Benjamin R Lee
- Department Chair, Urology
- Professor, Urology
- Director, GU Cancer - Disease Oriented Strategic Planning Team
- Member of the Graduate Faculty
Benjamin R. Lee, MD, an internationally recognized surgeon, scientist and innovator has been named Professor and Chief of the Division of Urology, Department of Surgery, at the University of Arizona College of Medicine Tucson and Banner University Medical Center Tucson. In addition to his position as Chief, Division of Urology, he will also serve as Director of the GU Cancer and Disease Oriented Strategic Planning Team, University of Arizona Cancer Center; and Team Leader for Urological Imaging, Department of Medical Imaging. Dr. Lee will assume his new duties in June.
Before joining the University of Arizona, Dr. Lee served as Professor of Urology at Tulane University School of Medicine, New Orleans, LA, where he was also the Director of Endourology, Laparoscopy and Robotic Surgery fellowship program. Dr. Lee, a leading authority on robotic surgical therapy of renal cell carcinoma and prostate cancer, is noted for his innovations in robotic and laparoscopic surgery. His research also encompasses the therapeutic application of nanotechnology for the treatment of urologic malignancies.
After graduating magna cum laude from Cornell University, he attended the Johns Hopkins School of Medicine, where he also did his residency in urology at the James Buchanan Brady Urological Institute. There he was mentored by Drs. Patrick Walsh and Alan Partin, and was trained in laparoscopy by Dr. Lou Kavoussi. After completing his training at Johns Hopkins, he joined the faculty at North Shore Long Island Jewish Medical Center, where he developed additional expertise in the treatment of stone disease with the founder of endourology, Dr. Arthur Smith.
Dr. Lee has focused his career on urologic oncology, especially the treatment of renal cell carcinoma. He is author or co-author of more than 200 manuscripts, book chapters and educational videos. He has published on applications of nanotechnology for improving drug delivery in the treatment of renal cell carcinoma; methodologies for lessening the morbidity of surgery and for decreasing recurrences of cancer; variations in the immune response following laparoscopic versus open surgery; and innovative approaches for the preservation of renal function during laparoscopic and robotic kidney surgery.
Dr. Lee’s research has been recognized by awards from the American Urological Association, the Endourological Society, and Urology Journal. He was awarded the prestigious Arthur Smith Award in 2008 for his many contributions to the discipline of robotic, laparoscopic, and minimally invasive surgery. He was Organizing Secretary of the 31st World Congress of Endourology which was held in New Orleans, LA in 2013. He also chaired the American Urological Association Task Force on e-learning for “AUA University”. He currently serves on the Board of Directors of the SES - American Urological Association, the finance committee of the Endourological Society, the editorial board of the Journal of Endourology, and is Co-editor of the Journal of Endourology Case Reports.
- M.D. Doctor of Medicine
- The Johns Hopkins School of Medicine, Baltimore, Maryland, United States
- B.A. Bachelor of Arts, Biological Sciences, Magna Cum Laude
- Cornell University, Ithaca, New York, United States
- Senior Honors Thesis: Binding Studies of Cell Surface Immunoglobulin E-Receptor Complexes
- The University of Arizona College of Medicine (2016 - Ongoing)
- Tulane University School of Medicine (2010 - 2016)
- Tulane University School of Medicine (2008 - 2016)
- North Shore-Long Island Jewish Medical Center (2004 - 2008)
- North Shore-Long Island Jewish Medical Center (2001 - 2004)
- The Johns Hopkins Hospital (2000 - 2001)
- Honorable Mention
- Westinghouse, Spring 1986 (Award Nominee)
- 3rd Best Over-all Poster
- Western Section, American Urological Association, Summer 2017
- Best poster in the Kidney Cancer and Stone Disease Session
- AUA, Fall 2016
- Best Basic Science Research Paper
- World Congress of Endourology, Oct 4, 2015, London, United Kingdom, Fall 2015
- Best Robotic & Laparoscopic Paper
- 33rd World Congress of Endourology, Oct 4, 2015, London, United Kingdom, Fall 2015
Licensure & Certification
- Diplomate, American Board of Urology (2005)
- Arizona Medical License, Arizona Medical Board (2016)
Robotic surgery, Laparoscopic surgery, Renal Cell Carcinoma, Prostate Cancer, Robotic Surgical Education
UrologySURG 848H (Spring 2022)
UrologySURG 848H (Fall 2021)
UrologySURG 848H (Fall 2018)
Urology (Surgery Subspecialty)SURG 837H (Fall 2018)
Urology (Surgery Subspecialty)SURG 837H (Spring 2018)
UrologySURG 848H (Fall 2017)
Urology (Surgery Subspecialty)SURG 837H (Fall 2017)
Urology (Surgery Subspecialty)SURG 837H (Fall 2016)
- Lee, B. R., & Lai, W. (2016). Complications in Robotic Assisted Partial Nephrectomy. In Robotics in Genitourinary Surgery. Springer.
- Lee, B. R., & Lai, W. (2016). Patient Preparation and Operating Room Set-Up for Laparoscopic Surgery. In Smith's Textbook of Endourology.
- Lee, B. R., & Liu, J. (2016). Nanotechnology in Urology: History of Development and Applications in Urology. In History of Technologic Advancements in Urology.
- Gachupin, F. C., Lee, B. R., Chipollini, J., Pulling, K. R., Cruz, A., Wong, A. C., Valencia, C. I., Hsu, C., & Batai, K. (2022). Renal Cell Carcinoma Surgical Treatment Disparities in American Indian/Alaska Natives and Hispanic Americans in Arizona. International Journal of Environmental Research and Public Health, 19(3), 1185; https://doi.org/10.3390/ijerph19031185.
- Chipollini, J., Pollock, G., Hsu, C. H., Batai, K., Recio-Boiles, A., & Lee, B. R. (2021). National trends and survival outcomes of penile squamous cell carcinoma based on human papillomavirus status. Cancer medicine, 10(21), 7466-7474.More infoThere are no series evaluating penile squamous cell carcinoma (pSCC) based on human papillomavirus (HPV) infection. Herein, we present national registry data on clinical and survival outcomes for pSCC based on HPV status.
- Pollock, G., Hsu, C. H., Batai, K., Lee, B. R., & Chipollini, J. (2021). Postoperative and Survival Outcomes After Cytoreductive Surgery in the Treatment of Metastatic Upper Tract Urothelial Carcinoma. Urology.More infoTo analyze utilization and outcomes of cytoreductive surgery (CRS) after systemic chemotherapy in select patients with metastatic upper tract urothelial carcinoma (UTUC).
