Stephen A Klotz
- Professor, Medicine
- Professor, Family and Community Medicine
- M.D. Medicine
- University of Kansas, Kansas City, Kansas, United States
- B.A. Zoology
- University of Kansas, Lawrence, Kansas, United States
- Professor, University of Kansas School of Medicine (1990 - 2000)
- Associate Professor, Louisiana State University-Shreveport (1984 - 1990)
- Physician, Emergency Room Corporation (1977 - 1979)
- Director Locum Tenens Program, University of Kansas School of Medicine (1976 - 1977)
- Physician, Indian Health Service (1975 - 1976)
- Best Doctors in Tucson
- Spring 2017
- Spring 2016
- Spring 2015
- University of Arizona, Spring 2017
Licensure & Certification
- Infectious Diseases Certification, ABIM (1984)
- Medical license, Arizona Board of Medical Licensure (2000)
- Internal Medicine Certification, ABIM (1981)
HIV; Candida adherence; Kissing bug behavior; Chagas
Infectious Diseases; HIV; Fungal Infections
Honors ThesisPSIO 498H (Fall 2016)
- Klotz, S. A., & Alpert, J. S. (2017). Infective Endocarditis. In Hurst's The Heart.
- Klotz, S. A., El Ramahi, R., & Zangeneh, T. (2017). Bacterial and fungal infections of the liver. In Hepatology, a textbook of liver disease.
- Elliott, S. P., Beatty, N., & Klotz, S. A. (2017). Ectoparasite Infestation of a Hospital Due to the Colonization of Nesting Cliff Swallows. Clinical Infectious Diseases.
- Klotz, S. A. (2017). Amyloid-like β-Aggregates as Force-sensitive Switches in Fungal Biofilms and Infections.. Microbiol Mol Biol Rev, online.
- Klotz, S. A. (2017). Candidiasis (oral and esophageal). Essential Evidence Plus.
- Klotz, S. A. (2017). The midnite bite. A kissing bug nightmare. Am J Med.
- Klotz, S. A., & Brown, C. B. (2017). Hantavirus. Essential Evidence Plus.
- Klotz, S. A., Beatty, N. L., & Elliot, S. P. (2017). Hematophagous ectoparasites of Cliff Swallows invade a hospital and feed on humans.. Clin Inf Dis., 65(12), 2119-2121. doi:10.1093/cid/cix697
- Klotz, S. A. (2016). Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty.. J Vis Exp.
- Klotz, S. A. (2016). Kissing Bug (Triatoma spp.) Intrusion into Homes: Troublesome Bites and Domiciliation.. Environ Health Insights.
- Klotz, S. A. (2016). Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?. Open Forum Infect Dis.
- Garcia-Sherman, M. C., Lundberg, T., Sobonya, R. E., Lipke, P. N., & Klotz, S. A. (2015). A unique biofilm in human deep mycoses: fungal amyloid is bound by host serum amyloid P component. NPJ biofilms and microbiomes, 1.More infoWe have demonstrated the presence of Candida cell surface amyloids that are important in aggregation of fungi and adherence to tissue. Fungal amyloid was present in invasive human candidal infections and host serum amyloid P component (SAP) bound to the fungal amyloid. SAP is a protease-resistant glycoprotein that binds avidly to amyloid and interferes with host defence, especially against bacterial pathogens for which neutrophils are important. In this study, we investigated whether biofilm of fungal amyloid and SAP was a feature of other disseminated fungal infections.
- Klotz, S. A. (2015). Contemporary HIV-patients and the Frailty Syndrome: A Short Review.. Austin J Infect Dis.
- Zamora, D., Klotz, S. A., Meister, E. A., & Schmidt, J. O. (2015). Repellency of the Components of the Essential Oil, Citronella, to Triatoma rubida, Triatoma protracta, and Triatoma recurva (Hemiptera: Reduviidae: Triatominae). Journal of medical entomology, 52(4), 719-21.More infoThe kissing bugs--Triatoma rubida (Uhler), Triatoma protracta (Uhler), and Triatoma recurva (Stal)--are common hematophagous bugs in southeastern Arizona and responsible for severe allergic reactions in some individuals who are bitten. They also possess the potential to transmit the blood parasite, Trypanosoma cruzi. We previously found the essential oil, citronella, to be an excellent deterrent of feeding of T. rubida on a restrained mouse. In this work, we tested major components--alcohols, aldehydes, and monoterpenes--of citronella oil for repellency against the three common triatome species endemic in southern Arizona. The following citronella oil components--geraniol, citronellol, limonene, and citronellal--in different concentrations and combinations were tested. All components of citronella oil demonstrated some inhibition of feeding, ranging from very weak inhibition (limonene) to significant inhibition (geraniol and citronellol). A mixture of geraniol and citronellol was found to be repellant at concentrations of .165 and .165 vol%, respectively, for all three triatome species. Citronellal and limonene had no significant repellent activity. The repellent activity of citronella oil appears to be acting through direct contact with the bugs rather than diffusion of vapors.
- Zangeneh, T. T., Malo, J., Luraschi-Monjagatta, C., Hage, C. A., Wheat, L. J., Strawter, C., Klotz, S. A., & Knox, K. S. (2015). Positive (1-3) B-d-glucan and cross reactivity of fungal assays in coccidioidomycosis. Medical mycology, 53(2), 171-3.More infoFungal antigen testing in immunosuppressed patients has emerged as a powerful diagnostic tool. Some assays are relatively nonspecific, and misinterpretation can have severe clinical consequences. Additionally, when new assays become commercially available it is important to evaluate the potential for cross reactivity. We recently observed several immunosuppressed patients with positive (1→3)-β-D-glucan (BG) who were eventually diagnosed with coccidioidomycosis in the endemic area of Tucson, Arizona. Although the BG assay is known to detect glucans of many fungal pathogens, reports of cross-reactivity with Coccidioides remain sparsely reported. To test the cross-reactivity of fungal antigens in detection assays, serum samples from patients with coccidioidomycosis testing positive for Coccidioides antigen were evaluated for BG. Of 12 samples positive for Coccidioides antigen (≥0.07 ng/ml), 11 (92%) were positive by BG (>80 pg/ml), and of 11 positive for Aspergillus galactomannan, 10 (91%) were positive by BG (>80 pg/ml). We conclude that the BG assay is nonspecific, detecting glucans from many fungal pathogens, including Coccidioides. In the endemic area, a positive BG warrants further specific testing.
- Klotz, S. A., Dorn, P. L., Stevens, L., Beatty, N., Schmidt, J. O., & Smith, S. (2017, October). Parasites, food, and manners: What can the ecology of Kissing bugs in the United States tell us about Chagas transmission risk?. SOVE Conference. Palma de Mallorca, Spain: SOVE.
- Klotz, S. A., Georgescu, A., Smith, S., Guido, A., Fisher, J., & Florita, C. (2017, October). PrEP uptake and emergent HIV infections in southern Arizona. Infectious Disease Society Annual Meeting. San Diego, CA: Infectious Disease Society.
Other Teaching Materials
- Klotz, S. A. (2015. Candidiasis (oral and esophageal. Essential Evidence Plus.More infophysician online resource
- Klotz, S. A. (2015. The Acute Retroviral Syndrome in HIV Infection. CME interactive program for Virtual Lecture Hall.. Virtual Lecture Hall.
- Klotz, S. A. (2015. Treating Hepatitis C in Patients with HIV Disease. Virtual Lecture Hall.More infophysician CME course