Jarrod M Mosier

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Scholarly Contributions

Chapters

• Mosier, J. M., & Keim, S. M. (2010). Complications of Cardiac Transplatation. In Rosen and Barkin's 5-Minute Emergency Medicine Consult. Philadelphia, Pennsylvania: Lippincott Williams & Wilkins.
• Antonuccio, D., & Mosier, J. M. (2006). Smoking (Nicotine Dependence). In Practitioner's Guide to Evidence Based Psychotherapy(pp 660-667). New York, NY: Springer US.

Journals/Publications

• Kornas, R. L., Owyang, C. G., Sakles, J. C., Foley, L. J., Mosier, J. M., & , S. f. (2021). Evaluation and Management of the Physiologically Difficult Airway: Consensus Recommendations From Society for Airway Management. Anesthesia and analgesia, 132(2), 395-405.
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  Multiple international airway societies have created guidelines for the management of the difficult airway. In critically ill patients, there are physiologic derangements beyond inadequate airway protection or hypoxemia. These risk factors contribute to the "physiologically difficult airway" and are associated with complications including cardiac arrest and death. Importantly, they are largely absent from international guidelines. Thus, we created management recommendations for the physiologically difficult airway to provide practical guidance for intubation in the critically ill. Through multiple rounds of in-person and telephone conferences, a multidisciplinary working group of 12 airway specialists (Society for Airway Management's Special Projects Committee) over a time period of 3 years (2016-2019) reviewed airway physiology topics in a modified Delphi fashion. Consensus agreement with the following recommendations among working group members was generally high with 80% of statements showing agreement within a 10% range on a sliding scale from 0% to 100%. We limited the scope of this analysis to reflect the resources and systems of care available to out-of-operating room adult airway providers. These recommendations reflect the practical application of physiologic principles to airway management available during the analysis time period.
• Brown, C. A., Mosier, J. M., Carlson, J. N., & Gibbs, M. A. (2020). Pragmatic recommendations for intubating critically ill patients with suspected COVID-19. Journal of the American College of Emergency Physicians open.
• Donovan, F. M., Ramadan, F. A., Khan, S. A., Bhaskara, A., Lainhart, W. D., Narang, A. T., Mosier, J. M., Ellingson, K. D., Bedrick, E. J., Saubolle, M. A., & Galgiani, J. N. (2020). Comparison of a Novel Rapid Lateral Flow Assay to Enzyme Immunoassay Results for Early Diagnosis of Coccidioidomycosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
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  Coccidioidomycosis (CM) is a common cause of community acquired pneumonia (CAP) where CM is endemic. Manifestations include self-limited pulmonary infection, chronic fibrocavitary pulmonary disease, and disseminated coccidioidomycosis (DCM). Most infections are identified by serological assays including enzyme-linked immunoassay (EIA), complement fixation (CF) and immunodiffusion (IMDF). These are time-consuming and take days to result, impeding early diagnosis. A new lateral flow assay (LFA, Sōna, IMMY, Norman OK) improves time-to-result to one hour.
• Driver, B. E., Mosier, J. M., & Brown, C. A. (2020). The Importance of the Intubation Process for the Safety of Emergency Airway Management. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 27(12), 1362-1365.
• Essay, P., Mosier, J., & Subbian, V. (2020). Rule-Based Cohort Definitions for Acute Respiratory Failure: Electronic Phenotyping Algorithm. JMIR medical informatics, 8(4), e18402.
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  Acute respiratory failure is generally treated with invasive mechanical ventilation or noninvasive respiratory support strategies. The efficacies of the various strategies are not fully understood. There is a need for accurate therapy-based phenotyping for secondary analyses of electronic health record data to answer research questions regarding respiratory management and outcomes with each strategy.
• Miller, D. C., Beamer, P., Billheimer, D., Subbian, V., Sorooshian, A., Campbell, B. S., & Mosier, J. M. (2020). Aerosol Risk with Noninvasive Respiratory Support in Patients with COVID-19. Journal of the American College of Emergency Physicians open.
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  This study evaluates aerosol production with high flow nasal cannula () and noninvasive positive pressure ventilation () compared to six liters per minute by low-flow nasal cannula.
• Miller, D. C., Bime, C., Partharsarathy, S., & Mosier, J. M. (2020). High-Flow Oxygen Therapy Concepts: Time to Standardize Nomenclature and Avoid Confusion. Journal of intensive care medicine, 35(5), 519-523.
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  High-flow nasal oxygen systems are rapidly being adopted as an initial noninvasive treatment for acute respiratory failure. However, the term "high-flow nasal cannula" is nonspecific and leads to imprecise communication between physicians, respiratory therapists, and nurses with the potential for patient harm. In this viewpoint and a brief review of the technology, we argue for a change in nomenclature in order to reduce the chance for future clinical, administrative, and research misunderstanding surrounding high-flow nasal oxygen systems.
• Mosier, J. M., Sakles, J. C., Law, J. A., Brown, C. A., & Brindley, P. G. (2020). Tracheal Intubation in the Critically Ill: Where We Came From and Where We Should Go. American journal of respiratory and critical care medicine.
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  Tracheal intubation is commonly performed in critically ill patients. Unfortunately, this procedure also carries a high risk of complications; half of critically ill patients with difficult airways experiencing life threatening complications. The high complication rates stem from difficulty with laryngoscopy and tube placement, consequences of physiologic derangement, and human factors including failure to recognize and reluctance to manage the failed airway. The last 10 years have seen a rapid expansion in devices available that help overcome anatomic difficulties with laryngoscopy and provide rescue oxygenation in the setting of failed attempts. Recent research in critically ill patients has highlighted other important considerations for critically ill patients and evaluated interventions to reduce the risks with repeated attempts, desaturation, and cardiovascular collapse during emergency airway management. There are three actions that should be implemented to reduce the risk of danger and include: 1. Preintubation assessment for potential difficulty (e.g. MACOCHA score), 2. Preparation and optimization of the patient and team for difficulty-including using a checklist, acquiring necessary equipment, maximizing preoxygenation, and hemodynamic optimization, and 3. Recognition and management of failure to restore oxygenation and reduce the risk of cardiopulmonary arrest. This review describes the history of emergency airway management and explores the challenges with modern emergency airway management in critically ill patients. We offer clinically relevant recommendations based on current evidence, guidelines, and expert opinion.
