Lynn M Coppola

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Scholarly Contributions

Journals/Publications

• Adegboyega, T., Adejuyigbe, E., Adesina, O., Adeyemi, B., Ahmed, S., Akinkunmi, F., Aluvaala, J., Anyabolu, H., Ariff, S., Arya, S., Awowole, I., Ayede, A., Babar, N., Bachani, S., Bahl, R., Baqui, A., Chellani, H., Chowdhury, S., Coppola, L., , Cousens, S., et al. (2024). The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries. Trials, 25(1). doi:10.1186/s13063-024-07941-0
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  Background: Preterm birth complications are the leading cause of newborn and under-5 mortality. Over 85% of all preterm births occur in the late preterm period, i.e. between 34 and < 37 weeks of gestation. Antenatal corticosteroids (ACS) prevent mortality and respiratory morbidity when administered to women at high risk of an early preterm birth, i.e. < 34 weeks’ gestation. However, the benefits and risks of ACS in the late preterm period are less clear; both guidelines and practices vary between settings. Emerging evidence suggests that the benefits of ACS may be achievable at lower doses than presently used. This trial aims to determine the efficacy and safety of two ACS regimens compared to placebo, when given to women with a high probability of late preterm birth, in hospitals in low-resource countries. Methods: WHO ACTION III trial is a parallel-group, three-arm, individually randomized, double-blind, placebo-controlled trial of two ACS regimens: dexamethasone phosphate 4 × 6 mg q12h or betamethasone phosphate 4 × 2 mg q 12 h. The trial is being conducted across seven sites in five countries—Bangladesh, India, Kenya, Nigeria, and Pakistan. Eligible women are those with a gestational age between 34 weeks 0 days and 36 weeks 5 days, who have a high probability of preterm birth between 12 h and 7 days (up to 36 weeks 6 days gestation). The primary outcome is a composite of stillbirth or neonatal death within 72 h of birth or use of newborn respiratory support within 72 h of birth or prior to discharge from hospital, whichever is earlier. Secondary outcomes include safety and health utilization measures for both women and newborns. The sample size is 13,500 women. Discussion: This trial will evaluate the benefits and possible harms of ACS when used in women likely to have a late preterm birth. It will also evaluate a lower-dose ACS regimen based on literature from pharmacokinetic studies. The results of this trial will provide robust critical evidence on the safe and appropriate use of ACS in the late preterm period internationally. Trial registration: ISRCTN11434567. Registered on 7 June 2021.
• Awomolo, A. M., McWhirter, A., Sadler, L. C., Coppola, L. M., & Hill, M. G. (2023). Intravenous infusions of ferumoxytol compared to oral ferrous sulfate for the treatment of anemia in pregnancy: a randomized controlled trial. American journal of obstetrics & gynecology MFM, 5(9), 101064.
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  Iron-deficiency anemia in pregnancy is highly prevalent and presents significant risk to patients. Initial treatment is often with oral medication. We hypothesized that intravenous ferumoxytol would result in superior treatment of anemia as compared to oral ferrous sulfate.
• Awomolo, A. M., McWhirter, A., Sadler, L. C., Coppola, L. M., & Hill, M. G. (2023). Neonatal outcomes from a randomized controlled trial of maternal treatment of iron deficiency anemia with intravenous ferumoxytol vs oral ferrous sulfate. American journal of obstetrics & gynecology MFM, 5(9), 101063.
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  Anemia in pregnancy is common worldwide and has known maternal risks. The relationship between the types of treatment offered for maternal anemia and the effects on the fetus and newborn are largely uninvestigated.
• Stephens, L., Miller, H., & Coppola, L. (2022). Transfusion medicine diagnostic error by facsimile. Transfusion, 62(6), 1157-1158.
• Coppola, L. (2016). Unique Case of Imperforate Hymen. Journal of pediatric and adolescent gynecology, 29(1), e1-3.
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  Imperforate hymen typically presents in adolescence with pain, hematocolpometra and primary amenorrhea. This case documents a previously unreported etiology for an atypical presentation with a history of recent menstruation.
• Coppola, L. M., Reed, K. L., & Herbert, W. N. (2014). Comparison of patient attitudes and provider perceptions regarding medical student involvement in obstetric/gynecologic care. Teaching and learning in medicine, 26(3), 239-43.
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  Community physicians are becoming increasingly involved in clinical medical education. Some obstetrician/gynecologists have expressed reluctance to participate as clinical preceptors for medical students due to the sensitive nature of many of their patient encounters and concern for diminished patient satisfaction.

Proceedings Publications

• Winget, V., McWhirter, A., Hendricks, S., Aguirre, A., & Coppola, L. (2022, June). Amniotic Sheet:  Prenatal Diagnosis, Obstetric Outcome and Successful Inter-Pregnancy Hysteroscopic Treatment. In AIUM Annual Integrative Ultrasound Meeting, 41, S164.
• McWhirter, A., Awomolo, A., Barber, B. J., & Coppola, L. (2021, Spring). Prenatal diagnosis of porencephaly in the setting of fetal congenital heart disease. In Journal of Ultrasound in Medicine, 40 (SUPPL), S123.
• Miller, H., Henry, M., & Coppola, L. (2021, Spring). Severe Fetal Megacystis on 13-week Obstetric Ultrasound: Evolving Diagnosis and Multi-Disciplinary Management of a Cloacal Malformation. In Journal of Ultrasound in Medicine, 40 (SUPPL), S125.

