Linan Jiang

Interests

Research

Microfluidics, microscale heat transfer.Lab-on-chips, organ-on-chips, bio microsensors and microdevices.Microscale optics, optical interconnection, polymer material and flexible thin film.Microdevice design, fabrication, integration and packaging.

Teaching

Fluid mechanics, Heat transfer, Microfabrication.

Courses

Scholarly Contributions

Journals/Publications

• Hamdoh, A., Miller, S., Gao, Y., Zou, Y., Smith, M., Jiang, L., & Pau, S. (2024). Polarization properties and Umov effect of human hair. Scientific reports, 14(1), 412.
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  This study delves into the polarization properties of various hair colors using several techniques, including polarization ray tracing, full Stokes, and Mueller matrix imaging. Our analysis involved studying hair in both indoor and outdoor settings under varying lighting conditions. Our results demonstrate a strong correlation between hair color and the degree of linear polarization. Specifically, light-colored hair, such as white and blond, exhibits high albedo and low DoLP. In contrast, dark hair, like black and brown hair, has low albedo and high DoLP. Our research also revealed that a single hair strand displays high diattenuation near specular reflections but high depolarization in areas with diffuse reflections. Additionally, we investigated the wavelength dependency of the polarization properties by comparing the Mueller matrix under illumination at 450 nm and 589 nm. Our investigation demonstrates the impact of hair shade and color on polarization properties and the Umov effect.
• Jiang, L., Khawaja, H., Tahsin, S., Clarkson, T., Miranti, C., & Zohar, Y. (2024). Microfluidic-based human prostate cancer on chip.. Frontiers in Bioengineering and Biotechnology, 1-15.
• Tello, J. A., Jiang, L., Zohar, Y., & Restifo, L. L. (2023). Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery. Neural development, 18(1), 6.
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  CASK-related neurodevelopmental disorders are untreatable. Affected children show variable severity, with microcephaly, intellectual disability (ID), and short stature as common features. X-linked human CASK shows dosage sensitivity with haploinsufficiency in females. CASK protein has multiple domains, binding partners, and proposed functions at synapses and in the nucleus. Human and Drosophila CASK show high amino-acid-sequence similarity in all functional domains. Flies homozygous for a hypomorphic CASK mutation (∆18) have motor and cognitive deficits. A Drosophila genetic model of CASK-related disorders could have great scientific and translational value.
• Jiang, L. (2022). Birefringent coating to remove polarization aberrations. Optics Express.
• Jiang, L. (2022). Rapid Photolithographic Fabrication of High Density Optical Interconnects using Refractive Index Contrast Polymers. Optical Materials Express.
• Jiang, L., Miller, S., Pau, S., & Tu, X. (2021). Patterned liquid crystal polymer C-plate retarder and color polarizer. Applied Optics, 60(6), 1500-1507. doi:https://doi.org/10.1364/AO.416845
• Frost, T. S., Jiang, L., & Zohar, Y. (2020). Pharmacokinetic Analysis of Epithelial/Endothelial Cell Barriers in Microfluidic Bilayer Devices with an Air–Liquid Interface. Micromachines, 11(5), 536-536.
• Jiang, L., Kim, K. J., Reininger, F. M., Jiguet, S., & Pau, S. (2020). Microfabrication of a color filter array utilizing colored SU-8 photoresists. Applied optics, 59(22), G137-G145. doi:https://doi.org/10.1364/AO.391579