• Mosier, J., Reardon, R. F., DeVries, P. A., Stang, J. L., Nelsen, A., Prekker, M. E., & Driver, B. E. (2020). Time to Loss of Preoxygenation in Emergency Department Patients. The Journal of emergency medicine, 59(5), 637-642.
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  In patients requiring emergency rapid sequence intubation (RSI), 100% oxygen is often delivered for preoxygenation to replace alveolar nitrogen with oxygen. Sometimes, however, preoxygenation devices are prematurely removed from the patient prior to the onset of apnea, which can lead to rapid loss of preoxygenation.
• Ripperger, T. J., Uhrlaub, J. L., Watanabe, M., Wong, R., Castaneda, Y., Pizzato, H. A., Thompson, M. R., Bradshaw, C., Weinkauf, C. C., Bime, C., Erickson, H. L., Knox, K., Bixby, B., Parthasarathy, S., Chaudhary, S., Natt, B., Cristan, E., Aini, T. E., Rischard, F., , Campion, J., et al. (2020). Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure. medRxiv : the preprint server for health sciences.
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  We conducted an extensive serological study to quantify population-level exposure and define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 cases, individuals with severe disease exhibited elevated authentic virus-neutralizing titers and antibody levels against nucleocapsid (N) and the receptor binding domain (RBD) and the S2 region of spike protein. Unlike disease severity, age and sex played lesser roles in serological responses. All cases, including asymptomatic individuals, seroconverted by 2 weeks post-PCR confirmation. RBD- and S2-specific and neutralizing antibody titers remained elevated and stable for at least 2-3 months post-onset, whereas those against N were more variable with rapid declines in many samples. Testing of 5882 self-recruited members of the local community demonstrated that 1.24% of individuals showed antibody reactivity to RBD. However, 18% (13/73) of these putative seropositive samples failed to neutralize authentic SARS-CoV-2 virus. Each of the neutralizing, but only 1 of the non-neutralizing samples, also displayed potent reactivity to S2. Thus, inclusion of multiple independent assays markedly improved the accuracy of antibody tests in low seroprevalence communities and revealed differences in antibody kinetics depending on the viral antigen. In contrast to other reports, we conclude that immunity is durable for at least several months after SARS-CoV-2 infection.
• Ripperger, T. J., Uhrlaub, J. L., Watanabe, M., Wong, R., Castaneda, Y., Pizzato, H. A., Thompson, M. R., Bradshaw, C., Weinkauf, C. C., Bime, C., Erickson, H. L., Knox, K., Bixby, B., Parthasarathy, S., Chaudhary, S., Natt, B., Cristan, E., El Aini, T., Rischard, F., , Campion, J., et al. (2020). Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity. Immunity, 53(5), 925-933.e4.
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  We conducted a serological study to define correlates of immunity against SARS-CoV-2. Compared to those with mild coronavirus disease 2019 (COVID-19) cases, individuals with severe disease exhibited elevated virus-neutralizing titers and antibodies against the nucleocapsid (N) and the receptor binding domain (RBD) of the spike protein. Age and sex played lesser roles. All cases, including asymptomatic individuals, seroconverted by 2 weeks after PCR confirmation. Spike RBD and S2 and neutralizing antibodies remained detectable through 5-7 months after onset, whereas α-N titers diminished. Testing 5,882 members of the local community revealed only 1 sample with seroreactivity to both RBD and S2 that lacked neutralizing antibodies. This fidelity could not be achieved with either RBD or S2 alone. Thus, inclusion of multiple independent assays improved the accuracy of antibody tests in low-seroprevalence communities and revealed differences in antibody kinetics depending on the antigen. We conclude that neutralizing antibodies are stably produced for at least 5-7 months after SARS-CoV-2 infection.
• Sakles, J. C., Pacheco, G. S., Kovacs, G., & Mosier, J. M. (2020). The difficult airway refocused. British journal of anaesthesia, 125(1), e18-e21.
• Self, W. H., Semler, M. W., Leither, L. M., Casey, J. D., Angus, D. C., Brower, R. G., Chang, S. Y., Collins, S. P., Eppensteiner, J. C., Filbin, M. R., Files, D. C., Gibbs, K. W., Ginde, A. A., Gong, M. N., Harrell, F. E., Hayden, D. L., Hough, C. L., Johnson, N. J., Khan, A., , Lindsell, C. J., et al. (2020). Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA, 324(21), 2165-2176.
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  Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed.
• Basken, R., Cosgrove, R., Malo, J., Romero, A., Patanwala, A., Finger, J., Kazui, T., Khalpey, Z., & Mosier, J. (2019). Predictors of Oxygenator Exchange in Patients Receiving Extracorporeal Membrane Oxygenation. The journal of extra-corporeal technology, 51(2), 61-66.
