
Brent J Barber
- Professor, Pediatrics - (Clinical Scholar Track)
Contact
- (520) 626-5585
- Arizona Health Sciences Center, Rm. 3302
- Tucson, AZ 85724
- barberb@peds.arizona.edu
Bio
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Interests
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Courses
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Scholarly Contributions
Books
- Abdy, N. A., Barber, B. J., Abdy, N. A., & Barber, B. J. (2011). Pulmonary Valve Stenosis. The 5-Minute Clinical Consult 2011: Lippincott Williams & Wilkins.
Journals/Publications
- Bader, M., Barber, B. J., Seckeler, M., Bhatia, S., Kylathu, R., & Kops, S. A. (2020). Genetic Characterization of a Model Ciliopathy: Bardet–Biedl's Syndrome. Journal of Pediatric Genetics. doi:DOI: 10.1055/s-0040-1708844
- Bernardi, A. M., Moses, S., Barber, B. J., Witte, M. H., & Seckeler, M. D. (2020). Higher Incidence of Protein-Losing Enteropathy in Patients with Single Systemic Right Ventricle. Pediatric cardiology.More infoPatients with single ventricle congenital heart disease are at risk of unpredictable protein-losing enteropathy (PLE) after surgical palliation. Based on prior reports of physiologic differences for patients with single morphologic right versus left ventricles, we hypothesized that those with right ventricular morphology would have a higher incidence of PLE. We performed a retrospective review of > 15 million pediatric hospitalizations from the Healthcare Cost and Utilization Project KID 2000-2012 databases for admissions 5-21 years old with ICD-9 codes for hypoplastic left heart syndrome (HLHS) and tricuspid atresia (TA) with and without PLE. Incidence of PLE was compared between those with HLHS and TA. In addition, outcomes and costs were compared between admissions with and without PLE and between HLHS and TA. Of 1623 HLHS admissions, 289 (17.8%) had PLE, and of 926 TA admissions, 58 (5.9%) had PLE (p
- Combs, D., Edgin, J. O., Klewer, S., Barber, B. J., Morgan, W. J., Hsu, C. H., Abraham, I., & Parthasarathy, S. (2020). OSA and Neurocognitive Impairment in Children With Congenital Heart Disease. Chest, 158(3), 1208-1217.More infoChildren with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of OSA, which is associated with neurocognitive impairment in children without CHD.
- Kops, S. A., Pangburn, S., Barber, B. J., & Seckeler, M. D. (2020). Transcatheter treatment of acquired coronary sinus ostium atresia in a child with complex congenital heart disease. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 95(2), E62-E65.More infoCongenital coronary sinus ostium atresia is a rare condition that is typically considered benign, as long as there is adequate drainage via another route. However, in children with single ventricle congenital heart disease, adequate drainage may not be assured after complex surgical interventions, putting them at risk for myocardial injury. We present a patient with complex single ventricle congenital heart disease who developed acquired coronary sinus ostium atresia after surgical intervention that was treated by a transcatheter approach to prevent the sequelae of coronary sinus hypertension.
- Seckeler, M., Witte, M. H., Barber, B. J., Moses, S., & Bernardi, A. (2020). Higher Incidence of Protein-Losing Enteropathy in Patients with Single Systemic Right Ventricle. American Journal of Cardiology. doi:10.1007/s00246-020-02468-y
- Ghishan, F. K., Dori, Y., Barber, B. J., Witte, M. H., & Kylat, R. (2019). Resolution of protein-losing enteropathy after congenital heart disease repair by selective lymphatic embolization. Pediatr Gastroenterol Hepatol Nutr, 22(6), 1-7.
