Sasha Taleban

Interests

Research

Characterization of IBD in elderly, Development of frail IBD mouse model, Clinical and translational research, Quality improvement in general GI and IBD

Courses

No activities entered.

Scholarly Contributions

Journals/Publications

• Taleban, S. (2023). S1081 Incidental Diagnosis of Coccidioidomycosis in Inflammatory Bowel Disease Is Less Likely Associated With Adverse Clinic Outcomes. American Journal of Gastroenterology.
• Alameri, A., Andres, B., Kathi, P., & Taleban, S. (2023).

  S1081 Incidental Diagnosis of Coccidioidomycosis in Inflammatory Bowel Disease Is Less Likely Associated With Adverse Clinic Outcomes

  . American Journal of Gastroenterology, 118(10S), S822-S823. doi:10.14309/01.ajg.0000953964.31097.7e
• Andres, B., Pepich, G., Rasool, A., Hsu, C., & Taleban, S. (2023).

  S920 Micronutrient Deficiencies Are Not Associated With Worsened Rates of Adverse Clinical Outcomes in Older Patients With Inflammatory Bowel Disease

  . American Journal of Gastroenterology, 118(10S), S686-S687. doi:10.14309/01.ajg.0000953320.51618.7a
• Madej, A., Vedamurthy, A., & Taleban, S. (2023).

  S3170 JAK(1i) to the Rescue! Upadacitinib as Rescue Therapy in Acute Severe Ulcerative Colitis

  . American Journal of Gastroenterology, 118(10S), S2116-S2116. doi:10.14309/01.ajg.0000962320.66241.35
• Taleban, S. (2023). Mo1251 A TOLL-LIKE RECEPTOR 9 (TLR9) SINGLE NUCLEOTIDE POLYMORPHISM MAY INCREASE COMPLICATIONS TO HELICOBACTER PYLORI INFECTION. Gastroenterology.
• Taleban, S. (2023). S3170 JAK(1i) to the Rescue! Upadacitinib as Rescue Therapy in Acute Severe Ulcerative Colitis. American Journal of Gastroenterology.
• Taleban, S. (2023). S887 Health-Related Social Needs & Disease Activity Are Independently Associated With Moderate-to-Severe IBD-Related Disability. American Journal of Gastroenterology.
• Tse, C. S., Shah, S. A., Saha, S., Taleban, S., Horst, S. N., Lutz, M., Fiske, H. W., Weng, C., Hunt, M. G., Brown, L. A., Bonhomme, B., Kuehnel, R. H., Weaver, A., Cross, R. K., Long, M. D., & Lewis, J. D. (2023).

  S887 Health-Related Social Needs & Disease Activity Are Independently Associated With Moderate-to-Severe IBD-Related Disability

  . American Journal of Gastroenterology, 118(10S), S661-S663. doi:10.14309/01.ajg.0000953188.38273.5d
• Andres, B., & Taleban, S. (2022). Exacerbation of Atopic Dermatitis Associated with Ustekinumab Treatment in Crohn's Disease. Cureus, 14(9), e29718.
  More info

  Ustekinumab inhibits interleukins 12 and 23 and modulates the T helper cell-mediated immune response of Crohn's disease. However, ustekinumab may also exacerbate atopic disease by increasing the T helper 2 cell-mediated pathway. We present the first known case of exacerbation of atopic dermatitis in a patient with Crohn's disease receiving ustekinumab. Additional associations in dose frequency, peripheral eosinophilia, and elevated serum IgE were observed. However, while novel in Crohn's disease, exacerbation of atopy after ustekinumab infusion has been observed in patients with psoriasis and psoriatic arthritis.
• Andres, B., Pepich, G., Rasool, A., Hsu, C., & Taleban, S. (2022).

  S931 Micronutrient Deficiencies in Elderly Inflammatory Bowel Disease Are Not Associated With Worse Adverse Outcomes

  . The American Journal of Gastroenterology, 674-675. doi:10.14309/01.ajg.0000860364.79527.5a
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  Abstract: IBD
• Lee, S., Varshney, N., & Taleban, S. (2021). Stomach This: Autoimmune Atrophic Pangastritis, a Rare Type of Gastritis. ACG case reports journal, 8(3), e00549.
  More info

  Atrophic gastritis can be environmental in origin and involve the antrum or autoimmune in origin and involve the body and fundus. We present a rare case of autoimmune atrophic pangastritis, a distinct type of autoimmune gastritis affecting the entire stomach, which should be considered in patients with other autoimmune disorders.
• Shrestha, M. P., Hu, C., & Taleban, S. (2021). Appointment Wait Time, Primary Care Provider Status, and Patient Demographics are Associated With Nonattendance at Outpatient Gastroenterology Clinic. Journal of clinical gastroenterology, 51(5), 433-438.
  More info

  We intended to identify the factors associated with missed appointments at a gastroenterology (GI) clinic in an academic setting.
• Taleban, S., & Andres, B. (2021). S2475 Exacerbation of Atopic Dermatitis Associated With Ustekinumab Treatment in Crohn’s Disease. American Journal of Gastroenterology, 116(1), S1045-S1045. doi:10.14309/01.ajg.0000783432.83450.ae
• Taleban, S., & Shrestha, M. P. (2021). Colectomy Rates Are Increasing Among Inpatients With Concomitant Ulcerative Colitis and Clostridioides difficile.. Journal of clinical gastroenterology, 55(8), 709-715. doi:10.1097/mcg.0000000000001412
  More info