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  Thrombosis within the membrane oxygenator (MO) during extracorporeal membrane oxygenation (ECMO) can lead to sudden oxygenator dysfunction with deleterious effects to the patient. The purpose of this study was to identify predictors of circuit exchange during ECMO. This is a single-center, retrospective study of all patients who received ECMO at our institution from January 2010 to December 2015. Changes in potential markers were compared on Day 3 vs. Day 0 before MO exchange. Of the 150 patients who received ECMO, there were 58 MO exchanges in 35 patients. Mean ECMO duration was 21.1 (±12.7) days. D-dimer (DD) (μg/mL) (mean difference -2.6; 95% confidence interval [CI]: -4.2 to -1.1; = .001) increased significantly in the 3 days leading up to MO exchange, whereas fibrinogen (mg/dL) (mean difference 90.7; 95% CI: 41.8-139.6; = .001), platelet (PLT) count (1,000/μL) (mean difference 23.3; 95% CI: 10.2-36.4; = .001), and heparin dose (units/h) (mean difference 261.7; 95% CI: 46.3-477.1; = .02) decreased. Increasing DD or decreasing fibrinogen, PLT count, or heparin dose may indicate an impending need for MO exchange in patients receiving ECMO. Early identification of these changes may help prevent sudden MO dysfunction.
• Driver, B. E., Reardon, R. F., & Mosier, J. (2019). Ketamine as Monotherapy in Difficult Airways Is Not Ready for Prime Time. The western journal of emergency medicine, 20(6), 970-971.
• Driver, B. E., Reardon, R. F., & Mosier, J. (2019). Ketamine as Monotherapy in Difficult Airways Is Not Ready for Prime Time. WESTERN JOURNAL OF EMERGENCY MEDICINE, 20(6), 970-971.
• Essay, P., Shahin, T. B., Balkan, B., Mosier, J., & Subbian, V. (2019). The Connected Intensive Care Unit Patient: Exploratory Analyses and Cohort Discovery From a Critical Care Telemedicine Database. JMIR MEDICAL INFORMATICS, 7(1).
• Essay, P., Shahin, T. B., Balkan, B., Mosier, J., & Subbian, V. (2019). The Connected Intensive Care Unit Patient: Exploratory Analyses and Cohort Discovery From a Critical Care Telemedicine Database. JMIR medical informatics, 7(1), e13006.
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  Many intensive care units (ICUs) utilize telemedicine in response to an expanding critical care patient population, off-hours coverage, and intensivist shortages, particularly in rural facilities. Advances in digital health technologies, among other reasons, have led to the integration of active, well-networked critical care telemedicine (tele-ICU) systems across the United States, which in turn, provide the ability to generate large-scale remote monitoring data from critically ill patients.
• Fuller, B. M., Roberts, B. W., Mohr, N. M., Knight, W. A., Adeoye, O., Pappal, R. D., Marshall, S., Alunday, R., Dettmer, M., Goyal, M., Gibson, C., Levine, B. J., Gardner-Gray, J. M., Mosier, J., Dargin, J., Mackay, F., Johnson, N. J., Lokhandwala, S., Hough, C. L., , Tonna, J. E., et al. (2019). The ED-SED Study: A Multicenter, Prospective Cohort Study of Practice Patterns and Clinical Outcomes Associated With Emergency Department SEDation for Mechanically Ventilated Patients. CRITICAL CARE MEDICINE, 47(11), 1539-1548.
• Insel, M., Natt, B., Mosier, J., Malo, J., & Bime, C. (2019). The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis. RESPIRATORY CARE, 64(3), 279-284.
• Insel, M., Natt, B., Mosier, J., Malo, J., & Bime, C. (2019). The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis. Respiratory care, 64(3), 279-284.
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  The 2009 H1N1 influenza epidemic saw a rise in the use of extracorporeal membrane oxygenation (ECMO) as a supportive therapy for refractory ARDS. We sought to determine whether ECMO utilization follows a seasonal pattern that matches the influenza season, and whether it can further be explained by the incidence of each influenza subtype.
• Mosier, J. M. (2019). Physiologically difficult airway in critically ill patients: winning the race between haemoglobin desaturation and tracheal intubation. British journal of anaesthesia.
• Mosier, J. M., & Hypes, C. D. (2019). Mechanical Ventilation Strategies for the Patient with Severe Obstructive Lung Disease. EMERGENCY MEDICINE CLINICS OF NORTH AMERICA, 37(3), 445-+.
• Mosier, J. M., & Hypes, C. D. (2019). Mechanical Ventilation Strategies for the Patient with Severe Obstructive Lung Disease. Emergency medicine clinics of North America, 37(3), 445-458.
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  Patients with respiratory failure due to obstructive lung disease present a challenge to the emergency physician. These patients have physiologic abnormalities that prevent adequate gas exchange and lung mechanics which render them at increased risk of cardiopulmonary decompensation when managed with invasive mechanical ventilation. This article addresses key principles when managing these challenging patients: patient-ventilator synchrony, air trapping and auto-positive end-expiratory pressure, and airway pressures. This article provides a practical workflow for the emergency physician responsible for managing these patients.
• Mosier, J. M., Stolz, U., Milligan, R., Roy-Chaudhury, A., Lutrick, K., Hypes, C. D., Billheimer, D., & Cairns, C. B. (2019). Impact of Point-of-Care Ultrasound in the Emergency Department on Care Processes and Outcomes in Critically Ill Nontraumatic Patients. Critical care explorations, 1(6), e0019.
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  Outcomes data on point-of-care ultrasound (POCUS) in critically ill patients are lacking. This study examines the association between POCUS in the emergency department and outcomes in critically ill patients.
• Sakles, J. C., Augustinovich, C. C., Patanwala, A. E., Pacheco, G. S., & Mosier, J. M. (2019). Improvement in the Safety of Rapid Sequence Intubation in the Emergency Department with the Use of an Airway Continuous Quality Improvement Program. WESTERN JOURNAL OF EMERGENCY MEDICINE, 20(4), 610-618.
• Acuna, J., Situ-LaCasse, E., & Mosier, J. (2018). A 33-Year-Old Woman With Progressive Dyspnea and Fatigue. CHEST, 154(3), E65-E67.
• Acuña, J., Situ-LaCasse, E., & Mosier, J. (2018). A 33-Year-Old Woman With Progressive Dyspnea and Fatigue. Chest, 154(3), e65-e67.
