Theodore G Tong
- Professor, Pharmacy Practice-Science
- Professor, Pharmacology and Toxicology
- Professor, Public Health
No activities entered.
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Clinical ToxicologyPCOL 874 (Spring 2021)
Special Topics in ScienceHNRS 195I (Spring 2021)
Intro to PharmacologyPHCL 412 (Fall 2020)
Intro to PharmacologyPHCL 512 (Fall 2020)
Clinical ToxicologyPCOL 874 (Spring 2020)
Special Topics in ScienceHNRS 195I (Spring 2020)
Intro to PharmacologyPHCL 412 (Fall 2019)
Intro to PharmacologyPHCL 512 (Fall 2019)
Clinical ToxicologyPCOL 874 (Spring 2019)
Special Topics in ScienceHNRS 195I (Spring 2019)
Intro to PharmacologyPHCL 412 (Fall 2018)
Intro to PharmacologyPHCL 512 (Fall 2018)
Persp:Hlth Care:Curr IsuPHPR 195A (Fall 2018)
Independent StudyPCOL 899 (Summer I 2018)
Clinical ToxicologyPCOL 874 (Spring 2018)
Pharmacy Practice ProjectPHPR 896B (Spring 2018)
Special Topics in ScienceHNRS 195I (Spring 2018)
Intro to PharmacologyPHCL 412 (Fall 2017)
Intro to PharmacologyPHCL 512 (Fall 2017)
Persp:Hlth Care:Curr IsuPHPR 195A (Fall 2017)
Clinical ToxicologyPCOL 874 (Spring 2017)
PHSC: From Bench to BedsidePCOL 195A (Spring 2017)
Intro to PharmacologyPHCL 412 (Fall 2016)
Intro to PharmacologyPHCL 512 (Fall 2016)
Persp:Hlth Care:Curr IsuPHPR 195A (Fall 2016)
Clinical ToxicologyPCOL 874 (Spring 2016)
PHSC: From Bench to BedsidePCOL 195A (Spring 2016)
- McNally, J., Boesen, K., & Tong, T. G. (2006). Toxicological Information Resources. Small Animal Toxicology, 29-37.
- Joyce, M. C., Tong, T. G., & Traynor, A. P. (2004). Reports of Academy presidents. Journal of the American Pharmacists Association, 44(3), 308-316.
- Pedersen, C. A., Canaday, B. R., Ellis, W. M., Keyes, E. K., Pietrantoni, A., Rothholz, M. C., Thomas, C. C., Tong, T. G., Tonrey, L. L., & Tucker, T. L. (2003). Pharmacists' opinions regarding level of involvement in emergency preparedness and response. Journal of the American Pharmacists Association, 43(6), 694-701.More infoPMID: 14717266;Abstract: Objective: To assess opinions of pharmacist-members of the American Pharmacists Association Academy of Pharmacy Practice and Management (APhA-APPM) regarding the appropriate level of pharmacists' involvement in emergency preparedness and response activities and to determine whether opinions differed according to demographic characteristics. Design: Cross-sectional, descriptive, Web-based survey. Setting: United States. Participants: Five hundred eighteen APhA-APPM member-pharmacists. Main Outcome Measures: Responses to survey questions. Results: Respondents to our survey indicated that pharmacists should have a high level of involvement in emergency preparedness and response activities. Traditional pharmacy practice activities (such as medication preparation and dispensing) and patient education were the most highly supported roles for pharmacists. Newer activities such as surveillance, vaccine administration, and mobilization were also strongly supported. Demographic characteristics, such as age, sex, degree, state of residence, practice setting, and employment setting, did not influence respondents' opinions. The only characteristic that influenced pharmacist opinions was previous participation in local and/or state emergency preparedness and response activities. Compared with other respondents, pharmacists who participated in these activities gave higher ratings to these possible roles for pharmacists: surveillance, triage/evaluation, community planning and preparation, mobilization, and training of others. Conclusion: Pharmacist-members of APhA-APPM who responded to this survey believe that participating in public health activities related to emergency preparedness and response is important for members of the pharmacy profession.