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  Patterned color filter arrays are important components in digital cameras, camcorders, scanners, and multispectral detection and imaging instruments. In addition to the rapid and continuous progress to improve camera resolution and the efficiency of imaging sensors, research into the design of color filter arrays is important to extend the imaging capability beyond conventional applications. This paper reports the use of colored SU-8 photoresists as a material to fabricate color filter arrays. Optical properties, fabrication parameters, and pattern spatial resolution are systematically studied for five color photoresists: violet, blue, green, yellow, and red. An end-to-end fabrication process is developed to realize a five-color filter array designed for a wide angle multiband artificial compound eye camera system for pentachromatic and polarization imaging. Colored SU-8 photoresists present notable advantages, including patternability, color tunability, low-temperature compatibility, and process simplicity. The results regarding the optical properties and the fabrication process for a colored SU-8 photoresist provide significant insight into its usage as an optical material to investigate nonconventional color filter designs.
• Jiang, L., Zou, Y., Tu, X., Smith, M. H., Pau, S. K., Miller, S., Mceldowney, S., Jiang, L., Guido, C., & Brock, N. (2020). Division of focal plane RGB full-Stokes imagingpolarimeter. Applied Optics. doi:10.6084/M9.FIGSHARE.C.4861596.V1
• Miller, S., Ding, Y., Jiang, L., Tu, X., & Pau, S. (2020). Observation of elliptically polarized light from total internal reflection in bubbles. Scientific Reports, 10(1), 8725-8725.
• Tu, X., McEldowney, S., Zou, Y., Smith, M., Guido, C., Brock, N., Miller, S., Jiang, L., & Pau, S. (2020). Division of focal plane red–green–blue full-Stokes imaging polarimeter. Applied Optics, 59(22), G33-G33.
• Frost, T. S., Estrada, V., Jiang, L., & Zohar, Y. (2019). Convection–diffusion molecular transport in a microfluidic bilayer device with a porous membrane. Microfluidics and Nanofluidics, 23(10).
• Frost, T. S., Jiang, L., Lynch, R. M., & Zohar, Y. (2019). Permeability of epithelial/endothelial barriers in transwells and microfluidic bilayer devices. Micromachines, 10(8).
• Jiang, L., Ivich, F., Tahsin, S., Tran, M., Frank, S. B., Miranti, C. K., & Zohar, Y. (2019). Human stroma and epithelium co-culture in a microfluidic model of a human prostate gland. Biomicrofluidics, 13(6).
• Miller, S., Tu, X., Jiang, L., & Pau, S. (2019). Polarizing beam splitter cube for circularly and elliptically polarized light. Optics Express, 27(11).
• Tu, X., Jiang, L., Ibn-Elhaj, M. .., & Pau, S. (2017). Design, fabrication and testing of achromatic elliptical polarizer. Optics Express, 25(9).
• Zohar, Y., Restifo, L. L., & Jiang, L. (2015). Dissociation of brain tissue into viable single neurons in a microfluidic device.. IEEE Nano/Molecular Medicine and Engineering, 9, 29-32.
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  A microfluidic technology-based tissue-dissociation device has for the first time been designed, fabricated and characterized for the purpose of primary neuronal cell culture.The system has been utilized for controlled dissociation, under an oscillatory flow field, of freshly explanted, enzyme-treated Drosophila larval central nervous system (CNS) into individual, viable neurons capable of robust outgrowth during in vitro culture. Device dimensions, constriction height and width, and operating conditions, flow-rate amplitude and frequency, have been determined based on video microscopy as well as quantitative analyses of the subsequent neuron-culture results.
• Riahi, R., Yang, Y. L., Kim, H., Jiang, L., Wong, P. K., & Zohar, Y. (2014). A microfluidic model for organ-specific extravasation of circulating tumor cells. Biomicrofluidics, 8(2).
• Stamm, M. T., Trickey-Glassman, A. S., Jiang, L., & Zohar, Y. (2014). Specific interactions between functionalised particles and circulating tumour cells. IET nanobiotechnology, 8(1), 18-23.