• Bime, C., Malo, J., Mosier, J. M., Natt, B., & Insel, M. (2018). The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis.. Respiratory Care.
• Crabbe, S., Malo, J., Natt, B., Kazui, T., Khalpey, Z., Roy-Chaudhury, A., Mosier, J., & Hypes, C. (2018). DURATION OF MECHANICAL VENTILATION AND PATIENT OUTCOMES FOR EXTRACORPOREAL MEMBRANE OXYGENATION. CRITICAL CARE MEDICINE, 46(1), 514-514.
• Crabbe, S., Malo, J., Natt, B., Khalpey, Z., Kazui, T., Roy-Chaudhury, A., Mosier, J., & Hypes, C. (2018). EVALUATION OF THE RESP SCORE FOR SURVIVAL PREDICTION IN VENOVENOUS ECMO. CRITICAL CARE MEDICINE, 46(1), 532-532.
• Gabe, L. M., Coffman, N., Mosier, J. M., & Bime, C. (2018). Do Lactated Ringers and Early Insulin Bolus Change the Clinical Course of Diabetic Ketoacidosis? A Single Center, Retrospective Review. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197.
• Milligan, R., Roy-Chaudhury, A., Adhikari, S., Stolz, L., Hypes, C., Cairns, C., & Mosier, J. (2018). UTILIZATION OF POINT-OF-CARE ULTRASOUND IN THE MANAGEMENT OF CRITICALLY ILL PATIENTS IN THE. CRITICAL CARE MEDICINE, 46(1), 138-138.
• Morrissette, K., Hypes, C. D., & Mosier, J. M. (2018). Effect of Implementation of Emergency Department Critical Care Response System on Patient Disposition and Outcome. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197.
• Morrissette, K., Mosier, J., Hypes, C., Milligan, R., & Sakles, J. (2018). INTERVENTIONS FOR HEMODYNAMIC INSTABILITY IN CRITICALLY ILL PATIENTS DO NOT REDUCE RISK OF MORTALITY. CRITICAL CARE MEDICINE, 46(1), 607-607.
• Park, P. K., Qadir, N., Bartz, R. R., Cooter, M., Lanspa, M. J., Chen, J., Banner-Goodspeed, V., Gomaa, D., Sjoding, M. W., Duggal, A., Khanna, A., Hajizadeh, N., Kashyap, R., Khan, A., Chang, S. Y., Tonna, J. E., Anderson, H., Liebler, J. M., Mosier, J. M., , Louh, I. K., et al. (2018). Variation in US Management Practices in Moderate-to-Severe ARDS: The Severe ARDS: Generating Evidence (SAGE) Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197.
• Qadir, N., Park, P. K., Bartz, R. R., Cooter, M., Lanspa, M. J., Chen, J., Banner-Goodspeed, V., Gomaa, D., Sjoding, M. W., Duggal, A., Khanna, A., Hajizadeh, N., Kashyap, R., Khan, A., Chang, S. Y., Tonna, J. E., Anderson, H., Liebler, J. M., Mosier, J. M., , Louh, I. K., et al. (2018). Use of Adjunctive Therapy in ARDS: Results from the Severe ARDS Generating Evidence (SAGE) Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197.
• Rao, P., Ali, H., Hypes, C., Natt, B., Kazui, T., Khalpey, Z., Cairns, C., & Mosier, J. (2018). RIGHT VENTRICULAR DYSFUNCTION IN ACUTE RESPIRATORY DISTRESS SYNDROME. CRITICAL CARE MEDICINE, 46(1), 67-67.
• Rao, P., Mosier, J., Malo, J., Dotson, V., Mogan, C., Smith, R., Keller, R., Slepian, M., & Khalpey, Z. (2018). Peripheral VA-ECMO with direct biventricular decompression for refractory cardiogenic shock. PERFUSION-UK, 33(6), 493-495.
• Rao, P., Mosier, J., Malo, J., Dotson, V., Mogan, C., Smith, R., Keller, R., Slepian, M., & Khalpey, Z. (2018). Peripheral VA-ECMO with direct biventricular decompression for refractory cardiogenic shock. Perfusion, 33(6), 493-495.
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  Cardiogenic shock and cardiac arrest are life-threatening emergencies that result in high mortality rates. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) via peripheral cannulation is an option for patients who do not respond to conventional therapies. Left ventricular (LV) distention is a major limitation with peripheral VA-ECMO and is thought to contribute to poor recovery and the inability to wean off VA-ECMO. We report on a novel technique that combines peripheral VA-ECMO with off-pump insertion of a trans-apical LV venting cannula and a right ventricular decompression cannula.
• Roy-Chaudhury, A., Milligan, R., Crabbe, S., Hypes, C., Adhikari, S., Stolz, L., Cairns, C., & Mosier, J. (2018). EARLY POINT-OF-CARE ULTRASOUND IN CRITICAL CARE: HELPFUL, CRITICAL, OR RECREATING THE SWAN PROBLEM?. CRITICAL CARE MEDICINE, 46(1), 141-141.
• Roy-Chaudhury, A., Milligan, R., Crabbe, S., Hypes, C., Adhikari, S., Stolz, L., Cairns, C., & Mosier, J. (2018). EARLY POINT-OF-CARE ULTRASOUND IN CRITICAL CARE: HELPFUL, CRITICAL, OR RECREATING THE SWAN PROBLEM?. JOURNAL OF INVESTIGATIVE MEDICINE, 66(1), 218-218.
• Swazo, R., Cairns, C., & Mosier, J. (2018). THE INCOMPLETE APPRECIATION OF ACUITY IN FEDERALLY FUNDED ACUTE LUNG INJURY RESEARCH. CRITICAL CARE MEDICINE, 46(1), 526-526.
