
John D Kanady
- Senior Lecturer, Physiology - (Educator Series Track)
Contact
- (520) 621-9895
- Ina A. Gittings Building, Rm. 119
- Tucson, AZ 85721
- jkanady@arizona.edu
Degrees
- Ph.D. Physiological Sciences
- University of Arizona, Tucson, Arizona, United States
- Morphogenesis of Lymphatic Vascular Networks: Insights from Connexin and Foxc2 Knockout Mice
- B.S. Physiology
- University of Arizona, Tucson, Arizona
Awards
- Nominee - Five Star Faculty Award
- University of Arizona Honors College, Spring 2020 (Award Nominee)
Interests
Research
Intercellular communication, network analysis, gap junctions, connexins, data visualization
Teaching
Large class teaching, online courses, facilitating undergraduate research experiences, multimedia production for educational material
Courses
2022-23 Courses
-
Fundamntls Human Physiol
PSIO 380 (Spring 2023) -
Human Anat+Physiology II
PSIO 202 (Spring 2023) -
Independent Study
PSIO 499 (Spring 2023) -
Leadership & Engagement in Tea
PSIO 497L (Spring 2023) -
Tackling Physiological Topics
PSIO 101 (Spring 2023) -
Fundamntls Human Physiol
PSIO 380 (Fall 2022) -
Human Anat+Physiology I
PSIO 201 (Fall 2022)
2021-22 Courses
-
Human Anat+Physiology II
PSIO 202 (Summer I 2022) -
Fundamntls Human Physiol
PSIO 380 (Spring 2022) -
Human Anat+Physiology II
PSIO 202 (Spring 2022) -
Fundamntls Human Physiol
PSIO 380 (Fall 2021) -
Human Anat+Physiology II
PSIO 202 (Fall 2021) -
Tackling Physiological Topics
PSIO 101 (Fall 2021)
2020-21 Courses
-
Human Anat+Physiology II
PSIO 202 (Summer I 2021) -
Fundamntls Human Physiol
PSIO 380 (Spring 2021) -
Human Anat+Physiology II
PSIO 202 (Spring 2021) -
Physio Sci Teaching Wksp
PS 697B (Spring 2021) -
Tackling Physiological Topics
PSIO 101 (Spring 2021) -
Fundamntls Human Physiol
PSIO 380 (Fall 2020) -
Human Anat+Physiology II
PSIO 202 (Fall 2020) -
Physio Sci Teaching Wksp
PS 697A (Fall 2020)
2019-20 Courses
-
Human Anat+Physiology II
PSIO 202 (Summer I 2020) -
Fundamntls Human Physiol
PSIO 380 (Spring 2020) -
Human Anat+Physiology II
PSIO 202 (Spring 2020) -
Fundamntls Human Physiol
PSIO 380 (Fall 2019) -
Human Anat+Physiology I
PSIO 201 (Fall 2019)
2018-19 Courses
-
Human Anat+Physiology I
PSIO 201 (Summer I 2019) -
Fundamntls Human Physiol
PSIO 380 (Spring 2019) -
Human Anat+Physiology II
PSIO 202 (Spring 2019) -
Preceptorship
PSIO 391 (Spring 2019) -
Fundamntls Human Physiol
PSIO 380 (Fall 2018) -
Human Anat+Physiology I
PSIO 201 (Fall 2018) -
Preceptorship
PSIO 391 (Fall 2018)
2017-18 Courses
-
Human Anat+Physiology II
PSIO 202 (Summer I 2018) -
Fundamntls Human Physiol
PSIO 380 (Spring 2018) -
Human Anat+Physiology II
PSIO 202 (Spring 2018) -
Preceptorship
PSIO 391 (Spring 2018) -
Fundamntls Human Physiol
PSIO 380 (Fall 2017) -
Hnrs Precept Physiology
PSIO 391H (Fall 2017) -
Human Anat+Physiology I
PSIO 201 (Fall 2017) -
Preceptorship
PSIO 391 (Fall 2017)
2016-17 Courses
-
Human Anat+Physiology I
PSIO 201 (Summer I 2017) -
Human Anat+Physiology II
PSIO 202 (Summer I 2017) -
Human Anat+Physiology II
PSIO 202 (Spring 2017)
2015-16 Courses
-
Integrative Cell Psio
PSIO 303B (Spring 2016)
Scholarly Contributions
Journals/Publications
- Pires, P., Erickson, R. P., Witte, M. H., Georgieva, T. G., Simon, A., Kanady, J. D., Jones, J. A., Myles, R. J., Bernas, M. J., Kylathu, R., & Mustacich, D. M. (2021). Abnormal lymphatic phenotype in a CRISPR mouse model of the human lymphedema-causing Connexin47 R260C point mutation.. Lymphology, 54(2), 78-91.More infoConnexin proteins form gap junctions controlling exchange of ions and small molecules between cells and play an important role in movement of lymph within lymphatic vessels. Connexin47 (CX47) is highly expressed in lymphatic endothelial cells and CX47 missense mutations, i.e., R260C, cosegregate with primary lymphedema in humans. However, studies utilizing CX47 knockout mice have failed to demonstrate any lymphatic anomalies. To unravel the lymphatic consequences of expressing a mutant CX47 protein, we used CRISPR technology to create a mouse carrying a Cx47 missense mutation (Cx47R259C) equivalent to the human CX47R260C missense mutation associated with human primary lymphedema. Intradermal Evans Blue dye injection identified a 2-fold increase in regional lymph nodes in homozygous Cx47R259C mice compared to wildtype, particularly in the jugular region (4.8 ± 0.4 and 2.0 ± 0.0, respectively, p
- Kylathu, R., Mustacich, D., Bernas, M. J., Myles, R., Kanady, J. D., Simon, A. M., Georgieva, T., Erickson, R. P., & Witte, M. H. (2019). Lymphatic Anomalies in Mice Expressing a Connexin47 Point Mutation. 27th World Congress of Lymphology Abstract Booklet.
Presentations
- Witte, M. H., Erickson, R. P., Georgieva, T., Simon, A. M., Kanady, J. D., Myles, R., Bernas, M. J., Mustacich, D., & Kylathu, R. (2019, September). Lymphatic Anomalies in Mice Expressing a Connexin47 Point Mutation. 27th World Congress of Lymphology. Buenos Aires and Iguazu, Argentina: International Society of Lymphology.
Poster Presentations
- Witte, M. H., Bernas, M., Mustacich, D. J., Kylat, R., & Erickson, R. P. (2018, Fall). The phenotype of a CRISPR mouse model of a human GapJunction C2 (connexin 47) mutant causing lymphedema. ASHG 2018. San Diego, CA: American Society of Human Genetics.