- Kuo, P. H., Barber, B. J., Kylat, R. I., Klewer, S. E., Behan, S., Lau-Braunhut, S., Bernas, M. J., Moedano, L., Bedrick, A. D., Mustacich, D. J., & Witte, M. H. (2019). Whole-body lymphangioscintigraphy and SPECT/CT in children with lymphatic complications after surgery for complex congenital heart disease. Lymphology, 52(4), 157-165.More infoThe number of patients surviving repair of complex congenital heart disease (CCHD) has increased due to improved surgical techniques, post operative management and outpatient care. Likewise, this growing patient population has demonstrated an increasing number and complexity of complications involving the lymphatic system. To evaluate the peripheral and central lymphatic system, whole-body lymphangioscintigraphy (LAS) is considered as the initial imaging evaluation of choice. To date, very few publications exist on the value of lymphatic imaging techniques in infants and small children with lymphatic complications following surgery for congenital heart disease. A retrospective review of medical records from 2008 to 2018 was performed for pediatric patients referred for lymphatic complications after CCHD surgery at an academic medical center. LAS and SPECT/CT was performed using intradermal bipedal injections of Tc 99m labeled filtered sulfur colloid, and in some patients also bilateral hand injections, followed by dynamic imaging and whole- body planar imaging typically up to 180 minutes post injection. Clinical decision making and outcomes were recorded. LAS and SPECT/CT were performed without complication in pediatric patients with prior surgery for CCHD. LAS successfully localized various lymphatic abnormalities such as lymphatic obstruction, reflux, and leaks, which were further delineated by SPECT/CT. LAS findings directed further evaluation with more definitive studies, management and prognosis. Five of the ten patients had follow up outcome data - 2 years and up to 10 years. LAS and SPECT/CT are safe and effective techniques for the initial evaluation of lymphatic abnormalities in pediatric patients with CCHD. LAS, particularly with further 3D localization by SPECT/CT, provides functional imaging of peripheral and central lymphatic flow and thus provides guidance for medical therapy, non operative interventional management, and surgical therapy for these diverse, debilitating, and often life threatening disorders.
- Kylat, R. I., Witte, M. H., Barber, B. J., Dori, Y., & Ghishan, F. K. (2019). Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization. Pediatric gastroenterology, hepatology & nutrition, 22(6), 594-600.More infoWith improving survival of children with complex congenital heart disease (CCHD), postoperative complications, like protein-losing enteropathy (PLE) are increasingly encountered. A 3-year-old girl with surgically corrected CCHD (ventricular inversion/L-transposition of the great arteries, ventricular septal defect, pulmonary atresia, post-double switch procedure [Rastelli and Glenn]) developed chylothoraces. She was treated with pleurodesis, thoracic duct ligation and subsequently developed chylous ascites and PLE (serum albumin ≤0.9 g/dL) and was malnourished, despite nutritional rehabilitation. Lymphangioscintigraphy/single-photon emission computed tomography showed lymphatic obstruction at the cisterna chyli level. A segmental chyle leak and chylous lymphangiectasia were confirmed by gastrointestinal endoscopy, magnetic resonance (MR) enterography, and MR lymphangiography. Selective glue embolization of leaking intestinal lymphatic trunks led to prompt reversal of PLE. Serum albumin level and weight gain markedly improved and have been maintained for over 3 years. Selective interventional embolization reversed this devastating lymphatic complication of surgically corrected CCHD.
- Tefera, E., Gedlu, E., Nega, B., Tadesse, B. T., Chanie, Y., Dawoud, A., Moges, F. H., Bezabih, A., Moges, T., Centella, T., Marianeschi, S., Coca, A., Collado, R., Kassa, M. W., Johansson, S., van Doorn, C., Barber, B. J., & Teodori, M. (2019). Factors associated with perioperative mortality in children and adolescents operated for tetralogy of Fallot: A sub-Saharan experience. Journal of cardiac surgery, 34(12), 1478-1485.More infoPatients with tetralogy of Fallot are now surviving to adulthood with timely surgical intervention. However, many patients in low-income countries have no access to surgical intervention. This paper reports the surgical access and perioperative mortality in a sub-Saharan center that was mainly dependent on visiting teams.
- Witte, M. H., Mustacich, D., Moedano, L., Behan, S., Bernas, M. J., Klewer, S. E., Barber, B. J., Kuo, P. H., & Kylathu, R. (2019). Whole Body Lymphangioscintigraphy and SPECT-CT in Infants and Children with Lymphatic Congestion after Surgical Repair of Complex Congenital Heart Disease. 27th World Congress of Lymphology Abstract Booklet.
- Combs, D., Skrepnek, G., Seckeler, M. D., Barber, B. J., Morgan, W. J., & Parthasarathy, S. (2018). Sleep-Disordered Breathing is Associated With Increased Mortality in Hospitalized Infants With Congenital Heart Disease. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 14(9), 1551-1558.More infoSleep-disordered breathing (SDB) has adverse cardiovascular effects in children and adults. In adults with cardiac disease, SDB is highly prevalent and confers increased mortality risk. It is unknown if SDB confers a similar risk in infants with congenital heart disease (CHD). We evaluated clinical and economic outcomes associated with SDB among inpatient infants with CHD in the United States from 1997-2012.