• Hypes, C. D., Sakles, J. C., & Mosier, J. M. (2017). Reply: Did Video Kill the Direct Laryngoscopy Star? Not Yet!. Annals of the American Thoracic Society, 14(4), 610-611.
• Hypes, C., Sakles, J., Joshi, R., Greenberg, J., Natt, B., Malo, J., Bloom, J., Chopra, H., & Mosier, J. (2017). Failure to achieve first attempt success at intubation using video laryngoscopy is associated with increased complications. INTERNAL AND EMERGENCY MEDICINE, 12(8), 1235-1243.
• Jaber, S., Bellani, G., Blanch, L., Demoule, A., Esteban, A., Gattinoni, L., Guerin, C., Hill, N., Laffey, J. G., Maggiore, S. M., Mancebo, J., Mayo, P. H., Mosier, J. M., Navalesi, P., Quintel, M., Vincent, J. L., & Marini, J. J. (2017). The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation. INTENSIVE CARE MEDICINE, 43(9), 1352-1365.
• Jaber, S., Bellani, G., Blanch, L., Demoule, A., Esteban, A., Gattinoni, L., Guérin, C., Hill, N., Laffey, J. G., Maggiore, S. M., Mancebo, J., Mayo, P. H., Mosier, J. M., Navalesi, P., Quintel, M., Vincent, J. L., & Marini, J. J. (2017). The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation. Intensive care medicine, 43(9), 1352-1365.
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  In an important sense, support of the respiratory system has been a defining characteristic of intensive care since its inception. The pace of basic and clinical research in this field has escalated over the past two decades, resulting in palpable improvement at the bedside as measured by both efficacy and outcome. As in all medical research, however, novel ideas built upon observations are continually proposed, tested, and either retained or discarded on the basis of the persuasiveness of the evidence. What follows are concise descriptions of the current standards of management practice in respiratory support, the areas of present-day uncertainty, and our suggested agenda for the near future of research aimed at testing current assumptions, probing uncertainties, and solidifying the foundation on which to base our progress to the next level.
• Mosier, J. M., Hypes, C. D., & Sakles, J. C. (2017). Understanding preoxygenation and apneic oxygenation during intubation in the critically ill. INTENSIVE CARE MEDICINE, 43(2), 226-228.
• Natt, B., Hypes, C., Basekn, R., Malo, J., Kazui, T., & Mosier, J. M. (2017). The use of extracorporeal membrane oxygenation in the bronchoscopic management of critical upper airway obstruction. Journal of Extra Corporeal Technology, 49(1), 54-58.
• Natt, B., Hypes, C., Basken, R., Malo, J., Kazui, T., & Mosier, J. (2017). Suspected Heparin-Induced Thrombocytopenia in Patients Receiving Extracorporeal Membrane Oxygenation. The journal of extra-corporeal technology, 49(1), 54-58.
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  Heparin-induced thrombocytopenia (HIT) is an immune reaction usually secondary to unfractionated heparin. Anticoagulation management is critical in patients while on extracorporeal membrane oxygenation (ECMO) to prevent thromboembolism and for the optimal functioning of the circuit. We identified five patients with respiratory failure at our hospital managed with ECMO in the last 2 years that were treated for HIT. A brief clinical course and their management are discussed. We also briefly review the literature for best evidence for management of such patients.
• Natt, B., Knepler, J. L., Kazui, T., & Mosier, J. M. (2017). The use of extracorporeal membrane oxygenation in the bronchoscopic management of critical upper airway obstruction. J Bronchology Interv Pulmonol, 24(1), e12-e14.
• Natt, B., Knepler, J., Kazui, T., & Mosier, J. M. (2017). The Use of Extracorporeal Membrane Oxygenation in the Bronchoscopic Management of Critical Upper Airway Obstruction. Journal of bronchology & interventional pulmonology, 24(1), e12-e14.
• Rao, P., Skaria, R., Mosier, J., Malo, J., Smith, R., & Khalpey, Z. (2017). Temporary Mechanical Circulatory Support Using a Novel Minimally-Invasive Approach for Central VA-ECMO. CIRCULATION, 136.
• Sakles, J. C., Corn, G. J., Hollinger, P., Arcaris, B., Patanwala, A. E., & Mosier, J. M. (2017). The Impact of a Soiled Airway on Intubation Success in the Emergency Department When Using the GlideScope or the Direct Laryngoscope. ACADEMIC EMERGENCY MEDICINE, 24(5), 628-636.
• Sakles, J. C., Corn, G. J., Hollinger, P., Arcaris, B., Patanwala, A. E., & Mosier, J. M. (2017). The Impact of a Soiled Airway on Intubation Success in the Emergency Department When Using the GlideScope or the Direct Laryngoscope. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 24(5), 628-636.
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  The objective was to determine the impact of a soiled airway on firstpass success when using the GlideScope video laryngoscope or the direct laryngoscope for intubation in the emergency department (ED).
• Sakles, J. C., Douglas, M. J., Hypes, C. D., Patanwala, A. E., & Mosier, J. M. (2017). Management of Patients with Predicted Difficult Airways in an Academic Emergency Department. The Journal of emergency medicine, 53(2), 163-171.
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  Patients with difficult airways are sometimes encountered in the emergency department (ED), however, there is a little data available regarding their management.
• Sakles, J. C., Douglas, M., Hypes, C. D., Patanwala, A. E., & Mosier, J. M. (2017). MANAGEMENT OF PATIENTS WITH PREDICTED DIFFICULT AIRWAYS IN AN ACADEMIC EMERGENCY DEPARTMENT. JOURNAL OF EMERGENCY MEDICINE, 53(2), 163-170.
• Baalachandran, R., Trutter, L. R., Raz, Y., Mosier, J., Kazui, T., & Malo, J. (2016). Successful Use Of Extracorporeal Membrane Oxygenation In A Patient With Pulmonary Coccidioidomycosis-Related Acute Respiratory Distress Syndrome. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193.
