Audrey Heather Baker

Interests

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Courses

Scholarly Contributions

Chapters

• Erman, A. B., & Faucett, E. A. (2017). Head and Neck. In Surgery Review Illustrated(pp 247-274).
• Erman, A. B., & Nielsen, T. J. (2017). Neck Dissection. In Operative Dictations in General and Vascular Surgery. Springer.
• Erman, A. B., & Emerick, K. (2014). Head and Neck Melanoma. In Facial Surgery: Plastic and Reconstructive(pp Second Edition). St. Louis Missouri: Quality Medical Publishing Inc.
• Erman, A. B., & Deschler, D. G. (2013). Oral Cavity Cancer. In Bailey's Head and Neck Surgery-Otoloaryngology(pp Fifth Edition). Lippincott Williams & Wilkins.
• Erman, A. B., & Bradford, C. R. (2011). Epidemiology, Staging and Prognosis. In Cutaneous Malignancy of the Head and Neck(pp First Edition). San Diego, California: Plural Publishing.
• Shepherd, N. T., Telian, S. A., & Erman, A. B. (2010). Vestibular and Balance Rehabilitation Therapy. In Cummings Otolaryngology - Head and Neck Surgery(pp Fifth Edition). Philadelphia, PA: Elsevier Mosby.

Journals/Publications

• Hamman, J., Howe, C. L., Borgstrom, M., Baker, A., Wang, S. J., & Bearelly, S. (2022). Impact of Close Margins in Head and Neck Mucosal Squamous Cell Carcinoma: A Systematic Review. The Laryngoscope, 132(2), 307-321.
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  The aim of the study is to investigate whether close surgical margins impact oncologic outcomes compared to clear or involved surgical margins. We hypothesize that close surgical margins portend worse outcomes compared with clear margins, but improved outcomes compared with involved margins.
• Chung, C. H., Caulin, C., Centuori, S., Baker, A., Bearelly, S., Bauman, J. E., Saba, N. F., Roe, D., Bauman, J. R., Kaczmar, J. M., Bhatia, A. K., Muzaffar, J., Julian, R. A., Wang, S., Steuer, C. E., Giri, A., Burtness, B., Saboda, K., & Obara, S. (2021). Randomized phase II trial of ficlatuzumab with or without cetuximab in pan-refractory, advanced head and neck squamous cell carcinoma (HNSCC).. Journal of Clinical Oncology, 39(15_suppl), 6015-6015. doi:10.1200/jco.2021.39.15_suppl.6015
• Wang, S. J., Baker, A., Groysman, M., Bearelly, S., & Symms, J. (2021). Association of Perioperative Complications with Vitamin D Levels in Major Head and Neck Surgery. The Laryngoscope, 132(3), 578-583. doi:10.1002/lary.29776
• Chung, C. H., Caulin, C., Baker, A., Bearelly, S., Roe, D., Bauman, J. E., Saba, N. F., Bauman, J. R., Kaczmar, J. M., Burtness, B., Muzaffar, J., Julian, R. A., Wang, S., Steuer, C. E., Bhatia, A. K., Giri, A., Stabile, L. P., & Centuori, S. (2020). Randomized, phase II study of ficlatuzumab with or without cetuximab in patients with pan-refractory, recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).. Journal of Clinical Oncology, 38(15_suppl), TPS6594-TPS6594. doi:10.1200/jco.2020.38.15_suppl.tps6594
• Zarins, K. R., Wolf, G. T., Victorina, A. P., Valentino, J., Thomas, D. G., Sartor, M. A., Saba, N. F., Rozek, L. S., Patel, M. R., Panwar, A., Oliveira, F., Nieva, J., Nguyen, A., Newman, J. G., Moyer, J. S., Mchugh, J. B., Mccaul, J., Martins, W. A., Liu, S., , Krempl, G. A., et al. (2020). Tumor infiltrating lymphocytes after neoadjuvant IRX-2 immunotherapy in oral squamous cell carcinoma: Interim findings from the INSPIRE trial.. Oral oncology, 111, 104928. doi:10.1016/j.oraloncology.2020.104928
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  IRX-2 is a primary-cell-derived immune-restorative consisting of multiple human cytokines that act to overcome tumor-mediated immunosuppression and provide an in vivo tumor vaccination to increase tumor infiltrating lymphocytes (TILs). A randomized phase II trial was conducted of the IRX regimen 3 weeks prior to surgery consisting of an initial dose of cyclophosphamide followed by 10 days of regional perilymphatic IRX-2 cytokine injections and daily oral indomethacin, zinc and omeprazole (Regimen 1) compared to the identical regimen without IRX-2 cytokines (Regimen 2)..A total of 96 patients with previously untreated, stage II-IV oral cavity SCC were randomized 2:1 to experimental (1) or