within dyads, potentially dismantling the possibility of shared negative affect.Methods: Dyads include survivors within 10 years of completing primary treatments (chemotherapy, radiation, surgery) and at least one member with mild depression or anxiety symptoms (determined by Patient Reported Outcomes Measurement Information System [PROMIS] 4a short forms). Dyads are randomized to either CBCT® or an 8-week active attention control (cancer health education, CHE). Feasibility was measured by retention, and acceptability by CBCT® and CHE intervention attendance and at-home practice (CBCT® only). We used PROMIS 8a forms to assess depression and anxiety, and PROMIS 7a to assess fatigue, before and after the 8-week interventions.Results: To date 16 individuals have been enrolled in the study. The retention rate is 88%. Participants randomized to CBCT and CHE attended 75% and 87.5% of classes, respectively. At-home practice of CBCT® averaged 4.90 (SD=1.92) sessions per week, with an average of 18.44 (SD=1.97) minutes per session. Baseline PROMIS depression, anxiety, and fatigue scores were 54.02 (SD=10.29), 61.59 (SD=3.53), and 56.49 (SD=5.82) for survivors and 51.44 (SD=6.56), 53.06 (SD=9.01), and 54.24 (SD=7.76) for caregivers, respectively.Conclusions: Intervention attendance and adherence were good, and better than prior studies involving CBCT® including with breast cancer survivors. Both CBCT® and CHE are feasible and acceptable in survivor-IC dyads experiencing mild-moderate depression, anxiety, and fatigue.Acknowledgement of funding: Jack Challem Trust
• Crane, T. E. (2018, Fall). Cancer-related symptoms and lifestyle behavior interventions: a need for integrated approaches. Seminar. Tucson, Az: College of Agriculture, Department of Nutrition Sciences University of Arizona.
• Crane, T. E., & Badger, T. A. (2018, Fall). Symptom Management in Latinas with Breast Cancer and Their Informal Caregivers. Grand Rounds. Tucson, Az: University of Arizona Health Sciences College of Medicine.
• Crane, T. E., & Badger, T. A. (2018, Spring). Cultivating Relationships, Diversifying Funding Streams and Mentoring Junior Investigators. American Psycosocial Oncology Society Annual Meeting. Tucson, AZ: American Psycosocial Oncology Society.
• Crane, T. E., Badger, T. A., Segrin, C. G., Sikorskii, A., & Pace, T. W. (2018, Fall). Personalizing Symptom Management Interventions: Symptom Burden among Latinas with Breast Cancer and Their Informal Caregivers. State of the Science Congress. Washington DC: American Academy of Nursing.
• Crane, T. E., Badger, T. A., Segrin, C. G., Sikorskii, A., & Pace, T. W. (2018, Spring). Body Mass Index and Depression among Latina Breast Cancer Survivors. American Psycosocial Oncology Society Annual Meeting. Tucson, AZ: American Psycosocial Oncology Society.
• Crane, T. E., Badger, T. A., Segrin, C. G., Sikorskii, A., & Pace, T. W. (2018, Spring). Depression and Anxiety is Associated with Body Mass Index, but not Fatigue among Latina Breast Cancer Survivors. Western Institute of Nursing Annual Meeting. Spokane, WA: Western Institute of Nursing.
• Crane, T. E., Sikorskii, A., Segrin, C. G., Badger, T. A., & Pace, T. W. (2018, April / Spring). Saliva C-reactive Protein and Diurnal Cortisol Rhythm in Hispanic Breast Cancer Survivors and Their Informal Caregivers: Relationship with Cancer Treatments and Health-Related Quality of Life. Western Institute of Nursing Annual Conference. Spokane, WA, United States: Western Institute of Nursing.
• Crane, T. E., Badger, T. A., Segrin, C. G., Hsu, C., Sikorskii, A., & Rosenfeld, A. G. (2017, February). Symptom Clusters in Latinas with Breast Cancer. American Psychosocial Oncology Society. Orlando, Florida: APOS.