• Chase, P. B., Hawkins, J., Mosier, J., Jimenez, E., Boesen, K., Logan, B. K., & Walter, F. G. (2016). Differential physiological and behavioral cues observed in individuals smoking botanical marijuana versus synthetic cannabinoid drugs. CLINICAL TOXICOLOGY, 54(1), 14-19.
• Chase, P. B., Hawkins, J., Mosier, J., Jimenez, E., Boesen, K., Logan, B. K., & Walter, F. G. (2016). Differential physiological and behavioral cues observed in individuals smoking botanical marijuana versus synthetic cannabinoid drugs. Clinical toxicology (Philadelphia, Pa.), 54(1), 14-9.
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  Synthetic cannabinoid use has increased in many states, and medicinal and/or recreational marijuana use has been legalized in some states. These changes present challenges to law enforcement drug recognition experts (DREs) who determine whether drivers are impaired by synthetic cannabinoids or marijuana, as well as to clinical toxicologists who care for patients with complications from synthetic cannabinoids and marijuana. Our goal was to compare what effects synthetic cannabinoids and marijuana had on performance and behavior, including driving impairment, by reviewing records generated by law enforcement DREs who evaluated motorists arrested for impaired driving.
• Cristan, E., Mosier, J., Hypes, C., Greenberg, J., Morrissette, K., Milligan, R., Sakles, J., & Malo, J. (2016). IMPROVEMENT IN TRACHEAL INTUBATION OVER TIME WITH THE INSTITUTION OF A QUALITY IMPROVEMENT PROGRAM. CRITICAL CARE MEDICINE, 44(12).
• Gaither, J. B., Stolz, U., Ennis, J., Moiser, J., & Sakles, J. C. (2016). Association Between Difficult Airway Predictors and Failed Prehosptial Endotracheal Intubation. Air medical journal, 34(6), 343-7.
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  Difficult airway predictors (DAPs) are associated with failure of endotracheal intubation (ETI) in the emergency department (ED). The purpose of this study was to determine if DAPs are associated with failure of prehospital ETI.
• Greenberg, J., Mosier, J., Malo, J., Morrissette, K., Cristan, E., Milligan, R., Sakles, J., & Hypes, C. (2016). REINTUBATION IN THE INTENSIVE CARE UNIT: IS IT TRULY AS DIFFICULT AS ASSUMED?. CRITICAL CARE MEDICINE, 44(12).
• Hypes, C. D., Sakles, J. C., & Mosier, J. M. (2016). Reply: Video Laryngoscopy: Take It to the Floor. Annals of the American Thoracic Society, 13(7), 1193-4.
• Hypes, C., Sakles, J., Joshi, R., Greenberg, J., Natt, B., Malo, J., Bloom, J., Chopra, H., & Mosier, J. (2016). Failure to achieve first attempt success at intubation using video laryngoscopy is associated with increased complications. Internal and emergency medicine.
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  The purpose of this investigation was to investigate the association between first attempt success and intubation-related complications in the Intensive Care Unit after the widespread adoption of video laryngoscopy. We further sought to characterize and identify the predictors of complications that occur despite first attempt success. This was a prospective observational study of consecutive intubations performed with video laryngoscopy at an academic medical Intensive Care Unit. Operator, procedural, and complication data were collected. Multivariable logistic regression was used to examine the relationship between the intubation attempts and the occurrence of one or more complications. A total of 905 patients were intubated using a video laryngoscope. First attempt success occurred in 739 (81.7 %), whereas >1 attempt was needed in 166 (18.3 %). One or more complications occurred in 146 (19.8 %) of those intubated on the first attempt versus 107 (64.5 %, p 1 attempt is associated with 6.4 (95 % CI 4.4-9.3) times the adjusted odds of at least one complication. Pre-intubation predictors of at least one complication despite first attempt success include vomit or edema in the airway as well as the presence of hypoxemia or hypotension. There are increased odds of complications with even a second attempt at intubation in the Intensive Care Unit. Complications occur frequently despite a successful first attempt, and as such, the goal of airway management should not be simply first attempt success, but instead first attempt success without complications.
• Joshi, R., Hypes, C. D., Greenberg, J., Snyder, L., Malo, J., Bloom, J. W., Chopra, H., Sakles, J. C., & Mosier, J. M. (2016). Difficult Airway Characteristics Associated with First Attempt Failure at Intubation Using Video Laryngoscopy in the Intensive Care Unit. Annals of the American Thoracic Society.
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  Video laryngoscopy has overcome the need to align the anatomic axes to obtain a view of the glottic opening in order to place a tracheal tube. However, despite this advantage, a large number of attempts are unsuccessful. There are no existing data on anatomic characteristics in critically ill patients associated with a failed first attempt at laryngoscopy when using video laryngoscopy.
• Milligan, R., Mosier, J., Greenberg, J., Morrissette, K., Cristan, E., Natt, B., Saldes, J., & Hypes, C. (2016). A COMPARISON OF C-MAC AND GLIDESCOPE VIDEO LARYNGOSCOPES FOR INTUBATION IN THE INTENSIVE CARE UNIT. CRITICAL CARE MEDICINE, 44(12).
• Minckler, M. R., Curry, M., & Mosier, J. M. (2016). First Time Seizure in the Setting of a Congenital Heart Abnormality and MCA Mycotic Aneurysms. Journal of clinical medicine, 5(4).
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  A 37 year-old man presented to the Emergency Department (ED) with new onset seizure and fall from standing.[...].
• Morrissette, K., Mosier, J., Cristan, E., Milligan, R., Greenberg, J., Natt, B., Sakles, J., & Hypes, C. (2016). FLEXIBLE FIBEROPTIC VERSUS VIDEO LARYGOSCOPY: INSIGHTS ON DIFFICULT AIRWAY SUCCESS AND COMPLICATIONS. CRITICAL CARE MEDICINE, 44(12).
