Christian Bime

Interests

Research

Genetics of Acute Respiratory Distress Syndrome (ARDS)Translational ARDS researchHealth Disparities in ARDSAsthma Clinical TrialsAsthma, Obesity, and Aerobic Exercise

Teaching

Pulmonary Physiology and PathophysiologyPrinciples of Acute Critical Care

Courses

No activities entered.

Scholarly Contributions

Books

• Bime, C., Gurguis, C. I., Hecker, L., Wang, T., Desai, A., & Garcia, J. G. (2016). MicroRNAs in inflammatory lung diseases. Translating MicroRNAs to the clinic. Elsevier.

Chapters

• Bime, C. (2019). Acute and Chronic Respiratory Failure. In Oncologic Critical Care(pp 1-31). Springer International Publishing.
• Bime, C. (2016). Health Disparities in Asthma. In Health Disparities in Respiratory Medicine(pp 173-187). B. L. Gerald and E. C. Berry: Cham, Springer International Publishing.
• Bime, C., Gurguis, C. I., Hecker, L., Wang, T., Desai, A., & Garcia, J. G. (2016). MicroRNAs in inflammatory lung diseases.. In Translating MicroRNAs to the clinic(pp 135-177). Elsevier.

Journals/Publications

• Bime, C., Casanova, N., Oita, R. C., Ndukum, J., Lynn, H., Camp, S. M., Lussier, Y., Abraham, I., Carter, D., Miller, E. J., Mekontso-Dessap, A., Downs, C. A., & Garcia, J. G. (2019). Development of a biomarker mortality risk model in acute respiratory distress syndrome. Critical care (London, England), 23(1), 410.
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  There is a compelling unmet medical need for biomarker-based models to risk-stratify patients with acute respiratory distress syndrome. Effective stratification would optimize participant selection for clinical trial enrollment by focusing on those most likely to benefit from new interventions. Our objective was to develop a prognostic, biomarker-based model for predicting mortality in adult patients with acute respiratory distress syndrome.
• Goel, K., Bailey, M., Borgstrom, M., Parthasarathy, S., Natt, B., Berry, C., & Bime, C. (2019). Trends in Chronic Obstructive Pulmonary Disease Hospitalization and In-Hospital Deaths in the United States by Sex: 2005 to 2014. Annals of the American Thoracic Society, 16(3), 391-393.
• Insel, M., Natt, B., Mosier, J., Malo, J., & Bime, C. (2019). The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis. Respiratory care, 64(3), 279-284.
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  The 2009 H1N1 influenza epidemic saw a rise in the use of extracorporeal membrane oxygenation (ECMO) as a supportive therapy for refractory ARDS. We sought to determine whether ECMO utilization follows a seasonal pattern that matches the influenza season, and whether it can further be explained by the incidence of each influenza subtype.
• Lynn, H., Sun, X., Casanova, N., Gonzales-Garay, M., Bime, C., & Garcia, J. G. (2019). Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality. Antioxidants & redox signaling, 31(14), 1027-1052.
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  Acute respiratory distress syndrome (ARDS) is a severe, highly heterogeneous critical illness with staggering mortality that is influenced by environmental factors, such as mechanical ventilation, and genetic factors. Significant unmet needs in ARDS are addressing the paucity of validated predictive biomarkers for ARDS risk and susceptibility that hamper the conduct of successful clinical trials in ARDS and the complete absence of novel disease-modifying therapeutic strategies. The current ARDS definition relies on clinical characteristics that fail to capture the diversity of disease pathology, severity, and mortality risk. We undertook a comprehensive survey of the available ARDS literature to identify genes and genetic variants (candidate gene and limited genome-wide association study approaches) implicated in susceptibility to developing ARDS in hopes of uncovering novel biomarkers for ARDS risk and mortality and potentially novel therapeutic targets in ARDS. We further attempted to address the well-known health disparities that exist in susceptibility to and mortality from ARDS. Bioinformatic analyses identified 201 ARDS candidate genes with pathway analysis indicating a strong predominance in key evolutionarily conserved inflammatory pathways, including reactive oxygen species, innate immunity-related inflammation, and endothelial vascular signaling pathways. Future studies employing a system biology approach that combines clinical characteristics, genomics, transcriptomics, and proteomics may allow for a better definition of biologically relevant pathways and genotype-phenotype connections and result in improved strategies for the sub-phenotyping of diverse ARDS patients molecular signatures. These efforts should facilitate the potential for successful clinical trials in ARDS and yield a better fundamental understanding of ARDS pathobiology.