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  Receptor-ligand binding has been one of the more popular approaches to specifically targeting tumour cells. In this work, targeting efficiency was quantitatively characterized using silica particles functionalized with EpCAM antibodies and EpCAM-expressing BT-20 breast cancer cells. The effects of incubation time and particle concentration on the number of functionalised particles bound to target cells were experimentally investigated. The number of bound particles was found to increase with particle concentration, but not necessarily with incubation time. Binding affinity loss because of cell-particle-cell interaction was identified as a limiting mechanism for the number of particles bound to target cells. While cell-surface coverage because of bound particles rises exponentially under low particle concentration, it features a peak value at high particle concentration. The current findings suggest that separation of a bound particle from a cell may be detrimental to cellular binding affinity.
• Zeng, L., Jiang, L., Teng, W., Cappello, J., Zohar, Y., & Wu, X. (2014). Engineering aqueous fiber assembly into silk-elastin-like protein polymers. Macromolecular rapid communications, 35(14), 1273-9.
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  Self-assembled peptide/protein nanofibers are valuable 1D building blocks for creating complex structures with designed properties and functions. It is reported that the self-assembly of silk-elastin-like protein polymers into nanofibers or globular aggregates in aqueous solutions can be modulated by tuning the temperature of the protein solutions, the size of the silk blocks, and the charge of the elastin blocks. A core-sheath model is proposed for nanofiber formation, with the silk blocks in the cores and the hydrated elastin blocks in the sheaths. The folding of the silk blocks into stable cores--affected by the size of the silk blocks and the charge of the elastin blocks--plays a critical role in the assembly of silk-elastin nanofibers. Furthermore, enhanced hydrophobic interactions between the elastin blocks at elevated temperatures greatly influence the nanoscale features of silk-elastin nanofibers.
• Zeng, L., Teng, W., Jiang, L., Cappello, J., & Wu, X. (2014). Ordering recombinant silk-elastin-like nanofibers on the microscale. Applied physics letters, 104(3), 033702.
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  Self-assembled peptide/polypeptide nanofibers are appealing building blocks for creating complex three-dimensional structures. However, ordering assembled peptide/polypeptide nanofibers into three-dimensional structures on the microscale remains challenging and often requires the employment of top-down approaches. We report that silk-elastin-like protein polymers self-assemble into nanofibers in physiologically relevant conditions, the assembled nanofibers further form fiber clusters on the microscale, and the nanofiber clusters eventually coalesce into three-dimensional structures with distinct nanoscale and microscale features. It is believed that the interplay between fiber growth and molecular diffusion leads to the ordering of the assembled silk-elastin-like nanofibers at the microscale.
• Zohar, Y., Jiang, L., Zohar, Y., Zha, Z., Stamm, M. T., Jiang, L., & Dai, Z. (2012). Functionalization of Ceramic Liposomal Nanoparticles, Cerasomes, with Antibodies. Journal of Physical Chemistry & Biophysics, 2(1), 1-5. doi:10.4172/2161-0398.1000105
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  Ceramic nanoparticles and silica microparticles are functionalized with antibodies on their surfaces that act as targeting ligands. For the ceramic liposomal nanoparticles, cerasomes, this is achieved by using the siloxane network present on the cerasome surface as the foundation for chemical treatment processes previously developed for silicon surfaces. The bio-functionality and physical integrity of the cerasomes are characterized, demonstrating successful immobilization of antibodies on the cerasome surface. The surface functionalization allows the cerasomes to deliver drugs to targeted cells expressing certain types of receptors with desired selectivity and specificity that are not possible using standard liposomes. The Silica microparticles are used to mimic cerasomes in experiments targeting cancer cells and the particle-cell specific binding due to the bio-functionalization process is demonstrated.