- Hurlbut, K., Tong, T. G., & Sullivan Jr., J. B. (2002). Pharmacotherapy for the toxicity of hazardous materials. Clinics in Occupational and Environmental Medicine, 2(2), 299-312.
- Tong, T. G., & Soloway, R. A. (1994). Fiscal antidotes needed.. Journal of toxicology. Clinical toxicology, 32(5), 509-511.More infoPMID: 7932910;
- Banner Jr., W., & Tong, T. G. (1986). Iron poisoning. Pediatric Clinics of North America, 33(2), 393-409.More infoPMID: 2870463;Abstract: Iron poisoning continues to be a major toxicologic problem, with major impact on the gastrointestinal and circulatory systems. Failure to recognize the severity of iron intoxication may result in an inappropriate level of intervention. By using estimates of the total body burden of iron, clinical symptoms, and the serum iron concentration, an appropriate decision can be made to initiate aggressive chelation therapy with deferoxamine. In severe intoxication, the use of intravenous deferoxamine is indicated, along with supportive care, with particular attention to maintaining the intravascular volume. Other important measures include correction of acidosis and disorders of coagulation and replacement of blood components when there is evidence of gastrointestinal hemorrhage. Under rare circumstances in which large numbers of iron tablets are present in the gastrointestinal tract, surgical removal may be indicated. In addition, measures such as hemodialysis and exchange transfusion should be reserved for those unusual poisonings in which more conservative therapy is unsuccessful. In rare cases of iron intoxication, late sequelae such as hepatic necrosis and gastrointestinal scarring with obstruction may occur. The prompt recognition and initiation of management of children with acute iron poisoning is the single most critical element in decreasing the morbidity and mortality associated with these products.
- Banner Jr., W., Koch, M., Capin, D. M., Hopf, S. B., Chang, S., & Tong, T. G. (1986). Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds. Toxicology and Applied Pharmacology, 83(1), 142-147.More infoPMID: 3952743;Abstract: The usefulness of N-acetylcysteine (NAC) as a chelating agent was studied for the toxin potassium dichromate, lead tetraacetate, and boric acid. Mature Sprague-Dawley rats were intoxicated with these substances and placed in metabolic cages. Urinary excretion rates of intoxicant and total urine volume were determined during treatment with N-acetylcysteine, calcium EDTA, and/or dimercaptosuccinic acid, N-acetylcysteine proved to be the most effective agent at increasing the excretion of chromium and boron and was also able to reverse the oliguria associated with these toxins. Dimercaptosuccinic acid was most effective at the chelation of lead. NAC did not increase the excretion of lead. We conclude that NAC may be useful in intoxications due to chromate and borate and is effective at reversing the oliguria associated with these intoxicants. © 1986.
- Pond, S. M., Kreek, M. J., Tong, T. G., Raghunath, J., & Benowitz, N. L. (1985). Altered methadone pharmacokinetics in methadone-maintained pregnant women. Journal of Pharmacology and Experimental Therapeutics, 233(1), 1-6.More infoPMID: 3981450;Abstract: We studied the influence of human pregnancy on the maternal disposition and effects of methadone. Nine healthy pregnant women who had been on p.o. methadone maintenance for at least 2 months were studied between 20 and 34 weeks of gestation (phase I), 35 and 40 weeks (phase II), 1 to 4 weeks post partum (phase III) and 8 to 9 weeks post partum (phase IV). Two subjects who breast-fed their infants had plasma and breast milk samples collected simultaneously. With or without normalization for dose and body weight, trough plasma concentrations of methadone were significantly lower and total or unbound methadone clearances greater during pregnancy than after delivery. Plasma protein binding of methadone was lower during pregnancy but the difference was only statistically significant between phases I and IV. The greater ratios of urinary excretion of the major metabolites to total and unbound methadone areas under the curve during pregnancy suggests that methadone metabolism was enhanced. The ratios of concentrations of methadone in milk to plasma were constant in 2 subjects, 0.32 ± 0.06 and 0.61 ± 0.07, respectively. Some of the women reported symptoms of methadone withdrawal during pregnancy, even when the daily methadone dose did not change. Because of the lower plasma methadone concentrations, increased methadone doses may be required during pregnancy to achieve methadone maintenance.