- Quinonez-Zanabria, E., Valencia, C. I., Asif, W., Zeng, J., Wong, A. C., Cruz, A., Chipollini, J., Lee, B. R., Gachupin, F. C., Hsu, C. H., & Batai, K. (2021). Racial and Ethnic Disparities in Preoperative Surgical Wait Time and Renal Cell Carcinoma Tumor Characteristics. Healthcare (Basel, Switzerland), 9(9).More infoRacial/ethnic minority groups have a disproportionate burden of kidney cancer. The objective of this study was to assess if race/ethnicity was associated with a longer surgical wait time (SWT) and upstaging in the pre-COVID-19 pandemic time with a special focus on Hispanic Americans (HAs) and American Indian/Alaska Natives (AIs/ANs). Medical records of renal cell carcinoma (RCC) patients who underwent nephrectomy between 2010 and 2020 were retrospectively reviewed ( = 489). Patients with a prior cancer diagnosis were excluded. SWT was defined as the date of diagnostic imaging examination to date of nephrectomy. Out of a total of 363 patients included, 34.2% were HAs and 8.3% were AIs/ANs. While 49.2% of HA patients experienced a longer SWT (≥90 days), 36.1% of Non-Hispanic White (NHW) patients experienced a longer SWT. Longer SWT had no statistically significant impact on tumor characteristics. Patients with public insurance coverage had increased odds of longer SWT (OR 2.89, 95% CI: 1.53-5.45). Public insurance coverage represented 66.1% HA and 70.0% AIs/ANs compared to 56.7% in NHWs. Compared to NHWs, HAs had higher odds for longer SWT in patients with early-stage RCC (OR, 2.38; 95% CI: 1.25-4.53). HAs (OR 2.24, 95% CI: 1.07-4.66) and AIs/ANs (OR 3.79, 95% CI: 1.32-10.88) had greater odds of upstaging compared to NHWs. While a delay in surgical care for early-stage RCC is safe in a general population, it may negatively impact high-risk populations, such as HAs who have a prolonged SWT or choose active surveillance.
- Singh, N., Ramnarine, V. R., Song, J. H., Pandey, R., Padi, S. K., Nouri, M., Olive, V., Kobelev, M., Okumura, K., McCarthy, D., Hanna, M. M., Mukherjee, P., Sun, B., Lee, B. R., Parker, J. B., Chakravarti, D., Warfel, N. A., Zhou, M., Bearss, J. J., , Gibb, E. A., et al. (2021). The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer. Nature communications, 12(1), 7349.More infoNeuroendocrine (NE) prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (PCa) arising either de novo or from transdifferentiated prostate adenocarcinoma following androgen deprivation therapy (ADT). Extensive computational analysis has identified a high degree of association between the long noncoding RNA (lncRNA) H19 and NEPC, with the longest isoform highly expressed in NEPC. H19 regulates PCa lineage plasticity by driving a bidirectional cell identity of NE phenotype (H19 overexpression) or luminal phenotype (H19 knockdown). It contributes to treatment resistance, with the knockdown of H19 re-sensitizing PCa to ADT. It is also essential for the proliferation and invasion of NEPC. H19 levels are negatively regulated by androgen signaling via androgen receptor (AR). When androgen is absent SOX2 levels increase, driving H19 transcription and facilitating transdifferentiation. H19 facilitates the PRC2 complex in regulating methylation changes at H3K27me3/H3K4me3 histone sites of AR-driven and NEPC-related genes. Additionally, this lncRNA induces alterations in genome-wide DNA methylation on CpG sites, further regulating genes associated with the NEPC phenotype. Our clinical data identify H19 as a candidate diagnostic marker and predictive marker of NEPC with elevated H19 levels associated with an increased probability of biochemical recurrence and metastatic disease in patients receiving ADT. Here we report H19 as an early upstream regulator of cell fate, plasticity, and treatment resistance in NEPC that can reverse/transform cells to a treatable form of PCa once therapeutically deactivated.
- Valencia, C. I., Asmar, S., Hsu, C. H., Gachupin, F. C., Wong, A. C., Chipollini, J., Lee, B. R., & Batai, K. (2021). Renal Cell Carcinoma Health Disparities in Stage and Mortality among American Indians/Alaska Natives and Hispanic Americans: Comparison of National Cancer Database and Arizona Cancer Registry Data. Cancers, 13(5).More infoRenal cell carcinoma (RCC) is one of the top 10 cancers in the United States. This study assessed RCC health disparities in American Indians/Alaska Natives (AIs/ANs) and Hispanic Americans (HAs) focusing on advanced-stage and mortality. RCC patients' data were obtained from the National Cancer Database (NCDB) and Arizona Cancer Registry (ACR). Logistic and Cox regression analyses were performed to ascertain the effect of race/ethnicity on stage and mortality, adjusting for neighborhood socioeconomic factors, rural/urban residence pattern, and other factors. In both data sets, AIs/ANs had significantly increased odds of advanced-stage RCC in the unadjusted model, but not in adjusted models. Mexican Americans had higher odds of advanced-stage compared to non-Hispanic Whites in NCDB (OR 1.22, 95% CI: 1.11-1.35) and ACR (OR 2.02, 95% CI: 1.58-2.58), even after adjusting for neighborhood characteristics. AIs/ANs did not show increased mortality risk in NCDB after adjusting for neighborhood characteristics, while the association remained significant in ACR (HR 1.33, 95% CI: 1.03-1.72). The great risk of all-cause and RCC-specific mortality was observed in U.S.-born Mexican Americans in Arizona (HR 3.21, 95% CI: 2.61-3.98 and sub-distribution HR 2.79, 95% CI: 2.05-3.81). RCC disparities in AIs/ANs is partially explained by neighborhood factors, but not in HAs.
- Zeng, J., Batai, K., & Lee, B. R. (2021). Nephrectomy Delay of More than 10 Weeks from Diagnosis Is Associated with Decreased Overall Survival in pT3 RCC. Journal of kidney cancer and VHL, 8(2), 27-33.More infoIn this study, we aimed to evaluate the impact of surgical wait time (SWT) on outcomes of patients with renal cell carcinoma (RCC), and to investigate risk factors associated with prolonged SWT. Using the National Cancer Database, we retrospectively reviewed the records of patients with pT3 RCC treated with radical or partial nephrectomy between 2004 and 2014. The cohort was divided based on SWT. The primary outcome was 5-year overall survival (OS). Logistic regression analysis was used to investigate the risk factors associated with delayed surgery. Cox proportional hazards models were fitted to assess relations between SWT and 5-year OS after adjusting for confounding factors. A total of 22,653 patients were included in the analysis. Patients with SWT > 10 weeks had higher occurrence of upstaging. Using logistic regression, we found that female patients, African-American or Spanish origin patients, treatment in academic or integrated network cancer center, lack of insurance, median household income of 10 weeks was associated with decreased 5-year OS (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.15-1.33). This risk was not markedly attenuated after adjusting for confounding variables, including age, gender, race, insurance status, Charlson-Deyo score, tumor size, and surgical margin status (adjusted HR, 1.13; 95% CI, 1.04-1.24). In conclusion, the vast majority of patients underwent surgery within 10 weeks. There is a statistically significant trend of increasing SWT over the study period. SWT > 10 weeks is associated with decreased 5-year OS.
- Bukavina, L., Mishra, K., Mahran, A., Fernstrum, A., Ray, A., Markt, S., Schumacher, F., Conroy, B., Abouassaly, R., MacLennan, G., Smith, G., Ferry, E., Wong, D., Lotan, Y., Chaparala, H., Sharp, D., Alazem, K., Moinzadeh, A., Adamic, B., , Zagaja, G., et al. (2020). "Robotic fatigue?" - The impact of case order on positive surgical margins in robotic-assisted laparoscopic prostatectomy. Urologic oncology.More infoMultiple robotic-assisted surgeries are often performed within a single operating day; however, the impact of this practice on patient outcomes has not been examined. We aim to determine whether outcomes for robotic-assisted laparoscopic prostatectomy (RALP) differed when performed sequentially.
