Sujata Saha

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Journals/Publications

• Saha, S., Vierkant, R. A., Johnson, G. B., Parvinian, A., Wermers, R. A., Foster, T. R., McKenzie, T. J., Dy, B. M., & Lyden, M. L. (2023). C11 choline PET/CT succeeds when conventional imaging for primary hyperparathyroidism fails. Surgery. doi:10.1016/j.surg.2022.08.024
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  Focused parathyroidectomy in primary hyperparathyroidism is possible with accurate preoperative localization. A growing body of data exists regarding the role of radio-labeled C11 choline positron emission tomography/computed tomography. In cases of nonlocalized disease, it may be a useful adjunct to ultrasound, (123)I/(99)Tc-sestamibi (I-123 sestamibi), or 4-dimensional computed tomography imaging.Patients who received a neck and chest limited coverage C11 choline positron emission tomography/computed tomography for evaluation of primary hyperparathyroidism from 2017 to 2021 at a single institution were retrospectively reviewed. We assessed the sensitivity, positive predictive value, and false negative rate. We also compared these rates to the standard modalities of ultrasound, I-123 sestamibi, 4-dimensional computed tomography, and examined concordance rates.We identified 43 patients, of whom 33 had a positive C11 choline positron emission tomography/computed tomography finding. This cohort of patients had failed to localize on multiple standard imaging modalities. Twenty-five patients proceeded to surgery, 72% of whom were reoperative cases. Twenty (80%) achieved an intraoperative cure. Analysis showed that C11 choline positron emission tomography/computed tomography achieved a sensitivity of 64% (95% confidence interval 47%-82%) and positive predictive value of 72% (95% confidence interval 54%-90%). There were 5/25 (20%) false positive positron emission tomography C11 choline results found to be lymph nodes, normal parathyroid, and 1 recurrent laryngeal nerve neuroma.C11 choline positron emission tomography/computed tomography is a useful adjunct for parathyroid localization in a complex population of patients who have failed standard localization techniques including ultrasound, I-123 sestamibi, or 4-dimensional computed tomography and/or prior operations. Although routine inclusion of C11 choline positron emission tomography/computed tomography imaging may not be necessary, it may aid in preoperative localization in the reoperative setting.
• Saha, S., Vierkant, R. A., Johnson, G. B., Parvinian, A., Wermers, R. A., Foster, T., McKenzie, T., Dy, B., & Lyden, M. (2023). C choline PET/CT succeeds when conventional imaging for primary hyperparathyroidism fails. Surgery, 173(1), 117-123.
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  Focused parathyroidectomy in primary hyperparathyroidism is possible with accurate preoperative localization. A growing body of data exists regarding the role of radio-labeled C choline positron emission tomography/computed tomography. In cases of nonlocalized disease, it may be a useful adjunct to ultrasound, (123)I/(99)Tc-sestamibi (I-123 sestamibi), or 4-dimensional computed tomography imaging.
• Saha, S., & Morris-Wiseman, L. (2020). Thyroid Cancer Prognosis Unchanged by Solid Organ Transplantation. Clinical Thyroidology, 32(10), 491-493.
• Saha, S., Bazzell, M., Dull, R., Nielsen, V., Bhattacharjee, S., Hsu, C., & Weinkauf, C. (2020). Protective Ventilation Measures Improve Outcomes During Major Vascular Surgery. Journal of Vascular Surgery, 72(1), E41-E43.
• Jain, U., Somerville, J., Saha, S., Ver Halen, J. P., Antony, A. K., Samant, S., & Kim, J. Y. (2017). Predictors of adverse events after neck dissection: An analysis of the 2006-2011 National Surgical Quality Improvement Program (NSQIP) Database. Ear, nose, & throat journal, 96(2), E37-E45.
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  While neck dissection is an important primary and adjunctive procedure in the treatment of head and neck cancer, there is a paucity of studies evaluating outcomes. A retrospective review of the National Surgical Quality Improvement Program (NSQIP) database was performed to identify factors associated with adverse events (AEs) in patients undergoing neck dissection. A total of 619 patients were identified, using CPT codes specific to neck dissection. Of the 619 patients undergoing neck dissection, 142 (22.9%) experienced an AE within 30 days of the surgical procedure. Risk factors on multivariate regression analysis associated with increased AEs included dyspnea (odds ratio [OR] 2.57; 95% confidence interval [CI] 1.06 to 6.22; p = 0.037), previous cardiac surgery (OR 3.38; 95% CI 1.08 to 10.52; p = 0.036), increasing anesthesia time (OR 1.005; 95% CI 1 to 1.009; p = 0.036), and increasing total work relative value units (OR 1.09; CI 1.04 to 1.13; p < 0.001). The current study is the largest, most robust analysis to identify specific risk factors associated with AEs after neck dissection. This information will assist with preoperative optimization, patient counseling, and appropriate risk stratification, and it can serve as benchmarking for institutions comparing surgical outcomes.