  Clostridioides difficile infection (CDI) is an important cause of inflammatory bowel disease (IBD) exacerbation and is associated with increased risk of hospitalization, colectomy, and mortality. Previous analysis have reported an increasing rate of CDI and associated mortality in IBD patients. We examined the trends in CDI-associated outcomes in hospitalized patients with Crohn's disease (CD) and ulcerative colitis (UC) over the last decade..We used data from the National Inpatient Sample to identify patients hospitalized with both CDI and IBD from 2006 to 2014. Outcomes included in-hospital mortality, partial/total colectomy, hospital length of stay, and charges. Analysis included univariate and multivariate regression analysis..Between 2006 and 2014, CDI-related hospitalizations increased in both CD (1.6% to 3.2%; P
• Unegbu, F., Taleban, S., Moazam, K., & Kathi, P. R. (2021). Sa500 IN AN ENDEMIC REGION, INCIDENT COCCIDIOIDOMYCOSIS INFECTION IS SIGNIFICANTLY HIGHER IN IBD POPULATION. Gastroenterology, 160(6), S-524. doi:10.1016/s0016-5085(21)01956-9
• Varshney, N., Taleban, S., & Lee, S. (2021). Stomach This: Autoimmune Atrophic Pangastritis, a Rare Type of Gastritis.. ACG case reports journal, 8(3), e00549. doi:10.14309/crj.0000000000000549
  More info

  Atrophic gastritis can be environmental in origin and involve the antrum or autoimmune in origin and involve the body and fundus. We present a rare case of autoimmune atrophic pangastritis, a distinct type of autoimmune gastritis affecting the entire stomach, which should be considered in patients with other autoimmune disorders.
• Anderson, C., Kim, D., & Taleban, S. (2020).

  S2311 A Rare Mimic of Crohn's Disease

  . Research Gate. doi:10.14309/01.ajg.0000711292.99779.f9
• Bach, L. E., & Taleban, S. (2020). Vedolizumab (VDZ) for UC and CD: Still Safe and Effective After All These Years. Digestive diseases and sciences.
• Lee, S., Taleban, S., & Varshney, N. (2020).

  S2995 Stomach This: A Novel Type of Gastritis

  . ResearchGate, S1578-S1579. doi:10.14309/01.ajg.0000714028.92792.dc
• Rokkam, V. R., Aggarwal, A., & Taleban, S. (2020). Esophagitis Dissecans Superficialis: Malign Appearance of a Benign Pathology. Cureus, 12(6), e8475.
  More info

  Esophagitis dissecans superficialis (EDS), also known as sloughing esophagitis, is a very rare condition and may affect the whole esophagus, resulting in complete sloughing of the mucous membrane. EDS has been associated with various medications and dermatological conditions. In our case, EDS was suspected secondary to methotrexate treatment in a patient with Crohn's disease, although the definitive etiology remains unknown. It is very important for physicians to recognize the endoscopic appearance of EDS to provide appropriate clinical management and differentiate it from other esophageal disorders.
• Shrestha, M. P., & Taleban, S. (2020). Colectomy Rates Are Increasing Among Inpatients With Concomitant Ulcerative Colitis and Clostridioides difficile. Journal of clinical gastroenterology.
  More info

  Clostridioides difficile infection (CDI) is an important cause of inflammatory bowel disease (IBD) exacerbation and is associated with increased risk of hospitalization, colectomy, and mortality. Previous analysis have reported an increasing rate of CDI and associated mortality in IBD patients. We examined the trends in CDI-associated outcomes in hospitalized patients with Crohn's disease (CD) and ulcerative colitis (UC) over the last decade.
• Taleban, S. (2020). A Rare Mimic of Crohn's Disease. American Journal of Gastroenterology.
• Taleban, S. (2020). FECAL BIOMARKERS MAY NOT ACCURATELY DETECT ACTIVE ENDOSCOPIC DISEASE IN OLDER INFLAMMATORY BOWEL DISEASE PATIENTS. Gastroenterology.
• Taleban, S. (2020). Stomach This: A Novel Type of Gastritis. American Journal of Gastroenterology.
• Taleban, S., Boone, J. H., & Irby, L. (2020).

  Sa1833 FECAL BIOMARKERS MAY NOT ACCURATELY DETECT ACTIVE ENDOSCOPIC DISEASE IN OLDER INFLAMMATORY BOWEL DISEASE PATIENTS

  . Gastroenterology. doi:10.1016/s0016-5085(20)31793-5
• Thompson, C., Taleban, S., Thompson, C., & Taleban, S. (2020). Incorporating Frailty in the Treatment Program of Elderly Patients with Gastrointestinal Disease. Current Treatment Options in Gastroenterology, 18(4), 635-656. doi:10.1007/s11938-020-00310-1
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  The goal of this paper is to review the utilization of frailty as a predictor of poor outcomes in gastrointestinal disease, hepatology, and gastrointestinal surgery. The frailty syndrome has been extensively described in the geriatric population as a predictor of poor clinical outcomes and its application has proven valuable in a variety of chronic and inflammatory disease states independent of age. In hepatology and gastroenterology, frailty has been associated with worsening pre- and post-liver transplant outcomes, post-operative complications, periprocedural adverse events during colonoscopy, and even possible early disruption of the gut microbiome. In patients undergoing immunosuppression, frailty has recently been independently associated with increased risk of infection, morbidity, and mortality. Frailty has been associated with a wide range of adverse health outcomes in multiple patient populations and disease states including in chronic gastrointestinal and liver disease. The standardization and routine clinical application of frailty evaluation in groups at risk for frailty progression and deleterious outcomes have been recommended. Challenges regarding translating frailty evaluation to individualized frailty treatment remain. With emerging research examining frailty in gastrointestinal and liver disease, there is hope to bridge this gap to deter and ideally reverse frailty progression and its deleterious outcomes.
• Balogun, R., Ding, L., Mallick, P., Borgstrom, M., Gavini, H. K., Leal, R. J., Taleban, S., Babaria, R., & Merchant, J. L. (2019).