• Rosenfeld, A. G., Sikorskii, A., Hsu, C., Segrin, C. G., Badger, T. A., & Crane, T. E. (2017, Spring). Symptom clusters in Latinas with breast cancer.. WIN. Denver, CO: Western Institute of Nursing 50th Annual Conference.
• Sikorskii, A., Wyatt, G., Victorson, D., OConnor, P., Hankin, V., Safikhani, A., Crane, T. E., & Badger, T. A. (2017, fall). Performance of PROMIS and legacy measures among advanced breast cancer patients and their caregivers.. HealthMeasures Users Conference. Chicago, IL: Health Measures Users Conference.
• Crane, T. E., Badger, T. A., Segrin, C. G., & Pasvogel, A. (2016, April). Symptom distress, depression and anxiety in Latinas with breast cancer and their supportive partners. Western Institute of Nursing Annual Communicating Research conference. Anaheim, CA: WIN.
• Crane, T. E., Badger, T. A., Segrin, C. G., & Pasvogel, A. (2016, February). Symptom distress, depression and anxiety in Latinas with breast cancer and their supportive partners. Annual American Psychosocial Oncology Society conference. San Diego, CA: American Psychosocial Oncology Society.

Poster Presentations

• Basen-Engquist, K., Crane, T. E., Robles, R., Lind, K. E., & Thomson, C. A. (2020, Fall). Co-morbidities in Relation to Mortality among Women Diagnosed with Endometrial Cancer: Results of the Women’s Health Initiative. University of Arizona Cancer Center Retreat. Tucson, AZ.
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  Thomson CA, Lind K, Robles R, Crane TE and Basen-Engquist KE. Co-morbidities in Relation to Mortality among Women Diagnosed with Endometrial Cancer: Results of the Women’s Health Initiative. UACC Fall Retreat. (November 2020).
• Crane, T. E., Harrison, T., Negi, L. T., Segrin, C. G., Badger, T. A., Sikorskii, A., Dodds, S., & Pace, T. W. (2020, April). Cognitively-Based Compassion Training to Improve Health-Related Quality of Life in Solid Tumor Cancer Survivors and Their Informal Caregivers: Findings from a Pilot Randomized Trial. American Society of Preventive Oncology. online.
• Crane, T. E., Harrison, T., Negi, L. T., Segrin, C. G., Badger, T. A., Sikorskii, A., Dodds, S., & Pace, T. W. (2020, March). Cognitively-Based Compassion Training to Improve Health-Related Quality of Life in Solid Tumor Cancer Survivors and Their Informal Caregivers: Findings from a Pilot Randomized Trial. American Psychosocial Oncology Society. online.
• Crane, T. E., Thomson, C. A., Hingle, M. D., West, J., Werts, S., Skiba, M., & Penaloza, I. (2020, April). Responsiveness to Motivational Interviewing among Latina Ovarian Cancer Survivors participating in the LIvES Study. Society of Behavioral Medicine Annual Meeting. San Francisco, CA: Society of Behavioral Medicine.
• Dolan, H. R., Crane, T. E., & Taylor-Piliae, R. E. (2020, Spring). How Wearable Sensors Can Improve Self-Care in Chronic Illness. Western Institute of Nursing's 53rd Annual Communicating Nursing Research Conference. Portland, OR.
• Carroll, K., Crane, T. E., Alberts, D. S., Skiba, M. B., Kohler, L. N., Yung, A., MIller, A., Walker, J., Basen-Engquist, K., & Thomson, C. A. (2019, March). Presence of Chemotherapy Induced Peripheral Neuropathy in Women Recently Treated for Ovarian Cancer – Preliminary Findings from the Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES) Study: GOG/NRG-0225.. American Society of Preventive Oncology. Tampa, Fl.
