- Professor, Medical Imaging - (Research Scholar Track)
- M.S. Medical Imaging
- China Medical University, Shenyang, Liaoning, China
- M.D. Medicine
- China Medical University, Shenyang, Liaoning, China
- University of Arizona, Tucson, Arizona (2010 - Ongoing)
- University of Arizona, Tucson, Arizona (2005 - 2010)
- University of Arizona, Tucson, Arizona (2000 - 2005)
- William K. Warren Medical Research Institute of the University of Oklahoma Health Sciences Center (1995 - 2000)
- The Second Clinical College of China Medical University (1991 - 1995)
- Best Scientific Paper Award in the Basic Science
- American Society of Nuclear Cardiology, Fall 1997
- First Place Poster – Cardiovascular Track: 61st Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging
- Society of Nuclear Medicine and Molecular Imaging, Summer 2014
- Sylvia Sorkin Greenfield Award for the Best Scientific Paper in Medical Physics
- American Association of Physicists in Medicine, Fall 2007
- Second Place Award for Basic Science Investigations
- The Journal of Nuclear Medicine, Society of Nuclear Medicine, Summer 2003
I have been engaged in research on nuclear medicine and molecular imaging for 20 years. My research focuses on characterizing and developing molecular imaging probes to study the cellular and molecular events of human disease. I implemented and validated a variety of animal tumor models, including xenografted and spontaneous tumors (colorectal cancer, breast cancer, pancreatic cancer, and skin cancer), to detect and quantify the pathogenetic development of cancer using molecular imaging probes and modern high-resolution SPECT imaging technologies. Using optical and novel direct positron/electron imaging techniques developed in our research center, I have established an imaging methodology in mouse tumor chamber model to study tumor microenvironment (TMI) modulation of colon cancer and interaction between TMI components and tumor cells. I have achieved significantly in my research projects to radiolabel investigational drugs, antibodies, peptides, and other small molecules using Tc-99m, In-111, and I-125 for specific molecular imaging, especially for inflammation imaging. I have developed multiple recombinant cytokine radioligands for specific imaging of inflammation. Among those, 99mTc-labeled TNFR2-Fc-IL-1ra, a dual-domain cytokine radioligand, has shown higher-affinity targeting of inflammatory sites than its individual component radioligands, Tc-99m-TNFR-Fc and Tc-99m-IL-1ra-Fc. The bispecific cytokine radioligand has been well applied in research projects for specific detection of upregulated inflammation in ischemic-reperfused hearts, atherosclerotic plaques, and TMI. As PI on an NHLBI-funded project, I used the cytokine-targeted SPECT imaging technique to study ischemia-reperfusion injury and post-infarct ventricular remodeling. I have a strong interest in development of fluorescent and radiolabeled small molecule peptides for specific imaging of colorectal cancer (CRC). Currently, I am working with my research partner, Dr. Brian Gray at the Molecular Targeting Technologies, Inc., to validate a new family of radiolabeled CRC-targeting probes for single-photon emission computed tomography (SPECT) imaging using a small peptide with the amino-acid sequence CTPSPFSHC (TCP-1).The novel generation of radiolabeled TCP-1 peptides will combine the specificity, ease of production, and stability for in vivo imaging of CRC.
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- Quijada, H., Bermudez, T., Kempf, C. L., Valera, D. G., Garcia, A. N., Camp, S. M., Song, J. H., Franco, E., Burt, J. K., Sun, B., Mascarenhas, J. B., Burns, K., Gaber, A., Oita, R. C., Reyes Hernon, V., Barber, C., Moreno-Vinasco, L., Sun, X., Cress, A. E., , Martin, D., et al. (2020). Endothelial eNAMPT Amplifies Preclinical Acute Lung Injury: Efficacy of an eNAMPT-Neutralising mAb. The European respiratory journal.More infoThe SARS-CoV-2/COVID-19 pandemic has highlighted the serious unmet need for effective therapies that reduce ARDS mortality. We explored whether extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a ligand for Toll-like receptor 4 and a master regulator of innate immunity and inflammation, is a potential ARDS therapeutic target.