• Bime, C., Malo, J., Mosier, J. M., Natt, B., & Insel, M. (2018). The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis.. Respiratory Care.
• Bime, C., Pouladi, N., Sammani, S., Batai, K., Casanova, N., Zhou, T., Kempf, C. L., Sun, X., Camp, S. M., Wang, T., Kittles, R. A., Lussier, Y. A., Jones, T. K., Reilly, J. P., Meyer, N. J., Christie, J. D., Karnes, J. H., Gonzalez-Garay, M., Christiani, D. C., , Yates, C. R., et al. (2018). Genome-Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor. American journal of respiratory and critical care medicine, 197(11), 1421-1432.
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  Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility. Identification of novel candidate genes associated with increased risk and severity will improve our understanding of ARDS pathophysiology and enhance efforts to develop novel preventive and therapeutic approaches.
• Dill, J., Bixby, B., Ateeli, H., Sarsah, B., Goel, K., Buckley, R., Finkelshteyn, I., Thajudeen, B., Kadambi, P. V., & Bime, C. (2018). Renal replacement therapy in patients with acute respiratory distress syndrome: a single-center retrospective study. International journal of nephrology and renovascular disease, 11, 249-257.
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  Patients with acute respiratory distress syndrome (ARDS) who develop acute kidney injury have increased mortality and frequently require renal replacement therapy (RRT). The optimal timing for initiation of RRT after onset of ARDS to improve survival is not known.
• Kempf, C., Bime, C., Zhou, T., Pouladi, N., Sammani, S., Casanova, N., Batai, K., Batai, K., Casanova, N., Sammani, S., Pouladi, N., Zhou, T., Kempf, C., & Bime, C. (2018). GWAS in African Americans identifies the Selectin P Ligand gene, SELPLG, as an ARDS risk gene. American J Respiratory Critical Care Medicine.
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  Rationale: Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility. Identification of novel candidate genes associated with increased risk and severity will improve our understanding of ARDS pathophysiology and enhance efforts to develop novel preventive and therapeutic approaches.Objectives: To identify genetic susceptibility targets for ARDS.Methods: A genome-wide association study was performed on 232 African American patients with ARDS and 162 at-risk control subjects. The Identify Candidate Causal SNPs and Pathways platform was used to infer the association of known gene sets with the top prioritized intragenic SNPs. Preclinical validation of SELPLG (selectin P ligand gene) was performed using mouse models of LPS- and ventilator-induced lung injury. Exonic variation within SELPLG distinguishing patients with ARDS from sepsis control subjects was confirmed in an independent cohort.Measurements and Main Results: Pathway prioritization analysis identified a nonsynonymous coding SNP (rs2228315) within SELPLG, encoding P-selectin glycoprotein ligand 1, to be associated with increased susceptibility. In an independent cohort, two exonic SELPLG SNPs were significantly associated with ARDS susceptibility. Additional support for SELPLG as an ARDS candidate gene was derived from preclinical ARDS models where SELPLG gene expression in lung tissues was significantly increased in both ventilator-induced (twofold increase) and LPS-induced (5.7-fold increase) murine lung injury models compared with controls. Furthermore, Selplg−/− mice exhibited significantly reduced LPS-induced inflammatory lung injury compared with wild-type C57/B6 mice. Finally, an antibody that neutralizes P-selectin glycoprotein ligand 1 significantly attenuated LPS-induced lung inflammation.Conclusions: These findings identify SELPLG as a novel ARDS susceptibility gene among individuals of European and African descent.
• Roman, J., Viegi, G., Schenker, M., Ojeda, V. D., Pérez-Stable, E. J., Nemery, B., Annesi-Maesano, I., Patel, S. R., La Grutta, S., Holguin, F., Moughrabieh, A., Bime, C., Lindberg, A., Migliori, G. B., de Vries, G., Ramírez, J., Aliberti, S., Feldman, C., & Celedón, J. C. (2018). Research Needs on Respiratory Health in Migrant and Refugee Populations. An Official American Thoracic Society and European Respiratory Society Workshop Report. Annals of the American Thoracic Society, 15(11), 1247-1255.