- Chipollini, J., Wright, J. R., Nwanosike, H., Kepler, C. Y., Batai, K., Lee, B. R., Spiess, P. E., Stewart, D. B., & Lamendella, R. (2020). Characterization of urinary microbiome in patients with bladder cancer: Results from a single-institution, feasibility study. Urologic oncology, 38(7), 615-621.More infoThe human microbiome has been linked to the development of several malignancies, but there is scarcity of data on the microbiome of bladder cancer patients. In this study, we analyzed microbial composition and diversity among patients with and without bladder cancer.
- Harb-De la Rosa, A., Garcia-Castaneda, J., Hsu, C. H., Zeng, J., Batai, K., Lee, B. R., & Chipollini, J. (2020). Perioperative outcomes of open vs. robotic radical cystectomy: a nationwide comparative analysis (2008-2014). Central European journal of urology, 73(4), 427-431.More infoRadical cystectomy (RC) is a complex procedure with high perioperative morbidity. In an effort to reduce complications, robotic-assisted RC (RARC) has been adopted as a minimally invasive alternative to the open approach (ORC). Herein, we examine post-operative outcomes of the two surgical approaches in the United States (US) using a large all-payer database.
- Loloi, J., Shingleton, W. B., Nakada, S. Y., Zagoria, R. J., Landman, J., Lee, B. R., Matin, S. F., Ahrar, K., Leveillee, R. J., Cadeddu, J. A., & Raman, J. D. (2020). Management of Residual or Recurrent Disease Following Thermal Ablation of Renal Cortical Tumors. Journal of kidney cancer and VHL, 7(2), 1-5.More infoManagement of residual or recurrent disease following thermal ablation of renal cortical tumors includes surveillance, repeat ablation, or surgical extirpation. We present a multicenter experience with regard to the management of this clinical scenario. Prospectively maintained databases were reviewed to identify 1265 patients who underwent cryoablation (CA) or radiofrequency ablation (RFA) for enhancing renal masses. Disease persistence or recurrence was classified into one of the three categories: (i) residual disease in ablation zone; (ii) recurrence in the ipsilateral renal unit; and (iii) metastatic/extra-renal disease. Seventy seven patients (6.1%) had radiographic evidence of disease persistence or recurrence at a median interval of 13.7 months (range, 1-65 months) post-ablation. Distribution of disease included 47 patients with residual disease in ablation zone, 29 with ipsilateral renal unit recurrences (all in ablation zone), and one with metastatic disease. Fourteen patients (18%) elected for surveillance, and the remaining underwent salvage ablation (n = 50), partial nephrectomy (n = 5), or radical nephrectomy (n = 8). Salvage ablation was successful in 38/50 (76%) patients, with 12 failures managed by observation (3), tertiary ablation (6), and radical nephrectomy (3). At a median follow-up of 28 months, the actuarial cancer-specific survival and overall survival in this select cohort of patients was 94.8 and 89.6%, respectively.
- Phung, M. C., Rouse, A. R., Pangilinan, J., Bell, R. C., Bracamonte, E. R., Mashi, S., Gmitro, A. F., & Lee, B. R. (2020). Investigation of confocal microscopy for differentiation of renal cell carcinoma versus benign tissue. Can an optical biopsy be performed?. Asian journal of urology, 7(4), 363-368.More infoNovel optical imaging modalities are under development with the goal of obtaining an "optical biopsy" to efficiently provide pathologic details. One such modality is confocal microscopy which allows visualization of cells within a layer of tissue and imaging of cellular-level structures. The goal of this study is to validate the ability of confocal microscopy to quickly and accurately differentiate between normal renal tissue and cancer.
- Zeng, J., & Lee, B. R. (2020). Editorial comment on END-2020-0043-TEC.R1. Journal of endourology.
- Batai, K., Harb-De la Rosa, A., Lwin, A., Chaus, F., Gachupin, F. C., Price, E., & Lee, B. R. (2019). Racial and Ethnic Disparities in Renal Cell Carcinoma: An Analysis of Clinical Characteristics. Clinical genitourinary cancer, 17(1), e195-e202.More infoRacial/ethnic minority groups, including Hispanic Americans (HAs) and Native Americans (NAs), have a heavier burden of kidney cancer than European Americans (EAs). We investigated variations in clinical characteristics of HA and NA patients with renal cell carcinoma (RCC) who were previously underrepresented.
- Batai, K., Harb-De la Rosa, A., Zeng, J., Chipollini, J. J., Gachupin, F. C., & Lee, B. R. (2019). Racial/ethnic disparities in renal cell carcinoma: Increased risk of early-onset and variation in histologic subtypes. Cancer medicine, 8(15), 6780-6788.More infoRacial/ethnic minority groups have a higher burden of renal cell carcinoma (RCC), but RCC among Hispanic Americans (HAs) and American Indians and Alaska Natives (AIs/ANs) are clinically not well characterized. We explored variations in age at diagnosis and frequencies of RCC histologic subtypes across racial/ethnic groups and Hispanic subgroups using National Cancer Database (NCDB) and Arizona Cancer Registry Data.
- Chaus, F. M., Craig, M., Bracamonte, E., Sundararajan, S., & Lee, B. R. (2019). Primary Malignant Melanoma of the Bladder Treated by Robotic Partial Cystectomy and Immunotherapy. Journal of endourology case reports, 5(4), 151-153.More infoPrimary malignant melanoma (PMM) of the urinary tract is a rare entity, with only 28 cases reported in the literature. We present an interesting case of a 27-year-old Caucasian woman, with family history of melanoma, who initially presented with gross hematuria, and was subsequently found to have PMM of the bladder. Initially diagnosis was made through transurethral resection of the bladder tumor with clinical suspicion of residual disease in the patient. Subsequently, she underwent robotic partial cystectomy with pelvic lymph node dissection followed by 1 year of pembrolizumab, a PD-1 checkpoint inhibitor. Subsequent imaging demonstrated no evidence of metastatic disease or local recurrence. This case report presents a unique management of a rare pathological diagnosis with the use of robotic partial cystectomy, and a PD-1 checkpoint inhibitor therapy that ultimately has led to a 2-year recurrence-free survival period for this young patient.
- Chaus, F., Craig, M., Bracamonte, E. R., Sundararajan, S., & Lee, B. R. (2019). Primary Malignant Melanoma of the Bladder Treated by Robotic Partial Cystectomy and Immunotherapy. Journal of Endourology Case Reports, Volume: 5 Issue 4:.
- Batai, K., Bergersen, A., Price, E., Hynes, K., Ellis, N., & Lee, B. R. (2018). Clinical and Molecular Characteristics and Burden of Kidney Cancer Among Hispanics and Native Americans: Steps Toward Precision Medicine. Clinical Genitourin Cancer, 16((3)), e535-541. doi:10.1016/j.clgc.2018.01.006
- Batai, K., Imler, E., Pangilinan, J., Bell, R., Lwin, A., Price, E., Milinic, T., Arora, A., Ellis, N. A., Bracamonte, E., Seligmann, B., & Lee, B. R. (2018). Whole-transcriptome sequencing identified gene expression signatures associated with aggressive clear cell renal cell carcinoma. Genes & cancer, 9(5-6), 247-256.More infoClear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer, yet molecular biomarkers have not been used for the prognosis of ccRCC to aide clinical decision making. This study aimed to identify genes associated with ccRCC aggressiveness and overall survival (OS). Samples of ccRCC tumor tissue were obtained from 33 patients who underwent nephrectomy. Gene expression was determined using whole-transcriptome sequencing. The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) RNA-seq data was used to test association with OS. 290 genes were differentially expressed between tumors with high and low stage, size, grade, and necrosis (SSIGN) score (≥7 . ≤3) with
- Batai, K., Lee, B. R., Bergersen, A., Ellis, N., Hynes, K., Price, E., Price, E., Hynes, K., Bergersen, A., Ellis, N., Lee, B. R., & Batai, K. (2017). The Clinical and Molecular Characteristics and Burden of Kidney Cancer among Hispanics and Native Americans: Steps toward Precision Medicine. Clinical Genitourinary Cancer.