• Jiang, L., Whitten, W. B., & Pau, S. (2011). A charged-particle manipulator utilizing a co-axial tube electrodynamic trap with an integrated camera. Journal of Instrumentation, 6(10).
• Jiang, L., Whitten, W. B., & Pau, S. (2011). A planar ion trapping microdevice with integrated waveguides for optical detection. Optics Express, 19(4).
• Stamm, M. T., Gudipaty, T., Rush, C., Jiang, L., & Zohar, Y. (2011). Particle aggregation rate in a microchannel due to a dilute suspension flow. Microfluidics and Nanofluidics, 11(4).
• Yetisen, A. K., Jiang, L., Cooper, J. R., Qin, Y., Palanivelu, R., & Zohar, Y. (2011). A microsystem-based assay for studying pollen tube guidance in plant reproduction. Journal of Micromechanics and Microengineering, 21(5).
• Jiang, L., Myer, B., Tellefsen, K., & Pau, S. (2009). A planar microfabricated electrolyzer for hydrogen and oxygen generation. Journal of Power Sources, 188(1).
• Jiang, L., Gerhardt, K. P., Myer, B., Zohar, Y., & Pau, S. (2008). Evanescent-wave spectroscopy using an SU-8 waveguide for rapid quantitative detection of biomolecules. Journal of Microelectromechanical Systems, 17(6).
• Jiang, L., & Pau, S. (2007). Integrated waveguide with a microfluidic channel in spiral geometry for spectroscopic applications. Applied Physics Letters, 90(11).
• Kenny, T. W., Goodson, K. E., Santiago, J. G., Wang, E., Koo, J., Jiang, L., Pop, E., Sinha, S., Zhang, L., Fogg, D., Yao, S., Flynn, R., Chang, C., & Hidrovo, C. H. (2006). Advanced cooling technologies for microprocessors. International Journal of High Speed Electronics and Systems, 16(1).
• Koo, J., Im, S., Jiang, L., & Goodson, K. E. (2005). Integrated microchannel cooling for three-dimensional electronic circuit architectures. Journal of Heat Transfer, 127(1).
• Wang, E. N., Zhang, L., Jiang, L., Koo, J., Maveety, J. G., Sanchez, E. A., Goodson, K. E., & Kenny, T. W. (2004). Correction to "Micromachined Jets for Liquid Impingement Cooling of VLSI Chips". Journal of Microelectromechanical Systems, 13(6).
• Wang, E. N., Zhang, L., Jiang, L., Koo, J., Maveety, J. G., Sanchez, E. A., Goodson, K. E., & Kenny, T. W. (2004). Micromachined jets for liquid impingement cooling of VLSI chips. Journal of Microelectromechanical Systems, 13(5).
• Jiang, L., Mikkelsen, J., Koo, J., Huber, D., Yao, S., Zhang, L., Zhou, P., Maveety, J. G., Prasher, R., Santiago, J. G., Kenny, T. W., & Goodson, K. E. (2002). Closed-loop electroosmotic microchannel cooling system for VLSI circuits. IEEE Transactions on Components and Packaging Technologies, 25(3).
• Zhang, L., Koo, J., Jiang, L., Asheghi, M., Goodson, K. E., Santiago, J. G., & Kenny, T. W. (2002). Measurements and modeling of two-phase flow in microchannels with nearly constant heat flux boundary conditions. Journal of Microelectromechanical Systems, 11(1).
• Zohar, Y., Lee, S., Lee, W. Y., Jiang, L., & Tong, P. (2002). Subsonic gas flow in a straight and uniform microchannel. Journal of Fluid Mechanics.
• Jiang, L., Wong, M., & Zohar, Y. (2001). Forced convection boiling in a microchannel heat sink. Journal of Microelectromechanical Systems, 10(1).
• Jiang, L., Wong, M., & Zohar, Y. (2000). Transient temperature performance of an integrated micro-thermal system. Journal of Micromechanics and Microengineering, 10(3).
• Jiang, L., Wong, M., & Zohar, Y. (2000). Unsteady characteristics of a thermal microsystem. Sensors and Actuators, A: Physical, 82(1).
• Jiang, L., Wang, Y., Wong, M., & Zohar, Y. (1999). Fabrication and characterization of a microsystem for a micro-scale heat transfer study. Journal of Micromechanics and Microengineering, 9(4).
• Jiang, L., Wong, M., & Zohar, Y. (1999). Micromachined polycrystalline thin film temperature sensors. Measurement Science and Technology, 10(8).
• Jiang, L., Wong, M., & Zohar, Y. (1999). Phase change in microchannel heat sinks with integrated temperature sensors. Journal of Microelectromechanical Systems, 8(4).
• Li, B., Xiong, B., Jiang, L., Zohar, Y., & Wong, M. (1999). Germanium as a versatile material for low-temperature micromachining. Journal of Microelectromechanical Systems, 8(4).