- Seckeler, M. D., Lawson, E., Barber, B. J., & Klewer, S. E. (2017). Percutaneous management of complex acquired aortic coarctation in an adult with tetralogy of Fallot and pulmonary atresia. Annals of pediatric cardiology, 10(3), 295-297.More infoWe present the case of a female adult with complex cyanotic congenital heart disease who had long-standing thoracic aortic obstruction due to scarring from earlier surgical procedures. She was symptomatic but felt to be too high risk for surgical intervention. With careful planning, she was able to undergo successful stenting of her aorta with subsequent clinical improvement. This case highlights some of the complexities of caring for adults with congenital heart disease and the importance of a thorough understanding of their anatomy and physiology and prior interventions before undertaking interventions.
- Abdy, N. A., Valdes, S. O., Sorrell, V. L., Klewer, S. E., & Barber, B. J. (2017). Apical hypertrophic cardiomyopathy in an adolescent. Congenital heart disease, 5(2), 182-7.More infoTo our knowledge, this is one of the few reported cases of apical hypertrophic cardiomyopathy in an adolescent patient in the United States. We describe a clinical presentation of an adolescent male who presented for cardiac evaluation and was found to have an apical variant of hypertrophic cardiomyopathy.
- Barber, B. J., Burch, G. H., Tripple, D., & Balaji, S. (2017). Resolution of plastic bronchitis with atrial pacing in a patient with fontan physiology. Pediatric cardiology, 25(1), 73-6.More infoWe describe a 5-year-old boy with Fontan physiology and a ventricular pacemaker who developed severe plastic bronchitis. Evaluation by cardiac catheterization revealed profoundly altered hemodynamics, which improved with atrial pacing. Following implantation of an atrial pacemaker, which restored atrioventricular (A-V) synchrony, the patient's hemodynamics greatly improved and his plastic bronchitis resolved.
- Barber, B. J., Donnerstein, R. L., Secomb, T. W., Pogreba-Brown, K., Steelman, R., Ellenby, M. S., Shen, I., & Ungerleider, R. M. (2017). The dicrotic pulse: a common, non-ominous finding after the Ross operation. Pediatric cardiology, 28(4), 247-9.More infoWe noted a dicrotic pulse in several patients following a Ross operation. Although the etiology of this unique arterial waveform is not completely understood, it has been reported as a sign of low cardiac output and a poor prognosis. We reviewed preoperative echocardiograms and postoperative radial arterial pressure tracings in 33 patients who underwent a Ross procedure between 2000 and 2004. We found a dicrotic pulse to occur commonly (20/33; 61%) following a Ross operation. Moderate to severe preoperative aortic insufficiency was present in 19/20 patients (95%) in whom a dicrotic pulse was noted and in only 3/13 (23%) who did not exhibit a postoperative dicrotic pulse (p
- Hainstock, M. R., Gruchala, N. E., Fike, N., Samson, R. A., Klewer, S. E., & Barber, B. J. (2017). Postural orthostatic tachycardia in a teenager with Klinefelter syndrome. Congenital heart disease, 3(6), 440-2.More infoTo our knowledge this is the first reported case of postural orthostatic tachycardia syndrome (POTS) in a patient with Klinefelter syndrome. We describe a classic clinical presentation of POTS in an adolescent male with Klinefelter syndrome. Although the etiology of POTS appears to be multifactorial, there is a strong female predominance that suggests a genetic basis. Our patient with Klinefelter syndrome may further support a link with POTS to the X chromosome.
- Ihnat, C. L., Zimmerman, H., Copeland, J. G., Meaney, F. J., Sobonya, R. E., Larsen, B. T., Blair, B., Lax, D., & Barber, B. J. (2017). Left ventricular assist device support as a bridge to recovery in young children. Congenital heart disease, 6(3), 234-40.More infoLeft ventricular assist device (LVAD) experience and follow-up data in children are limited. We report the deployment and successful weaning from LVAD in young children with severe heart failure (HF).