- Pond, S. M., Olson, K. R., Osterloh, J. D., & Tong, T. G. (1984). Randomized study of the treatment of phenobarbital overdose with repeated doses of activated charcoal. Journal of the American Medical Association, 251(23), 3104-3108.More infoPMID: 6726981;Abstract: We performed a prospective randomized study of the effectiveness of repeated oral doses of activated charcoal in the treatment of phenobarbital overdose. Ten comatose patients who required intubation and mechanical ventilation completed the protocol. Five patients received repeated doses of activated charcoal and sorbitol. Five other patients who received a single dose of charcoal and cathartic served as control subjects. The serum half-life of phenobarbital (mean ± SD, 36 ± 13 hours) during repeated administration of charcoal and sorbitol was significantly shorter than that after charcoal administration was discontinued (93 ± 7 hours) and shorter than the half-life in the single-dose group (93 ± 52 hours). The length of time that patients in each group required mechanical ventilation, 39 ± 24 hours (single-dose group) and 48 ± 8 hours (repeated-dose group), did not differ significantly, nor did the time spent in the hospital. Although administration of repeated doses of activated charcoal to patients with phenobarbital overdose significantly increased the elimination of phenobarbital, it had no clear effects on the patients' clinical course.
- Rachesky, I. J., Banner Jr., W., Dansky, J., & Tong, T. (1984). Treatments for Centruroides exilicauda envenomation. American Journal of Diseases of Children, 138(12), 1136-1139.More infoPMID: 6507396;Abstract: We treated two cases of severe envenomation by the scorpion Centruroides exilicauda. The first infant was treated with a species-specific scorpion antivenom, which produced a delayed but dramatic return of all vital signs to normal. A second infant was treated with two doses of intravenous propranolol hydrochloride and had a rapid, dramatic decrease in heart rate but only gradual resolution of neurologic symptoms. These cases demonstrate the severe symptoms of envenomation by this scorpion in the infant and show two possible treatments.
- Rhoads, P. M., Tong, T. G., Banner Jr., W., & Anderson, R. (1984). Anticholinergic poisonings associated with commercial burdock root tea. Journal of Toxicology - Clinical Toxicology, 22(6), 581-584.More infoPMID: 6535850;Abstract: A case of anticholinergic poisoning associated with the consumption of a commercial burdock root tea preparation and confirmed by laboratory analysis in Arizona is reported.
- Woo, O. F., Healey, K. M., Sheppard, D., & Tong, T. G. (1983). Chest pain and hypoxemia from inhalation of a trichloroethane aerosol product. Journal of Toxicology - Clinical Toxicology, 20(4), 333-341.More infoPMID: 6689182;Abstract: A 25-year-old man developed severe shortness of breath, constricting chest pressure, chest pain, cough and myalgia following acute exposure to a waterproofing aerosol that contained trichloroethane. He became febrile and developed a small area of atetectasis with significant hypoxemia. Recovery was complete within 36 hours. This experience suggests that casual use of a trichloroethane aerosol with a surface active agent can cause acute pulmonary toxicity. The mechanism of this injury is unknown.
- Becker, C. E., & Tong, T. G. (1982). Poison control centers. A vital community resource. Western Journal of Medicine, 137(4), 320-321.More infoPMID: 7179949;PMCID: PMC1274121;
- Pond, S. M., Kreek, M. J., Tong, T. G., & Benowitz, N. L. (1982). Changes in methadone pharmacokinetics during pregnancy. Clinical Research, 30(2), 257A.