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  Migrants represent a diverse population comprising workers, students, undocumented individuals, and refugees. Worldwide, approximately 1 billion people were considered migrants in 2016. Notably, about 65 million of these migrants were forcibly displaced from their homes, and 20 million were considered refugees. While the geopolitical consequences of such migration continue to be considered, less is known about the impact of these events on the respiratory health of migrants and refugees. In recognition of this knowledge gap, the American Thoracic Society and the European Respiratory Society brought together investigators with diverse and relevant expertise to participate in a workshop and develop a consensus on research needs on the respiratory health of migrants and refugees. The workshop focused on environmental and occupational hazards, chronic noninfectious diseases, and respiratory infectious diseases, which were presented by experts in three distinct sessions, each culminating with panel discussions. A writing committee collected summaries prepared by speakers and other participants, and the information was collated into a single document. Recommendations were formulated, and differences were resolved by discussion and consensus. The group identified important areas of research need, while emphasizing that reducing the burden of pulmonary, critical care, and sleep disorders in migrants and refugees will require a concerted effort by all stakeholders. Using best research practices, considering how research impacts policies affecting migrant and refugee populations, and developing new approaches to engage and fund trainees, clinical investigators, and public health practitioners to conduct high-quality research on respiratory health of migrants and refugees is essential.
• Shrestha, M. P., Bime, C., & Taleban, S. (2018). Decreasing Clostridium difficile-Associated Fatality Rates Among Hospitalized Patients in the United States: 2004-2014. The American journal of medicine, 131(1), 90-96.
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  Clostridium difficile infection has emerged as a major public health problem in the United States over the last 2 decades. We examined the trends in the C. difficile-associated fatality rate, hospital length of stay, and hospital charges over the last decade.
• Bime, C., Fiero, M., Lu, Z., Oren, E., Berry, C. E., Parthasarathy, S., & Garcia, J. G. (2017). High Positive End-Expiratory Pressure Is Associated with Improved Survival in Obese Patients with Acute Respiratory Distress Syndrome. The American journal of medicine, 130(2), 207-213.
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  In acute respiratory distress syndrome, minimizing lung injury from repeated collapse and reopening of alveoli by applying a high positive end-expiratory pressure improves oxygenation without influencing mortality. Obesity causes alveolar atelectasis, thus suggesting that a higher positive end-expiratory pressure might be more protective among the obese. We hypothesized that the effect of applying a high positive end-expiratory pressure on mortality from acute respiratory distress syndrome would differ by obesity status.
• Bime, C., Natt, B., Desai, H., Poongkunran, C., & Borgstrom, M. (2017). Reply: Racial Disparities in Acute Respiratory Distress Syndrome Mortality. Annals of the American Thoracic Society, 14(2), 300-301.
• Natt, B., Desai, H., Bime, C., Dill, J., Dalen, J. E., & Alpert, J. S. (2017). The Reply. The American journal of medicine, 130(4), e165.
• Shrestha, M. P., Bime, C., & Taleban, S. (2017). Decreasing Clostridium difficile-Associated Fatality Rates Among Hospitalized Patients in the United States: 2004-2014. Am J Med. doi:10.1016/j.amjmed.2017.07.022
• Toosizadeh, N., Berry, C., Bime, C., Najafi, B., Kraft, M., & Mohler, J. (2017). Assessing upper-extremity motion: An innovative method to quantify functional capacity in patients with chronic obstructive pulmonary disease. PloS one, 12(2), e0172766.
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  Assessment of functional capacity is important in directing chronic obstructive pulmonary disease (COPD) care (e.g., rehabilitation and discharge readiness), and in predicting outcomes (e.g., exacerbation, hospitalization, and mortality). The 6-minute walk distance (6MWD) test for functional capacity assessment, may be time-consuming and burdensome.
• Bime, C., Gerald, J. K., Wei, C. Y., Holbrook, J. T., Teague, W. G., Wise, R. A., & Gerald, L. B. (2016). Measurement characteristics of the childhood Asthma-Control Test and a shortened, child-only version. NPJ primary care respiratory medicine, 26, 16075.