• Washburn, L., Meacham, R., Smith, A., Shih, K., Qin, C. D., Jain, U., Saha, S., Samant, S., & Ver Halen, J. P. (2016). No additional morbidity associated with adding neck dissection to a thyroidectomy: a NSQIP analysis of 44,887 patients. Journal of Surgery: Open Access, 2(1).
• Catanzarite, T., Saha, S., Pilecki, M. A., Kim, J. Y., & Milad, M. P. (2015). Longer Operative Time During Benign Laparoscopic and Robotic Hysterectomy Is Associated With Increased 30-Day Perioperative Complications. Journal of minimally invasive gynecology, 22(6), 1049-58.
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  The relationship between operative time and perioperative morbidity has not been fully characterized in gynecology. We aimed to determine the impact of operative time on 30-day perioperative complications after laparoscopic and robotic hysterectomy.
• Jain, U., Somerville, J., Saha, S., Hackett, N. J., Ver Halen, J. P., Antony, A. K., & Samant, S. (2015). Oropharyngeal Contamination Predisposes to Complications after Neck Dissection: An Analysis of 9462 Patients. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 153(1), 71-8.
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  While neck dissection is important in the treatment of head and neck cancer, there is a paucity of studies evaluating outcomes. We sought to compare preoperative variables and outcomes between clean and contaminated neck dissections, using the 2006-2011 American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data sets.
• Catanzarite, T., Saha, S., Rambachan, A., Kim, J. Y., & Milad, M. P. (2014). Impact of operative time on perioperative morbidity in abdominal myomectomy. Journal of Minimally Invasive Gynecology, 21(2), S34-35.
• Edelstein, A. I., Lovecchio, F. C., Saha, S., Hsu, W. K., & Kim, J. Y. (2014). Impact of Resident Involvement on Orthopaedic Surgery Outcomes: An Analysis of 30,628 Patients from the American College of Surgeons National Surgical Quality Improvement Program Database. The Journal of bone and joint surgery. American volume, 96(15), e131.
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  Operative procedural training is a key component of orthopaedic surgery residency. The influence of intraoperative resident participation on the outcomes of surgery has not been studied extensively using large, population-based databases.
• Khavanin, N., Gart, M. S., Berry, T., Thornton, B., Saha, S., & Kim, J. Y. (2014). Sentinel lymph node biopsy versus axillary lymphadenectomy in patients treated with lumpectomy: an analysis of short-term outcomes. Annals of surgical oncology, 21(1), 74-80.
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  Sentinel lymph node biopsy (SLNB) has been shown to reduce many of the long-term complications associated with a traditional axillary lymph node dissection (ALND); however, short-term outcomes have yet to be characterized. This study was designed to identify trends and differences in 30-day outcomes of partial mastectomy with concurrent SLNB or complete ALND to more effectively determine which patients may be at risk for perioperative complications.
• Kim, B. D., Hsu, W. K., De Oliveira, G. S., Saha, S., & Kim, J. Y. (2014). Operative duration as an independent risk factor for postoperative complications in single-level lumbar fusion: an analysis of 4588 surgical cases. Spine, 39(6), 510-20.
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  Multicenter retrospective cohort study.
• Qin, C. D., Saha, S., Meacham, R., Samant, S., Ver Halen, J. P., & Kim, J. (2014). Surgical Risk after Unilateral Lobectomy Versus Total Thyroidectomy: A Review of 47,434 Patients. Austin Journal of Otolaryngology, 1(3), 8.
• Rambachan, A., Smith, T. R., Saha, S., Eskandari, M. K., Bendok, B. R., & Kim, J. Y. (2014). Reasons for readmission after carotid endarterectomy. World neurosurgery, 82(6), e771-6.
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  With increasing oversight of postoperative outcomes with the Patient Protection and Affordable Care Act, the reduction of readmissions is necessary to avoid financial penalties. This article provides a multi-institutional, multivariate analysis of the pre- and postoperative patient factors associated with readmission after carotid endarterectomy (CEA).
• Rambachan, A., Saha, S., Mioton, L. M., Fine, N. A., & `Kim, J. Y. (2013). The impact of surgical duration on plastic surgery outcomes. European Journal of Plastic Surgery, 36(11), 707-714.
• Saha, D., Davila, A. A., Ver Halen, J. P., Jain, U. K., Hansen, N., Bethke, K., Khan, S. A., Jeruss, J., Fine, N., & Kim, j. Y. (2013). Post-mastectomy reconstruction: a risk-stratified comparative analysis of outcomes. Breast (Edinburgh, Scotland), 22(6), 1072-80.
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  Although breast reconstruction following mastectomy plays a role in the psychological impact of breast cancer, only one in three women undergo reconstruction. Few multi-institutional studies have compared complication profiles of reconstructive patients to non-reconstructive.