- Pond, S. M., Tong, T. G., Benowitz, N. L., III, P. J., & Rigod, J. (1982). Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts. Clinical Pharmacology and Therapeutics, 31(2), 139-143.More infoPMID: 7056020;Abstract: Four methadone-maintained subjects were given diazepam (0.3 mg/kg) for 9 days. During the dual drug period, the effects and kinetics of methadone and of its major pyrrolidine metabolite were not altered. These findings indicate that, unlike its effects in rodents, diazepam does not inhibit the metabolism of methadone in man. © 1982.
- Pond, S. M., Tong, T. G., Kaysen, G. A., Menke, D. J., Galinsky, R. E., Roberts, S. M., & Levy, G. (1982). Massive intoxication with acetaminophen and propoxyphene: Unexpected survival and unusual pharmacokinetics of acetaminophen. Clinical Toxicology, 19(1), 1-16.More infoPMID: 7154136;Abstract: A 28-year-old woman ingested an estimated 58 g acetaminophen and 9 g propoxyphene 20 h before hospitalization. Her serum acetaminophen concentration at 22 h was 485 μg/mL and declined with an unusually long half-life of 14 h. Hemodialysis for 4 h (started at 36 h) reduced the acetaminophen concentration from 250 to 32 μg/mL. The patient's complete recovery was remarkable because of the large amounts of drugs ingested, the delayed treatment, and prior exposure to enzyme inducers (known to increase acetaminophen hepatotoxicity). Administration of N-acetylcysteine prevented inorganic sulfate depletion usually caused by acetaminophen and may have increased the formation of acetaminophen sulfate. Some patients eliminate large overdoses of acetaminophen very slowly. Measures to enhance the elimination of this drug and its toxic metabolite by these individuals may be useful even when diagnosis or hospitalization is delayed.
- Pond, S., III., P. J., Humphreys, M., Weiss, R., & Tong, T. (1982). Impaired metabolism of methylphenobarbital after a combined drug overdose: Treatment by resin hemoperfusion. Journal of Toxicology - Clinical Toxicology, 19(2), 187-196.More infoPMID: 7109008;Abstract: A 38-yr-old woman who by history ingested 13 g methylphenobarbital, alcohol, and 6 g acetaminophen became comatose slowly over 4 d. Acute hepatic injury appeared to impair the oxidative N-demethylation of methylphenobarbital to its product, phenobarbital. On the eighth day after ingestion she was treated because of protracted coma with Amberlite XAD-4 resin hemoperfusion. Hemoperfusion, which removed 0.83 g methylphenobarbital and 2.10 g phenobarbital, led to transient clinical improvement. When supportive patient management fails to produce a satisfactory clinical course in a methylphenobarbital-intoxicated patient, hemoperfusion could be a useful adjunct to therapy.
- Tong, T. G. (1982). The alcohols. Critical Care Quarterly, 4(4), 75-87.
- Tong, T. G., Becker, C. E., Foliart, D., & Morse, L. (1982). A model poison control system. Western Journal of Medicine, 137(4), 346-350.More infoPMID: 7179955;PMCID: PMC1274134;
- Peters, K. S., Tong, T. G., Kutz, K., & Benowitz, N. L. (1981). Diabetes mellitus and orthostatic hypotension resulting from ingestion of Vacor rat poison: Endocrine and autonomic function studies. Western Journal of Medicine, 134(1), 65-68.More infoPMID: 7210664;PMCID: PMC1272465;
- Pond, S. M., Tong, T., Bertowitz, N. L., Jacob, P., & Rigod, J. (1981). Presystemic metabolism of meperidine to normeperidine in normal and cirrhotic subjects. Clinical Pharmacology and Therapeutics, 30(2), 183-188.More infoPMID: 7249503;Abstract: Plasma concentrations and urinary excretion of meperidine and its metabolite normeperidine were determined after intravenous and oral administration to II men; five men had hepatic cirrohosis and six were normal. Systemic clearance of meperidine was smaller and bioavailability and half-life greater in the cirrhotic patients than in the normal subjects. Plasma concentrations and 24-hr urinary excretion of normeperidine was lower and persistence of normeperidine in plasma longer in the patients with cirrhosis. The route of administration did not alter the fraction of normeperidine generated from meperidine. The results suggest that in patients requiring repeated meperidine dosage the drug should be taken parenterally rather than orally to allow maximal analgesia and minimal formation of normeperidine. Patients with cirrhosis may be relatively protected from normeperidine toxicity because of impaired formation, but the risk of cumulative toxicity may be greater than in normal subjects because of slower elimination of the metabolite and greater sensitivity to the effects of narcotics on the central nervous system. © 1981.
