Wei-Hsuan Jenny Lo-Ciganic, PhD, MSCP, MS, is an Assistant Professor in the University of Arizona College of Pharmacy Department of Pharmacy, Practice and Science, and the University of Arizona College of Public Health, Department of Epidemiology and Biostatistics. She is a pharmacoepidemiologist and biostatistician who has interests in medication adherence to essential chronic medications, drug safety, cancer prevention, quality and value of prescribing, and diffusion of new drugs for chronic disease management, especially among populations who are vulnerable or minorities. Several of her previous projects have focused on evaluating cholesterol-lowering medication use in older adults, associations between statin use and physical function decline in older adults, and associations between non-opioid analgesics and risk of ovarian cancer. She has been involved in the largest population-based case-control study of ovarian cancer in the U.S (Hormone and Ovarian Cancer Prediction [HOPE] Study) and the Ovarian Cancer Association Consortium (OCAC). Methodologically, Dr. Lo-Ciganic is experienced in a wide range of both quantitative and qualitative methods. She has expertise in analyses of big health care data, supervised machine-learning methods, group based trajectory models, and the development and evaluation of an integrated program intervention with a community-based design.
Dr. Lo-Ciganic received her pharmacy degree from National Taiwan University (Taipei, Taiwan) in 2003, and a MS in Clinical Pharmacy from National Cheng-Kung University (Tainan, Taiwan) in 2005. She also completed a MS in Biostatistics at the University of Pittsburgh in 2010 and received her PhD in Epidemiology at the University of Pittsburgh in 2013. Prior to arriving at the University of Arizona, she worked as a post-doctoral associate for the Center for Pharmaceutical Policy and Prescribing at the University of Pittsburgh Health Policy Institute. In that role, she collaborated on a variety of studies focused on application of novel statistical methods for improving medication adherence measures in diabetes and treatment for opioid use disorders. Her long-range career objective is to conduct pharmacoepidemiologic, comparative effectiveness and health service research to better understand the patient, provider, health system, and regional factors that impact drug utilization to inform clinical medicine, health promotion, and health policy, and ultimately to improve health outcomes and quality. She is a recipient of both the 2015 Faculty Seed Grant (University of Arizona Office for Research and Discovery), and University of Arizona Health Sciences Center Career Development Award. She is also a recipient of the 2016 American Association of College of Pharmacy New Investigator Award. Her recent work is focused on using machine learning approaches to prevent problematic prescription opioid use.
- Ph.D. Epidemiology
- University of Pittsburgh, Pittsburgh, Pennsylvania, United States
- Pharmacoepidemiologic Studies: An Interrupted-Time Series Analysis on Drug Utilization and Evaluation of Beneficial or Adverse Drug Effects
- M.S. Biostatistics
- University of Pittsburgh, Pittsburgh, Pennsylvania, United States
- Identifying and Validating Type 1 and Type 2 Diabetic Cases Using Administrative Data: A Tree-Structured Model
- M.S. Clinical Pharmacy
- National Cheng Kung University, Tainan, Taiwan, Province of China
- "Effects of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Protection of Cardiovascular Disease and Residual Renal Function in Peritoneal Dialysis Patients"
- B.S. Pharmacy
- National Taiwan University, Taipei, Taiwan, Province of China
- Center for Population Science and Discovery, University of Arizona (2015 - Ongoing)
- College of Pharmacy, University of Arizona (2015 - Ongoing)
- Mel and Enid Zuckerman College of Public Health, University of Arizona (2015 - Ongoing)
- Health Policy Institute, University of Pittsburgh (2013 - 2014)
- Graduate School of Public Health, University of Pittsburgh (2011 - 2013)
- Graduate School of Public Health, University of Pittsburgh (2011 - 2013)
- Department of Epidemiology, University of Pittsburgh (2011)
- Institute for Clinical Research and Education, University of Pittsburgh (2010 - 2011)
- University of Pittsburgh Diabetes Institute (2010)
- University of Pittsburgh, Pittsburgh, Pennsylvania (2009 - 2010)
- University of Pittsburgh Cancer Institute, Graduate School of Public Health, University of Pittsburgh (2007 - 2013)