- Bergersen, A., & Lee, B. R. (2017). Step-by-step technical considerations for laparoscopic and robotic partial nephrectomy. British Journal of Urology.
- Bergersen, A., & Lee, B. R. (2018). Robotic Pyeloplasty Step by Step Guitde. Journal of Endourology, 32(S1), S68-S72. doi:doi: 10.1089/end.2017.0726
- Bergersen, A., R, T., & Lee, B. R. (2017). Robotic Pyeloplasty. British Journal of Urology.
- Bergersen, A., Thomas, R., & Lee, B. R. (2018). Robotic Pyeloplasty. Journal of endourology, 32(S1), S68-S72.More infoHistorically, the gold standard for management of ureteropelvic junction obstruction (UPJO) has been open pyeloplasty. However, continued technological and surgical advances have ultimately led to the robotic approach. Continued advances in minimally invasive surgery have led to shorter hospital stays and hastened recovery. Here we present our step by step guide and video to robotic-assisted laparoscopic pyeloplasty.
- Phung, M. C., & Lee, B. R. (2018). Recent advancements of robotic surgery for kidney cancer. Asian J Endosc Surg, 11(4), 300-307. doi:10.1111/ases.12635
- Phung, M. C., & Lee, B. R. (2018). Recent advancements of robotic surgery for kidney cancer. Asian journal of endoscopic surgery, 11(4), 300-307.More infoSurgical management of renal cell carcinoma has undergone a transformation in recent decades, especially with the dissemination of the robotic platform. Increasingly, larger and more complex renal lesions are now being treated in a minimally invasive fashion. The purpose of this article is to review advances in the use of the robotic approach for treatment of renal cell carcinoma, including nephron-sparing surgery, radical nephrectomy, and cytoreductive nephrectomy.
- Wang, M., Tulman, D. B., Scholl, A. B., Mandava, S. H., Maddox, M. M., Lee, B. R., & Brown, Q. J. (2018). Partial Nephrectomy margin imaging using structured illumination microscopy. Journal of Biophotonics.
- Wang, M., Tulman, D. B., Sholl, A. B., Mandava, S. H., Maddox, M. M., Lee, B. R., & Brown, J. Q. (2018). Partial nephrectomy margin imaging using structured illumination microscopy. Journal of Biophontonics, 11((3)). doi:10.1002/jbio.201600328
- Golan, S., Johnson, S. C., Maurice, M. J., Kaouk, J. H., Lai, W. R., Lee, B. R., Kheyfets, S. V., Sundaram, C. P., Cahn, D. B., Uzzo, R. G., & Shalhav, A. L. (2017). Safety and early effectiveness of robot-assisted partial nephrectomy for large angiomyolipomas. BJU International.
- Phung, M. C., Lee, B. R., & Funk, J. T. (2017). Percutaneous Management of Pyocystic Fistulizing Continent Urinary Diversion. Journal Endorurology Case Report, 162-164.
- Phung, M. C., Lee, B. R., & Funk, J. T. (2017). Percutaneous Management of a Pyocystic Fistulizing Continent Urinary Diversion. Journal of endourology case reports, 3(1), 162-164.More infoContinent diversions have since been performed with increasing frequency since the 1950s, with some providers espousing the use of orthotopic diversions as being the new gold standard. However, patients must be counseled to take great care in the maintenance of their diversions because of complications such as metabolic abnormalities, pouch stones, and mucus retention. A 21-year-old male with a history of posterior urethral valves underwent a continent catheterizable diversion as a child. He is undocumented and without health insurance and as a result unable to follow-up with an urologist for >10 years. He subsequently develops pyocystis with cutaneous fistulization and pouch stones necessitating percutaneous management. Patients may benefit greatly from a continent urinary diversion, however, selection must include patients who are able to maintain their pouch and follow-up with their providers to avoid major complications that may occur up to years following the procedure.
- Callaghan, C., Peralta, D., Liu, J., Mandava, S. H., Maddox, M., Dash, S., Tarr, M. A., & Lee, B. R. (2016). Combined Treatment of Tyrosine Kinase Inhibitor-Labeled Gold Nanorod Encapsulated Albumin With Laser Thermal Ablation in a Renal Cell Carcinoma Model. Journal of pharmaceutical sciences, 105(1), 284-92.More infoTo characterize and evaluate human serum albumin-encapsulated nanoparticles for drug delivery of a tyrosine kinase inhibitor combined with induction of photothermal ablation combination therapy of renal cell carcinoma (RCC), nanoparticles of varying preparations and concentrations were characterized via zeta potential, drug loading, and release profile. Cytotoxicity and uptake trials were also studied using clear cell RCC cell line RCC 786-0, a human metastatic carcinoma. Target temperatures of >50°C were consistently attained by 0.1 and 0.05 μM concentrations of irradiated human serum albumin nanoparticle-gold nanorods (HSAP-AuNRs). Irradiated trials of HSAP-AuNRs demonstrated significantly decreased cell viabilities compared with nonirradiated "dark" controls (p < 0.01). Increasing loaded masses of sorafenib (SRF) also significantly decreased relative cell viability of RCC (p < 0.05). Photothermal ablation using HSAP-AuNRs is capable of inducing significant hyperthermia while the loading of SRF further enhances cytotoxicity relative to treatment with HSAP-AuNRs alone. HSAP-AuNR-SRFs have the potential to be an effective, novel combination treatment for advanced RCC.
- Colli, J. L., Dorsey, P., Grossman, L., & Lee, B. R. (2016). Retrograde renal cooling to minimize ischemia. International braz j urol : official journal of the Brazilian Society of Urology, 39(1), 37-45.More infoDuring partial nephrectomy, renal hypothermia has been shown to decrease ischemia induced renal damage which occurs from renal hilar clamping. In this study we investigate the infusion rate required to safely cool the entire renal unit in a porcine model using retrograde irrigation of iced saline via dual-lumen ureteral catheter.
- Ellimoottil, C., Skolarus, T., Gettman, M., Boxer, R., Kutikov, A., Lee, B. R., Shelton, J., & Morgan, T. (2016). Telemedicine in Urology: State of the Art. Urology, 94, 10-6.More infoWhereas telemedicine is recognized as one of the fastest-growing components of the healthcare system, the status of telemedicine use in urology is largely unknown. In this narrative review, we detail studies that investigate the use of televisits and teleconsultations for urologic conditions. Moreover, we discuss current regulatory and reimbursement policies. Finally, we discuss the significant barriers to widespread dissemination and implementation of telemedicine and reasons why the field of urology may be positioned to become a leader in the provision of telemedicine services.