- Tong, T. G., Pond, S. M., Kreek, M. J., Jaffery, N. F., & Benowitz, N. L. (1981). Phenytoin-induced methadone withdrawal. Annals of Internal Medicine, 94(3), 349-351.More infoPMID: 7224382;Abstract: Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses. The area under the methadone plasma concentration-time curve decreased while the ratio of the pyrrolidine-to-metabolite excretion in urine to this area increased significantly. This suggests that phenytoin accelerates methadone metabolism. Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients.
- Pond, S. M., Tong, T., Benowitz, N. L., & Jacob, P. (1980). Enhanced bioavailability of pethidine and pentazocine in patients with cirrhosis of the liver. Australian and New Zealand Journal of Medicine, 10(5), 515-519.More infoPMID: 6937164;Abstract: We studied the bioavailability and disposition kinetics of pethidine and pentazocine in patients with alcoholic cirrhosis and age-matched healthy subjects. In the presence of liver disease, the bioavailability of pethidine was 31% and pentazocine 233% greater than in normals. systemic clearance was approximately half and terminal half-life double normal for both drugs, whereas volumes of distribution were unchanged. Because of greater bioavailability, oral doses of pethidine and pentazine should be reduced substantially in patients with cirrhosis. When multiple oral or parenteral doses are required, dosing interval should be lengthened or repeated doses reduced below initial doses because of lower systemic clearance.
- Tong, T. G., Benowitz, N. L., & Kreek, M. J. (1980). Methadone-disulfiram interaction during metadone maintenance. Journal of Clinical Pharmacology, 20(8-9), 506-513.More infoPMID: 7430415;Abstract: In an attempt to characterize a possible drug interaction between methadone and disulfiram, 500 mg/day disulfiram was administered orally for seven days to seven subjects on methadone maintenance. Plasma methadone concentrations and urinary excretion of methadone and its pyrrolidine and pyrrolidone metabolites were measured, and subjective symptoms of opiate intoxication and abstinence were noted before, during, and after disulfiram administration. Mean trough plasma methadone concentrations and terminal half-lives were lowest and shortest during disulfiram treatment, although this finding was not statistically significant. The ratio of urinary methadone to its pyrrolidine metabolite decreased during disulfiram treatment in all subjects. There is no evidence to support our original hypothesis that disulfiram might inhibit methadone metabolism. In contrast, urinary excretion of the major pyrrolidine metabolite increased relative to excretion of methadone. This suggests enhanced N-demethylation during disulfiram treatment. Disulfiram had no effect on opiate intoxication or abstinence symptoms. Disulfiram may alter methadone disposition, but in this study it was shown that in doses used for management of alcoholism there was no significant interaction between disulfiram and methadone.
- Ayus, J. C., Eneas, J. F., Tong, T. G., Benowitz, N. L., Schoenfeld, P. Y., Hadley, K. L., Becker, C. E., & Humphreys, M. H. (1979). Peritoneal clearance and total body elimination of vancomycin during chronic intermittent peritoneal dialysis. Clinical Nephrology, 11(3), 129-132.More infoPMID: 436339;Abstract: Vancomycin is a useful antimicrobial agent in patients undergoing chronic hemodialysis treatment; its efficacy in chronic peritoneal dialysis (CPD) has not been established. Serum (V(S)) and peritoneal fluid (V(PF)) vancomycin concentrations were measured in two CPD patients with staphylococcal peritonitis. Half-life of V(S) agreed with the half-life of V(PF) in each patient and the V(S)/V(PF) ratio was 1.27 in both patients. Distribution volumes were 37.2 and 58.7 l, values approximating total body water in these patients. V(S) and V(PF) persisted in the therapeutic range (>5 μg/ml) for more than 16 days. In one patient, mean peritoneal clearance was 9.8 ml/min and overall drug clearance averaged 2.3 ml/min; in the other patient, overall clearance was 2.1 ml/min. These results indicate that therapeutic vancomycin levels can be maintained for more than 16 days with a single 1 g intravenous dose in patients receiving intermittent CPD, as is the case for hemodialysis patients. Because of this, parenteral vancomycin is useful in the treatment of staphylococcal peritonitis in CPD patients.