• Mosier, J. M., Hypes, C. D., & Sakles, J. C. (2016). Understanding preoxygenation and apneic oxygenation during intubation in the critically ill. Intensive care medicine.
• Natt, B. S., Malo, J., Hypes, C. D., Sakles, J. C., & Mosier, J. M. (2016). Strategies to improve first attempt success at intubation in critically ill patients. BRITISH JOURNAL OF ANAESTHESIA, 117, 60-68.
• Natt, B. S., Malo, J., Hypes, C. D., Sakles, J. C., & Mosier, J. M. (2016). Strategies to improve first attempt success at intubation in critically ill patients. British journal of anaesthesia, 117 Suppl 1, i60-i68.
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  Tracheal intubation in critically ill patients is a high-risk procedure. The risk of complications increases with repeated or prolonged attempts, making expedient first attempt success the goal for airway management in these patients. Patient-related factors often make visualization of the airway and placement of the tracheal tube difficult. Physiologic derangements reduce the patient's tolerance for repeated or prolonged attempts at laryngoscopy and, as a result, hypoxaemia and haemodynamic deterioration are common complications. Operator-related factors such as experience, device selection, and pharmacologic choices affect the odds of a successful intubation on the first attempt. This review will discuss the 'difficult airway' in critically ill patients and highlight recent advances in airway management that have been shown to improve first attempt success and decrease adverse events associated with the intubation of critically ill patients.
• Natt, B., Mosier, J., Lutrick, K., Hypes, C., Malo, J., Kazui, T., & Cairns, C. (2016). DEMOGRAPHICS OF SEVERE INFLUENZA DURING THE 2016 SEASON: A TERTIARY CARE HOSPITAL EXPERIENCE. CRITICAL CARE MEDICINE, 44(12).
• Natt, B., Natt, B., Malo, J., Malo, J., Hypes, C., Hypes, C., Sakles, J. C., Sakles, J. C., Mosier, J. M., & Mosier, J. M. (2016). Strategies to improve first attempt success at intubation in critically ill patients.. British Journal of Anaesthesia, 117, i60-i68.
• Sakles, J. C., & Mosier, J. M. (2016). COMPARATIVE PERFORMANCE OF GLIDESCOPE VIDEOLARYNGOSCOPE WITH DIRECT LARYNGOSCOPE FOR EMERGENCY INTUBATION REPLY. JOURNAL OF EMERGENCY MEDICINE, 51(2), 188-189.
• Sakles, J. C., & Mosier, J. M. (2016). Reply. The Journal of emergency medicine, 51(2), 188-9.
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., & Dicken, J. M. (2016). Apneic oxygenation is associated with a reduction in the incidence of hypoxemia during the RSI of patients with intracranial hemorrhage in the emergency department. INTERNAL AND EMERGENCY MEDICINE, 11(7), 983-992.
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., & Dicken, J. M. (2016). Apneic oxygenation is associated with a reduction in the incidence of hypoxemia during the RSI of patients with intracranial hemorrhage in the emergency department. Internal and emergency medicine, 11(7), 983-92.
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  Critically ill patients undergoing emergent intubation are at risk of oxygen desaturation during the management of their airway. Patients with intracranial hemorrhage (ICH) are particularly susceptible to the detrimental effects of hypoxemia. Apneic oxygenation (AP OX) may be able to reduce the occurrence of oxygen desaturation during the emergent intubation of these patients. We sought to assess the effect AP OX on oxygen desaturation during the rapid sequence intubation (RSI) of patients with ICH in the emergency department (ED). We prospectively collected data on all patients intubated in an urban academic ED over the 2-year period from July 1, 2013 to June 30, 2015. Following each intubation, the operator completed a standardized continuous quality improvement (CQI) data form, which included information on patient, operator and intubation characteristics. Operators recorded data on the use of AP OX, the oxygen flow rate used for AP OX, and the starting and lowest saturations during intubation. Adult patients with ICH who underwent RSI by emergency medicine (EM) residents were included in the analyses. The primary outcome variable was any oxygen saturation
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., Arcaris, B., & Dicken, J. M. (2016). First Pass Success Without Hypoxemia Is Increased With the Use of Apneic Oxygenation During Rapid Sequence Intubation in the Emergency Department. ACADEMIC EMERGENCY MEDICINE, 23(6), 703-710.
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., Arcaris, B., & Dicken, J. M. (2016). First Pass Success Without Hypoxemia Is Increased With the Use of Apneic Oxygenation During Rapid Sequence Intubation in the Emergency Department. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 23(6), 703-10.
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  The objective was to determine the effect of apneic oxygenation (AP OX) on first pass success without hypoxemia (FPS-H) in adult patients undergoing rapid sequence intubation (RSI) in the emergency department (ED).
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., Arcaris, B., & Dicken, J. M. (2016). THE UTILITY OF THE C-MAC AS A DIRECT LARYNGOSCOPE FOR INTUBATION IN THE EMERGENCY DEPARTMENT. JOURNAL OF EMERGENCY MEDICINE, 51(4), 349-357.
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., Arcaris, B., & Dicken, J. M. (2016). The Utility of the C-MAC as a Direct Laryngoscope for Intubation in the Emergency Department. The Journal of emergency medicine, 51(4), 349-357.
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  Although the C-MAC (Karl Storz, Tuttlingen, Germany) is a video laryngoscope (VL), it can also be used as a direct laryngoscope (DL).
• Sakles, J., Arcaris, B., Patanwala, A., & Mosier, J. (2016). First-pass success without hypoxaemia is increased with the use of apnoeic oxygenation with rapid sequence induction in the emergency department. BRITISH JOURNAL OF ANAESTHESIA, 117, 108-108.