- Lee, B. R., & Lai, W. R. (2016). Techniques to Resect the Distal Ureter in Robotic/Laparoscopic Nephroureterectomy. Asian Journal of Urology. doi:10.1016/j.ajur.2016.04.001
- Lee, B. R., Feibus, A. H., Sartor, O., Moparty, K., Chagin, K., Kattan, M. W., Ledet, E., Levy, J., Thomas, R., & Silberstein, J. L. (2016). Clinical Utility of PCA3 and TMPRSS2:ERG Urinary Biomarkers in African American Men Undergoing Prostate Biopsy. Urology.
- Lee, B. R., Kowalewski, T. M., Comstock, B., Sweet, R., Schaffhausen, C., Menhadji, A., Averch, T., Box, G., Brand, T., Ferrandino, M., Kaouk, J., Knudsen, B., Landman, J., Schwartz, B. F., McDougall, E., & Lendvay, T. S. (2016). Crowd Sourced Assessment of Technical Skills for Validation of Basic Laparoscopic Urologic Skills (BLUS) Tasks. Urology, 6(195), 1859-65.
- Lee, B. R., Kowalewski, T., Sweet, R., Lendvay, T. S., Menhadji, A., Averch, T., Box, G., Brand, T., Ferrandino, M., Kaouk, J., Knudsen, B., Landman, J., Schwartz, B., & McDougall, E. (2016). Validation of the AUA Basic Laparoscopic Urologic Surgery Skills (BLUS) Tasks. Urology, 195, 998-1005.
- Lee, B. R., Liu, X., Ledet, E., Li, D., Dotiwala, A., Steinberger, A., Feibus, A., Li, J., Qi, Y., Silberstein, J., Dong, Y., Sartor, O., & Zhang, H. (2016). A Whole Blood-Based Detection Assay for Androgen Receptor Splice Variants in Patients with Advanced Prostate Cancer. Urology.
- Lee, B. R., Powers, M. K., & Silberstein, J. (2016). 3-Dimensional Printing of Surgical Anatomy. Current Opinion in Urology, 3(26), 283-8.
- Liu, J., Abshire, C., Carry, C., Sholl, A. B., Mandava, S. H., Datta, A., Ranjan, M., Callaghan, C., Peralta, D. V., Williams, K. S., Lai, W. R., Abdel-Mageed, A. B., Tarr, M., & Lee, B. R. (2016). Nanotechnology combined therapy: tyrosine kinase-bound gold nanorod and laser thermal ablation produce a synergistic higher treatment response of renal cell carcinoma in a murine model. BJU international.More infoTo investigate tyrosine kinase inhibitors (TKI) and gold nanorods (AuNRs) paired with photothermal ablation in a human metastatic clear cell renal cell carcinoma (RCC) mouse model. Nanoparticles have been successful as a platform for targeted drug delivery in the treatment of urological cancers. Likewise, the use of nanoparticles in photothermal tumour ablation, although early in its development, has provided promising results. Our previous in vitro studies of nanoparticles loaded with both TKI and AuNRs and activated with photothermal ablation have shown significant synergistic cell kill greater than each individual arm alone. This study is a translation of our initial findings to an in vivo model.
- Liu, J., Wang, M., Tulman, D., Mandava, S. H., Elfer, K. N., Gabrielson, A., Lai, W., Abshire, C., Sholl, A. B., Brown, J. Q., & Lee, B. R. (2016). Non-Destructive Diagnosis of Kidney Cancer on 18- Gauge Core Needle Renal Biopsy Using Dual-Color Fluorescence Structured Illumination Microscopy. Urology.More infoTo present a novel imaging technique used for rapid, non-destructive histological assessment of renal neoplasias using a dual-component fluorescence stain and structured illumination microscopy (SIM).
- Mandava, S. H., Liu, J., Maddox, M. M., Woodson, B., Thomas, R., & Lee, B. R. (2016). Stratification of Expert vs Novice Laparoscopists Using the Basic Laparoscopic Urologic Surgery (BLUS) Curriculum at a Single Institution. Journal of surgical education, 72(5), 964-8.More infoTo assess determinants of performance applying the tasks of the Basic Laparoscopic Urologic Surgery (BLUS) skills curriculum administered at a single institution.
- Powers, M. K., Boonjindasup, A., Pinsky, M., Dorsey, P., Maddox, M., Su, L., Gettman, M., Sundaram, C. P., Castle, E. P., Lee, J. Y., & Lee, B. R. (2016). Crowdsourcing Assessment of Surgeon Dissection of Renal Artery and Vein During Robotic Partial Nephrectomy: A Novel Approach for Quantitative Assessment of Surgical Performance. Journal of endourology / Endourological Society, 30(4), 447-52.More infoWe sought to describe a methodology of crowdsourcing for obtaining quantitative performance ratings of surgeons performing renal artery and vein dissection of robotic partial nephrectomy (RPN). We sought to compare assessment of technical performance obtained from the crowdsourcers with that of surgical content experts (CE). Our hypothesis is that the crowd can score performances of renal hilar dissection comparably to surgical CE using the Global Evaluative Assessment of Robotic Skills (GEARS).
- Powers, M. K., Lee, B. R., & Silberstein, J. (2016). Three-dimensional printing of surgical anatomy. Current opinion in urology, 26(3), 283-8.More infoOver the past decade, three-dimensional printing for the medical field has been expanding rapidly throughout all of medicine. This manuscript reviews the current and potential applications for three-dimensional printing, including education, presurgical planning, surgical simulation, bioprinting, and printed surgical equipment.
- Viriyasiripong, S., Lopez, A., Mandava, S. H., Lai, W. R., Mitchell, G. C., Boonjindasup, A., Powers, M. K., Silberstein, J. L., & Lee, B. R. (2016). Accelerometer Measurement of Head Movement During Laparoscopic Surgery as a Tool to Evaluate Skill Development of Surgeons. Journal of surgical education, 73(4), 589-94.More infoTo detect and measure surgeons' head movement during laparoscopic simulator performance to determine whether expert surgeons have economy of motion in their head movement, including change of direction, compared with intermediate and novice surgeons. We investigated head movement as an objective tool for assessment of laparoscopic surgical skill and its potential use for assessing novice surgeons' progress on the learning curve.
- Wang, J. C., Lai, W. R., Traore, E. J., Liu, J., Sholl, A. B., Mandava, S. H., Maddox, M. M., Mitchell, G. C., Viriyasiripong, S., Silberstein, J. L., Kittles, R., & Lee, B. R. (2016). Racial Disparities in Histology and Short-Term Renal Functional Outcomes Following Robotic Nephron-Sparing Surgery. Clinical genitourinary cancer.More infoTo identify variations in renal function and histology between Caucasian Americans (CA) and African Americans (AA) undergoing robotic nephron-sparing surgery (NSS).