• Crane, T. E., Badger, T. A., Sikorskii, A., Segrin, C., Pace, T. W., Thomson, C. A., Slack, S., Penalosa, I. A., Alvarez, A. A., & Wright, S. J. (2019, March). Improving Adherence to ACS Guidelines on Nutrition and Physical Activity Through Integrated Symptom Management in Latinas with Cancer and their Informal Caregivers. American Society of Preventive Oncology. Tampa, Fl.
• Lopez-Pentecost, M., Kohler, L. N., Crane, T. E., Garcia, D. O., Wertheim, B. C., Hebert, J. R., Steck, S. E., Shivappan, N., Santiago-Torres, M., Neuhouser, M. L., Snetselaar, L., Datta, M., Kroenke, C. H., Sarto, G. E., & Thomson, C. A. (2019, Spring). Relationship between the Mexican diet score and cancer risk by language of preference in postmenopausal Hispanic women from the Women’s Health Initiative.. NCI Conference.
• Lopez-Pentecost, M., Thomson, C. A., Sarto, G. E., Kohler, L. N., Kroenke, C. H., Crane, T. E., Datta, M., Garcia, D. O., Snetselaar, L., Wertheim, B. C., Neuhouser, M. L., Hebert, J. R., Santiago-Torres, M., Steck, S. E., Shivappan, N., Shivappan, N., Steck, S. E., Santiago-Torres, M., Hebert, J. R., , Neuhouser, M. L., et al. (2019, Spring). Relationship between the Mexican diet score and cancer risk by language of preference in postmenopausal Hispanic women from the Women’s Health Initiative.. NCI Conference.
• Pace, T. W., Dodds, S., Badger, T. A., Sikorskii, A., Negi, L. T., Segrin, C. G., Harrison, T., & Crane, T. E. (2019, April). FEASIBILITY AND ACCEPTABLITY OF COGNITIVELY-BASED COMPASSION TRAINING FOR SOLID TUMOR CANCER SURVIVORS AND THEIR INFORMAL CAREGIVERS. Western Institute of Nursing 2019 Conference. San Diego, CA.
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  Purpose/Aims: The purpose of this study was to determine the feasibility and acceptability of an 8-week compassion meditation-based intervention called CBCT® (Cognitively-Based Compassion Training) for survivors of solid tumor cancers and their informal caregivers (ICs) (i.e. family members or friends). We also worked to demonstrate feasibility of measuring features of depression, anxiety, and fatigue in survivor-IC dyads taking part in the intervention.Rationale/Conceptual Basis/Background: Cancer survivors and their ICs often experience higher depression, anxiety, and fatigue both during and after primary cancer treatment. Our prior work suggests these impairments are interdependent between survivors and ICs. The goal of this trial was to assess feasibility and acceptability of CBCT for survivor-IC dyads, with the longer-term goal of establishing CBCT in order to promote well-being in survivor-IC dyads. We expect that CBCT will leverage “emotional contagion” within survivor-IC dyads to promote sharing of positive affect and well-being for both dyad members, potentially dismantling the possibility of shared negative affect.Methods: Dyads included survivors within 10 years of completing primary treatments (chemotherapy, radiation, surgery) and at least one member with mild depression or anxiety symptoms (determined by Patient Reported Outcomes Measurement Information System [PROMIS] 4a short forms). Dyads were randomized to either CBCT or an 8-week active attention control (cancer health education, CHE). Both the CBCT and CHE groups met for 90 minutes each week, for 8 continuous weeks. At-home meditation practice was encouraged in the CBCT group. Feasibility was measured by retention, and acceptability by CBCT and CHE intervention attendance and at-home practice (CBCT only). We used PROMIS 8a forms to assess depression and anxiety, and the PROMIS 7a to assess fatigue.Results: Thirty-two individuals were enrolled in the study with a retention rate of 88%. Participants randomized to CBCT and CHE attended 75% and 87.5% of classes, respectively. At-home practice of CBCT averaged 4.90 (SD=1.92) sessions per week, with an average of 18.44 (SD=1.97) minutes per session. Baseline PROMIS depression, anxiety, and fatigue scores were 53.29 (SD=7.49), 58.19 (SD=5.35), and 55.83 (SD=4.86) for survivors and 52.55 (SD=5.21), 53.58 (SD=7.37), and 54.98 (SD=5.88) for caregivers, respectively.Conclusions: Intervention attendance and adherence was good, and better than prior studies involving CBCT including a study by us with breast cancer survivors. Both CBCT and CHE are feasible and acceptable in survivor-IC dyads experiencing mild-moderate depression, anxiety, and fatigue. The results of this trial are an important step toward exploring the benefits of CBCT for both survivors of solid tumor cancers and their informal caregivers.Acknowledgement of funding: Jack Challem Trust
• Skiba, M., Thomson, C. A., Qui, L., Kohler, L. N., Snetselaar, L., Crane, T. E., Kato, I., Jacobs, E. T., Shadyab, A. H., Shadyab, A. H., Kato, I., Jacobs, E. T., Snetselaar, L., Crane, T. E., Qui, L., Kohler, L. N., Skiba, M., & Thomson, C. A. (2019, Spring). Prebiotic fiber supplement use and colorectal cancer risk in post-menopausal women.. MEZCOPH Research Poster Forum.