- Barrett, H. H., Furenlid, L. R., Han, H., Jha, A. K., Liu, Z., & Caucci, L. (2019). Towards Continuous-to-Continuous 3D Imaging in the Real World. Physics in Medicine and Biology.More infoImaging systems are often modeled as continuous-to-discrete mappings that map the object (i.e., a function of continuous variables such as space, time, energy, wavelength, etc.) to a finite set of measurements. When it comes to reconstruction, some discretized version of the object is almost always assumed, leading to a discrete-to-discrete representation of the imaging system. In this paper, we discuss a method for single photon emission computed tomography~(SPECT) imaging that avoids discrete representations of the object or the imaging system, thus allowing reconstruction on arbitrarily fine set of points.
- Liu, Z., Barber, C., Gupta, A., Wan, L., Won, Y. W., Furenlid, L. R., Chen, Q., Desai, A. A., Zhao, M., Bull, D. A., Unger, E. C., & Martin, D. R. (2019). Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction. Nuclear medicine and biology, 70, 67-77.More infoThe objective of this study was to investigate the cardioprotective effects of a dodecafluoropentane (DDFP)-based perfluorocarbon emulsion (DDFPe) as an artificial carrier for oxygen delivery to ischemic myocardium, using Tc-duramycin SPECT imaging.
- Dickinson, S. E., Janda, J., Criswell, J., Blohm-Mangone, K., Olson, E. R., Liu, Z., Barber, C., Rusche, J. J., Petricoin, E., Calvert, V., Einspahr, J. G., Dickinson, J. E., Stratton, S. P., Curiel-Lewandrowski, C., Saboda, K., Hu, C., Bode, A. M., Dong, Z., Alberts, D. S., & Bowden, G. T. (2016). Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin. Cancer prevention research (Philadelphia, Pa.).More infoThe PI3Kinase/Akt/mTOR pathway has important roles in cancer development for multiple tumor types, including UV-induced non-melanoma skin cancer. Immunosuppressed populations are at increased risk of aggressive cutaneous squamous cell carcinoma (SCC). Individuals who are treated with rapamycin, (sirolimus, a classical mTOR inhibitor) have significantly decreased rates of developing new cutaneous SCCs compared to those that receive traditional immunosuppression. However, systemic rapamycin use can lead to significant adverse events. Here we explored the use of topical rapamycin as a chemopreventive agent in the context of solar simulated light (SSL)-induced skin carcinogenesis. In SKH-1 mice, topical rapamycin treatment decreased tumor yields when applied after completion of 15 weeks of SSL exposure compared to controls. However, applying rapamycin during SSL exposure for 15 weeks, and continuing for 10 weeks after UV treatment, increased tumor yields. We also examined whether a combinatorial approach might result in more significant tumor suppression by rapamycin. We validated that rapamycin causes increased Akt (S473) phosphorylation in the epidermis after SSL, and show for the first time that this dysregulation can be inhibited in vivo by a selective PDK1/Akt inhibitor, PHT-427. Combining rapamycin with PHT-427 on tumor prone skin additively caused a significant reduction of tumor multiplicity compared to vehicle controls. Our findings indicate that patients taking rapamycin should avoid sun exposure, and that combining topical mTOR inhibitors and Akt inhibitors may be a viable chemoprevention option for individuals at high risk for cutaneous SCC.