  Mo1251 A TOLL-LIKE RECEPTOR 9 (TLR9) SINGLE NUCLEOTIDE POLYMORPHISM MAY INCREASE COMPLICATIONS TO HELICOBACTER PYLORI INFECTION

  . World J Gastrointestinal Oncology, 998-1010. doi:10.1016/s0016-5085(23)02857-3
• Bilal, M., Taleban, S., Riegler, J. L., Surawicz, C. M., & Feld, A. D. (2019).

  The Do’s and Don’ts of Social Media

  . The American Journal of Gastroenterology, 375-376. doi:10.14309/00000434-900000000-99849
• Bilal, M., Taleban, S., Riegler, J., Surawicz, C., & Feld, A. (2019). The Do's and Don'ts of Social Media: A Guide For Gastroenterologists. The American journal of gastroenterology, 114(3), 375-376.
• Kim, D., & Taleban, S. (2019). A Comprehensive Review of the Diagnosis and Pharmacological Management of Crohn's Disease in the Elderly Population. Drugs & aging, 36(7), 607-624.
  More info

  Crohn's disease (CD) in the elderly is rising in prevalence, which is related to an increase in its incidence and improving life expectancies. There are differences in the presentation, natural history, and treatment of CD between adult-onset patients who progress to older age and patients who are initially diagnosed at an older age. Presentation at an older age may also delay or make diagnosis challenging due to accumulating co-morbidities that mimic inflammatory bowel disease. Differences exist between adult- and older-onset disease, yet many guidelines do not specifically distinguish the management of these two distinct populations. Identifying patients at high risk for progression or aggressive disease is particularly important as elderly patients may respond differently to medical and surgical treatment, and may be at higher risk for adverse effects. Despite newer agents being approved for CD, the data regarding efficacy and safety in the elderly are currently limited. Balancing symptom management with risks of medical and surgical therapy is an ongoing challenge and requires special consideration in these two distinct populations.
• Mosadeghi, S., & Taleban, S. (2019). Alternate Settings for Infusions in Inflammatory Bowel Disease Patients: Homing in on Optimal Care. Digestive diseases and sciences, 64(3), 611-613.
• Shrestha, M. P., & Taleban, S. (2019). Management of Ulcerative Colitis in the Elderly. Drugs & aging, 36(1), 13-27.
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  The incidence rate of ulcerative colitis (UC) in older patients is rising. Diagnosis of UC may be difficult in older patients as several common gastrointestinal disorders can mimic UC in these patients. Compared with younger adults, left-sided colitis is more common in older-onset UC, while rectal bleeding, abdominal pain, and extraintestinal manifestations are less common. The disease course of older-onset UC may be similar to that of adult-onset UC. The management of UC in older patients includes medical and surgical options. A majority of older UC patients are treated with 5-aminosalicylates. The underuse of immunosuppressants or biologics may lead to poor disease control, higher use of corticosteroids, and worse clinical outcomes in older UC patients. Serious infections and malignancy are the most concerning complications of immune-modifying agents or biologics in the elderly. Timely surgical referral of older UC patients with poor disease control is of utmost importance as elective colectomy may be associated with improved survival in these patients.
• Stewart, D., Stewart, D. B., Taleban, S., Kim, D. H., Gopireddy, D., & Anderson, C. (2019). P005 Signet Ring Cell Carcinoma Mimicking Crohn’s Disease. The American Journal of Gastroenterology, 114(1), S2-S2. doi:10.14309/01.ajg.0000612988.36311.a2
• Taleban, S., & Shrestha, M. P. (2019). Obesity Is Associated with Increased Risk of Colectomy in Inflammatory Bowel Disease Patients Hospitalized with Clostridium difficile Infection.. Digestive diseases and sciences, 64(6), 1632-1639. doi:10.1007/s10620-018-5423-7
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  Obesity and inflammatory bowel disease (IBD) are associated with increased risk of Clostridium difficile infection (CDI). The effect of obesity on IBD course and development of complications is poorly understood. We performed this study to examine the effect of obesity on CDI-related morbidity and mortality in hospitalized patients with IBD..We used data from the National Inpatient Sample across five study years (2010-2014) to identify patients ≥ 18 years hospitalized with both CDI and IBD. We compared the outcomes of in-hospital mortality, partial or total colectomy, hospital length of stay, and hospital charges between obese and non-obese IBD-CDI patients. Analysis included univariate and multivariate linear and logistic regression analyses..Of 304,298 hospitalized patients with IBD, 13,517 (4.4%) patients had CDI. Of these, 996 (7.4%) patients were obese. Obese IBD-CDI patients had a higher risk of colectomy (adjusted odds ratio, AOR 1.60, 95% CI 1.30-1.96; p 
• Taleban, S., & Shrestha, M. P. (2019). Su1955 – Clostridium Difficile-Associated Outcomes Among Hospitalized Inflammatory Bowel Disease Patients in the United States: 2006-2014. Gastroenterology, 156(6), S-672. doi:10.1016/s0016-5085(19)38589-0
• Bilal, M., Taleban, S., Riegler, J. L., Surawicz, C. M., & Feld, A. D. (2018).