- Pond, S. M., Phillips, M., Benowitz, N. L., Galinsky, R. E., Tong, T. G., & Becker, C. E. (1979). Diazepam kinetics in acute alcohol withdrawal. Clinical Pharmacology and Therapeutics, 25(6), 832-836.More infoPMID: 445950;Abstract: We performed a within-subject comparison of the kinetics of diazepam given to 7 alcoholic subjects during acute alcohol withdrawal and again after detoxification. The initial rapid exponential decline of plasma diazepam concentrations (t 1 2α was more rapid during (0.21 ± 0.03 hr) than after withdrawal (0.44 ± 0.14 hr, p < 0.05). Terminal t 1 2 clearance, and volumes of distribution changed in individual patients, but mean values did not change. Protein binding was less in patients (93.4 ± 2.4 %) than in healthy controls (97.0 ± 1.0, p < 0.05). The effects of alcohol withdrawal on diazepam disposition do not explain the high doses of diazepam commonly required to treat the withdrawal. © 1979.
- Pond, S. M., Tong, T., Benowitz, N. L., & Jacob, P. (1979). Bioavailability and clearance of meperidine in patients with chronic liver disease. Clinical Pharmacology and Therapeutics, 25(2), 242-.
- Tong, T. G., Benowitz, N. L., & Kreek, M. J. (1978). Methadone disulfiram interaction during methadone maintenance. Clinical Pharmacology and Therapeutics, 23(1), 132-.
- Tong, T. G. (1977). Poisoning and its treatment, part 2: treatment of poisoning and toxic overdose.. Nurse Practitioner, 2(3), 29-32.More infoPMID: 583796;
- Becker, C. E., Tong, T. G., Boerner, U., Roe, R. L., ScoTT, A. T., MacQuarrie, M. B., & Bartter, F. (1976). Diagnosis and treatment of Amanita phalloides type mushroom poisoning: use of thioctic acid. Western Journal of Medicine, 125(2), 100-109.More infoPMID: 788340;PMCID: PMC1237216;Abstract: The number of cases of mushroom poisoning is increasing as a result of the increasing popularity of 'wild' mushroom consumption. Amanitin and phalloidin cytotoxins found in some Amanita and Galerina species produce the most severe and frequent life threatening symptoms of Amanita phalloidestype poisoning. Delay in onset of symptoms, individual susceptibility variation and lack of rapid and reliable identification have contributed to the significant morbidity and mortality of this type of poisoning. A rapid chromatographic assay for identifying the potent cytotoxins and apparently successful management using thioctic acid of two cases of A. phalloides type mushroom poisoning are reported. All known cases of A. phalloides type mushroom poisoning treated with thioctic acid in the United States are summarized.
- Phillips, M., Rogers, W., & Tong, T. (1976). Hazards of cephalosporins in penicillin allergic patients with meningitis. British Medical Journal, 1(6006), 397-398.More infoPMID: 1247870;PMCID: PMC1638779;
- Tong, T. G. (1976). Poisoning and its treatment, part 1: incidence and clinical signs of poisoning and toxic overdose.. Nurse Practitioner, 2(2), 35-36.More infoPMID: 1049401;
- Tong, T. G., Benowitz, N. L., Becker, C. E., & Forni, P. J. (1976). Tricyclic antidepressant overdose. Drug Intelligence and Clinical Pharmacy, 10(12), 711-713.