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  The childhood Asthma-Control Test (C-ACT) is validated for assessing asthma control in paediatric asthma. Among children aged 4-11 years, the C-ACT requires the simultaneous presence of both parent and child. There is an unmet need for a tool that can be used to assess asthma control in children when parents or caregivers are not present such as in the school setting. We assessed the psychometric properties and estimated the minimally important difference (MID) of the C-ACT and a modified version, comprising only the child responses (C-ACTc). Asthma patients aged 6-11 years (n=161) from a previously completed multicenter randomised trial were included. Demographic information, spirometry and questionnaire scores were obtained at baseline and during follow-up. Participants or their guardians kept a daily asthma diary. Internal consistency reliabilities of the C-ACT and C-ACTc were 0.76 and 0.67 (Cronbach's α), respectively. Test-retest reliabilities of the C-ACT and C-ACTc were 0.72 and 0.66 (intra-class correlation), respectively. Significant correlations were noted between C-ACT scores and ACQ scores (Spearman's correlation r=-0.56, 95% CI (-0.66, -0.44), P
• Bime, C., Poongkunran, C., Borgstrom, M., Natt, B., Desai, H., Parthasarathy, S., & Garcia, J. G. (2016). Racial Differences in Mortality from Severe Acute Respiratory Failure in the United States, 2008-2012. Annals of the American Thoracic Society, 13(12), 2184-2189.
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  Racial disparities in health and healthcare in the United States are well documented and are increasingly recognized in acute critical illnesses such as sepsis and acute respiratory failure.
• Bime, C., Zhou, T., Wang, T., Slepian, M. J., Garcia, J. G., & Hecker, L. (2016). Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis. Pulmonary circulation, 6(2), 196-201.
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  Sepsis-related multiple organ dysfunction syndrome is a leading cause of death in intensive care units. There is overwhelming evidence that oxidative stress plays a significant role in the pathogenesis of sepsis-associated multiple organ failure; however, reactive oxygen species (ROS)-associated biomarkers and/or diagnostics that define mortality or predict survival in sepsis are lacking. Lung or peripheral blood gene expression analysis has gained increasing recognition as a potential prognostic and/or diagnostic tool. The objective of this study was to identify ROS-associated biomarkers predictive of survival in patients with sepsis. In-silico analyses of expression profiles allowed the identification of a 21-gene ROS-associated molecular signature that predicts survival in sepsis patients. Importantly, this signature performed well in a validation cohort consisting of sepsis patients aggregated from distinct patient populations recruited from different sites. Our signature outperforms randomly generated signatures of the same signature gene size. Our findings further validate the critical role of ROSs in the pathogenesis of sepsis and provide a novel gene signature that predicts survival in sepsis patients. These results also highlight the utility of peripheral blood molecular signatures as biomarkers for predicting mortality risk in patients with sepsis, which could facilitate the development of personalized therapies.
• Desai, H., Natt, B., Bime, C., Dill, J., Dalen, J. E., & Alpert, J. S. (2016). Pulmonary Embolism with Right Ventricular Dysfunction: Who Should Receive Thrombolytic Agents?. The American journal of medicine.
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  Appropriate management of pulmonary embolism patients with right ventricular dysfunction is uncertain. Recent guidelines have stressed the need for more data on the use of thrombolytic agents in the stable pulmonary embolism patient with right ventricular dysfunction. The objective of this study is to investigate the hypothesis that thrombolytic therapy in hemodynamically stable pulmonary embolism patients with right ventricular dysfunction is not associated with improved mortality.
• Desai, H., Natt, B., Kim, S. S., & Bime, C. (2016). Decreased In-hospital Mortality after Lobectomy Using Video-Assisted Thoracoscopic Surgery Compared to Open Thoracotomy.. Annals of American Thoracic Society.
• Desai, H., Natt, B., Kim, S., & Bime, C. (2016). Decreased In-hospital Mortality after Lobectomy Using Video-Assisted Thoracoscopic Surgery Compared to Open Thoracotomy. Annals of the American Thoracic Society.