- Liu, Z., Gray, B. D., Barber, C., Bernas, M., Cai, M., Furenlid, L. R., Rouse, A., Patel, C., Banerjee, B., Liang, R., Gmitro, A. F., Witte, M. H., Pak, K. Y., & Woolfenden, J. M. (2016). Characterization of TCP-1 probes for molecular imaging of colon cancer. Journal of controlled release : official journal of the Controlled Release Society, 239, 223-30.More infoMolecular probes capable of detecting colorectal cancer (CRC) are needed for early CRC diagnosis. The objective of this study was to characterize c[CTPSPFSHC]OH (TCP-1), a small peptide derived from phage display selection, for targeting human CRC xenografts using technetium-99m ((99m)Tc)-labeled TCP-1 and fluorescent cyanine-7 (Cy7)-labeled form of the peptide (Cy7-TCP-1). (99m)Tc-TCP-1 was generated by modifying TCP-1 with succinimidyl-6-hydrazino-nicotinamide (S-HYNIC) followed by radiolabeling. In vitro saturation binding experiments were performed for (99m)Tc-TCP-1 in human HCT116 colon cancer cells. SCID mice with human HCT116 cancer xenografts were imaged with (99m)Tc-TCP-1 or control peptide using a small-animal SPECT imager: Group I (n=5) received no blockade; Group II (n=5) received a blocking dose of non-radiolabeled TCP-1. Group III (n=5) were imaged with (99m)Tc-labeled control peptide (inactive peptide). SCID mice with human PC3 prostate cancer xenografts (Group IV, n=5) were also imaged with (99m)Tc-TCP-1. Eight additional SCID mice bearing HCT116 xenografts in dorsal skinfold window chambers (DSWC) were imaged by direct positron imaging of (18)F-fluorodeoxyglucose ((18)F-FDG) and fluorescence microscopy of Cy7-TCP-1. In vitro(99m)Tc-HYNIC-TCP-1 binding assays on HCT 116 cells indicated a mean Kd of 3.04±0.52nM. In cancer xenografts, (99m)Tc-TCP-1 radioactivity (%ID/g) was 1.01±0.15 in the absence of blockade and was reduced to 0.26±0.04 (P
- Liu, Z., Larsen, B. T., Lerman, L. O., Gray, B. D., Barber, C., Hedayat, A. F., Zhao, M., Furenlid, L. R., Pak, K. Y., & Woolfenden, J. M. (2016). Detection of atherosclerotic plaques in ApoE-deficient mice using (99m)Tc-duramycin. Nuclear medicine and biology, 43(8), 496-505.More infoApoptosis of macrophages and smooth muscle cells is linked to atherosclerotic plaque destabilization. The apoptotic cascade leads to exposure of phosphatidylethanolamine (PE) on the outer leaflet of the cell membrane, thereby making apoptosis detectable using probes targeting PE. The objective of this study was to exploit capabilities of a PE-specific imaging probe, (99m)Tc-duramycin, in localizing atherosclerotic plaque and assessing plaque evolution in apolipoprotein-E knockout (ApoE(-/-)) mice.
- Woolfenden, J. M., Pak, K. Y., Witte, M. H., Gmitro, A. F., Liang, R., Banerjee, B., Patel, C., Rouse, A. R., Furenlid, L. R., Bernas, M., Cai, M., Barber, C., Gray, B. D., & Liu, Z. (2016). Characterization of TCP-1 molecular imaging probes in mouse models with xenografted human colon cancer.. J Control Release, 239, 223-230.
- Barrett, H. H., Alberts, D. S., Woolfenden, J. M., Liu, Z., Caucci, L., & Hoppin, J. W. (2015). Quantifying and Reducing Uncertainties in Cancer Therapy. Proc SPIE Int Soc Opt Eng, 9412, 94120N.
- Barrett, H. H., Alberts, D. S., Woolfenden, J. M., Liu, Z., Caucci, L., & Hoppin, J. W. (2015). Quantifying and Reducing Uncertainties in Cancer Therapy. Proceedings of SPIE--the International Society for Optical Engineering, 9412.More infoThere are two basic sources of uncertainty in cancer chemotherapy: how much of the therapeutic agent reaches the cancer cells, and how effective it is in reducing or controlling the tumor when it gets there. There is also a concern about adverse effects of the therapy drug. Similarly in external-beam radiation therapy or radionuclide therapy, there are two sources of uncertainty: delivery and efficacy of the radiation absorbed dose, and again there is a concern about radiation damage to normal tissues. The therapy operating characteristic (TOC) curve, developed in the context of radiation therapy, is a plot of the probability of tumor control vs. the probability of normal-tissue complications as the overall radiation dose level is varied, e.g. by varying the beam current in external-beam radiotherapy or the total injected activity in radionuclide therapy. The TOC can be applied to chemotherapy with the administered drug dosage as the variable. The area under a TOC curve (AUTOC) can be used as a figure of merit for therapeutic efficacy, analogous to the area under an ROC curve (AUROC), which is a figure of merit for diagnostic efficacy. In radiation therapy AUTOC can be computed for a single patient by using image data along with radiobiological models for tumor response and adverse side effects. In this paper we discuss the potential of using mathematical models of drug delivery and tumor response with imaging data to estimate AUTOC for chemotherapy, again for a single patient. This approach provides a basis for truly personalized therapy and for rigorously assessing and optimizing the therapy regimen for the particular patient. A key role is played by Emission Computed Tomography (PET or SPECT) of radiolabeled chemotherapy drugs.