control (2) regimens (64:32). Paired biopsy and resection specimens from 62 patients were available for creation of tissue microarray (n = 39), and multiplex immunohistology (n = 54). Increases in CD8+ TIL infiltrate scores of at least 10 cells/mm2 were used to characterize immune responders (IR)..Regimen 1 was associated with significant increases in CD8+ infiltrates (p = 0.01) compared to Regimen 2. In p16 negative cancers (n = 26), significant increases in CD8+ and overall TILs were evident in Regimen 1 (p = 0.004, and 0.04 respectively). IRs were more frequent in Regimen 1 (74% vs 31%, p = 0.01). Multiplex immunohistology for PD-L1 expression confirmed an increase in PD-L1 H score for Regimen 1 compared to Regimen 2 (p = 0.11)..The findings demonstrate significant increases in TILs after perilymphatic IRX-2 injections. Three quarters of patients showed significant immune responses to IRX-2. (NCT02609386).
• Cravens, M., Baker, A. B., Faucett, E., & Nielsen, T. (2018). An Unusual Presentation of Papillary Thyroid Carcinoma in a Pediatric Patient: A Case Report. Ear, Nose & Throat Journal, 97, 12.
• Faucett, E., Baker, A. B., Barry, J., & Hilary, M. (2018). Otolaryngology Resident Education Core Competencies: A Systematic Review. JAMA Otolaryngology-Head & Neck Surgery, 144, 4.
• Erman, A. B., Chang, E., Michael, L., Sharma, S., Le, C., & SK, P. (2017). Complex Skull Base Reconstructions in Kadish D Esthesioneuroblastoma: Case Report. Journal of Neurological Surgery. doi:10.1055/s-0037-1601877
• Erman, A. B., Faucett, E. A., McCrary, H., Barry, J., & Ishman, S. (2017). High-Quality Feedback Regarding Professionalism and Communication Skills in Otolaryngology Resident Education. Otolaryngology Head Neck Surgery. doi:10.1177/0194599817737758
• McCrary, H. C., Faucett, E. A., & Erman, A. B. (2016). Immunoglobulin G4-Related Sclerosing Disease Mimicking Sjogren's Syndrome: A Case Report. The Laryngoscope. doi:10.1002/lary.26112
• Faucett, E. A., Marsh, K. M., Farshad, K., Erman, A. B., & Chiu, A. G. (2015). Maxillary sinus manifestations of methamphetamine abuse. Allergy & rhinology (Providence, R.I.), 6(1), 76-9.
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  Methamphetamines are the second most commonly used illicit drug worldwide and cost the United States health-care system ∼$23.4 billion annually. Use of this drug affects multiple organ systems and causes a variety of clinical manifestations. Although there are commonly known sequelae of methamphetamine abuse such as "meth mouth," there is limited evidence regarding maxillary sinus manifestations. The following cases highlight the initial evaluation and management of two methamphetamine abusers with loculated purulent collections within the maxillary sinus as a result of methamphetamine abuse. Our aim was to delineate the otolaryngologic symptoms associated with the patients' methamphetamine abuse. Computed tomography and magnetic resonance imaging studies revealed loculated purulent collections within the maxillary sinus of probable odontogenic origin in both patients. Methamphetamine abuse leading to rampant caries and poor oral hygiene may predispose individuals for craniofacial infections and fluid collections. These cases illustrate the development of maxillary sinusitis and maxilla mucoceles that have been associated with methamphetamine use.
• Miller, C., Hanley, J. C., Gernon, T. J., Erman, A., & Jacob, A. (2015). The submental island flap for reconstruction of temporal bone defects. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 36(5), 879-85.
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  Untreated cutaneous malignancies involving the lateral aspect of the cranium often invade the temporal bone, necessitating a resection of this site. The reconstruction of the associated complex defect typically requires a reconstructive flap placement to obliterate the resection cavity and provide an aesthetically pleasing restoration. We performed a retrospective case review of 30 patients undergoing temporal bone resection and reconstruction with a submental island flap (SIF), free flap, or temporalis rotation flap. We sought to evaluate the benefit of the submental island flap over the other reconstructive options in terms of cost benefit, patient aesthetic satisfaction, complications, morbidity, and duration of hospitalization.