  The Do’s and Don’ts of Social Media: A Guide For Gastroenterologists

  . American Journal Gastroenterology, 375-376. doi:10.1038/s41395-018-0369-0
• Ehsani, H., Golden, T., Mohler, J., Taleban, S., Tirambulo, C. V., & Toosizadeh, N. (2018).

  Screening Colonoscopy Adverse Events in Aging Adults: Does Frailty Matter?

  . Journal of geriatric medicine and gerontology. doi:10.23937/2469-5858/1510055
• Ghazala, S., Golden, T. R., Gonzalez, M., Junna, S., Mohler, J., Taleban, S., Tirambulo, C. V., Toosizadeh, N., & Wadeea, R. (2018).

  Mo1629 - Frailty Predicts Colonoscopy Outcomes in Patients Undergoing Screening

  . Gastroenterology, 154(6), S-775. doi:10.1016/s0016-5085(18)32680-5
• Pham, T., Bajaj, A., Berberi, L., Hu, C., & Taleban, S. (2018). Mis-sizing of Adenomatous Polyps is Common among Endoscopists and Impacts Colorectal Cancer Screening Recommendations. Clinical endoscopy, 51(5), 485-490.
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  To determine the accuracy of identifying ≥6-mm adenomatous polyps during colonoscopy and define its impact on subsequent interval screening.
• Shrestha, M. P., & Taleban, S. (2018).

  Clostridium difficile-Associated Outcomes Among Hospitalized Inflammatory Bowel Disease Patients in the United States: 2006-2014

  . Medicine. doi:10.14309/00000434-201810001-00578
• Shrestha, M. P., & Taleban, S. (2018).

  Management of Ulcerative Colitis in the Elderly

  . Drugs & Aging, 13-27. doi:10.1007/s40266-018-0611-x
• Shrestha, M. P., & Taleban, S. (2018). Obesity Is Associated with Increased Risk of Colectomy in Inflammatory Bowel Disease Patients Hospitalized with Clostridium difficile Infection. Digestive diseases and sciences.
  More info

  Obesity and inflammatory bowel disease (IBD) are associated with increased risk of Clostridium difficile infection (CDI). The effect of obesity on IBD course and development of complications is poorly understood. We performed this study to examine the effect of obesity on CDI-related morbidity and mortality in hospitalized patients with IBD.
• Shrestha, M. P., Bime, C., & Taleban, S. (2018).

  Sa1830 - Obesity is Associated with Increased Risk of Colectomy in Inflammatory Bowel Disease Patients Hospitalized with Clostridium Difficile Infection

  . Digestive Diseases and sciences, 1632-1639. doi:10.1016/s0016-5085(18)31653-6
• Shrestha, M. P., Bime, C., & Taleban, S. (2018). Decreasing Clostridium difficile-Associated Fatality Rates Among Hospitalized Patients in the United States: 2004-2014. The American journal of medicine, 131(1), 90-96.
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  Clostridium difficile infection has emerged as a major public health problem in the United States over the last 2 decades. We examined the trends in the C. difficile-associated fatality rate, hospital length of stay, and hospital charges over the last decade.
• Stavrakis, D., Meiklejohn, K. M., & Taleban, S. (2018). Lymphocytic Colitis Diagnosis 40 Years after Onset of Ulcerative Colitis. ACG case reports journal, 5, e82.
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  Lymphocytic colitis is a subtype of microscopic colitis characterized by normal colonoscopy findings and microscopic evidence of lymphocytic infiltration of colonic epithelial cells. The concomitant diagnosis of lymphocytic colitis and ulcerative colitis has been rarely reported. We present a 68-year-old man with a 40-year history of ulcerative colitis who was referred to our hospital for 3-4 weeks of non-bloody diarrhea with subsequent colonoscopy and biopsies confirming lymphocytic colitis.
• Taleban, S. (2018). Editorial: older-onset inflammatory bowel disease-is it time to start looking beyond a number?. Alimentary Pharmacology & Therapeutics, 47(7), 1034-1035. doi:10.1111/apt.14552
• Taleban, S. (2018). Editorial: older-onset inflammatory bowel disease-is it time to start looking beyond a number?. Alimentary pharmacology & therapeutics, 47(7), 1034-1035.
• Taleban, S., & Shrestha, M. (2018). Clostridium difficile infection-associated outcomes among hospitalized inflammatory bowel disease patients in the United States: 2006-2014.. The American Journal of Gastroenterology. doi:10.1038/ajg.2018.296
• Taleban, S., Toosizadeh, N., Junna, S., Golden, T., Ghazala, S., Wadeea, R., Tirambulo, C., & Mohler, J. (2018). Frailty Assessment Predicts Acute Outcomes in Patients Undergoing Screening Colonoscopy. Digestive diseases and sciences, 63(12), 3272-3280.
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  Colonoscopy is associated with multiple adverse outcomes. With an aging population undergoing colorectal cancer screening, few modalities exist to assess the patient risk prior to colonoscopy. Frailty, the age-related decline in reserve and function across multiple organ systems, predicts poor surgical outcomes, but its role in endoscopy is unclear.
• Young, R., Taleban, S., & Sifuentes, J. (2018). Gastroenterologists Underestimate Endoscopic Risk in Patients Undergoing Routine Procedures: 517. The American Journal of Gastroenterology, 113(Supplement), S296-S297. doi:10.14309/00000434-201810001-00517
• Golden, T. R., Mei, Y., Miramontes, M., Mohler, J., Taleban, S., Toosizadeh, N., & Zaldizar, C. (2017).