- Qin, Y., Li, Q., Ingram, P., Barber, C., Liu, Z., & Witte, R. S. (2015). Ultrasound current source density imaging of the cardiac activation wave using a clinical cardiac catheter. IEEE transactions on bio-medical engineering, 62(1), 241-7.More infoUltrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method for mapping electrical current in 4-D (space + time). This technique potentially overcomes limitations with conventional electrical mapping procedures typically used during treatment of sustained arrhythmias. However, the weak AE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 μV/MPa) than 1.0 MHz (0.42 μV/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activation maps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of real-time 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.
- Ryan, C. M., Brown, J. A., Bourke, E., Prendergast, Á. M., Kavanagh, C., Liu, Z., Owens, P., Shaw, G., Kolch, W., O'Brien, T., & Barry, F. P. (2015). ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells. Stem cell research & therapy, 6, 136.More infoBone marrow-derived stromal cells (BMSCs), also known as mesenchymal stem cells, are the focus of intensive efforts worldwide to elucidate their function and biology. Despite the importance of BMSC migration for their potential therapeutic uses, the mechanisms and signalling governing stem cell migration are still not fully elucidated.
- Furenlid, L. R., Barrett, H. H., Barber, H. B., Clarkson, E. W., Kupinski, M. A., Liu, Z., Stevenson, G. D., & Woolfenden, J. M. (2014). Molecular Imaging in the College of Optical Sciences - An Overview of Two Decades of Instrumentation Development. Proceedings of SPIE--the International Society for Optical Engineering, 9186.More infoDuring the past two decades, researchers at the University of Arizona's Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.
- Liu, Z., Lerman, L. O., Tang, H., Barber, C., Wan, L., Hui, M. M., Furenlid, L. R., & Woolfenden, J. M. (2014). Inflammation imaging of atherosclerosis in Apo-E-deficient mice using a (99m)Tc-labeled dual-domain cytokine ligand. Nuclear medicine and biology, 41(10), 785-92.More infoInterleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) play a critical role in initiating and accelerating atherosclerosis. This study evaluated the imaging properties of (99m)Tc-TNFR2-Fc-IL-1RA ((99m)Tc-TFI), a dual-domain cytokine radioligand that targets TNF-α and IL-1β pathways, in assessing atherosclerosis development in apolipoprotein-E-deficient (ApoE(-)(/)(-)) mice.
- Elster, J. L., Rathbone, C. R., Liu, Z., Liu, X., Barrett, H. H., Rhoads, R. P., & Allen, R. E. (2013). Skeletal muscle satellite cell migration to injured tissue measured with 111In-oxine and high-resolution SPECT imaging. Journal of muscle research and cell motility, 34(5-6), 417-27.More infoThe delivery of adult skeletal muscle stem cells, called satellite cells, to several injured muscles via the circulation would be useful, however, an improved understanding of cell fate and biodistribution following their delivery is important for this goal to be achieved. The objective of this study was to evaluate the ability of systemically delivered satellite cells to home to injured skeletal muscle using single-photon emission computed tomography (SPECT) imaging of (111)In-labeled satellite cells. Satellite cells labeled with (111)In-oxine and green fluorescent protein (GFP) were injected intravenously after bupivicaine-induced injury to the tibialis anterior muscle. Animals were imaged with a high-resolution SPECT system called FastSPECT II for up to 7 days after transplantation. In vivo FastSPECT II imaging demonstrated a three to five-fold greater number of transplanted satellite cells in bupivicaine-injured muscle as compared to un-injured muscle after transplantation; a finding that was verified through autoradiograph analysis and quantification of GFP expression. Satellite cells also accumulated in other organs including the lung, liver, and spleen, as determined by biodistribution measurements. These data support the ability of satellite cells to home to injured muscle and support the use of SPECT and autoradiograph imaging techniques to track systemically transplanted (111)In labeled satellite cells in vivo, and suggest their homing may be improved by reducing their entrapment in filter organs.