• Yi, S. K., Kratz, S. L., Gernon, T. J., Erman, A. B., Khan, R., Avery, R. J., Aly, F. Z., Kuo, P. H., Cheung, M. K., & Georgiev, G. (2014). Morbidity Associated with False-Positive Findings in Post-Treatment Positron Emission Tomography/Computed Tomography in Chemoradiation Treated Head and Neck Cancer Patients. J J Rad Oncol, 1(2).
• Herr, M. W., Gray, S. T., Erman, A. B., Curry, W. T., Deschler, D. G., & Lin, D. T. (2013). Orbital preservation in patients with esthesioneuroblastoma. Journal of neurological surgery. Part B, Skull base, 74(3), 142-5.
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  Objectives Surgical resection in addition to adjuvant radiation with or without chemotherapy is the mainstay of treatment for esthesioneuroblastoma (ENB). However, management of patients with orbital involvement remains controversial. Historically, orbital exenteration has been advocated when there is evidence of periorbital invasion. Recently, the indications for orbital exenteration have become more selective and orbital preservation has been advocated. We report our experience with anterior craniofacial resection and orbital preservation in patients with ENB. Design Retrospective review of all patients diagnosed with esthesioneuroblastoma who underwent traditional open anterior craniofacial resection at the Massachusetts General Hospital/Massachusetts Eye and Ear Infirmary Cranial Base Center from 1997 to 2008. Results Sixteen patients were identified with a mean follow-up of 76 months. All patients underwent anterior craniofacial resection via an open approach and adjuvant proton beam radiation. Six of the 16 patients had evidence of either periorbital or lacrimal sac involvement at the time of surgery. All of these patients underwent periorbital resection to negative histologic margins with preservation of the orbit. Conclusion In our study, patients with ENB and periorbital invasion-who were treated with anterior craniofacial resection and periorbital resection with orbital preservation-had no evidence of decreased survival. In all patients, negative histologic margins of the periorbital resection were achieved.
• Erman, A. B., Collar, R. M., Griffith, K. A., Lowe, L., Sabel, M. S., Bichakjian, C. K., Wong, S. L., McLean, S. A., Rees, R. S., Johnson, T. M., & Bradford, C. R. (2012). Sentinel lymph node biopsy is accurate and prognostic in head and neck melanoma. Cancer, 118(4), 1040-7.
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  Sentinel lymph node biopsy (SLNB) has emerged as a widely used staging procedure for cutaneous melanoma. However, debate remains around the accuracy and prognostic implications of SLNB for cutaneous melanoma arising in the head and neck, as previous reports have demonstrated inferior results to those in nonhead and neck regions. Through the largest single-institution series of head and neck melanoma patients, the authors set out to demonstrate that SLNB accuracy and prognostic value in the head and neck region are comparable to other sites.
• Baker, A., Combs, D., Fu, J., Herring, A., Jeter, J., & Cranmer, L. (2009). Feasibility study of neurocognitive assessment of melanoma patients treated with adjuvant interferon. Journal of Clinical Oncology, 27(15_suppl), e20567-e20567. doi:10.1200/jco.2009.27.15_suppl.e20567
• Erman, A. B., Kejner, A. E., Hogikyan, N. D., & Feldman, E. L. (2009). Disorders of cranial nerves IX and X. Seminars in neurology, 29(1), 85-92.
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  The glossopharyngeal and vagus nerves mediate the complex interplay between the many functions of the upper aerodigestive tract. Defects may occur anywhere from the brainstem to the peripheral nerve and can result in significant impairment in speech, swallowing, and breathing. Multiple etiologies can produce symptoms. In this review, the authors broadly examine the normal functions, clinical examination, and various pathologies of cranial nerves IX and X.