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  There is a paucity of data regarding the optimal surgical approach for lung lobectomy. Lobectomy performed by video-assisted thoracoscopic surgery (VATS) has been associated with lower morbidity as compared to thoracotomy. However, no multicenter studies have shown improved mortality with VATS lobectomy compared to open surgical lobectomy.
• Ghazala, L., Bime, C., Cortopassi, F., Golden, T., & Berry, C. E. (2016). Inhaler preferences in older adults with chronic lung disease. Southwest Journal of Pulmonary and Critical Care Medicine, 13, 225-234.
• Huthayfa, A., Bime, C., & Gerald, J. K. (2016). Tucson Critical Care Journal Club: Albumin Use in the Critical Care Unit. Southwest J Pulm Crit Care.
• Malaisamy, S., Dalal, B., Bimenyuy, C., & Soubani, A. O. (2016). The clinical and radiologic features of nodular pulmonary sarcoidosis. Lung, 187(1), 9-15.
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  Nodular sarcoidosis is an uncommon presentation of sarcoidosis. Our objective was to describe the clinical characteristics of a large cohort of patients with nodular sarcoidosis.
• Natt, B. S., Desai, H., Singh, N., Poongkunran, C., Parthasarathy, S., & Bime, C. (2016). Extracorporeal Membrane Oxygenation for ARDS: National Trends in the United States 2008-2012. Respiratory care, 61(10), 1293-8.
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  Recent advances in technology and protocols have made the use of extracorporeal membrane oxygenation (ECMO) a viable rescue therapy for patients with ARDS who present with refractory hypoxemia. Despite the lack of strong evidence supporting the use of ECMO in ARDS, its use seems to be increasing. We sought to determine recent trends in the use of ECMO for ARDS. We also assessed trends in mortality among patients with ARDS in whom ECMO was used.
• Pouladi, N., Bime, C., Garcia, J. G., & Lussier, Y. A. (2016). Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing. Translational research : the journal of laboratory and clinical medicine, 168, 22-39.
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  The advent of high-throughput technologies has provided exceptional assistance for lung scientists to discover novel genetic variants underlying the development and progression of complex lung diseases. However, the discovered variants thus far do not explain much of the estimated heritability of complex lung diseases. Here, we review the literature of successfully used genome-wide association studies (GWASs) and identified the polymorphisms that reproducibly underpin the susceptibility to various noncancerous complex lung diseases or affect therapeutic responses. We also discuss the inherent limitations of GWAS approaches and how the use of next-generation sequencing technologies has furthered our understanding about the genetic determinants of these diseases. Next, we describe the contribution of the metagenomics to understand the interactions of the airways microbiome with lung diseases. We then highlight the urgent need for new integrative genomics-phenomics methods to more effectively interrogate and understand multiple downstream "omics" (eg, chromatin modification patterns). Finally, we address the scarcity of genetic studies addressing under-represented populations such as African Americans and Hispanics.
• Dill, J., Gerald, J. K., Bime, C., & Knepler, J. L. (2015). September 2015 Tucson pulmonary journal club: genomic classifier for lung cancer. .. Southwest J Pulm Crit Care. doi:doi: http://dx.doi.org/10.13175/swjpcc125-15 PDF
• Dill, J., Gerald, J. K., Bime, C., & Knepler, J. L. (2015). Tucson pulmonary journal club: genomic classifier for lung cancer.. Southwest J Pulm Crit Care.
• Dill, J., Gerald, J., & Knepler, J. (2015). A bronchial genomic classifier for the diagnostic evaluation of lung cancer.. Southwest Journal of Pulmonary & Critical Care, 11(3), 119-20.
• Ganesh, A., Bime, C., & Gerald, J. (2015). Fibrinolysis for patients with intermediate-risk pulmonary embolism. Southwest Journal of Pulmonary & Critical Care, 10(2), 97-8.
• Ganesh, A., Bime, C., & Gerald, J. K. (2015). Tucson pulmonary journal club: fibrinolysis for Pulmonary Embolus. Southwest J Pulm Crit Care.
• Hecker, L., Bime, C., Zhou, T., Wang, T., Slepian, M., & Garcia, G. (2015). Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis. Pulmonary Circulation, 0(0).
• Kempf, C., Bime, C., Pouladi, N., Zhou, T., Casanova, N., Sammani, S., Batai, K., Batai, K., Sammani, S., Casanova, N., Zhou, T., Pouladi, N., Kempf, C., & Bime, C. (2018). GWAS in African Americans identifies the Selectin P Ligand gene, SELPLG, as an ARDS risk gene. American J Respiratory Critical Care Medicine.
  More info