- Liu, Z., Barber, C., Wan, L., Liu, S., Hui, M. M., Furenlid, L. R., Xu, H., & Woolfenden, J. M. (2013). SPECT imaging of inflammatory response in ischemic-reperfused rat hearts using a 99mTc-labeled dual-domain cytokine ligand. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(12), 2139-45.More infoSoluble tumor necrosis factor (TNF) receptor-2 (TNFR2) and interleukin-1 receptor antagonist (IL-1ra) were fused to the Fc portion of IgG1 using recombinant DNA technology. The resulting dual-domain cytokine ligand, TNFR2-Fc-IL-1ra, specifically binds to TNF and to the type I IL-1 receptor (IL-1RI). This study was designed to characterize the kinetic profile of (99m)Tc-labeled TNFR2-Fc-IL-1ra (TFI) for imaging inflammatory response in an ischemic-reperfused (IR) rat heart model.
- Zhang, Y., Stevenson, G. D., Barber, C., Furenlid, L. R., Barrett, H. H., Woolfenden, J. M., Zhao, M., & Liu, Z. (2013). Imaging of rat cerebral ischemia-reperfusion injury using(99m)Tc-labeled duramycin. Nuclear medicine and biology, 40(1), 80-8.More infoPrompt identification of necrosis and apoptosis in the infarct core and penumbra region is critical in acute stroke for delineating the underlying ischemic/reperfusion molecular pathologic events and defining therapeutic alternatives. The objective of this study was to investigate the capability of (99m)Tc-labeled duramycin in detecting ischemia-reperfusion injury in rat brain after middle cerebral artery (MCA) occlusion.
- Liu, Z., Wyffels, L., Barber, C., Wan, L., Xu, H., Hui, M. M., Furenlid, L. R., & Woolfenden, J. M. (2012). Characterization of 99mTc-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways. Nuclear medicine and biology, 39(7), 905-15.More infoTNFR2-Fc and IL-1ra-Fc are recombinant cytokine ligands that target TNF and IL-1. TNFR2-Fc-IL-1ra, a dual-domain agent that incorporates both ligands, allows bifunctional binding of IL-1 receptors and TNF. This study was designed to characterize (99m)Tc-labeled forms of these ligands, (99m)Tc-IL-1ra-Fc (IF), (99m)Tc-TNFR2-Fc (TF), and (99m)Tc-TNFR2-Fc-IL-1ra (TFI), for inflammation imaging.
- Miller, B. W., Barber, H. B., Barrett, H. H., Liu, Z., Nagarkar, V. V., & Furenlid, L. R. (2012). Progress in BazookaSPECT: High-Resolution, Dynamic Scintigraphy with Large-Area Imagers. Proceedings of SPIE--the International Society for Optical Engineering, 8508.More infoWe present recent progress in BazookaSPECT, a high-resolution, photon-counting gamma-ray detector. It is a new class of scintillation detector that combines columnar scintillators, image intensifiers, and CCD (charge-coupled device) or CMOS (complementary metal-oxide semiconductors) sensors for high-resolution imaging. A key feature of the BazookaSPECT paradigm is the capability to easily design custom detectors in terms of the desired intrinsic detector resolution and event detection rate. This capability is possible because scintillation light is optically amplified by the image intensifier prior to being imaging onto the CCD/CMOS sensor, thereby allowing practically any consumer-grade CCD/CMOS sensor to be used for gamma-ray imaging. Recent efforts have been made to increase the detector area by incorporating fiber-optic tapers between the scintillator and image intensifier, resulting in a 16× increase in detector area. These large-area BazookaSPECT detectors can be used for full-body imaging and we present preliminary results of their use as dynamic scintigraphy imagers for mice and rats. Also, we discuss ongoing and future developments in BazookaSPECT and the improved event-detection rate capability that is achieved using Graphics Processing Units (GPUs), multi-core processors, and new high-speed, USB 3.0 CMOS cameras.