- Kim, S., Zhu, Y., Romitti, P. A., Fox, D. J., Sheehan, D. W., Valdez, R., Matthews, D., Barber, B. J., & , M. S. (2017). Associations between timing of corticosteroid treatment initiation and clinical outcomes in Duchenne muscular dystrophy. Neuromuscular disorders : NMD, 27(8), 730-737.More infoThe long-term efficacy of corticosteroid treatment and timing of treatment initiation among Duchenne muscular dystrophy (DMD) patients is not well-understood. We used data from a longitudinal, population-based DMD surveillance program to examine associations between timing of treatment initiation (early childhood [before or at age 5 years], late childhood [after age 5 years], and naïve [not treated]) and five clinical outcomes (age at loss of ambulation; ages at onset of cardiomyopathy, scoliosis, and first fracture; and pulmonary function). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using survival analysis. DMD patients who initiated corticosteroid treatment in early childhood had a higher risk of earlier onset cardiomyopathy compared to cases who initiated treatment in late childhood (HR = 2.0, 95% CI = [1.2, 3.4]) or treatment naïve patients (HR = 1.9, 95% CI = [1.1, 3.2]), and higher risk of suffering a fracture (HR = 2.3, 95% CI = [1.4, 3.7] and HR = 2.6, 95% CI = [1.6, 4.2], respectively). Patients with early childhood treatment had slightly decreased respiratory function compared with those with late childhood treatment. Ages at loss of ambulation or scoliosis diagnosis did not differ statistically among treatment groups. We caution that the results from our study are subject to several limitations, as they were based on data abstracted from medical records. Further investigations using improved reporting of disease onset and outcomes are warranted to obtain a more definitive assessment of the association between the timing of corticosteroid treatment and disease severity.
- Kylat, R. I., Johnson, D., Bedrick, A. D., Barber, B. J., Kurland, Y., & Bader, M. (2017). Intravenous Immunoglobulin for congenital Parvovirus myocarditis. Journal of Pediatric Infectious diseases. doi:10.1055/s-0037-1620249
- Kylathu, R., Kylathu, R., Johnson, D., Johnson, D., Bedrick, A. D., Bedrick, A. D., Barber, B. J., Barber, B. J., Kurland, Y., Kurland, Y., Bader, M., & Bader, M. (2017). Intravenous Immunoglobulin for congenital Parvovirus myocarditis. Journal of Pediatric Infectious diseases.
- Colombo, J. N., Seckeler, M. D., Barber, B. J., Krupinski, E. A., Weinstein, R. S., Sisk, D., & Lax, D. (2016). Application and Utility of iPads in Pediatric Tele-echocardiography. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 22(5), 429-33.More infoTelemedicine is used with increasing frequency to improve patient care in remote areas. The interpretation of medical imaging on iPad(®) (Apple, Cupertino, CA) tablets has been reported to be accurate. There are no studies on the use of iPads for interpretation of pediatric echocardiograms. We compared the quality of echo images, diagnostic accuracy, and review time using three different modalities: remote access on an iPad Air (iPad), remote access via a computer (Remote), and direct access on a computer linked through Ethernet to the server, the "gold standard" (Direct).
- Abdy, N. A., Valdes, S. O., Sorrell, V. L., Klewer, S. E., & Barber, B. J. (2015). Apical hypertrophic cardiomyopathy in an adolescent. Congenital heart disease, 5(2), 182-7.More infoTo our knowledge, this is one of the few reported cases of apical hypertrophic cardiomyopathy in an adolescent patient in the United States. We describe a clinical presentation of an adolescent male who presented for cardiac evaluation and was found to have an apical variant of hypertrophic cardiomyopathy.
- Barber, B. J., Burch, G. H., Tripple, D., & Balaji, S. (2015). Resolution of plastic bronchitis with atrial pacing in a patient with fontan physiology. Pediatric cardiology, 25(1), 73-6.More infoWe describe a 5-year-old boy with Fontan physiology and a ventricular pacemaker who developed severe plastic bronchitis. Evaluation by cardiac catheterization revealed profoundly altered hemodynamics, which improved with atrial pacing. Following implantation of an atrial pacemaker, which restored atrioventricular (A-V) synchrony, the patient's hemodynamics greatly improved and his plastic bronchitis resolved.
