Lise Kathleen Harper
- Assistant Clinical Professor, Internal Medicine
Contact
- (520) 626-2612
- COLLEGE OF MEDICINE PHX
- lkharper@arizona.edu
Bio
No activities entered.
Interests
No activities entered.
Courses
No activities entered.
Scholarly Contributions
Journals/Publications
- M Shaw, O., Nyanhanda, T., K McGhie, T., L Harper, J., & D Hurst, R. (2017). Blackcurrant anthocyanins modulate CCL11 secretion and suppress allergic airway inflammation. Molecular nutrition & food research.More infoCCL11, a chemokine, is linked to the early development of airways eosinophilia in allergic asthma. Therefore, CCL11 production is a target for abrogating eosinophilic-driven airway inflammation. Blackcurrants are high in compounds that regulate inflammation, particularly anthocyanins. In this study we investigated the effect of oral blackcurrant supplementation on allergen-induced eosinophilia and CCL11 production; we also profiled key compounds in blackcurrants that were linked to this effect. 10 mg/kg (total anthocyanins) of a commercially available, anthocyanin-rich New Zealand 'Ben Ard' blackcurrant extract ('Currantex 30') attenuated ovalbumin-induced inflammation, eosinophilia (by 52.45 ± 38.50%) and CCL11 production (by 48.55 ± 28.56%) in a mouse model of acute allergic lung inflammation. Ten blackcurrant polyphenolic extracts were also found to suppress CCL11 secretion by stimulated human lung epithelial cells in vitro. Correlation analysis identified potential blackcurrant polyphenolic anthocyanin constituents specifically delphinidins and cyanidins, involved in CCL11 suppression. Our findings show oral supplementation with New Zealand blackcurrant is effective in reducing lung inflammation, and highlight the potential benefit of developing cultivars with specific polyphenolic profiles for the creation of functional foods with desirable biological activity. This article is protected by copyright. All rights reserved.
Presentations
- Franco, N., Harper, L., & Shinar, B. (2019, September). High Value Care. Best Practices in Hospital Medicine 2019. Banner University Medical Center Phoenix: Banner University Medical Center Phoenix Division of Hospital Medicine.
Poster Presentations
- Mallin, E., Harper, L., & Bergin, C. (2018, April). 3-In-1: Meeting the Needs of Patients, Residents, and the Institution During Hospital Discharge. Hospital Medicine 2018. Orlando, FL: Society of Hospital Medicine.
- Hourani, C., & Harper, L. (2014, May). Evaluating the Appropriateness of Nuclear Stress Testing Among Patients Admitted to Banner Good Samaritan Medical Center with Chest Pain. Academic Excellence Day. University of Arizona College of Medicine - Phoenix.