- University of Pittsburgh, Pittsburgh, Pennsylvania (2006 - 2007)
- Department of Health Taiwan (2006)
- National Cheng Kung University (2004 - 2005)
- Department of Health Taiwan (2004 - 2005)
- National Cheng Kung University Hospital (2004 - 2005)
- National Taiwan University Hospital (2003 - 2004)
- National Cheng Kung University Hospital (2003)
- Shin-Hsin-Ho Community Pharmacy (2002 - 2003)
- Merck Sharp & Dohme (LA) Corp. (2002)
- Best Podium Presentation Award
- 2017 International Society of Pharmacoeconomics and Outcomes Research, 22nd Annual Meeting, Fall 2017
- U.S. Bone and Joint Initiative/Bone and Joint Canada Young Investigators Initiative (YII) Grant Mentoring and Career Development Program Awardee
- U.S. Bone and Joint Initiative/Bone and Joint Canada Young Investigators Initiative (YII), Fall 2017
- Opioid Addiction Interviewee
- KGUN9 TV channel, Spring 2017
- Outstanding Reviewer
- Annals of Internal Medicine, Spring 2016
- Annals of Internal Medicine, Spring 2015
- 2015 Top 10 Addiction Article
- American Society of Addiction Medicine (ASAM)., Winter 2015
- Poster Finalist Award
- International Society of Pharmacoeconomics and Outcomes Research (ISPOR), Summer 2015 (Award Finalist)
- Best Reviewer
- Pharmacoepidemiology and Drug Safety, Spring 2015
- Honorable Mention for the Erikson Foundation Award
- American Public Health Association, Spring 2013
- Graduate Student Honoree
- Graduate School of Public Health, University of Pittsburgh, Spring 2012
- Best Thesis Award in the Department of Biostatistics
- Graduate School of Public Health, University of Pittsburgh, Spring 2011
- Public Health Deans Scholarship
- Graduate School of Public Health, University of Pittsburgh, Spring 2007
- Best Clinical Thesis Award
- Taiwan Society of Nephrology, Fall 2005
Pharmacoepidemiology,Pharmaceutical health service research,Medication Adherence,Drug Safety,Cancer Prevention,Quality of Prescribing,Value of Prescribing,Diffusion of New Drugs for Management of Chronic Disease
DissertationPHSC 920 (Spring 2018)
Drug Lit Eval-Stat MethdPHPR 861A (Spring 2018)
Independent StudyPHSC 699 (Spring 2018)
Pharmacy AdministrationPHSC 596E (Spring 2018)
DissertationPHSC 920 (Fall 2017)
Drug Lit Eval-Stat MethdPHPR 861A (Spring 2017)
Independent StudyPHSC 699 (Spring 2017)
Health Tech AssessmentPHSC 513 (Fall 2016)
Drug Lit Eval-Stat MethdPHPR 861A (Spring 2016)
Independent StudyPHSC 699 (Spring 2016)
Pharmacy AdministrationPHSC 596E (Spring 2016)
- Almutairi, A. R., Zhou, L., Gellad, W. F., Lee, J. K., Slack, M. K., Martin, J. R., & Lo-Ciganic, W. H. (2017). Effectiveness and Safety of Non-vitamin K Antagonist Oral Anticoagulants for Atrial Fibrillation and Venous Thromboembolism: A Systematic Review and Meta-analyses. Clinical therapeutics, 39(7), 1456-1478.e36.More infoThe findings from the observational studies comparing the effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) versus vitamin K antagonists (VKAs) for atrial fibrillation (AF) and venous thromboembolism (VTE) are inconsistent. We conducted separate meta-analyses examining the efficacy/effectiveness and safety of NOACs versus VKAs by disease (AF vs VTE), study design (randomized controlled trials [RCTs] vs observational studies), and NOAC (dabigatran, rivaroxaban, apixaban, and edoxaban).
- Anderson, T. S., Lo-Ciganic, W. H., Gellad, W. F., Zhang, R., Huskamp, H. A., Choudhry, N. K., Chang, C. H., Richards-Shubik, S., Guclu, H., Jones, B., & Donohue, J. M. (2017). Patterns and predictors of physician adoption of new cardiovascular drugs. Healthcare (Amsterdam, Netherlands).More infoLittle is known about physicians' approaches to adopting new cardiovascular drugs and how adoption varies between drugs of differing novelty.
- Cochran, G., Gordon, A. J., Gellad, W. F., Chang, C. H., Lo-Ciganic, W. H., Lobo, C., Cole, E., Frazier, W., Zheng, P., Kelley, D., & Donohue, J. M. (2017). Medicaid prior authorization and opioid medication abuse and overdose. The American journal of managed care, 23(5), e164-e171.More infoThe US opioid medication epidemic has resulted in serious health consequences for patients. Formulary management tools adopted by payers, specifically prior authorization (PA) policies, may lower the rates of opioid medication abuse and overdose. We compared rates of opioid abuse and overdose among enrollees in plans that varied in their use of PA from "High PA" (ie, required PA for 17 to 74 opioids), with "Low PA" (ie, required PA for 1 opioid), and "No PA" policies for opioid medications.