Proceedings Publications

• Frost, T. S., Jiang, L., & Zohar, Y. (2019, 2019///). Characterizing A549 Cell Line as an Epithelial Cell Monolayer Model for Pharmacokinetic Applications. In IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED, 2018-Decem.
• Ivich, F., Tran, M., Tahsin, S., Frank, S. B., Kraft, A., Miranti, C. K., Zohar, Y., & Jiang, L. (2019, 2019///). Application of a Microfluidic-Based Model of a Human Prostate Gland for Cancer Research. In IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED, 2018-Decem.
• Frost, T. S., Estrada, V., Jiang, L., & Zohar, Y. (2018, 2018///). Protein transsport through a separation membrane in a microfluidic device. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, 4.
• Jiang, L., Ivich, F., Tran, M., Frank, S. B., Miranti, C. K., & Zohar, Y. (2018, 2018///). Development of a microfluidic-based model of a human prostate gland. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, 3.
• Jiang, L., Zohar, Y., Zohar, Y., Jiang, L., & Frost, T. S. (2018). Characterizing A549 Cell Line as an Epithelial Cell Monolayer Model for Pharmacokinetic Applications. In 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED), 27-30.
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  Transport of three different molecules across a porous membrane, with and without a confluent A549 cell monolayer, has been investigated in Transwells and microfluidic devices. The A549 cell line was selected since it has extensively been utilized in toxicology studies due to its potential target for drug delivery of macro molecules. The measured molecular transport rate was found to decrease with increasing molecular size due to lower diffusivity. The confluent cell monolayer presents a barrier to molecular, significantly reducing the transport rate of larger molecules with little effect on the paracellular transport of smaller molecules. The results indicate that the microfluidic system is a good model for pharmacokinetic applications.
• Jiang, L., Kraft, R., Restifo, L. L., & Zohar, Y. (2016, 2016///). Dissociation of brain tissue into viable single neurons in a microfluidic device. In IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED, 2016-June.
• Jiang, L., Restifo, L. L., Zohar, Y., Zohar, Y., Restifo, L. L., Kraft, R., & Jiang, L. (2015). Dissociation of brain tissue into viable single neurons in a microfluidic device. In 2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED), 29-32.
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  A microfluidic technology-based tissue-dissociation device has for the first time been designed, fabricated and characterized for the purpose of primary neuronal cell culture. The system has been utilized for controlled dissociation, under an oscillatory flow field, of freshly explanted, enzyme-treated Drosophila larval central nervous system (CNS) into individual, viable neurons capable of robust outgrowth during in vitro culture. Device dimensions, constriction height and width, and operating conditions, flow-rate amplitude and frequency, have been determined based on video microscopy as well as quantitative analyses of the subsequent neuron-culture results.
• Riahi, R., Yang, Y., Kim, H., Jiang, L., Wong, P. K., & Zohar, Y. (2013, 2013). A microfluidic-based platform for in vitro studies of cell signaling in blood vessels. In 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013.
• Stamm, M. T., Trickey-Glassman, A. S., Jiang, L., & Zohar, Y. (2013, 2013///). Quantitative characterization of specific targeting of tumor cells by antibody-functionalized particles. In 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013.
• Zheng, X., Jiang, L., Schroeder, J. A., Marron, M., Iannone, M., Stopeck, A. T., & Zohar, Y. (2012, 2012///). Flow-rate dependent capture of circulating tumor cells in bio-functional microchannels. In IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED.
• Zheng, X., Jiang, L., Schroeder, J. A., Marron, M., Iannone, M., Stopeck, A. T., & Zohar, Y. (2012, 2012///). On the minimum detection limit of circulating tumor cells in an antibody-functionalized microchannel array. In IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED.
• Stamm, M. T., Zha, Z., Jiang, L., Dai, Z., & Zohar, Y. (2011, 2011///). Functionalization of ceramic liposomal nanoparticles, cerasomes, with antibodies. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11.
• Zheng, X. J., Cheung, L., Jiang, L., Schroeder, J. A., Heimark, R. L., Baygents, J. C., Guzman, R., & Zohar, Y. (2011, 2011///). Dynamic states of adhering cancer cells under shear flow in an antibody-functionalized microchannel. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS).
• Cooper, J. R., Qin, Y., Jiang, L., Palanivelu, R., & Zohar, Y. (2009, 2009///). Microsystem-based study of pollen-tube attractants secreted by ovules. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS).
• Gudipaty, T., Cheung, L., Jiang, L., & Zohar, Y. (2009, 2009///). Cluster formation and growth in flow of dilute particle suspension in microchannels. In 2008 Proceedings of the 9th Biennial Conference on Engineering Systems Design and Analysis, 4.
• Gudipaty, T., Stamm, M. T., Cheung, L., Zohar, Y., & Jiang, L. (2009, 2009///). Cluster dynamics in flow of suspended particles in microchannels. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS).
• Gudipaty, T., Cheung, L., Jiang, L., & Zohar, Y. (2008, 2008///). Cluster formation and evolution in particle-laden microchannel flow. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference.
• Jiang, L., Gerhardt, K. P., Myer, B., Zohar, Y., & Pau, S. (2008, 2008///). An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS).
• Chang, C., Flynn, R. D., Fogg, D. W., Goodson, K. E., Hidrovo, C., Jiang, L., Kenny, T. W., Koo, J., Pop, E., Santiago, J. G., Sinha, S., Wang, E. N., Yao, S., & Zhang, L. (2006, July, 9, 2005).