- Wyffels, L., Gray, B. D., Barber, C., Pak, K. Y., Forbes, S., Mattis, J. A., Woolfenden, J. M., & Liu, Z. (2012). Detection of myocardial ischemia-reperfusion injury using a fluorescent near-infrared zinc(II)-dipicolylamine probe and 99mTc glucarate. Molecular imaging, 11(3), 187-96.More infoA fluorescent zinc 2,2'-dipicolylamine coordination complex PSVue®794 (probe 1) is known to selectively bind to phosphatidylserine exposed on the surface of apoptotic and necrotic cells. In this study, we investigated the cell death targeting properties of probe 1 in myocardial ischemia-reperfusion injury. A rat heart model of ischemia-reperfusion was used. Probe 1, control dye, or 99mTc glucarate was intravenously injected in rats subjected to 30-minute and 5-minute myocardial ischemia followed by 2-hour reperfusion. At 90 minutes or 20 hours postinjection, myocardial uptake was evaluated ex vivo by fluorescence imaging and autoradiography. Hematoxylin-eosin and cleaved caspase-3 staining was performed on myocardial sections to demonstrate the presence of ischemia-reperfusion injury and apoptosis. Selective accumulation of probe 1 could be detected in the area at risk up to 20 hours postinjection. Similar topography and extent of uptake of probe 1 and 99mTc glucarate were observed at 90 minutes postinjection. Histologic analysis demonstrated the presence of necrosis, but only a few apoptotic cells could be detected. Probe 1 selectively accumulates in myocardial ischemia-reperfusion injury and is a promising cell death imaging tool.
- Barrett, H. H., Barrett, H. H., Barrett, H. H., Alberts, D. S., Alberts, D. S., Alberts, D. S., Woolfenden, J. M., Woolfenden, J. M., Woolfenden, J. M., Liu, Z., Liu, Z., Liu, Z., Clarkson, E. W., Clarkson, E. W., Clarkson, E. W., Kupinski, M. A., Kupinski, M. A., Kupinski, M. A., Furenlid, L. R., , Furenlid, L. R., et al. (2015, august). Quantifying and Reducing Uncertainties in Cancer Therapy. In Proceedings of SPIE, 9412, 9412N-4.
- Caucci, L., Barrett, H. H., Liu, Z., Han, H., & Furenlid, L. R. (2015, September). Towards Continuous-To-Continuous 3D Data Reconstruction. In 13th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine.
- Liu, Z., Gray, B. D., Barber, C., Wan, L., Furenlid, L. R., & Woolfenden, J. M. (2019, June). Comparative evaluation of TCP-1 molecular probes in colorectal and pancreatic cancer models. 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Anaheim, CA: The Society of Nuclear Medicine and Molecular Imaging.
- Liu, Z., Gray, B., Barber, C., Wan, L., Gmitro, A. F., Liang, R., Banerjee, B., Pak, K. Y., & Woolfenden, J. M. (2019, May). Characterization of TCP-1 multimodality imaging probes in targeting colorectal cancer cells. The 23rd International Symposium on Radiopharmaceutical Sciences. Beijing, China: The Society of Radiopharmaceutical Sciences.
- Liu, Z., Wan, L., Barber, C., Han, L., Furenlid, L. R., & Woolfenden, J. M. (2019, May). Radioiodinated hyaluronan for imaging pancreatic stromal remodeling related to pancreatic cancer development. The 23rd International Symposium on Radiopharmaceutical Sciences. Beijing, China: The Society of Radiopharmaceutical Sciences.
- Liu, Z., Barber, C., Wan, L., Furenlid, L., Unger, E. C., Woolfenden, J. M., & Martin, D. R. (2018, April). SPECT assessment of left ventricular remodeling and angiogenesis in ischemic-reperfused rat hearts protected by dodecafluoropentane oxygen-carrier. 12th Congress of the World Federation of Nuclear Medicine and Biology. Melbourne, Australia: The World Federation of Nuclear Medicine & Biology.