- Wang, M., Tulman, D. B., Sholl, A. B., Kimbrell, H. Z., Mandava, S. H., Elfer, K. N., Luethy, S., Maddox, M. M., Lai, W., Lee, B. R., & Brown, J. Q. (2016). Gigapixel surface imaging of radical prostatectomy specimens for comprehensive detection of cancer-positive surgical margins using structured illumination microscopy. Scientific reports, 6, 27419.More infoAchieving cancer-free surgical margins in oncologic surgery is critical to reduce the need for additional adjuvant treatments and minimize tumor recurrence; however, there is a delicate balance between completeness of tumor removal and preservation of adjacent tissues critical for normal post-operative function. We sought to establish the feasibility of video-rate structured illumination microscopy (VR-SIM) of the intact removed tumor surface as a practical and non-destructive alternative to intra-operative frozen section pathology, using prostate cancer as an initial target. We present the first images of the intact human prostate surface obtained with pathologically-relevant contrast and subcellular detail, obtained in 24 radical prostatectomy specimens immediately after excision. We demonstrate that it is feasible to routinely image the full prostate circumference, generating gigapixel panorama images of the surface that are readily interpreted by pathologists. VR-SIM confirmed detection of positive surgical margins in 3 out of 4 prostates with pathology-confirmed adenocarcinoma at the circumferential surgical margin, and furthermore detected extensive residual cancer at the circumferential margin in a case post-operatively classified by histopathology as having negative surgical margins. Our results suggest that the increased surface coverage of VR-SIM could also provide added value for detection and characterization of positive surgical margins over traditional histopathology.
- Liu, J., Boonkaew, B., Arora, J., Mandava, S. H., Maddox, M. M., Chava, S., Callaghan, C., He, J., Dash, S., John, V. T., & Lee, B. R. (2015). Comparison of sorafenib-loaded poly (lactic/glycolic) acid and DPPC liposome nanoparticles in the in vitro treatment of renal cell carcinoma. Journal of pharmaceutical sciences, 104(3), 1187-96.More infoThe objective of this study is to develop and compare several Sorafenib-loaded biocompatible nanoparticle models in order to optimize drug delivery and tumor cellular kill thereby improving the quality of Sorafenib-regimented chemotherapy. Sorafenib-loaded poly (lactic-co-glycolic) acid (PLGA), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes, and hydrophobically modified chitosan (HMC)-coated DPPC liposomes were evaluated for several characteristics including zeta potential, drug loading, and release profile. Cytotoxicity and uptake trials were also studied using cell line RCC 786-0, a human metastatic clear cell histology renal cell carcinoma cell line. Sorafenib-loaded PLGA particles and HMC-coated DPPC liposomes exhibited significantly improved cell kill compared to Sorafenib alone at lower concentrations, namely 10-15 and 5-15 μM from 24 to 96 h, respectively. At maximum dosage and time (15 μM and 96 h), Sorafenib-loaded PLGA and HMC-coated liposomes killed 88.3 ± 1.8% and 98 ± 1.1% of all tumor cells, significant values compared with Sorafenib 81.8 ± 1.7% (p < 0.01). Likewise, HMC coating substantially improved cell kill for liposome model for all concentrations (5-15 μM) and at time points (24-96 h) (p < 0.01). PLGA and HMC-coated liposomes are promising platforms for drug delivery of Sorafenib. Because of different particle characteristics of PLGA and liposomes, each model can be further developed for unique clinical modalities.
- Maddox, M. M., Lopez, A., Mandava, S. H., Boonjindasup, A., Viriyasiripong, S., Silberstein, J. L., & Lee, B. R. (2015). Electroencephalographic Monitoring of Brain Wave Activity During Laparoscopic Surgical Simulation to Measure Surgeon Concentration and Stress: Can the Student Become the Master?. Journal of endourology / Endourological Society, 29(12), 1329-33.More infoTo measure gamma and alpha brain wave activity as a measurement of concentration and stress levels during surgical simulator performance of laparoscopic tasks to determine if expert surgeons have different brain activity patterns compared with intermediate and novice surgeons.
- Maddox, M., Mandava, S., Liu, J., Boonjindasup, A., & Lee, B. R. (2015). Robotic partial nephrectomy for clinical stage T1b tumors: intermediate oncologic and functional outcomes. Clinical genitourinary cancer, 13(1), 94-9.More infoThe objective of this study was to examine our intermediate oncologic and functional outcomes of robotic partial nephrectomy for clinical T1b tumors. Partial nephrectomy has become the gold standard of treatment for small renal masses. Recently, indications for minimally invasive partial nephrectomy have extended to larger and more complicated renal masses in some centers.
- Patil, U. S., Adireddy, S., Jaiswal, A., Mandava, S., Lee, B. R., & Chrisey, D. B. (2015). In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles. International journal of molecular sciences, 16(10), 24417-50.More infoIncreasing biomedical applications of iron oxide nanoparticles (IONPs) in academic and commercial settings have alarmed the scientific community about the safety and assessment of toxicity profiles of IONPs. The great amount of diversity found in the cytotoxic measurements of IONPs points toward the necessity of careful characterization and quantification of IONPs. The present document discusses the major developments related to in vitro and in vivo toxicity assessment of IONPs and its relationship with the physicochemical parameters of IONPs. Major discussion is included on the current spectrophotometric and imaging based techniques used for quantifying, and studying the clearance and biodistribution of IONPs. Several invasive and non-invasive quantification techniques along with the pitfalls are discussed in detail. Finally, critical guidelines are provided to optimize the design of IONPs to minimize the toxicity.
- Powers, M. K., Sartor, O., & Lee, B. R. (2015). Neoadjuvant Tyrosine Kinase Downstaging of T2 Renal Cell Carcinoma in Solitary Kidney Before Robotic Partial Nephrectomy. Journal of endourology case reports, 1(1), 47-9.More infoWe highlight the use of a tyrosine kinase inhibitor, pazopanib, for neoadjuvant downstaging a 7.4 cm right biopsy-proven clear cell renal-cell carcinoma in a solitary kidney before surgical intervention of robotic partial nephrectomy with retrograde cooling to induce cold ischemia in a 79-year-old male.
- Wang, M., Kimbrell, H. Z., Sholl, A. B., Tulman, D. B., Elfer, K. N., Schlichenmeyer, T. C., Lee, B. R., Lacey, M., & Brown, J. Q. (2015). High-Resolution Rapid Diagnostic Imaging of Whole Prostate Biopsies Using Video-Rate Fluorescence Structured Illumination Microscopy. Cancer research, 75(19), 4032-41.More infoRapid assessment of prostate core biopsy pathology at the point-of-procedure could provide benefit in a variety of clinical situations. Even with advanced transrectal ultrasound guidance and saturation biopsy protocols, prostate cancer can be missed in up to half of all initial biopsy procedures. In addition, collection of tumor specimens for downstream histologic, molecular, and genetic analysis is hindered by low tumor yield due to inability to identify prostate cancer grossly. However, current point-of-procedure pathology protocols, such as frozen section analysis (FSA), are destructive and too time- and labor-intensive to be practical or economical. Ex vivo microscopy of the excised specimens, stained with fast-acting fluorescent histology dyes, could be an attractive nondestructive alternative to FSA. In this work, we report the first demonstration of video-rate structured illumination microscopy (VR-SIM) for rapid high-resolution diagnostic imaging of prostate biopsies in realistic point-of-procedure timeframes. Large mosaic images of prostate biopsies stained with acridine orange are rendered in seconds and contain excellent contrast and detail, exhibiting close correlation with corresponding hematoxylin and eosin histology. A clinically relevant review of VR-SIM images of 34 unfixed and uncut prostate core biopsies by two independent pathologists resulted in an area under the receiver operative curve (AUC) of 0.82-0.88, with a sensitivity ranging from 63% to 88% and a specificity ranging from 78% to 89%. When biopsies contained more than 5% tumor content, the sensitivity improved to 75% to 92%. The image quality, speed, minimal complexity, and ease of use of VR-SIM could prove to be features in favor of adoption as an alternative to destructive pathology at the point-of-procedure.