  ADVANCED COOLING TECHNOLOGIES FOR MICROPROCESSORS

  . In International Journal of High Speed Electronics and Systems.
• Hu, X., Jiang, L., & Goodson, K. E. (2004, 2004///). Thermal characterization of eutectic alloy thermal interface materials with void-like inclusions. In Annual IEEE Semiconductor Thermal Measurement and Management Symposium, 20.
• Hu, X., Jiang, L., & Goodson, K. E. (2004, 2004///). Thermal conductance enhancement of particle-filled thermal interface materials using carbon nanotube inclusions. In Thermomechanical Phenomena in Electronic Systems -Proceedings of the Intersociety Conference, 1.
• Bari, A., Koo, J., Jiang, L., Paidipati, J., & Goodson, K. E. (2003, 2003///). Frictional characteristics of microchannel gas flow. In International Conference on Microchannels and Minichannels, 1.
• Cho, E. S., Koo, J., Jiang, L., Prasher, R. S., Kim, M. S., Santiago, J. G., Kenny, T. W., & Goodson, K. E. (2003, 2003///). Experimental study on two-phase heat transfer in microchannel heat sinks with hotspots. In Annual IEEE Semiconductor Thermal Measurement and Management Symposium.
• Fogg, D. W., Koo, J. M., Jiang, L., & Goodson, K. E. (2003, 2003///). Numerical simulation of transient boiling convection in microchannels. In Proceedings of the ASME Summer Heat Transfer Conference, 2003.
• Hu, X., Jiang, L., & Goodson, K. E. (2003, 2003///). Impact of wall region particle volume fraction distribution on thermal resistance of particle filled thermal interface materials. In Annual IEEE Semiconductor Thermal Measurement and Management Symposium.
• Jain, A., Ness, K., McConnell, A., Jiang, L., & Goodson, K. (2003, 2003///). Design, fabrication and thermal characterization of a MEMS device for control of nerve cell growth. In American Society of Mechanical Engineers, Micro-Electromechanical Systems Division Publication (MEMS), 5.
• Ashegi, M., Banerjee, S., Goodson, K. E., Jiang, L., Kenny, T. W., Koo, J., Santiago, J. G., & Zhang, L. (2002, Feb).

  Measurements and Modeling of Two-Phase Flow in Microchannels With Nearly-Constant Heat Flux Boundary Conditions