  Frailty and age may not Adequately Predict Colonoscopy Outcomes in Adults

  . Gastroenterology, 152(5), S530. doi:10.1016/s0016-5085(17)31943-1
• Joshua, S., & Taleban, S. (2017).

  P-029 An Unusual Case of Metastatic Signet Cell Carcinoma Presenting as Crohn's Disease

  . Inflammatory Bowel Diseases, S15. doi:10.1097/01.mib.0000512553.90047.4f
• Shrestha, M. P., Bime, C., & Taleban, S. (2017).

  Decreasing Clostridium difficile-associated Mortality Rates Among Hospitalized Patients in the United States: 2004-2014: 2017 Category Award (Practice Management): 2017 Presidential Poster Award

  . The American Journal of Medicine, 90-96. doi:10.14309/00000434-201710001-01089
• Shrestha, M. P., Bime, C., & Taleban, S. (2017). Decreasing Clostridium difficile-Associated Fatality Rates Among Hospitalized Patients in the United States: 2004-2014. Am J Med. doi:10.1016/j.amjmed.2017.07.022
• Shrestha, M. P., Hu, C., & Taleban, S. (2017).

  Appointment Wait Time, Primary Care Provider Status, and Patient Demographics are Associated With Nonattendance at Outpatient Gastroenterology Clinic

  . Journal of Clinical Gastroenterology, 433-438. doi:10.1097/mcg.0000000000000706
• Shrestha, M. P., Ruel, J., & Taleban, S. (2017). Health Care maintenance in elderly patients with inflammatory bowel disease. Annals of Gastroenterology. doi:10.20524/aog.2017.0130
• Shrestha, M. P., Ruel, J., & Taleban, S. (2017). Healthcare maintenance in elderly patients with inflammatory bowel disease. Annals of gastroenterology, 30(3), 273-286.
  More info

  The increasing number of older patients (age ≥60 years) with inflammatory bowel disease (IBD) highlights the importance of healthcare maintenance in this vulnerable population. Older IBD patients are more susceptible and have higher rates of many disease- and treatment-related adverse effects. Compared to younger IBD patients, older patients are at increased risk for infection, malignancy, bone disease, eye disease, malnutrition and thrombotic complications. Preventive strategies in the elderly differ from those in younger adults and are imperative. Changes to the immune system with aging can decrease the efficacy of vaccinations. Cancer screening guidelines in older IBD patients have to account for unique considerations, such as life expectancy, functional performance status, multimorbidity, financial status, and patient desires. Additionally, providers need to be vigilant in screening for osteoporosis, ocular disease, depression, and adverse events arising from polypharmacy.
• Taleban, S., & Bime, S. M. (2017). Decreasing Clostridium Difficile-Associated Fatality Rates Among Hospitalized Patients in the Unites States:. American Journal of Medicine.
• Taleban, S., & Golden, T. (2017). Younger Age Is Associated With Outpatient Colonoscopy Non-attendance: 1090. The American Journal of Gastroenterology, 112, S597. doi:10.14309/00000434-201710001-01091
• Young, R., Mosadeghi, S., Samiollah, G., & Taleban, S. (2017).

  P-033 Metastatic Crohn's Disease Without Gastrointestinal Involvement

  . Inflammatory Bowel Diseases, 23, S16. doi:10.1097/01.mib.0000512556.35790.aa
• Pham, T. N., Berberi, L., Hu, C., & Taleban, S. (2016).

  Tu1048 Mis-Sizing of Adenomatous Polyps >5 mm Is Common Among Endoscopists and Impacts Interval Colorectal Cancer Screening Recommendations