- Goel, U. O., Maddox, M. M., Elfer, K. N., Dorsey, P. J., Wang, M., McCaslin, I. R., Brown, J. Q., & Lee, B. R. (2014). Feasibility of quantitative diffuse reflectance spectroscopy for targeted measurement of renal ischemia during laparoscopic partial nephrectomy. Journal of biomedical optics, 19(10), 107001.More infoReduction of warm ischemia time during partial nephrectomy (PN) is critical to minimizing ischemic damage and improving postoperative kidney function, while maintaining tumor resection efficacy. Recently, methods for localizing the effects of warm ischemia to the region of the tumor via selective clamping of higher-order segmental artery branches have been shown to have superior outcomes compared with clamping the main renal artery. However, artery identification can prolong operative time and increase the blood loss and reduce the positive effects of selective ischemia. Quantitative diffuse reflectance spectroscopy (DRS) can provide a convenient, real-time means to aid in artery identification during laparoscopic PN. The feasibility of quantitative DRS for real-time longitudinal measurement of tissue perfusion and vascular oxygenation in laparoscopic nephrectomy was investigated in vivo in six Yorkshire swine kidneys (n=three animals ). DRS allowed for rapid identification of ischemic areas after selective vessel occlusion. In addition, the rates of ischemia induction and recovery were compared for main renal artery versus tertiary segmental artery occlusion, and it was found that the tertiary segmental artery occlusion trends toward faster recovery after ischemia, which suggests a potential benefit of selective ischemia. Quantitative DRS could provide a convenient and fast tool for artery identification and evaluation of the depth, spatial extent, and duration of selective tissue ischemia in laparoscopic PN.
- Maddox, M., Liu, J., Mandava, S. H., Callaghan, C., John, V., & Lee, B. R. (2014). Nanotechnology applications in urology: a review. BJU international, 114(5), 653-60.More infoThe objectives of this review are to discuss the current literature and summarise some of the promising areas with which nanotechnology may improve urological care. A Medline literature search was performed to elucidate all relevant studies of nanotechnology with specific attention to its application in urology. Urological applications of nanotechnology include its use in medical imaging, gene therapy, drug delivery, and photothermal ablation of tumours. In vitro and animal studies have shown initial encouraging results. Further study of nanotechnology for urological applications is warranted to bridge the gap between preclinical studies and translation into clinical practice, but nanomedicine has shown significant potential to improve urological patient care.
- Silberstein, J. L., Maddox, M. M., Dorsey, P., Feibus, A., Thomas, R., & Lee, B. R. (2014). Physical models of renal malignancies using standard cross-sectional imaging and 3-dimensional printers: a pilot study. Urology, 84(2), 268-72.More infoTo construct high-fidelity, patient customized, physical, 3-dimensional (3D) models of renal units with enhancing renal lesions identified on cross-sectional imaging, which may aid patients, trainees, and clinicians in their comprehension, characterization, localization, and extirpation of suspicious renal masses.
- Keel, C. E., Wang, Z., Colli, J., Grossman, L., Majid, D., & Lee, B. R. (2013). Protective effects of reducing renal ischemia-reperfusion injury during renal hilar clamping: use of allopurinol as a nephroprotective agent. Urology, 81(1), 210.e5-10.More infoTo investigate the relationship between renal ischemia injury and concentrations of 8-isoprostane in a rat kidney model during renal hilar clamping and their correlation with the administration of allopurinol before clamping.
- Saitz, T. R., Dorsey, P. J., Colli, J., & Lee, B. R. (2013). Induction of cold ischemia in patients with solitary kidney using retrograde intrarenal cooling: 2-year functional outcomes. International urology and nephrology, 45(2), 313-20.More infoRenal hypothermia is commonly utilized during nephron sparing surgery to minimize ischemic tissue damage. We propose a method to induce renal hypothermia using continuous retrograde irrigation of iced saline via dual-lumen ureteral catheter. We will report results in an ex vivo porcine model followed by clinical outcomes in a series of patients with solitary kidney undergoing robotic-assisted laparoscopic partial nephrectomy (RALPN).
- Wang, L., & Lee, B. R. (2013). Robotic partial nephrectomy: current technique and outcomes. International journal of urology : official journal of the Japanese Urological Association, 20(9), 848-59.More infoOver the past decade, management of the T1 renal mass has focused on nephron-sparing surgery. Robotic partial nephrectomy has played an increasing role in the technique of preserving renal function by decreasing warm ischemia time, as well as optimizing outcomes of hemorrhage and fistula. Robot-assisted partial nephrectomy is designed to provide a minimally-invasive nephron-sparing surgical option utilizing reconstructive capability, decreasing intracorporeal suturing time, technical feasibility and safety. Ultimately, its benefits are resulting in its dissemination across institutions. Articulated instrumentation and three-dimensional vision facilitate resection, collecting system reconstruction and renorrhaphy, leading to decreased warm ischemia time while preserving oncological outcomes. The aim of the present review was to present our surgical sequence and technique, as well as review the current status of robot-assisted partial nephrectomy.
- Woodson, B. W., Wang, L., Mandava, S., & Lee, B. R. (2013). Urinary cystatin C and NGAL as early biomarkers for assessment of renal ischemia-reperfusion injury: a serum marker to replace creatinine?. Journal of endourology / Endourological Society, 27(12), 1510-5.More infoTo assess application of cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) as biomarkers for renal ischemic injury. We also evaluated the use of allopurinol as a renoprotective agent. A second goal was to assess cystatin C as a biomarker in patients undergoing partial nephrectomy.
- Woodson, B., Fernandez, R., Stewart, C., Mandava, S., Wang, L., & Lee, B. R. (2013). Bilateral synchronous sporadic renal masses: intermediate functional and oncological outcomes at a single institution. International urology and nephrology, 45(3), 619-25.More infoTo review the intermediate term oncologic and functional outcomes after the surgical management of bilateral renal masses (BRM).
- Ghishan, F. K., Harris, D. T., Lee, B. R., Chaus, F., Jernigan, B., Badowski, M., & Tzou, D. (2019, Nov./Fall). Feasibility of Detecting Both Superficial and Intra-renal Stone Endotoxin Concentrations.. 95th Annual Western Section American Urological Association Annual Conference. Monterey, CA: Western Section American Urological Association.
- Lee, B. R., Zeng, J., & Batai, K. (2019, November). Renal cell carcinoma surgical disparities in Arizona. Western Section American Urological Association Annual Meeting. Monterey, CA: Western Section American Urological Association.
- Tzou, D. T., Hamilton, A. J., Lee, B. R., Biffar, D. E., Phung, M., & Lovett, M. (2019, Nov./Fall). Development of a Low-Cost, High-Fidelity Simulator for Ultrasound- Guided Percutaneous Nephrolithotomy (PCNL) Training.. 95th Annual Western Section American Urological Association Annual Conference. Monterey, CA: Western Section American Urological Association.