  . In Journal of Microelectromechanical Systems, vol. 11, no. 1, pp. 12-19, Feb. 2002, doi: 10.1109/84.982858..
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  Abstract Two-phase forced convective flow in microchannels can be used as an effective means of cooling microelectronics. However, the number of studies on boiling in microchannels with dimensions smaller than 100 microns is limited. Particularly, the impact of small dimensions on bubble formation and the critical heat flux have received little attention. This work develops single and multi-channel silicon test devices with integrated heaters and thermometers, in an effort toward precisely determining the flow condition, the temperature distribution, and the heat transfer coefficients within microchannels. Rectangular channels with hydraulic diameter below 100 microns and varying aspect ratios were fabricated. The test devices have channel walls with widths below 350 microns, which minimizes solid conduction along the test section and reduces variations in the heat flux boundary condition. A semiconductor resistor strip measures the wall temperature distribution along the channel during phase change. A thermal resistance model has been developed to estimate the heat loss from the system. Down to hydraulic diameters as small as 25 microns, nucleation boiling under 5 °C of wall superheating was observed in plasma etched silicon microchannels.
• Jiang, L., Koo, J., Wang, E., Bari, A., Cho, E. S., Ong, W., Prasher, R. S., Maveety, J., Kim, M. S., Kenny, T. W., Santiago, J. G., & Goodson, K. E. (2002, 2002///). Cross-linked microchannels for vlsi hotspot cooling. In ASME International Mechanical Engineering Congress and Exposition, Proceedings.
• Koo, J., Im, S., Cho, E. S., Prasher, R. S., Wang, E., Jiang, L., Bari, A., Campion, D., Fogg, D., Kim, M. S., Kenny, T. W., Santiago, J. G., & Goodson, K. E. (2002, 2002///). VLSI hotspot cooling using two-phase microchannel convection. In American Society of Mechanical Engineers, Process Industries Division (Publication) PID, 7.
• Koo, J., Jiang, L., Bari, A., Zhang, L., Wang, E., Kenny, T. W., Santiago, J. G., & Goodson, K. E. (2002, 2002///). Convective boiling in microchannel heat sinks with spatially-varying heat generation. In Thermomechanical Phenomena in Electronic Systems -Proceedings of the Intersociety Conference.
• Zhang, L., Wang, E. N., Koo, J., Jiang, L., Goodson, K. E., Santiago, J. G., & Kenny, T. W. (2002, 2002///). Enhanced nucleate boiling in microchannels. In Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS).
• Goodson, K. E., Jiang, L., Kenny, T. W., Koo, J., Santiago, J. G., & Zhang, L. (2001).

  Study of Boiling Regimes and Transient Signal Measurements in Microchannels

  . In Transducers ’01 Eurosensors XV.
• Jiang, L., Koo, J., Zeng, S., Mikkelsen, J. C., Zhang, L., Zhou, P., Santiago, J. G., Kenny, T. W., & Goodson, K. E. (2001, 2001///). Two-phase microchannel heat sinks for an electrokinetic VLSI chip cooling system. In Annual IEEE Semiconductor Thermal Measurement and Management Symposium.
• Koo, J., Jiang, L., Zhang, L., Zhou, P., Banerjee, S. S., Kenny, T. W., Santiago, J. G., & Goodson, K. E. (2001, 2001///). Modeling of two-phase microchannel heat sinks for VLSI chips. In Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS).
• Zhang, L., Wang, E. N., Koch, J. D., Liu, J., Koo, J., Jiang, L., Goodson, K. E., Santiago, J. G., & Kenny, T. W. (2001, 2001///). Microscale liquid impingement cooling. In ASME International Mechanical Engineering Congress and Exposition, Proceedings, 2.
• Jiang, L., Wong, M., & Zohar, Y. (2000, 2000///). Phase change in microchannel heat sink under forced convection boiling. In Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS).
• Jiang, L., Wong, M., & Zohar, Y. (1999, 1999///). Micro-channel heat sink with integrated temperature sensors for phase transition study. In Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS).
• Li, B., Xiong, B., Jiang, L., Zohar, Y., & Wong, M. (1999, 1999///). Applications of germanium to low temperature micro-machining. In Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS).

Poster Presentations

• Jiang, L., Khawaja, H., Clarkson, T. A., Cernyar, B. M., Miranti, C., & Zohar, Y. (2023, September). Prostate-Cancer-on-Chip model to study therapeutic responses. NCI Patient-Derived Models of Cancer (PDMC) and Cancer Tissue Engineering Collective (TEC) Joint Annual Meeting. OHSU Knight Cancer Center Portland, Oregon: National Cancer Institute.

Others

• Zohar, Y., Restifo, L. L., & Jiang, L. (2017, December). Systems for Dissociation of Biological Tissues. US Patent & Trademark Office. https://pdfaiw.uspto.gov/.aiw?PageNum=0&docid=20170355950
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  This is a patent application. Here are the unique identifiers:PCT/US15/63978Publication No. US 2017/0355950 A1Abstract: Provided herein is technology relating to processing biological samples and particularly, but not exclusively, to systems and apparatuses for dissociating biological tissues into viable cells.