- Barber, B. J., Donnerstein, R. L., Secomb, T. W., Pogreba-Brown, K., Steelman, R., Ellenby, M. S., Shen, I., & Ungerleider, R. M. (2015). The dicrotic pulse: a common, non-ominous finding after the Ross operation. Pediatric cardiology, 28(4), 247-9.More infoWe noted a dicrotic pulse in several patients following a Ross operation. Although the etiology of this unique arterial waveform is not completely understood, it has been reported as a sign of low cardiac output and a poor prognosis. We reviewed preoperative echocardiograms and postoperative radial arterial pressure tracings in 33 patients who underwent a Ross procedure between 2000 and 2004. We found a dicrotic pulse to occur commonly (20/33; 61%) following a Ross operation. Moderate to severe preoperative aortic insufficiency was present in 19/20 patients (95%) in whom a dicrotic pulse was noted and in only 3/13 (23%) who did not exhibit a postoperative dicrotic pulse (p
- Hainstock, M. R., Gruchala, N. E., Fike, N., Samson, R. A., Klewer, S. E., & Barber, B. J. (2015). Postural orthostatic tachycardia in a teenager with Klinefelter syndrome. Congenital heart disease, 3(6), 440-2.More infoTo our knowledge this is the first reported case of postural orthostatic tachycardia syndrome (POTS) in a patient with Klinefelter syndrome. We describe a classic clinical presentation of POTS in an adolescent male with Klinefelter syndrome. Although the etiology of POTS appears to be multifactorial, there is a strong female predominance that suggests a genetic basis. Our patient with Klinefelter syndrome may further support a link with POTS to the X chromosome.
- Hill, M. G., Sekhon, M. K., Reed, K. L., Anderson, C. F., Borjon, N. D., Tardiff, J. C., & Barber, B. J. (2015). Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation. Pediatric cardiology, 36(8), 1774-7.More infoThere is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.
- Ihnat, C. L., Zimmerman, H., Copeland, J. G., Meaney, F. J., Sobonya, R. E., Larsen, B. T., Blair, B., Lax, D., & Barber, B. J. (2015). Left ventricular assist device support as a bridge to recovery in young children. Congenital heart disease, 6(3), 234-40.More infoLeft ventricular assist device (LVAD) experience and follow-up data in children are limited. We report the deployment and successful weaning from LVAD in young children with severe heart failure (HF).
- Kylathu, R., Kylat, R. I., Kylathu, R., Johnson, D., Johnson, D., Johnson, D., Bedrick, A. D., Bedrick, A. D., Bedrick, A. D., Barber, B. J., Barber, B. J., Barber, B. J., Kurland, Y., Kurland, Y., Kurland, Y., Bader, M., Bader, M., & Bader, M. (2017). Intravenous Immunoglobulin for congenital Parvovirus myocarditis. Journal of Pediatric Infectious diseases.
- Barber, B. J., Andrews, J. G., Lu, Z., West, N. A., Meaney, F. J., Price, E. T., Gray, A., Sheehan, D. W., Pandya, S., Yang, M., & Cunniff, C. (2013). Oral corticosteroids and onset of cardiomyopathy in Duchenne muscular dystrophy. The Journal of pediatrics, 163(4), 1080-4.e1.More infoTo estimate the age when cardiomyopathy develops in boys with Duchenne muscular dystrophy (DMD) and to analyze the effect of corticosteroid treatment on the age of cardiomyopathy onset.
- Han, L. M., Klewer, S. E., Blank, K. M., Seckeler, M. D., & Barber, B. J. (2013). Feasibility of pulse oximetry screening for critical congenital heart disease at 2643-foot elevation. Pediatric cardiology, 34(8), 1803-7.More infoTo evaluate the feasibility of implementing a pulse oximetry screening protocol at a city of mild elevation with a specific focus on the false-positive screening rate. Pulse oximetry screening was performed according to the proposed guidelines endorsed by the American Academy of Pediatrics at a center in Tucson, AZ, at an elevation of 2,643 ft (806 m). During a 10-month period in 2012, 1069 full-term asymptomatic newborns were screened ≥ 24 h after birth. The mean preductal oxygen saturation was 98.5 ± 1.3 % (range 92-100 %), and the mean postductal oxygen saturation was 98.6 ± 1.3 % (range 94-100 %). Of 1,069 patients screened, 7 were excluded secondary to protocol violations, and 1 screened positive. An echocardiogram was performed on the newborn with the positive screen, and it was normal with the exception of right-to-left shunting across a patent foramen ovale. The false-positive rate was 1/1,062 or 0.094 %. The pulse oximetry screening guidelines recommended by the American Academy of Pediatrics are feasible at an elevation of 2,643 ft (806 m) with a low false-positive rate. Adjustments to the protocol are not required for centers at elevations ≤ 2,643 ft. Future studies at greater elevations are warranted.
- Haley, J. E., Klewer, S. E., Barber, B. J., Meaney, F. J., Donnerstein, R. L., Weinstein, R. S., Krupinski, E., Warda, G., Lopez, A. M., & Lax, D. (2012). Remote diagnosis of congenital heart disease in southern Arizona: comparison between tele-echocardiography and videotapes. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 18(10), 736-42.More infoWe report our experience with tele-echocardiography and echocardiograms recorded digitally or on videotape (recorded-echos) at The University of Arizona from August 2006 to December 2010 and compare their quality and diagnostic accuracy.