  Rationale: Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility. Identification of novel candidate genes associated with increased risk and severity will improve our understanding of ARDS pathophysiology and enhance efforts to develop novel preventive and therapeutic approaches.Objectives: To identify genetic susceptibility targets for ARDS.Methods: A genome-wide association study was performed on 232 African American patients with ARDS and 162 at-risk control subjects. The Identify Candidate Causal SNPs and Pathways platform was used to infer the association of known gene sets with the top prioritized intragenic SNPs. Preclinical validation of SELPLG (selectin P ligand gene) was performed using mouse models of LPS- and ventilator-induced lung injury. Exonic variation within SELPLG distinguishing patients with ARDS from sepsis control subjects was confirmed in an independent cohort.Measurements and Main Results: Pathway prioritization analysis identified a nonsynonymous coding SNP (rs2228315) within SELPLG, encoding P-selectin glycoprotein ligand 1, to be associated with increased susceptibility. In an independent cohort, two exonic SELPLG SNPs were significantly associated with ARDS susceptibility. Additional support for SELPLG as an ARDS candidate gene was derived from preclinical ARDS models where SELPLG gene expression in lung tissues was significantly increased in both ventilator-induced (twofold increase) and LPS-induced (5.7-fold increase) murine lung injury models compared with controls. Furthermore, Selplg−/− mice exhibited significantly reduced LPS-induced inflammatory lung injury compared with wild-type C57/B6 mice. Finally, an antibody that neutralizes P-selectin glycoprotein ligand 1 significantly attenuated LPS-induced lung inflammation.Conclusions: These findings identify SELPLG as a novel ARDS susceptibility gene among individuals of European and African descent.
• Malaisamy, S., Dalal, B., Bimenyuy, C., & Soubani, A. O. (2015). The clinical and radiologic features of nodular pulmonary sarcoidosis. Lung, 187(1), 9-15.
  More info