- Momsen, N., Richards, G., Liu, Z., & Furenlid, L. (2018, June). A Preclinical SPECT System with Optimized Data Acquisition for Imaging Larger Animals. 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Philadelphia, PA: The Society of Nuclear Medicine and Molecular Imaging.
- Barber, C., Wan, L., Gray, B., Pak, K., & Liu, Z. (2017, September). Assessment of solar ultraviolet radiation and topical rapamycin effects in mouse skin with 99mTc-duramycin imaging. 2017 World Molecular Imaging Congress (WMIC). Philadelphia, Pennsylvania: World Molecular Imaging Society.
- Liu, Z. (2017, May). 99mTc-duramycin imaging for non-invasive assessment of myocardial infarction and cardioprotection in a dodecafluoropentane oxygen-carrier animal model. 22nd International Symposium on Radiopharmaceutical Sciences.
- Liu, Z. (2017, May). Characterization of 99mTc-labeled TCP-1 peptide as a molecular imaging probe in mouse orthotopic colorectal cancer model. 22nd International Symposium on Radiopharmaceutical Sciences 2017.
- Liu, Z. (2016, June). Uptake of TCP-1 peptide labeled with a near-infrared dye in xenografted human colon cancer and tumor-associated vasculature. 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. San Diego, CA.: The Society of Nuclear Medicine and Molecular Imaging.
- Liu, Z. (2016, November). Identification of atherosclerotic plaque evolution by imaging cell death. The American Heart Association's Scientific Sessions 2016.
- Liu, Z., Barber, C., Furenlid, L. R., & Woolfenden, J. M. (2015, June). A novel molecular imaging probe for differentiating colorectal cancer lesions from inflammatory tissues. 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Baltimore, MD: The Society of Nuclear Medicine and Molecular Imaging.
- Gray, B., Barber, C., Wan, L., Pak, K. Y., Furenlid, L. R., & Liu, Z. (2020, October). Characterization of PEGylated TCP1 probes for molecular imaging of colorectal cancer. 2020 World Molecular Imaging Congress (WMIC) VirtualWorld Molecular Imaging Society.
- Liu, Z., Barber, C., Wan, L., Won, Y., Furenlid, L. R., & Babiker, H. (2019, September). Multimodality imaging of hyaluronan expression in pancreatic cancer. 2019 World Molecular Imaging Congress. Montreal, Canada: the World Molecular Imaging Society (WMIS).
- Barber, C., Tang, H., Wan, L., Furenlid, L. R., Woolfenden, J. M., Lerman, L., & Liu, Z. (2018, September). Detection of renal ischemia/reperfusion injury in mouse models by Tc-99m-duramycin SPECT imaging. 2018 World Molecular Imaging Congress. Seattle, WA: The World Molecular Imaging Society.
- Liu, Z. (2018, April). Radiolabeling of extracellular vesicles by targeting externalized phosphatidyl-ethanolamine. 12th Congress of the World Federation of Nuclear Medicine & Biology. Melbourne, Australia: The World Federation of Nuclear Medicine & Biology.
- Liu, Z., Barber, C., Wan, L., Zhao, M., & Furenlid, L. R. (2018, September). Characterization of Tc-99m-duramycin bound to circulating extracellular vesicles as a predictor of atherosclerotic plaque destabilization. 2018 World Molecular Imaging Congress. Seattle, WA: The World Molecular Imaging Society.
- Wan, L., Barber, C., Han, L., Furenlid, L. R., Woolfenden, J. M., & Liu, Z. (2018, September). Radioiodination and biodistribution of hyaluronan in mouse models. 2018 World Molecular Imaging Congress. Seattle, WA: The World Molecular Imaging Society.
- Liu, Z., Barber, C., Furenlid, L. R., Woolfenden, J. M., & Bernas, M. (2015, June). Imaging of atherosclerotic evolution with 99mTc-labeled duramycin. 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Baltimore, MD: The Society of Nuclear Medicine and Molecular Imaging.
- Liu, Z., Han, L., Furenlid, L. R., & Woolfenden, J. M. (2015, September). Imaging tumor microenvironment with 125I-iodinated hyaluronan. 2015 World Molecular Imaging Congress. Honolulu, Hawaii: World Molecular Imaging Society.