- Parikh, K., Witte, M. H., Samson, R., Teodori, M., Carpenter, J. B., Lowe, M. C., Morgan, W., Hardin, C., Brown, M., Naughton, Y., Sinha, S., & Barber, B. J. (2012). Successful treatment of plastic bronchitis with low fat diet and subsequent thoracic duct ligation in child with fontan physiology. Lymphology, 45(2), 47-52.More infoPlastic bronchitis is a rare condition characterized by the formation and expectoration of long, branching bronchial casts that develop in the tracheobronchial tree and cause airway obstruction. Plastic bronchitis has become increasingly recognized as a feared complication of the Fontan operation with a mortality of up to 50%. We report an 11 year old boy who developed severe plastic bronchitis following Fontan repair and the successful long-term control of cast formation utilizing a low-fat diet and subsequent thoracic duct ligation.
- Redford, D. T., Quigley, T. W., Gandy, K. L., & Barber, B. J. (2008). Transesophageal echocardiography for the intraoperative evaluation and management of a left ventricular vegetation. Anesthesia and analgesia, 106(6), 1636-8.
- Bagatell, R., Hainstock, M., Lowe, M. C., Barber, B. J., & Samson, R. A. (2007). The perfect storm: Torsades de Pointes in a child with leukemia. Pediatric blood & cancer, 49(7), 996-9.More infoTorsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.
- Cripe, L. H., Barber, B. J., Spicer, R. L., Wong, B. L., Weidner, N., Benson, D. W., & Markham, L. W. (2006). Outpatient continuous inotrope infusion as an adjunct to heart failure therapy in Duchenne muscular dystrophy. Neuromuscular disorders : NMD, 16(11), 745-8.More infoWe report the use of continuous intravenous inotrope infusion as a palliative management strategy for the treatment of symptomatic, refractory, end stage cardiac dysfunction in patients with Duchenne muscular dystrophy. Milrinone and/or dobutamine administered by continuous intravenous infusion provided symptomatic and objective cardiovascular improvement up to 30 months in 3 individuals with Duchenne muscular dystrophy and severe dilated cardiomyopathy. Continuous inotrope infusion should be considered a practical treatment strategy for end stage cardiac dysfunction in Duchenne muscular dystrophy patients when cardiac transplantation is not a viable option.
- Redford, D. T., Kim, A. S., Barber, B. J., & Copeland, J. G. (2006). Transesophageal echocardiography for the intraoperative evaluation of a large anterior mediastinal mass. Anesthesia and analgesia, 103(3), 578-9.
- Barber, B. J., Batra, A. S., Burch, G. H., Shen, I., Ungerleider, R. M., Brown, J. W., Turrentine, M. W., Mori, M., Hsieh, Y. C., & Balaji, S. (2005). Acute hemodynamic effects of pacing in patients with Fontan physiology: a prospective study. Journal of the American College of Cardiology, 46(10), 1937-42.More infoThe purpose of this research was to assess the hemodynamic response to atrial, ventricular, and dual-chamber pacing in patients with Fontan physiology.
- Broberg, C. S., Pantely, G. A., Barber, B. J., Mack, G. K., Lee, K., Thigpen, T., Davis, L. E., Sahn, D., & Hohimer, A. R. (2003). Validation of the myocardial performance index by echocardiography in mice: a noninvasive measure of left ventricular function. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 16(8), 814-23.More infoThe myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice.
- Li, X., Jones, M., Wang, H. F., Davies, C. H., Swanson, J. C., Hashimoto, I., Rusk, R. A., Schindera, S. T., Barber, B. J., & Sahn, D. J. (2003). Strain rate acceleration yields a better index for evaluating left ventricular contractile function as compared with tissue velocity acceleration during isovolumic contraction time: an in vivo study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 16(12), 1211-6.More infoOur study aimed to investigate whether strain rate acceleration (SRA) during isovolumic contraction time (IVCT) could serve as a sensitive indicator of myocardial function.
- Erdman, S. H., Barber, B. J., & Barton, L. L. (2002). Aspergillus cholangitis: A late complication after Kasai portoenterostomy. Journal of pediatric surgery, 37(6), 923-5.More infoAscending bacterial cholangitis can be a recurring complication in older children and adolescents who have undergone successful surgery for biliary atresia. The authors describe a 19-year-old girl with a history of recurrent late-onset, febrile cholangitis in whom persistent jaundice developed. Aspergillus terreus was isolated from her biliary fluid obtained at percutaneous transhepatic cholangiography. Despite prolonged external biliary drainage and systemic amphotericin B therapy, the fungus was not eliminated from her biliary system. Aspergillus cholangitis can occur in the portoenterostomy patient and may be highly resistant to conventional therapy.