• Skiba, M., Thomson, C. A., Qui, L., Kohler, L. N., Snetselaar, L., Crane, T. E., Kato, I., Jacobs, E. T., Shadyab, A. H., Shadyab, A. H., Kato, I., Jacobs, E. T., Snetselaar, L., Crane, T. E., Qui, L., Kohler, L. N., Skiba, M., & Thomson, C. A. (2019, Spring). The association between prebiotic fiber supplement use and colorectal cancer risk and mortality in the Women’s Health Initiative. ASPO.
• Zhang, X., Pennell, M. L., Bernardo, B. M., Clark, J., Focht, B. C., Krok-Schoen, J., Crane, T. E., Shadyab, A., Chlebowski, R., & Paskett, E. D. (2019, March). The Mediation Effect of Body Image on Physical Activity and Psychological Health in Older Female Cancer Survivors.. American Society of Preventive Oncology. Tampa, Fl.
• Bea, J. W., Crane, T. E., Walker, J., Hile, E., Lefkowits, C., & Thomson, C. A. (2018, Fall). Abstract: Design of PrEvention of Falls among OldeR Multiethnic gynecologic cANcEr patients (PErFORM ANEw). UACC Scientific Retreat. Tucson, AZ: UACC.
• Crane, T. E., O'Connor, P. A., Brady, B. R., Yuan, N. P., Vidrine, J. L., Garland, L. L., & Thomson, C. A. (2017, Spring). Abstract: Smoking bans in cancer patients enrolling for quitline cessation services: results from the Arizona Smokers’ Helpline (ASHLine). American Society of Preventive Oncology. Seattle, WA.
• Crane, T. E., Thomson, C. A., Segrin, C., Sikorskii, A., Badger, T. A., Slack, S., & Yatsenko, S. (2018, Fall). Abstract: Neustra Salud Study: An integrated intervention for symptom management and adoption of healthy lifestyle behaviors in Latina breast cancer survivors and their informal caregivers. UACC Scientific Retreat. Tucson, AZ.
• Lavelle, S. A., Rodriguez, I., Younger, A., Yung, A., Crane, T. E., & Thomson, C. A. (2017, Summer). Abstract: Promoting study participant retention in a national, multi-site ovarian cancer survivor lifestyle intervention trial. Arizona Academy of Nutrition & Dietetics. Phoenix, AZ.
• Lavelle, S., Basen-Engquist, K., Thomson, C. A., Crane, T. E., Garcia, D. O., & Skiba, M. (2018, Fall). Abstract: Measurement of physical activity in ovarian cancer survivors using accelerometry. UACC Scientific Retreat. Tucson, AZ.