- Batai, K., Imler, E., Phung, M., Bell, R., Lwin, A., Price, E., Milinic, T., Bracamonte, E. R., Seligmann, B., & Lee, B. R. (2018, May). Whole-transcriptome sequencing identified gene expression signatures associated with aggressive clear cell renal cell carcinoma. American Urological Association Annual Meeting. San Francisco, CA: American Urological Association.
- Phung, M., Lee, B. R., Gmitro, A. F., Rouse, A. R., Price, E., Bell, R., Bracamonte, E. R., Bracamonte, E. R., Bell, R., Price, E., Rouse, A. R., Gmitro, A. F., Phung, M., & Lee, B. R. (2018, May). Optical Biopsy using Confocal Microscopy for Differentiation of Renal Cell Carcinoma versus Benign Tissue. American Urological Association National Meeting. San Francisco: American Urological Association.
- Phung, M., Rouse, A. R., Bell, R., Bracamonte, E. R., Price, E., Gmitro, A. F., & Lee, B. R. (2018, September). Optical Biopsy using Confocal Microscopy for Differentiation of Renal Cell Carcinoma versus Benign Tissue. American Urological Association National Meeting. Paris, France: World Congress of Endourology.
- Batai, K., Lee, B. R., Asmar, S., Chipollini, J., Gachupin, F. C., Gachupin, F. C., Asmar, S., Chipollini, J., Lee, B. R., & Batai, K. (2020, April). Renal cell carcinoma health disparities in American Indians Alaska Natives and Hispanic Americans: Comparison of National Cancer Database and Arizona Cancer Registry data. American Association for Cancer Research Annual Meeting. Virtual: American Association for Cancer Research.
- Lee, B. R. (2020, Fall). Intra-renal pathology of non-neoplastic kidney is associated with long term renal deterioration after partial and radical nephrectomy: A single institution experience.. Western Section American Urological Association.
- Lee, B. R., Chipollini, J., Gachupin, F. C., Pollock, G., & Batai, K. (2020, May). Assessment of Renal Cell Carcinoma Surgical Disparities in American Indians and Hispanic Americans. American Urological Association Annual Meeting. Washington, DC: American Urological Association.
- Lee, B. R., Batai, K., & Zeng, J. (2019, May). Nephrectomy Delay More Than Ten Weeks from Diagnosis Is Associated with Decreased Overall Survival in pT3 RCC. American Urological Association Annual Meeting.
- Lee, B. R., Gachupin, F. C., Harb de la Rosa, A., & Batai, K. (2019, May). Renal cell carcinoma disparities: Younger age at diagnosis and increased clear cell renal cell carcinoma incidence in American Indians and Hispanics. American Urological Association Annual Meeting. Chicago, IL: American Urological Association.
- Kim, S., Hinkel, C., Coffey, D., Zohar, Y., Lee, B. R., & Gretzer, M. (2018, May). Fluid Dynamics and Morphology in the Obstructed Urethra. American Urological Association Conference. San Francisco: American Urological Association.
- Lee, B. R., Batai, K., Pangilinan, J., Bracamonte, E., Phung, M., Bell, R., Bell, R., Phung, M., Bracamonte, E., Pangilinan, J., Batai, K., & Lee, B. R. (2018, September). Gene overexpression in aggressive clear cell renal cell carcinoma identified with whole-transcriptome sequencing and validated against The Cancer Genome Atlas. World Congress of Endourology Conference.
- Lee, B. R., Seligmann, B., Bracamonte, E. R., Imler, E., Gachupin, F. C., Harb de la Rosa, A., & Batai, K. (2018, November). Clinical and molecular profile of renal cell carcinoma in Hispanic Americans, Native Americans, and European Americans. The 11th American Association of Cancer Research Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. New Orleans, LA: American Association of Cancer Research.
- Lovett, M., Lee, S., Katz, K., Batai, K., Biffar, D., Phung, M., Pangilinan, J., Lee, B. R., Nguyen, M., Hamilton, A., & Hua, H. (2018, Fall). Autotracking Surgeon's Instrument Movement with Motorized Multiresolution Foveated Laparoscope Camera. World Congress of Endourology. Paris, France.
- Pangilinan, J., Batai, K., Imler, E., Phung, M., Bell, R., Lwin, A., Price, E., Milinic, T., Bracamonte, E., Seligmann, B., & Lee, B. R. (2018, October). Gene Expression Associated with Overall Survival in Clear Cell Renal Cell Carcinoma. World Congress of Endourology Conference. Maui, HI.
- Shi, X., Batai, K., Wang, X., Bergersen, A., Gu, K., & Lee, B. R. (2018, September). Renal Cell Carcinoma Detection Using Targeted Metabolic Profiling. World Congress of Endourology Conference.
- Batai, K., Michalak, J., Craig, M., Bergersen, A., Price, E., & Lee, B. R. (2017, August). Urologic Cancer Disparities among Hispanic Americans and Native Americans in Four U.S.-Mexico Border States. Western Section American Urological Association Annual Meeting. Vancouver, BC: Western Section American Urological Association.
- Lee, B. R. (2016, October). Crowdsourcing Assessment of Surgeon Dissection of Renal Artery and Vein during Robotic Partial Nephrectomy: A Novel Approach for Quantitative Assessment of Surgical Performance. AUA - Western Section. Kaua'I, Hawaii: AUA.
- Lee, B. R., Allison, H. H., Feibus, A., Sartor, O., Moparty, K., Kattan, M. W., Chagin, K. M., Ledet, E. M., Levy, J., Thomas, R., & Silberstein, J. L. (2016, April). Utility of PCA3 and TMPRSS2:ERG Urinary Biomarkers in African American Men Undergoing Prostate Biopsy. ASCO.
- Lee, B. R., Lai, W., & Mitchell, G. (2016, May). Robotic Resection of Locally Recurrent Renal Cell Carcinoma. AUA National Meeting.More infoVideo presentation
- Lee, B. R., Lai, W., Abshire, C., Mandava, S. H., Carry, C., Liu, J., Gabrielson, A., & Tarr, M. (2016, May). Nanotechnology Combination Therapy for Renal Cell Carcinoma: Goild Nanorods Bound with Tyrosine Kinase Inhibitor Procuces Synergistic Treatment Response when Combined with Laser Thermal Ablation in an Animal Model. AUA National Meeting.
- Lee, B. R., Lai, W., Wang, M., Tulman, D., Mandava, S. H., Liu, J., & Brown, J. (2016, May). Video Rate-Structured Illumination Microscopy to Diagnose Presence of Kidney Cancer on 18-gauge Core Needle Renal Biopsy. AUA National Meeting.
- Lee, B. R., Power, M., Lendvay, T., Boonjindasup, A., Pinsky, M., Dorsey, P., Maddox, M., Comstock, B., Su, L., Gettman, M., Sundaram, C., Castle, E., & Lee, J. (2016, May). Crowdsourcing Assessment of Surgeon Dissection of Renal Artery and Vein During Robotic Partial Nephrectomy: A Novel Approach for Quantitative Assessment of Surgical Performance. AUA National Meeting.
- Lee, B. R., Viriyasiripong, S., Lopez, A., Lai, W., Mitchell, G., Mandava, S. H., Boonjindasup, A., Powers, M., & Silberstein, J. (2016, May). Accelerometer Measurement of Head Movement During Laparoscopic Surgery: Will it Help Optimize Ergonomics of Surgery?. AUA National Meeting.