  Nodular sarcoidosis is an uncommon presentation of sarcoidosis. Our objective was to describe the clinical characteristics of a large cohort of patients with nodular sarcoidosis.
• Poongkunran, C., John, S. G., Kannan, A. S., Shetty, S., Bime, C., & Parthasarathy, S. (2015). A meta-analysis of sleep-promoting interventions during critical illness. The American journal of medicine, 128(10), 1126-1137.e1.
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  Sleep quality and quantity are severely reduced in critically ill patients receiving mechanical ventilation with a potential for adverse consequences. Our objective was to synthesize the randomized controlled trials (RCTs) that measured the efficacy of sleep-promoting interventions on sleep quality and quantity in critically ill patients.
• Bime, C., Sun, K., Ulliman, E., & Hypes, C. (2014). Medical image of the week: secondary pneumonia presenting as hemoptysis. Southwest J Pulm Crit Care.
• Natt, B., Berry, C. E., Bime, C., & Gerald, J. K. (2014). Tucson critical care journal club: early goal-directed therapy. Southwest J Pulm Crit Care.
• Natt, B., Berry, C. E., Bime, C., & Gerald, J. K. (2014). Tucson critical care journal club: early goal-directed therapy. Southwest Journal of Pulmonary and Critical Care.
• Strawter, C., Berry, C. E., Bime, C., & Gerald, J. K. (2014). Tucson critical care journal club: esmolol in septic shock. Southwest J Pulm Crit Care.
• Bime, C., Nguyen, J., & Wise, R. A. (2012). Measures of asthma control. Current opinion in pulmonary medicine, 18(1), 48-56.
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  Over the past decade, the concept of asthma control as distinct from asthma severity has been clearly defined. Well controlled asthma is the goal of therapy in all asthma patients. This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research.
• Bime, C., Wei, C. Y., Holbrook, J. T., Sockrider, M. M., Revicki, D. A., & Wise, R. A. (2012). Asthma symptom utility index: reliability, validity, responsiveness, and the minimal important difference in adult asthmatic patients. The Journal of allergy and clinical immunology, 130(5), 1078-84.
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  The evaluation of asthma symptoms is a core outcome measure in asthma clinical research. The Asthma Symptom Utility Index (ASUI) was developed to assess the frequency and severity of asthma symptoms. The psychometric properties of the ASUI are not well characterized, and a minimal important difference (MID) is not established.
• Bime, C., Wei, C. Y., Holbrook, J., Smith, L. J., & Wise, R. A. (2012). Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial. Primary care respiratory journal : journal of the General Practice Airways Group, 21(4), 398-404.
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  Broad dietary patterns have been linked to asthma but the relative contribution of specific nutrients is unclear. Soy genistein has important anti-inflammatory and other biological effects that might be beneficial in asthma. A positive association was previously reported between soy genistein intake and lung function but not with asthma exacerbations.
• Hammad, H., Bimenyuy, C., Rau, S., & Siddiqui, F. (2006). Upper Extremity Venous Thrombosis after Infliximab Therapy. American Journal of Gastroenterology.