- Frazier, W., Cochran, G., Lo-Ciganic, W. H., Gellad, W. F., Gordon, A. J., Chang, C. H., & Donohue, J. M. (2017). Medication-Assisted Treatment and Opioid Use Before and After Overdose in Pennsylvania Medicaid. JAMA, 318(8), 750-752.
- Hill, M. G., Gonzalez, M. G., Lo-Ciganic, W. H., & Reed, K. L. (2017). Misoprostol in Addition to a Double-Balloon Catheter for Induction: A Double-Blind Randomized Controlled Trial. American journal of perinatology.
- Lo-Ciganic, W. H., Floden, L., Lee, J. K., Ashbeck, E. L., Zhou, L., Chinthammit, C., Purdy, A. W., & Kwoh, C. K. (2017). Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis and cartilage.More infoFew studies have compared the risk of recurrent falls across different types of analgesic use, and with limited adjustment for potential confounders (e.g., pain/depression severity). We assessed analgesic use and the subsequent risk of recurrent falls, among participants with or at risk of knee osteoarthritis (OA).
- Cochran, G., Gordon, A. J., Lo-Ciganic, W., Gellad, W. F., Frazier, W., Lobo, C., Chang, C. H., Zheng, P., & Donohue, J. M. (2016). An Examination of Claims-based Predictors of Overdose from a Large Medicaid Program. Medical care.More infoHealth systems may play an important role in identification of patients at-risk of opioid medication overdose. However, standard measures for identifying overdose risk in administrative data do not exist.
- Gordon, A., Lo-Ciganic, W., Cochran, G., Gellad, W. F., Cathers, T., & Donohue, J. M. (2016). Treatment Quality for Buprenorphine Care: The Pot at the End of the Rainbow. Journal of addiction medicine, 10(3), 210-1.
- Lo Ciganic, W. H., Jacob, M., Schlenk, E., Terhost, L., Bilt, J., Zgibor, J., Simkin-Silverman, L., Albert, S., & Newman, A. (2016). The Preventative Services Use Self-Efficacy (PRESS) Scale in Older Women; Development and Psychometric Properties. BMC Health Services Research.
- Lo-Ciganic, W., Boudreau, R. M., Gray, S. L., Zgibor, J. C., Donohue, J. M., Perera, S., Newman, A. B., Simonsick, E. M., Bauer, D. C., Satterfield, S., & Hanlon, J. T. (2013). Changes in cholesterol-lowering medications use over a decade in community-dwelling older adults. The Annals of pharmacotherapy, 47(7-8), 984-92.More infoThe impact of evidence-based guidelines and controlled trial data on use of cholesterol-lowering medications in older adults is unclear.
- Lo-Ciganic, W., Donohue, J. M., Jones, B. L., Perera, S., Thorpe, J. M., Thorpe, C. T., Marcum, Z. A., & Gellad, W. F. (2016). Trajectories of Diabetes Medication Adherence and Hospitalization Risk: A Retrospective Cohort Study in a Large State Medicaid Program. Journal of general internal medicine, 31(9), 1052-60.More infoNumerous interventions are available to boost medication adherence, but the targeting of these interventions often relies on crude measures of poor adherence. Group-based trajectory models identify individuals with similar longitudinal prescription filling patterns. Identifying distinct adherence trajectories may be more useful for targeting interventions, although the association between adherence trajectories and clinical outcomes is unknown.
- Lo-Ciganic, W., Gellad, W. F., Huskamp, H. A., Choudhry, N. K., Chang, C. H., Zhang, R., Jones, B. L., Guclu, H., Richards-Shubik, S., & Donohue, J. M. (2016). Who Were the Early Adopters of Dabigatran?: An Application of Group-based Trajectory Models. Medical care, 54(7), 725-32.More infoVariation in physician adoption of new medications is poorly understood. Traditional approaches (eg, measuring time to first prescription) may mask substantial heterogeneity in technology adoption.
- Zgibor, J. C., Schlenk, E. A., Vater, L., Kola, S., Vander Bilt, J., Woody, S., Jacob, M. E., Lo-Ciganic, W., Brenckle, A., Brandenstein, J., Kwoh, C. K., Boudreau, R., Albert, S., Conroy, M., Rodgers, E., & Newman, A. B. (2016). Partnership Building and Implementation of an Integrated Healthy-Aging Program. Progress in community health partnerships : research, education, and action, 10(1), 123-32.More infoEvidence-based interventions exist for prevention of chronic disease in older adults. Partnering with community organizations may provide a mechanism for disseminating these interventions.