Proceedings Publications
- Witte, M. H., Mustacich, D., Moedano, L., Behan, S., Bernas, M. J., Klewer, S. E., Barber, B. J., Kuo, P. H., & Kylathu, R. (2019, September). Whole Body Lymphangioscintigraphy and SPECT-CT in Infants and Children with Lymphatic Congestion after Surgical Repair of Complex Congenital Heart Disease. In 27th World Congress of Lymphology Abstract Booklet.
- Parthasarathy, S., Abraham, I. L., Hsu, C., Morgan, W. J., Barber, B. J., Edgin, J. O., & Combs, D. (2018, Fall). Sleep-disordered breathing is associated with neurocognitive impairment in children with congenital heart disease. In Sleep, 41, A277.
- Parthasarathy, S., Abraham, I. L., Hsu, C., Morgan, W. J., Klewer, S. E., Barber, B. J., Edgin, J. O., & Combs, D. (2018, Fall). Obstructive sleep apnea is a novel risk factor for neurocognitive impairment in children with congenital heart disease. In Circulation, 138(Suppl 1), 14956.
Presentations
- Seckeler, M., Witte, M. H., Barber, B. J., Moses, S., & Bernardi, A. (2019, October). Higher incidence of protein-losing enteropathy in patients with single systemic right ventricle. Finalist, Young Investigator Award, 2019 American Academy of Pediatrics National Conference & Exhibition. New Orleans, LA.
- Witte, M. H., Mustacich, D., Moedano, L., Behan, S., Bernas, M. J., Klewer, S. E., Barber, B. J., Kuo, P. H., & Kylathu, R. (2019, September). Whole Body Lymphangioscintigraphy and SPECT-CT in Infants and Children with Lymphatic Congestion after Surgical Repair of Complex Congenital Heart Disease. 27th World Congress of Lymphology. Buenos Aires and Iguazu, Argentina: International Society of Lymphology.
- Parthasarathy, S., Abraham, I. L., Hsu, C., Morgan, W. J., Barber, B. J., Edgin, J. O., & Combs, D. (2018, June). Sleep-disordered breathing is associated with neurocognitive impairment in children with congenital heart disease. 2018 meeting of the Associated Professional Sleep Societies. Baltimore, MD.
- Parthasarathy, S., Parthasarathy, S., Abraham, I. L., Abraham, I. L., Hsu, C., Hsu, C., Morgan, W. J., Morgan, W. J., Barber, B. J., Barber, B. J., Edgin, J. O., Edgin, J. O., Combs, D., & Combs, D. (2018, June). Sleep-disordered breathing is associated with neurocognitive impairment in children with congenital heart disease. 2018 meeting of the Associated Professional Sleep Societies. Baltimore, MD.
- Combs, D. A., Skrepnek, G., Seckeler, M., Barber, B. J., & Parthasarathy, S. (2016, June). Sleep-disordered breathing is associated with increased mortality among hospitalized infants with congenital heart disease. 2016 meeting of the Associated Professional Sleep Societies. Denver, CO.
Poster Presentations
- Seckeler, M., Seckeler, M., Seckeler, M., Klewer, S. E., Klewer, S. E., Klewer, S. E., Parthasarathy, S., Parthasarathy, S., Parthasarathy, S., Andrews, J. G., Andrews, J. G., Andrews, J. G., Hsu, C., Hsu, C., Hsu, C., Morgan, W. J., Morgan, W. J., Morgan, W. J., Barber, B. J., , Barber, B. J., et al. (2020, November). Obstructive Sleep Apnea Is Associated with Cardiac Dysfunction In Children With Congenital Heart Disease. 2020 American Heart Association Scientific SessionsAmerican Heart Association.
- Barber, B. J., Nigro, J. J., Seckeler, M., & Nayak, S. (2018, May). Multimodality Imaging and 3-D Model of Anatomically Corrected Malposition of the Great Arteries (S, L, D). Arizona Chapter of the American College of Cardiology Annual Meeting. Scottsdale, AZ.