Presentations

• Bime, C., Gerald, L. B., Stern, D., Garcia, D. L., & Lowe, A. (2018, May). Home based exercise intervention versus remote asthma care guidance via telephone/text message in obese asthmatics. American Thoracic Society International Conference. San Diego, CA: American Thoracic Society.
• Lowe, A., Garcia, D. L., Stern, D., Gerald, L. B., & Bime, C. (2018, May). Feasibility of home based exercise intervention with remote guidance for obese asthmatics. American Thoracic Society International Conference. San Diego, CA: American Thoracic Society.

Poster Presentations

• Shrestha, M. P., Bime, C., & Taleban, S. (2017, Oct/ Fall). Decreasing Clostridium difficile-Associated Mortality Rates Among Hospitalized Patients in the Unites States: 2004-2014. WCOG. Orlando: ACG.
• Desai, H., Natt, B., & Bime, C. (2016, May/Spring). Decreased in-hospital mortality after lobectomy using video-assisted thoracoscopic surgery compared to open thoracotomy. ATS International Conference. San Francisco, CA.
• Berry, C. E., Berry, C. E., Ghazala, L., Ghazala, L., Mohler, M. J., Mohler, M. J., Bime, C., & Bime, C. (2015, June). Frailty features are common in ambulatory patients with COPD and may be associated with respiratory muscle weakness. COPD9USA. Chicago, IL.
• Ghazala*, L., Ghazala*, L., Ghazala*, L., Gordon, J. S., Gordon, J. S., Gordon, J. S., Berry, C. E., Berry, C. E., Berry, C. E., Bime, C., Bime, C., Bime, C., Gerald, L. B., Gerald, L. B., Gerald, L. B., Golden*, T., Golden*, T., Golden*, T., Sekhon*, K., , Sekhon*, K., et al. (2015, October). Cross-section survey of electronic cigarette use among ambulatory COPD patients. CHEST.
• Ghazala, L., Bime, C., Cortopassi, F., Baalachandran, R., Oren, E., Berry, C. E., Ghazala, L., Bime, C., Cortopassi, F., Baalachandran, R., Oren, E., & Berry, C. E. (2015, May). Inhaler Device Preferences In Older Adults With Chronic Lung Disease. American Thoracic Society. Denver, CO.
• Natt, B., Desai, H., Poongkunran, C., & Bime, C. (2015, October/Fall). Extracorporeal Membrane Oxygenator Use in ARDS. CHEST Annual Meeting. Montreal, Québec, Canada.
• Natt, B., Desai, H., Singh, N., Poongkunran, C., & Bime, C. (2015, October/Fall). ARDS Prevalence and Survival Trends in the United States; 2008-2012. CHEST Annual Meeting. Montreal, Québec, Canada.
• Toosizahdeh, N., Berry, C. E., Bime, C., Najafi, B., Mohler, M. J., Toosizahdeh, N., Berry, C. E., Bime, C., Najafi, B., & Mohler, M. J. (2015, May). An Association between Frailty and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease (COPD) – Application of a Routine Frailty Assessment Approach using Wearable Technology. American Aging Association. Marina del Rey, CA.

Others

• Bime, C., Bhupinder, N., Singh, N., Desai, H., Poongkunran, C., Parthasarathy, S., & Garcia, G. (2015, Jan). Racial and ethnic differences in Acute Respiratory Distress Syndrome mortality in the United States.
• Bime, C., Oren, E., Fierro, M., Berry, C., Parthasarathy, S., & Garcia, G. (2015, Jan). Obesity, Positive End-Expiratory Pressure, and Acute Respiratory Distress Syndrome Survival - Submitted to Journal of Critical Care Medicine. Journal of Critical Care Medicine.
• Bime, C., Wei, R., & Gerald, J. (2015, Jan). Measurement characteristics of the Childhood Asthma Control Test (C-ACT) and a shortened, child-only version (C-ACTc).. Nature Publication Journals Primary Care Respiratory Medicine.
• Natt, B., Singh, N., Desai, H., Poongkunran, C., Parthasarathy, S., & Bime, C. (2015, Jan). Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: National Trends in the United States 2008-2012. Respiratory Care Journal.
• Toosizahdeh, N., Berry, C., Bime, C., Najafi, B., & Mohler, J. (2015, Jan). An Association between Frailty and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease (COPD) – Application of a Routine Frailty Assessment Approach using Wearable Technology. Journal of COPD.
• Bime, C., Oren, E., Fierro, M., Berry, C., Parthasarathy, S., & Garcia, G. (2015, March). High versus low PEEP and ARDS survival: Effect modification by BMI. ATS 2015 Denver, CO.
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