Siobhan M Hoscheidt

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• Barnes, C. A., Bolla, Y., Both, M. D., Brinton, R. D., Glisky, E. L., Haberg, A. K., Hay, M., Hoscheidt, S. M., Huentelman, M. J., Levin, B. E., Lewis, C. R., Naymik, M. A., Rundek, T., Ryan, L., Schmidt, A. M., & Talboom, J. S. (2021). Smoking is associated with impaired verbal learning and memory performance in women more than men.. Scientific reports, 11(1), 10248. doi:10.1038/s41598-021-88923-z
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  Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating vascular disease risks. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific relationships between smoking and memory performance and with contradictory results. We investigated the associations between sex, smoking, and cardiovascular disease with verbal learning and memory function. Using MindCrowd, an observational web-based cohort of ~ 70,000 people aged 18-85, we investigated whether sex modifies the relationship between smoking and cardiovascular disease with verbal memory performance. We found significant interactions in that smoking is associated with verbal learning performance more in women and cardiovascular disease more in men across a wide age range. These results suggest that smoking and cardiovascular disease may impact verbal learning and memory throughout adulthood differently for men and women.
• Anderson, A., Brinton, R. D., Carmichael, O., Espeland, M. A., Hoscheidt, S. M., Hugenschmidt, C. E., Keller, J. N., Peters, A. L., Pi-sunyer, X., Yassine, H. N., & Hoscheidt, S. M. (2020). Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?. Neurobiology of aging, 92, 61-72. doi:10.1016/j.neurobiolaging.2020.03.020
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  In the Look AHEAD trial, randomization to Intensive Lifestyle Intervention (ILI) or Diabetes Support and Education (DSE) did not result in differences in cognitive outcomes. However, menopause and APOE genotype are factors that affect the response to this intervention. The effect of this intervention on a single cognitive assessment was examined in 3 groups of women: premenopausal or
• Brinton, R. D., Carmichael, O., Espeland, M. A., Hayden, K. M., Hoscheidt, S. M., Lockhart, S. N., Luchsinger, J. A., Neiberg, R. H., Yasar, S., Yassine, H. N., & Hoscheidt, S. M. (2020). Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study.. The journals of gerontology. Series A, Biological sciences and medical sciences, 75(4), 771-778. doi:10.1093/gerona/glz090
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  Sex may be an important modifier of brain health in response to risk factors. We compared brain structure and function of older overweight and obese women and men with type 2 diabetes mellitus..Cross-sectional cognitive assessments and magnetic resonance images were obtained in 224 women and 95 men (mean age 69 years) with histories of type 2 diabetes mellitus and overweight or obesity. Prior to magnetic resonance images, participants had completed an average of 10 years of random assignment to either multidomain intervention targeting weight loss or a control condition of diabetes support and education. Total (summed gray and white) matter volumes, white matter hyperintensity volumes, and cerebral blood flow across five brain regions of interest were analyzed using mixed-effects models..After covariate adjustment, women, compared with men, averaged 10.9 [95% confidence interval 3.3, 18.5; ≈1%] cc greater summed region of interest volumes and 1.39 [0.00002, 2.78; ≈54%] cc greater summed white matter hyperintensity volumes. Sex differences could not be attributed to risk factor profiles or intervention response. Their magnitude did not vary significantly with respect to age, body mass index, intervention assignment, or APOE-ε4 genotype. Sex differences in brain magnetic resonance images outcomes did not account for the better levels of cognitive functioning in women than men..In a large cohort of older overweight or obese adults with type 2 diabetes mellitus, differences in brain volumes and white matter disease were apparent between women and men, but these did not account for a lower prevalence of cognitive impairment in women compared with men in this cohort..NCT00017953.
• Brinton, R. D., Carmichael, O. T., Espeland, M. A., Hayden, K. M., Hoscheidt, S. M., Lockhart, S. N., Luchsinger, J. A., Neiberg, R. H., Yasar, S., Yassine, H. N., & Hoscheidt, S. M. (2019). IC-P-155: SEX-RELATED DIFFERENCES IN BRAIN VOLUMES AND CEREBRAL BLOOD FLOW AMONG OVERWEIGHT AND OBESE ADULTS WITH TYPE 2 DIABETES. Alzheimers & Dementia, 15(7), P125-P125. doi:10.1016/j.jalz.2019.06.4270