- Cochran, G., Woo, B., Lo-Ciganic, W., Gordon, A. J., Donohue, J. M., & Gellad, W. F. (2015). Defining Nonmedical Use of Prescription Opioids Within Health Care Claims: A Systematic Review. Substance abuse, 36(2), 192-202.More infoHealth insurance claims data may play an important role for health care systems and payers in monitoring the nonmedical use of prescription opioids (NMPO) among patients. However, these systems require valid methods for identifying NMPO if they are to target individuals for intervention. Limited efforts have been made to define NMPO using administrative data available to health systems and payers. We conducted a systematic review of publications that defined and measured NMPO within health insurance claims databases in order to describe definitions of NMPO and identify areas for improvement.
- Gordon, A. J., Lo-Ciganic, W., Cochran, G., Gellad, W. F., Cathers, T., Kelley, D., & Donohue, J. M. (2015). Patterns and Quality of Buprenorphine Opioid Agonist Treatment in a Large Medicaid Program. Journal of addiction medicine, 9(6), 470-7.More infoUse of buprenorphine - an effective treatment for opioid use disorders (OUDs) - has increased rapidly in recent years and is often financed by Medicaid. We investigated predictors of buprenorphine treatment, patterns of care, and quality of care in a large state Medicaid program.
- Lo-Ciganic, W., Donohue, J. M., Thorpe, J. M., Perera, S., Thorpe, C. T., Marcum, Z. A., & Gellad, W. F. (2015). Using machine learning to examine medication adherence thresholds and risk of hospitalization. Medical care, 53(8), 720-8.More infoQuality improvement efforts are frequently tied to patients achieving ≥80% medication adherence. However, there is little empirical evidence that this threshold optimally predicts important health outcomes.
- Lo-Ciganic, W., Gellad, W. F., Gordon, A. J., Cochran, G., Zemaitis, M. A., Cathers, T., Kelley, D., & Donohue, J. M. (2015). Associations between trajectories of buprenorphine treatment and emergency department and inpatient utilization. Addiction (Abingdon, England).More infoUncertainty about optimal treatment duration for buprenorphine opioid agonist therapy may lead to substantial variation in provider and payer decision-making regarding treatment course. We aimed to identify distinct trajectories of buprenorphine use and examine outcomes associated with these trajectories to guide health system interventions regarding treatment length.
- Lo-Ciganic, W., Perera, S., Gray, S. L., Boudreau, R. M., Zgibor, J. C., Strotmeyer, E. S., Donohue, J. M., Bunker, C. H., Newman, A. B., Simonsick, E. M., Bauer, D. C., Satterfield, S., Caserotti, P., Harris, T., Shorr, R. I., Hanlon, J. T., & , H. A. (2015). Statin use and decline in gait speed in community-dwelling older adults. Journal of the American Geriatrics Society, 63(1), 124-9.More infoTo examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults.
- Minlikeeva, A. N., Freudenheim, J. L., Lo-Ciganic, W., Eng, K. H., Friel, G., Diergaarde, B., Modugno, F., Cannioto, R., Gower, E., Szender, J. B., Grzankowski, K., Odunsi, K., Ness, R. B., & Moysich, K. B. (2015). Use of common analgesics is not associated with ovarian cancer survival. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24(8), 1291-4.More infoUse of analgesics has been associated with lower risk of ovarian cancer, but, to date, very few studies have explored the association between analgesics and ovarian cancer survival.
- Schlenk, E. A., Bilt, J. V., Lo-Ciganic, W., Jacob, M. E., Woody, S. E., Conroy, M. B., Kwoh, C. K., Albert, S. M., Boudreau, R., Newman, A. B., & Zgibor, J. C. (2015). Pilot Enhancement of the Arthritis Foundation Exercise Program with a Healthy Aging Program. Research in gerontological nursing, 1-10.More infoOlder adults with arthritis or joint pain were targeted for a pilot program enhancing the Arthritis Foundation Exercise Program with the 10 Keys™ to Healthy Aging Program. Using a one-group, pre-post design, feasibility was examined and improvements in preventive behaviors, arthritis outcomes, and cardiometabolic outcomes were explored. A 10-week program was developed, instructors were recruited and trained, and four sites and 51 participants were recruited. Measures included attendance, adherence, satisfaction, preventive behaviors, Western Ontario and McMaster Universities Osteoarthritis Index (pain and stiffness), glucose, and cholesterol. Three fourths of participants attended >50% of the sessions. At 6 and 12 months, more than one half performed the exercises 1 to 2 days per week, whereas 28% and 14% exercised 3 to 7 days per week, respectively. Participants (92%) rated the program as excellent/very good. Nonsignificant changes were observed in expected directions. Effect sizes were small for arthritis and cardiometabolic outcomes. This program engaged community partners, demonstrated feasibility, and showed improvements in some preventive behaviors and health risk profiles. [Res Gerontol Nurs. 2015; x(x):xx-xx.].