Presentations

• Coppola, L. (2023, November). International Medical Education:  Building Effective Partnerships. 2nd Annual Kenneth D. Hatch Memorial Lectureship. Tucson, Arizona: University of Arizona College of Medicine, Department of Obstetrics & Gynecology.
• Coppola, L. (2022, May/2022). “Intravenous Infusions of Ferumoxytol versus Oral Ferrous Sulfate for the Treatment of Anemia in Pregnancy.”. Perinatal Society of Australia and New Zealand 2022 Annual Congress. Adelaide, Australia: Perinatal Society of Australia and New Zealand.
• Coppola, L. (2022, November/2022). “First Trimester Bleeding.” . Myanmar Medical Association. Online: Myanmar Medical Association.
• Coppola, L. (2022, October/2022). “Fetal Biometry in the Third Trimester". Karnataka Institute of Medical Sciences,. Hubballi, India: Karnataka Institute of Medical Sciences.
• Coppola, L. (2020, February). Twin-Twin Transfusion Syndrome. Annual Neonatal Nurse Practitioners of Arizona Conference. Phoenix, Arizona: Neonatal Nurse Practitioners of Arizona.
• Coppola, L. (2017, June). Intrauterine growth restriction and complications. 11th Annual Perinatal Symposium, The Hospitals of Providence, June 2, 2017, El Paso, TX. El Paso, TX: The Hospitals of Providence.
• Coppola, L. (2016, March). Introducing Ultrasonography into a Low-Resource Setting: Tales from the Front Line. American Institute of Ultrasound in Medicine Annual Convention, New York, March 19, 2016.. New York, NY: AIUM.

Poster Presentations

• Coppola, L., Lesser, K. B., Bah, O., Barber, B. J., & Sisti, G. (2024, April). Intermittent reversed end-diastolic flow in the middle cerebral artery of a fetus with congenital heart disease.. UltraCon. Austin, Texas: American Institute of Ultrasound in Medicine.
• McWhirter, A., Tigner, A., & Coppola, L. (2024, September).

  Empowering Obstetric Providers through Education in Ghana:  A Pathway to Reduce Maternal Mortality

  . Global Health Research Day, University of Arizona College of Medicine. Tucson, Arizona: University of Arizona College of Medicine.
• Coppola, L., Sisti, G., Crawford, C., J, J., R, K., & Amaraneni, A. (2023, March). Management of Pregnancy and Delivery in a Patient with Glanzmann's Thrombasthenia. University of Arizona College of Medicine Research Day. Tucson, Arizona: University of Arizona College of Medicine.
• Coppola, L. (2022, March/2022). Amniotic Sheet:  Prenatal diagnosis, obstetric outcome, and successful inter-pregnancy    hysteroscopic treatment.. AIUM 2022 Annual Integrative Ultrasound Meeting. San Diego, CA: AIUM 2022 Annual Integrative Ultrasound Meeting.
• Coppola, L., Barber, B. J., Awomolo, A., & McWhirter, A. (2021, Spring). Prenatal diagnosis of porencephaly in the setting of fetal congenital heart disease. AIUM Annual Integrative Ultrasound Meeting.
• Miller, H., Henry, M., & Coppola, L. (2021). Severe fetal megacystis on 13-week obstetric ultrasound: Evolving diagnosis and multi-disciplinary management of a cloacal malformation. AIUM Annual Integrative Ultrasound MeetingAIUM.

Case Studies

• Bah, O., Sisti, G., Barber, B. J., Lesser, K. B., & Coppola, L. (2024. Intermittent reversed end-diastolic flow in the middle cerebral artery of a fetus with congenital heart disease.(pp S1-S259).
  More info

  Bah O, Sisti G, Barber B, Lesser K, Coppola L.  Intermittent reversed end-diastolic flow in the middle cerebral artery of a fetus with congenital heart disease.  J Ultrasound Med 43 (suppl 1):S1-S259, 2024.

Other Teaching Materials

• Coppola, L. (2023. Obstetric Life Saving Skills
  Workshop for midwives in northern Ghana. Baptist Medical Centre, Nalerigu, Ghana.
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  Worshop for midwives in northern GhanaAttended by 138 midwives and nursing students
• Coppola, L. (2022. Obstetric Life Saving Skills
  Midwife Training Workshop
  Baptist Medical Centre, Nalerigu, Ghana. Baptist Medical Centre, Nalerigu, Ghana.
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  Workshop for midwives in northern GhanaAttended by approximately 50 midwives
• Coppola, L. (2019. "Management of Obstetric Hypertensive Emergencies in Low-Resource Settings"
  Global Obstetrics and Life-Saving Skills (GOALS) course
  ACOG 2019 Annual Clinical and Scientific Meeting
  Nashville, Tennessee. American College of Obstetricians and Gynecologists.
• Coppola, L. (2019. Survival Skills for Cross-Cultural Communication
  Global Obstetrics and Life-Saving Skills (GOALS) Course
  ACOG 2019 Annual Clinical and Scientific Meeting
  Nashville, Tennessee. American College of Obstetricians and Gynecologists.