  . Gastrointestinal Endoscopy, 83(5). doi:10.1016/j.gie.2016.03.1108
• Shapiro, J. M., Hagin, S. E., Shah, S. A., Bright, R., Law, M., Moniz, H., Giacalone, J., Jackvony, T., Taleban, S., Samad, Z., Merrick, M., Sands, B. E., & LeLeiko, N. S. (2016). Corticosteroid Use in a Prospective, Community-Based Cohort of Newly Diagnosed Inflammatory Bowel Disease Patients. Digestive diseases and sciences.
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  Systemic corticosteroids (CS) are a mainstay of treatment for patients with newly diagnosed inflammatory bowel disease (IBD). Previous population-based studies report CS exposure rates range from 39 to 75 % within the first year of diagnosis with surgical resection rates as high as 13-18 % in the same time frame. These reports represent an older cohort of patients enrolled over prolonged periods of time and do not necessarily reflect current treatment approaches. We examine CS use during the first year of IBD diagnosis in a community-based, inception cohort.
• Taleban, S. (2016). Cancer and Inflammatory Bowel Disease in the Elderly. Digestive and Liver Disease.
• Taleban, S., Elquza, E., Gower-Rousseau, C., & Peyrin-Biroulet, L. (2016). Cancer and inflammatory bowel disease in the elderly. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 48(10), 1105-11.
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  Cancer may be a complication of inflammatory bowel disease (IBD) or its treatments. In older Crohn's disease and ulcerative colitis patients, the risk of malignancy is of particular concern. IBD diagnosis at an advanced age is associated with earlier development of colitis-associated colorectal cancer. Thiopurine use in older IBD patients is tied to an increased risk of non-Hodgkin's lymphoma, nonmelanoma skin cancer, and urinary tract cancers. Additionally, older age is accompanied by multimorbidity, an increased risk of malnutrition, and decreased life expectancy, factors that complicate the management of cancer in the elderly. The optimal approach to the increased risk of malignancy in older age IBD is appropriate cancer screening and medical treatment. This may include age-specific colorectal cancer screening and limiting UV radiation exposure. With a growing number of older IBD patients, further studies are necessary to delineate the risk of cancer in this population.
• Taleban, S., Stewart, K. O., Li, D. K., Singh, P., Pardi, D. S., Sturgeon, H. C., Yajnik, V., Xavier, R. J., Ananthakrishnan, A. N., & Khalili, H. (2016). Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes. Digestive diseases and sciences, 61(9), 2627-35.
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  Clinical activity and quality of life (QOL) indices assess disease activity in Crohn's disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics.
• Shrestha, M., Hu, C., & Taleban, S. (2016). Ethnicity, Marital status, primary care provider status and Appointment wait time predict attendance at Outpatient Gastroenterology clinic. Journal of Clinical Gastroenterology.
• Taleban, S. (2015). Advanced Inflammatory Bowel Disease Fellowship.. The New Gastroenterologist.
• Taleban, S. (2015). Challenges in the Diagnosis and Management of Inflammatory Bowel Disease in the Elderly. Current treatment options in gastroenterology, 13(3), 275-86.
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  Among inflammatory bowel disease (IBD) patients, 4-12 % is diagnosed after the age of 60. Both the rates of elderly and IBD are increasing worldwide. In older patients, the diagnosis of Crohn's disease (CD) and ulcerative colitis (UC) is made more difficult due to polypharmacy and multimorbidity along with disease processes that mimic IBD. The clinical presentation in older-onset IBD differs from younger patients, and there is minimal disease progression over time. The management of the older IBD patient involves a combination of medical and surgical strategies. Few treatment efficacy studies exist in elderly IBD as most authors have focused on the adverse events related to therapy. A vast number of incident CD and UC cases in elderly have been treated with 5-aminosalicylic acid agents and do not require the use of immune modifying agents or biologics. Many other older IBD patients are prescribed long-term corticosteroids despite guidelines recommending more effective and safer maintenance therapy regimens. Serious infections, malignancy, and drug interactions are the most concerning complications of medical therapy. There are particularly important health care maintenance issues in older IBD patients including vaccinations, colorectal cancer screening, and bone loss prevention.
• Taleban, S. (2015). Correlations Between Clinical Activity Indices or Quality of Life Scores to Endoscopic Activity Scores do not Vary According to Age at Diagnosis, Disease Location and Disease Behavior in Inflammatory Bowel Disease. Digestive Diseases and Sciences.
• Taleban, S. (2015). Infection Risk Among Elderly with Inflammatory Bowel Disease. Pract Gastroenterol.
• Taleban, S., & Pham, T. (2015). Mis-sizing of Polyps During Colonoscopy Does Not Significantly Impact Colorectal Cancer Surveillance Recommendations: 1562. The American Journal of Gastroenterology, 110, S675. doi:10.14309/00000434-201510001-01562
• Taleban, S., & Pham, T. (2015). Primary Varicella Infection During Infliximab Treatment for Fistulizing Crohnʼs Disease: 650. The American Journal of Gastroenterology, 110, S287. doi:10.14309/00000434-201510001-00650
• Taleban, S., & Shrestha, M. P. (2015). Ethnicity, Marital Status, Primary Care Provider Status and Appointment Wait Time Predict Attendance at Outpatient Gastroenterology Clinic: 2227. The American Journal of Gastroenterology, 110, S924-S925. doi:10.14309/00000434-201510001-02228
• Taleban, S., Colombel, J. F., Mohler, M. J., & Fain, M. J. (2015).