- Combs, D., Edgin, J. O., Barber, B. J., Klewer, S. E., Morgan, W. J., Hsu, C., Abraham, I. L., & Parthasarathy, S. (2018, November). Obstructive Sleep Apnea is a Novel Risk Factor for Neurocognitive Impairment in Children with Congenital Heart Disease. 2018 American Heart Association Scientific Sessions. Chicago, IL.
- Coombs, D., Edgin, J. O., Barber, B. J., Klewer, S. E., Morgan, W. J., Hsu, C., & Parthasarathy, S. (2018, Nov). Obstructive sleep apnea is a novel risk factor for neurocognitive impairment in children with congenital heart disease. American Heart Association. Chicago.
- Parthasarathy, S., Abraham, I. L., Hsu, C., Morgan, W. J., Barber, B. J., Edgin, J. O., & Combs, D. (2018, Fall). Sleep-disordered breathing is associated with neurocognitive impairment in children with congenital heart disease. Sleep Research SocietySleep Research Society.
- Parthasarathy, S., Abraham, I. L., Hsu, C., Morgan, W. J., Klewer, S. E., Barber, B. J., Edgin, J. O., & Combs, D. (2018, Fall). Obstructive sleep apnea is a novel risk factor for neurocognitive impairment in children with congenital heart disease. American Heart AssociationAmerican Heart Association.
- Summerford, K., Bernardi, A., Shehab, Z. M., Barber, B. J., & Janet, L. (2018, June). Meningitis-like presentation of Haemophilus parainfluenzae endocarditis in an otherwise healthy adolescent.. Pediatrics in the Red Rocks. Sedona, AZ: Arizona Chapter of the American Academy of Pediatrics.
- Barber, B. J. (2017, Fall). Intravenous immunoglobulin for congenital parvovirus myocarditis.. American Academy of Pediatrics. Chicago, IL: AAP.
- Combs, D., Edgin, J. O., Barber, B. J., Morgan, W. J., Hsu, C., Abraham, I. L., & Parthasarathy, S. (2017, July). Sleep-disordered breathing is associated with memory impairment in children with congenital heart disease. 15th International Symposium on Sleep and Breathing. Madison, WI.
- Sylvester, M., & Barber, B. J. (2017, Jan). Comparison of outcomes and costs for protein losing enteropathy following single ventricle palliation for right and left ventricle morphology.. Oral presentation Western Regional Meeting of Pediatric Research. Carmel, California: Oral Presentation at nal Meeting of Pediatric Research.
- Young, K., & Barber, B. J. (2017, July). Improvement of hyperechogenic myocardium after prenatal treatment with dexamethasone in fetus exposed to maternal anti-SSA/Ro and anti-SSB/La antibodies.. 7th World Congress of Pediatric Cardiology and Cardiac Surgery. Barcelona, Spain. Barcelona, Spain: World Congress.
- Parthasarathy, S., Combs, D. A., Morgan, W. J., Edgin, J. O., Archbold, K., Rice, S. A., Barber, B. J., Barber, B. J., Archbold, K., Rice, S. A., Edgin, J. O., Morgan, W. J., Combs, D. A., & Parthasarathy, S. (2015, May). Prevalence of Sleep-Disordered Breathing in Children with Congenital Heart Disease. 2015 International meeting of the American Thoracic Society. Denver, CO.
- Seckeler, M., Seckeler, M., Klewer, S. E., Klewer, S. E., Parthasarathy, S., Parthasarathy, S., Andrews, J. G., Andrews, J. G., Hsu, C., Hsu, C., Morgan, W. J., Morgan, W. J., Barber, B. J., Barber, B. J., Fernandez, V., Fernandez, V., Combs, D. A., & Combs, D. A. (2020, November). Obstructive Sleep Apnea Is Associated with Cardiac Dysfunction In Children With Congenital Heart Disease. 2020 American Heart Association Scientific SessionsAmerican Heart Association.
- Zahedieh, S., Seckeler, M., Andrews, J., Klewer, S. E., Scherer, K., Daines, C. L., & Barber, B. J. (2015, Fall). Regional and Racial Variation in Hospitalization Costs in Patients with Duchenne Muscular Dystrophy. American Academy of Pediatrics National Conference and Exhibition. Washington, DC: AAP.
- Parthasarathy, S., Morgan, W. J., Rice, S. A., Barber, B. J., Archbold, K., Edgin, J. O., & Combs, D. A. (2015, May). Prevalence of Sleep-Disordered Breathing in Children with Congenital Heart Disease. 2015 International meeting of the American Thoracic Society. Denver, CO.