Presentations

• Anand, T., Fox, K., Joseph, B. A., Saha, S., Kim, M., & Suri, Y. (2022, November). The Implementation and Evaluation of a Surgical Learning Module and the Near-Peer Learning Model. Academic Surgical Congress. Washington, DC: Association for Academic Surgery.
• Saha, S., & Lyden, M. (2022, May). C¹¹ Choline PET/CT Succeeds When Conventional Approaches to Primary Hyperparathyroidism Fail. American Association of Endocrine Surgeons Annual Meeting. Cleveland, OH: American Association of Endocrine Surgeons.
• Saha, S. (2021, May). Endocrine Surgery: Days of Future Past. Department of Surgery Grand Rounds. Tucson, AZ: The University of Arizona.
• Saha, S., & Morris-Wiseman, L. (2021, Feb). Medullary Thyroid Cancer Presenting as Diarrhea. ATA Career Connections: Case Presentation Series. Virtual Meeting: American Thyroid Association.
• Saha, S., Bazzell, M., Dull, R., & Weinkauf, C. (2020, March). Protective Ventilation Measures Improve Outcomes During Major Vascular Surgery. International Fast Talk at Society for Vascular Surgeons. Virtual Meeting: Society for Vascular Surgeons.
• Saha, S., & Myers, S. (2019, Oct). A Systematic Review of Gender-Based Differences in Hirsch Index Among Academic Surgeons. Association of Women Surgeons, Landmark Paper Session. San Francisco, CA: Association of Women Surgeons.
• Jordan, S. W., & Saha, S. (2015, April). The Progression of Seroma To Prosthesis Failure In Breast Reconstruction: An Analysis of Temporal Relationships. 94th American Association of Plastic Surgeons (AAPS) 2015 Annual Meeting. Scottsdale, AZ: American Association of Plastic Surgeons.

Poster Presentations

• Saha, S., & Lyden, M. (2022, May). C¹¹ Choline PET/CT Succeeds When Conventional Approaches to Primary Hyperparathyroidism Fail. Mayo Young Investigators Research Symposium. Virtual Meeting: Mayo Clinic.
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  Winner: Best Clinical Fellow Poster Presentation
• Saha, S., & Catanzarite, T. (2016, May). The effect of operative time on perioperative morbidity after laparoscopic hysterectomy. American Congress of Obstetricians and Gynecologists. Washington D.C.: American Congress of Obstetricians and Gynecologists.
• Saha, S. (2015, April). Post-mastectomy reconstruction: a risk-stratified comparative analysis of outcomes. Lewis Landberg Research Day at Northwestern University. Chicago, IL: Northwestern University.