  Inflammatory Bowel Disease and the Elderly: A Review

  . Journal of Crohn's and Colitis, 507-515. doi:10.1093/ecco-jcc/jjv059
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  Inflammatory bowel disease among the elderly is common, with growing incident and prevalence rates. Compared with younger IBD patients, genetics contribute less to the pathogenesis of older-onset IBD, with dysbiosis and dysregulation of the immune system playing a more significant role. Diagnosis may be difficult in older individuals, as multiple other common diseases can mimic IBD in this population. The clinical manifestations in older-onset IBD are distinct, and patients tend to have less of a disease trajectory. Despite multiple effective medical and surgical treatment strategies for adults with Crohn’s disease and ulcerative colitis, efficacy studies typically have excluded older subjects. A rapidly ageing population and increasing rates of Crohn’s and ulcerative colitis make the paucity of data in older adults with IBD an increasingly important clinical issue.
• Taleban, S., Colombel, J., Mohler, M. J., & Fain, M. J. (2015). Inflammatory bowel disease and the elderly: a review. Journal of Crohn's & colitis, 9(6), 507-15.
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  Inflammatory bowel disease among the elderly is common, with growing incident and prevalence rates. Compared with younger IBD patients, genetics contribute less to the pathogenesis of older-onset IBD, with dysbiosis and dysregulation of the immune system playing a more significant role. Diagnosis may be difficult in older individuals, as multiple other common diseases can mimic IBD in this population. The clinical manifestations in older-onset IBD are distinct, and patients tend to have less of a disease trajectory. Despite multiple effective medical and surgical treatment strategies for adults with Crohn's disease and ulcerative colitis, efficacy studies typically have excluded older subjects. A rapidly ageing population and increasing rates of Crohn's and ulcerative colitis make the paucity of data in older adults with IBD an increasingly important clinical issue.
• Taleban, S., Gundogan, F., Chien, E. K., Degli-Esposti, S., & Saha, S. (2015). Placental inflammation is not increased in inflammatory bowel disease. Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology, 28(4), 457-63.
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  Women with inflammatory bowel disease (IBD) are at increased risk for adverse birth outcomes such as preterm delivery and small for gestational age (SGA) infants. Most recognized cases of fetal growth restriction in singleton pregnancies have underlying placental causes. However, studies in IBD examining poor birth outcomes have focused on maternal factors. We examined whether women with IBD have a higher rate of placental inflammation than non-IBD controls.
• Taleban, S., Li, D., Targan, S. R., Ippoliti, A., Brant, S. R., Cho, J. H., Duerr, R. H., Rioux, J. D., Silverberg, M. S., Vasiliauskas, E. A., Rotter, J. I., Haritunians, T., Shih, D. Q., Dubinsky, M., Melmed, G. Y., & McGovern, D. P. (2015). Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits. Journal of Crohn's & colitis, 10(1), 43-9.
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  There has been considerable progress in identifying inflammatory bowel disease [IBD] susceptibility genes but little progress in examining the role of genetic variation in the development of the extra-intestinal manifestations [EIMs] of IBD. This study identified clinical, serological, and genetic factors associated with ocular EIMs [O-EIMs] in IBD.
• Taleban, S., Van Oijen, M. G., Vasiliauskas, E. A., Fleshner, P. R., Shen, B., Ippoliti, A. F., Targan, S. R., & Melmed, G. Y. (2015). Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis. Digestive diseases and sciences.
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  Much of the economic burden of Crohn's disease (CD) is related to surgery. Twenty percent of patients with CD have isolated colonic disease. While permanent end ileostomy (EI) is generally the procedure of choice for patients with refractory CD colitis, single-center experiences suggest that restorative proctocolectomy (IPAA) is durable in select patients.
• Taleban, S. (2014). Biologic Use in Elderly with Inflammatory Bowel Disease. Elderly Care Provider Sheet.
• Eric, V., Fleshner, P., Ippoliti, A., Melmed, G. Y., Oijen, M. G., Shen, B., Taleban, S., & Targan, S. R. (2013).

  P-161 Cost-Effectiveness of Colectomy with IPAA versus Colectomy with Permanent End-Ileostomy for Crohnʼs Colitis

  . Inflammatory Bowel Diseases, 19, S90. doi:10.1097/01.mib.0000438903.94123.20
• Lee, S., Melmed, G. Y., Taleban, S., & Targan, S. R. (2013).

  P-182 YI E-cigarettes as Salvage Therapy for Medically Refractory Ulcerative Colitis

  . Inflammatory Bowel Diseases, 19, S99. doi:10.1097/01.mib.0000438924.81005.63
• Vasiliauskas, E. A., Rotter, J. I., Melmed, G. Y., Mcgovern, D. P., Dubinsky, M., Ippoliti, A., Kaur, M., Li, D., Shih, D. Q., Taleban, S., & Targan, S. R. (2013).

  Mo1304 Clinical, Serologic, and Genetic Associations in Patients With Ocular Manifestations in Inflammatory Bowel Disease

  . Gastroenterology, 144(5), S-631. doi:10.1016/s0016-5085(13)62337-9
• Taleban, S., Saha, S., Gundogan, F., Degli-esposti, S., & Chien, E. K. (2011). Placental histopathology is not more prevalent in women with IBD: P-1.. Inflammatory Bowel Diseases, 17, S12-S13. doi:10.1097/00054725-201112002-00038
• Wu, W., Taleban, S., & Okpara, N. (2011). Adenoma Detection Rate in Average Risk Women: ACG /Radhika Srinivasan Gender-Based Research Award: 2011 ACG Presidential Poster: 1466. The American Journal of Gastroenterology, 106, S561. doi:10.14309/00000434-201110002-01466
• Taleban, S., Smith, J., Shoukeir, H., & Lin, C. (2010). Splenic Rupture as a Complication of Colonoscopy: 1019. The American Journal of Gastroenterology, 105, S369. doi:10.14309/00000434-201010001-01019
• Taleban, S., & Decross, A. J. (2008). Closing the Circle on the 360 Degree Evaluation: Can Subspecialty Fellows Be Evaluated as Consultants by Their General Medical Resident Peers?. The American Journal of Gastroenterology, 103, S96. doi:10.14309/00000434-200809001-00249
• Taleban, S., Carew, H. T., Dichek, H. L., Deeb, S. S., Hollenback, D., Weigle, D. S., Cummings, D. E., & Brunzell, J. D. (2008). Energy balance in congenital generalized lipodystrophy type I. Metabolism: clinical and experimental, 57(8), 1155-61.
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  Congenital generalized lipodystrophy type 1 (CGL-1) is characterized by an absence of adipose tissue and decreased serum leptin levels. Low leptin levels in CGL-1 support the claim that subjects are hypermetabolic and hyperphagic. The present study examines this claim. We determined 24-hour energy expenditure (24-h EE) (kilocalories) (n = 2) and resting metabolic rate (RMR) per kilogram of lean body mass (LBM) (n = 3) in CGL-1 and in 18 healthy control subjects. The 24-h EEs of control and subjects with CGL were compared with respect to kilocalories required per day relative to kilograms of LBM and with respect to RMR relative to kilograms of LBM. Fasting leptin, adiponectin, and 24-hour ghrelin levels were also measured in subjects with CGL-1. The 24-h EE per kilogram of LBM for the subjects with CGL-1 falls on the same regression line observed for this relationship in the controls. The RMR per kilogram of LBM in subjects with CGL-1 also was similar to that in controls. Both 24-h EE and RMR were quite increased when reported per kilogram of total body weight. Subjects with CGL-1 also have decreased fasting leptin and adiponectin hormone levels and no premeal ghrelin rise. People with CGL-1 have similar RMR and daily caloric requirements as healthy controls when these parameters are expressed as a function of LBM. Appetite-regulating hormone levels in CGL-1 suggest that multiple factors act to control appetite in these individuals.
• Brunzell, J. D., Carew, H., Dichek, H. L., Hollenback, D., L, B., & Taleban, S. (2005).