Proceedings Publications

• Khan, R., Probst, J., & Erman, A. B. (2016, May). MRI of the Post-operative Neck: Revisiting the Expected and Unexpected.. In ASNR 54th Annual Meeting, Washington D.C..
• Khan, R., Probst, J., Wang, J., Albasha, H., Reyes, D., Squires, R., & Erman, A. B. (2016, May). Nodal Drainage Patterns in the Head and Neck: Recognizing Them and Why Not to Miss Them!. In ASNR 54th Annual Meeting, Washington D.C..

Presentations

• Baker, A. B. (2022). COVID Panel Discussion. ENT in the Desert.
• Baker, A. B. (2022). Cases from Head & Neck Tumor Board-Panel Discussion. ENT in the Desert.
• Baker, A. B. (2022). Cutaneous Oncology & Surgical Considerations . Dermatology Grand Rounds.
• Baker, A. B. (2022). Intersessions Q &A with COM 3^rd year Medical Students. College of Medicine.
• Baker, A. B. (2022). Technology and Innovation in Practice – Multidisciplinary Case Discussions in the Management of Advanced Non-Melanoma Skin Cancer: Multidisciplinary Panel. American Head & Neck Society 2022 Meeting at COSM. Dallas, TX.
• Baker, A. B. (2022). Updates in Melanoma Management. ENT in the Desert.
• Baker, A. B. (2020, February). "HPV-Related Disease". THMEP 42nd Annual Winter Medical Conference. Telluride, CO: Tucson Hospitals Medical Education Program.
• Baker, A. B. (2020, January). "Advanced H & N Skin Cancer Cases Panel Discussion". ENT in the Desert.
• Baker, A. B. (2020, January). "Head & Neck Tumor Board". ENT in the Desert 2020.
• Baker, A. B. (2020, January). "Physician Wellness - Achieving Balance in Life". ENT in the Desert.
• Baker, A. B. (2020, January). "Sentinel Lymph Node Biopsy Update". ENT in the Desert 2020.
• Baker, A. B. (2020, January). "Tips on Wellness, Mentoring, Sponsorship & Coaching Panel Discussion". ENT in the Desert 2020.
• Baker, A. B. (2019, February). Panel Discussion: Transoral Endoscopic Surgical Approaches. ENT in the Desert.
• Baker, A. B. (2019, February). Supraclavicular Flaps for TORS Defects: How I Do It. ENT in the Desert.
• Baker, A. B. (2018, February). Panel Discussion: Challenging Thyroid Cases. ENT in the Desert.
• Baker, A. B. (2018, February). Panel Discussion: Head & Neck Surgery Cases. ENT in the Desert.
• Baker, A. B. (2018, February). Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma. ENT in the Desert.
• Baker, A. B. (2018, October). Neck Dissection Update: When and How. Combined Otolaryngology Spring Meeting.
• Erman, A. B. (2017, February). Panel: Challenging Thyroid Cases. ENT in the Desert. Tucson, AZ: University of Arizona.
• Erman, A. B. (2017, February). Panel: Head & Neck Tumor Board. ENT in the Desert. Tucson, AZ: University of Arizona.
• Erman, A. B. (2017, February). Regional Flap Alternatives to Free Flaps for Head & Neck Reconstruction. ENT in the Desert. Tucson, AZ: University of Arizona.
• Erman, A. B. (2017, February). Surgery for Advanced Skin Cancers of the Head & Neck. ENT in the Desert. Tucson, AZ: University of Arizona.
• Erman, A. B. (2016, September / 2016). Complex Head and Neck Reconstruction. 2016 Annual Clinical Assembly of Osteopathic Surgeons. Phoenix, Arizona: Assembly of Osteopathic Surgeons.
• Erman, A. B. (2015, February / 2015). Oropharyngeal Carcinoma Panel Discussion Moderator. ENT in the Desert. Tucson, Arizona: The University of Arizona College of Medicine, Department of Otolaryngology.
• Erman, A. B. (2015, February / 2015). Thyroid Panel Discussion Moderator. ENT in the Desert. Tucson, Arizona: The University of Arizona College of Medicine, Department of Otolaryngology.

Poster Presentations

• Erman, A. B., Faucett, E. A., & McCrary, H. (2017, April). Otolaryngology Resident Education and the Core Competencies: A Systematic Review. Combined Otolaryngology Spring Meetings. San Diego, CA: COSM.
• Erman, A. B., Faucett, E. A., & Nielsen, T. J. (2017, January). An Unusual Presentation of Papillary Thyroid Carcinoma. Triological Society Combined Sections Meeting. New Orleans, LA: Triological Society.
• Erman, A. B., Faucett, E. A., Barry, J., & McCrary, H. (2017, May). Feedback Regarding Professionalism and Communication Skills in Otolaryngology Resident Education. American Society of Pediatric Otolaryngology. Austin, TX: ASPO.
• Erman, A. B., Faucett, E. A., McCrary, H., & Miller, C. (2016, January). IgG4-related Disease Mimicking Sjorgen's Syndrome. Triological Society Combined Sections Meeting. Miami Beach, FL: Triological Society.
• Reyes, D., Albasha, H., Wang, J., Probst, J., Erman, A. B., & Khan, R. (2016, May). MRI of the Post-operative Neck: Revisiting the Expected and Unexpected. ASNR 54th Annual Meeting, Washington D.C.. Washington D.C.: ASNR 54th Annual Meeting.
• Erman, A. B., & Deschler, D. G. (2011, January / 2011). The Chicken Thigh Model for Head and Neck Microvascular Training. Triological Society Combined MeetingTriological Society.
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  Second place poster prize