• Thomson, C. A., Alberts, D. S., Walker, J., Basen-Engquist, K., Lakes, H., Miller, A., Lopez-Pentecost, M., Skiba, M., Garcia, D. O., Kohler, L. N., & Crane, T. E. (2018, Fall). Abstract: Cardiometabolic health of ovarian cancer survivors enrolled in GOG/NRG 0225 randomized controlled trial of diet and physical activity. UACC Scientific Retreat. Tucson, AZ.
• Thomson, C. A., Basen-Engquist, K. M., Walker, J., Miller, A., Yung, A., Kohler, L. N., Skiba, M., Alberts, D. S., Crane, T. E., & Carroll, K. (2018, Fall). Abstract: Presence of chemotherapy incuded peripheral neuropathy in women recently treated for ovarian cancer – preliminary finding from the Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES) Study: GOG/NRG-0025. UACC Scientific Retreat. Tucson, AZ: UACC.
• Thomson, C. A., Kroenke, C. H., Datta, M., Snetselaar, L., Hatsu, I. E., Neuhouser, M. L., Santiago-Torres, M., Shivappa, N., Steck, S., Hebert, J., Wertheim, B. C., Garcia, D. O., Crane, T. E., & Lopez-Pentecost, M. (2018, Fall). Abstract: Association between diet quality and obesity related cancer risk in postmenopausal Hispanic women: results from the WHI. UACC Scientific Retreat. Tucson, AZ.
• Thomson, C. A., Krouse, R., Fakih, M., Melstrom, K., Sentovich, S., Wright, S., Yung, A., Slack, S., Crane, T. E., & Sun, V. (2018, Spring). Abstract: Dietary modifications for bowel dysfunction in in rectal cancer survivors: the altering intake, managing symptoms (AIMS) intervention study. ASCO Cancer Survivorship Symposium. Orlando, FL.
• Thomson, C. A., Nair, U. S., Franks, H., Brady, B. R., Slack, S., O'Connor, P., & Crane, T. E. (2018, Spring). Abstract: Preliminary findings of a tailored tobaccoo cessation services with short messaging in the Arizona Smokers Helpline (ASHLine). ASPO. New York, NY.
• Thomson, C. A., Sikorskii, A., Ayala-Peacock, D., Vidrine, J., Crane, T. E., & Slack, S. (2018, Fall). Abstract: Wellness intervention for smoking cessastion and health (WISH) study in women with cancer undergoing radiation therapy. UACC Scientific Retreat. Tucson, AZ.
• Crane, T. E., Slack, S. D., O'Connor, P. A., Franks, G. H., Klimowski, C., Anderson, A. A., Nair, U., & Thomson, C. A. (2017, April). Tailoring Tobacco Cessation Services with Short Messaging Services (SMS): Preliminary Findings from the Arizona Smokers' Helpline. University of Arizona Cancer Center Annual Meeting. Tucson, AZ.
• Thomson, C. A., Hingle, M., Wertheim, B. C., Crane, T. E., & Neuhouser, M. L. (2017, March). Eating Frequency and Chronic Disease Risk Among Postmenopausal Women: Results from the Women’s Health Initiative. Society of Behavioral Medicine. San Diego, Ca.
• Yung, A., Crane, T. E., Loescher, L. L., Younger, A., Bingham, L., & Thomson, C. A. (2017, March). A Novel Model to Support Lifestyle Interventions in Cancer Survivors: Undergraduate Students and Multimodal Software Platform.. Society of Behavioral Medicine. San Diego, Ca: SBM.
• Bea, J. W., Crane, T. E., Jacobs, E. T., Thompson, P. A., Garcia, D. O., & Thomson, C. A. (2016, November). Abstract: Cruciferous vegetable intake is associated with changes in inflammatory biomarkers among breast cancer survivors in a physical activity program. American Institute for Cancer Research. Washington DC.
• Bea, J. W., Crane, T. E., Jacobs, E. T., Thompson, P., Garcia, D. O., & Thomson, C. A. (2016, Nov). Cruciferous vegetable intake is associated with changes in inflammatory biomarkers among breast cancer survivors in a physical activity program. American Institute for Cancer Research Annual Conference. North Bethesda, MD.