- Trabert, B., Ness, R. B., Lo-Ciganic, W., Murphy, M. A., Goode, E. L., Poole, E. M., Brinton, L. A., Webb, P. M., Nagle, C. M., Jordan, S. J., , A. O., Risch, H. A., Rossing, M. A., Doherty, J. A., Goodman, M. T., Lurie, G., Kjær, S. K., Hogdall, E., Jensen, A., , Cramer, D. W., et al. (2014). Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium. Journal of the National Cancer Institute, 106(2), djt431.More infoRegular aspirin use is associated with reduced risk of several malignancies. Epidemiologic studies analyzing aspirin, nonaspirin nonsteroidal anti-inflammatory drug (NSAID), and acetaminophen use and ovarian cancer risk have been inconclusive.
- Terry, K. L., Karageorgi, S., Shvetsov, Y. B., Merritt, M. A., Lurie, G., Thompson, P. J., Carney, M. E., Weber, R. P., Akushevich, L., Lo-Ciganic, W., Cushing-Haugen, K., Sieh, W., Moysich, K., Doherty, J. A., Nagle, C. M., Berchuck, A., Pearce, C. L., Pike, M., Ness, R. B., , Webb, P. M., et al. (2013). Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls. Cancer prevention research (Philadelphia, Pa.), 6(8), 811-21.More infoGenital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with number of genital powder applications and for all histologic types of ovarian cancer also remains uncertain. Therefore, we estimated the association between self-reported genital powder use and epithelial ovarian cancer risk in eight population-based case-control studies. Individual data from each study were collected and harmonized. Lifetime number of genital powder applications was estimated from duration and frequency of use. Pooled ORs were calculated using conditional logistic regression matched on study and age and adjusted for potential confounders. Subtype-specific risks were estimated according to tumor behavior and histology. 8,525 cases and 9,859 controls were included in the analyses. Genital powder use was associated with a modest increased risk of epithelial ovarian cancer [OR, 1.24; 95% confidence interval (CI), 1.15-1.33] relative to women who never used powder. Risk was elevated for invasive serous (OR, 1.20; 95% CI, 1.09-1.32), endometrioid (OR, 1.22; 95% CI, 1.04-1.43), and clear cell (OR, 1.24; 95% CI, 1.01-1.52) tumors, and for borderline serous tumors (OR, 1.46; 95% CI, 1.24-1.72). Among genital powder users, we observed no significant trend (P = 0.17) in risk with increasing number of lifetime applications (assessed in quartiles). We noted no increase in risk among women who only reported nongenital powder use. In summary, genital powder use is a modifiable exposure associated with small-to-moderate increases in risk of most histologic subtypes of epithelial ovarian cancer.
- Lo-Ciganic, W., Zgibor, J. C., Bunker, C. H., Moysich, K. B., Edwards, R. P., & Ness, R. B. (2012). Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, or acetaminophen and risk of ovarian cancer. Epidemiology (Cambridge, Mass.), 23(2), 311-9.More infoAspirin, nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) and acetaminophen all have biologic effects that might reduce the risk of ovarian cancer. However, epidemiologic data on this question are mixed.
- Lo-Ciganic, W., Zgibor, J. C., Ruppert, K., Arena, V. C., & Stone, R. A. (2011). Identifying type 1 and type 2 diabetic cases using administrative data: a tree-structured model. Journal of diabetes science and technology, 5(3), 486-93.More infoTo date, few administrative diabetes mellitus (DM) registries have distinguished type 1 diabetes mellitus (T1DM) from type 2 diabetes mellitus (T2DM).
- Lo Ciganic, W. H., Kao Yang, Y., & Sung, J. (2004). Antihypertensive agents and new-onset diabetes. ;. Kidney and Dialysis, 16, 225-240.
- Lo Ciganic, W. H., Li, Y., & Lin, C. (2004). Selective serotonin reuptake inhibitors (SSRI). National Cheng Kung University Pharmacy Forum (Chinese), 14, 6.
- Slack, M. K., Lo Ciganic, W. H., Almutari, A., Lili, Z., Lee, J. K., & Martin, J. R. (2016, Mary 2016). Comparative effectiveness and safety of dabigatran versus vitamin K antagonists in atrial fibrillation: A meta-analysis of observational studies. ISPOR. Washington, D.C.: ISPOR.