- Becker, C. E., Roe, R., Scott, R., Tong, T., Boerner, U., & Luce, J. (1975). Rational drug therapy of alcoholism with sedative hypnotic drugs! Is this possible?. Annals of the New York Academy of Sciences, 252, 379-384.More infoPMID: 238452;
- Galinsky, R. E., Forni, P. J., McGuire, G. G., Tong, T. G., Benowitz, N., & Becker, C. E. (1975). Letter: "Post hoc" and hypoprothrombinemia.. Annals of Internal Medicine, 83(2), 286-287.More infoPMID: 1147473;
- McGurire, G. G., Scott, R. A., Tong, T. G., & Becker, C. E. (1975). Letter:pupil size in heat stroke.. Western Journal of Medicine, 122(3), 255-.More infoPMID: 1146297;PMCID: PMC1129698;
- Smith, G. H., & Tong, T. G. (1975). Ulcreative colitis.. Journal of the American Pharmaceutical Association, 15(4), 202-212.More infoPMID: 1127211;
- Tong, T. G., Benowitz, N. L., Becker, C. E., Forni, P. J., & Boerner, U. (1975). Phencyclidine poisoning.. Journal of the American Medical Association, 234(5), 512-513.More infoPMID: 1242170;Abstract: Phencyclidine hydrochloride abuse has become increasingly common and should be considered in patients with unexplained acute psychosis, dystonic reactions, status epilepticus, or coma. Two phencyclidine-intoxicated patients had bizarre combinations or disorientation, hallucination, agitation, and dyskinetic motor activity. Supportive care and reduction of sensory stimulation are the basis for management of the symptoms.
- Gee, L., Berg, B., Tong, T. G., & Becker, C. E. (1974). Enteric coated potassium supplements. Journal of the American Medical Association, 228(8), 975-976.More infoPMID: 4406351;
- Tozer, T. N., Witt, L. D., Gee, L., Tong, T. G., & Gambertoglio, J. (1974). Evaluation of hemodialysis for ethchlorvynol ('Placidyl') overdose. American Journal of Hospital Pharmacy, 31(10), 986-989.More infoPMID: 4440696;
- Lee, K. H., Fu, C. C., Spencer, M. R., Tong, T. G., & Poon, R. (1973). Mechanism of action of retinyl compounds on wound healing. 3. Effect of retinoic acid homologs on granuloma formation.. Journal of Pharmaceutical Sciences, 62(6), 895-899.More infoPMID: 4712619;
- Tong, T. G. (1973). Aminophylline: Review of clinical use. Drug Intelligence and Clinical Pharmacy, 7(4), 156-167.
- Tong, T. G., & Ignoffo, R. J. (1972). Glaucoma.. Journal of the American Pharmaceutical Association, 12(10), 520-523 passim.More infoPMID: 5069355;
- Lee, K. H., & Tong, T. G. (1970). Mechanism of action of retinyl compounds on wound healing. I. Structural relationship of retinyl compounds and wound healing.. Journal of Pharmaceutical Sciences, 59(6), 851-854.More infoPMID: 5423093;
- Lee, K. H., & Tong, T. G. (1970). Mechanism of action of retinyl compounds on wound healing. II. Effect of active retinyl derivatives on granuloma formation.. Journal of Pharmaceutical Sciences, 59(8), 1195-1197.More infoPMID: 5457346;
- Lee, K. H., & Tong, T. G. (1970). Mechanism of action of salicylates. 8. Effect of topical application of retinoic acid on wound-healing retardation action of a few anti-inflammatory agents.. Journal of Pharmaceutical Sciences, 59(7), 1036-1038.More infoPMID: 5428078;
- Lee, K. H., & Tong, T. G. (1969). Studies on the mechanism of action of salicylates. VI. Effect of topical application of retinoic acid on wound-healing retardation action of salicylic acid.. Journal of Pharmaceutical Sciences, 58(6), 773-774.More infoPMID: 5799777;