  450 LOW LEVELS OF LYSOPHOSPHATIDIC ACID ACETYLTRANSFERASEβ ACTIVITY IN CONGENITAL GENERALIZED LIPODYSTROPHY

  . Journal of Investigative Medicine. doi:10.2310/6650.2005.00005.449
• Carew, H., Taleban, S., Dichek, H. L., Bonham, L., Hollenback, D., & Brunzell, J. D. (2005).

  Low Levels of Lysophosphatidic Acid Acetyltransferaseβ Activity in Congenital Generalized Lipodystrophy

  . Researchgate, 157. doi:10.1177/1081558905053001441
• Brunzell, J. D., & Taleban, S. (2004).

  ENERGY BALANCE IN CONGENITAL GENERALIZED LIPODYSTROPHY TYPE I.

  . Journal of Investigative Medicine. doi:10.1097/00042871-200401001-00421
• Taleban, S., & Brunzell, J. D. (2004).

  421 ENERGY BALANCE IN CONGENITAL GENERALIZED LIPODYSTROPHY TYPE I.

  . HHS Author Manuscripts, 115-1161. doi:10.1136/jim-52-suppl1-421
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  Author Manuscript

Poster Presentations

• Taleban, S., & Shrestha, M. (2018, October). Clostridium difficile infection-associated outcomes among hospitalized inflammatory bowel disease patients in the United States: 2006-2014.. ACG 2018 Annual Scientific Meeting. Philadelphia: ACG.
• Taleban, S. (2016, Winter). An Unusual Case of Metastatic Signet Cell Carcinoma Presenting as Crohn’s Disease. Advances in Inflammatory Bowel Disease.
• Taleban, S. (2016, Winter). Metastatic Crohn's Disease Without Gastrointestinal Involvement. Advances in Inflammatory Bowel Disease.
• Pham, T., & Taleban, S. (2015, Spring). Mis-sizing of polyps during colonoscopy does not significantly impact colorectal cancer surveillance recommendations. ACG.
• Pham, T., & Taleban, S. (2015, Spring). Primary Varicella Infection During Infliximab Treatment for Fistulizing Crohn’s Disease. ACG.
• Shrestha, M., & Taleban, S. (2015, Spring). Ethnicity, Marital status, primary care provider status and Appointment wait time predict attendance at Outpatient Gastroenterology clinic. ACG.
• Taleban, S. (2015, Spring). Correlations Between Clinical Activity Indices or Quality of Life Scores to Endoscopic Activity Scores do not Vary According to Age at Diagnosis, Disease Location and Disease Behavior in Inflammatory Bowel Disease. ACG.
• Taleban, S. (2013, Spring). E-cigarettes as Salvage Therapy for Medically Refractory Ulcerative Colitis. Advances in IBD.
• Taleban, S. (2011, Spring). Adenoma Detection Rate in Average Risk Women. ACG.
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  Awarded the ACG Radhika Srinivasan Gender-Based Research Award
• Taleban, S. (2010, October). Splenic Rupture as a Complication of Colonoscopy. American College of Gastroenterology.
• Taleban, S. (2008, October). Closing the Circle on the 360 Degree Evaluation. American College of Gastroenterology.
• Taleban, S. (2007, September). Recurrent Transverse Myelitis in SLE: A Case of Neuromyelitis Optica. Department of Medicine Poster Day.
• Taleban, S. (2005, April). Low Levels of Lysophosphatidic Acid Acetyltransferase Beta Activity in Congenital Generalized Lipodystrophy. American Federation of Medical Research Western Meeting.
• Taleban, S. (2003, April). Emphasizing the Important of Child Safety Seats in a Native American Population. American Federation of Medical Research Western Meeting.

Case Studies

• Andres, B., & Taleban, S. (2022. Exacerbation of Atopic Dermatitis Associated with Ustekinumab Treatment in Crohn's Disease(pp e29718-e29724).
• Taleban, S., & Andres, B. (2021. Exacerbation of Atopic Dermatitis Associated with Ustekinumab Treatment in Crohn's Disease(pp S2475).