• Chopra, H., Mosier, J. M., Sackles, J. C., Malo, J., & Bloom, J. W. (2015). NEUROMUSCULAR BLOCKADE IMPROVES FIRST ATTEMPT SUCCESS FOR INTUBATION IN THE INTENSIVE CARE UNIT. JOURNAL OF INVESTIGATIVE MEDICINE, 63(1), 192-193.
• Gaither, J. B., Stolz, U., Ennis, J., Moiser, J., & Sakles, J. C. (2015). Association Between Difficult Airway Predictors and Failed Prehosptial Endotracheal Intubation. Air medical journal, 34(6), 343-7.
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  Difficult airway predictors (DAPs) are associated with failure of endotracheal intubation (ETI) in the emergency department (ED). The purpose of this study was to determine if DAPs are associated with failure of prehospital ETI.
• Greenberg, J., Mosier, J., Joshi, R., Bloom, J., Malo, J., Sakles, J., & Hypes, C. (2015). FIRST ATTEMPT SUCCESS AT INTUBATION IS ASSOCIATED WITH A LOWER ODDS OF ADVERSE EVENTS IN THE ICU.. CRITICAL CARE MEDICINE, 43(12).
• Hypes, C. D., Stolz, U., Sakles, J. C., Joshi, R. R., Natt, B., Malo, J., Bloom, J. W., & Mosier, J. M. (2015). Video Laryngoscopy Improves Odds of First Attempt Success at Intubation in the ICU: A Propensity-Matched Analysis. Annals of the American Thoracic Society.
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  Urgent tracheal intubation is performed frequently in intensive care units and incurs higher risk than when intubation is performed under more controlled circumstances. Video laryngoscopy may improve the chances of successful tracheal intubation on the first attempt; however existing comparative data on outcomes are limited.
• Johnston, D., Mosier, J., Joshi, R., Malo, J., Sakles, J., Bloom, J., & Hypes, C. (2015). REASON FOR FAILED ATTEMPTS AT LARYNGOSCOPY DIFFERS BETWEEN VIDEO AND DIRECT LARYNGOSCOPES. CRITICAL CARE MEDICINE, 43(12).
• Joshi, R., Hypes, C., Malo, J., Bloom, J., Sakles, J., & Mosier, J. (2015). PREDICTORS OF DIFFICULT INTUBATION WHEN USING VIDEO LARYNGOSCOPY IN THE ICU. CRITICAL CARE MEDICINE, 43(12).
• Joshi, R., de Witt, B., & Mosier, J. M. (2015). OPTIMIZING OXYGEN DELIVERY IN THE CRITICALLY ILL: THE UTILITY OF LACTATE AND CENTRAL VENOUS OXYGEN SATURATION (SCVO2) AS A ROADMAP OF RESUSCITATION IN SHOCK. JOURNAL OF EMERGENCY MEDICINE, 47(4), 493-500.
• Kelsey, M., Hypes, C., Joshi, R., Malo, J., Bloom, J., Sakles, J., & Mosier, J. (2015). DERIVATION OF A BUNDLE TO IMPROVE FIRST ATTEMPT SUCCESS AT INTUBATION IN THE ICU. CRITICAL CARE MEDICINE, 43(12).
• Michailidou, M., O'Keeffe, T., Mosier, J. M., Friese, R. S., Joseph, B., Rhee, P., & Sakles, J. C. (2015). A comparison of video laryngoscopy to direct laryngoscopy for the emergency intubation of trauma patients. World journal of surgery, 39(3), 782-8.
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  Direct laryngoscopy (DL) has long been the gold standard for tracheal intubation in emergency and trauma patients. Video laryngoscopy (VL) is increasingly used in many settings and the purpose of this study was to compare its effectiveness to direct laryngoscopy in trauma patients. Our hypothesis was that the success rate of VL would be higher than that of DL.
• Mosier, J. M., Hypes, C., Joshi, R., Whitmore, S., Parthasarathy, S., & Cairns, C. B. (2015). Ventilator Strategies and Rescue Therapies for Management of Acute Respiratory Failure in the Emergency Department. Annals of emergency medicine, 66(5), 529-41.
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  Acute respiratory failure is commonly encountered in the emergency department (ED), and early treatment can have effects on long-term outcome. Noninvasive ventilation is commonly used for patients with respiratory failure and has been demonstrated to improve outcomes in acute exacerbations of chronic obstructive lung disease and congestive heart failure, but should be used carefully, if at all, in the management of asthma, pneumonia, and acute respiratory distress syndrome. Lung-protective tidal volumes should be used for all patients receiving mechanical ventilation, and FiO2 should be reduced after intubation to achieve a goal of less than 60%. For refractory hypoxemia, new rescue therapies have emerged to help improve the oxygenation, and in some cases mortality, and should be considered in ED patients when necessary, as deferring until ICU admission may be deleterious. This review article summarizes the pathophysiology of acute respiratory failure, management options, and rescue therapies including airway pressure release ventilation, continuous neuromuscular blockade, inhaled nitric oxide, and extracorporeal membrane oxygenation.
• Mosier, J. M., Joshi, R., Hypes, C., Pacheco, G. S., Valenzuela, T. D., & Sakles, J. C. (2015). The Physiologically Difficult Airway. Western Journal of Emergency Medicine, 16(7), 1109-1117.
• Mosier, J. M., Joshi, R., Hypes, C., Pacheco, G., Valenzuela, T. D., & Sakles, J. C. (2015). The physiologically difficult airway. Western Journal of Emergency Medicine, 16(7), 1109-1117.
• Mosier, J. M., Joshi, R., Hypes, C., Pacheco, G., Valenzuela, T., & Sakles, J. C. (2015). The Physiologically Difficult Airway. The western journal of emergency medicine, 16(7), 1109-17.
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  Airway management in critically ill patients involves the identification and management of the potentially difficult airway in order to avoid untoward complications. This focus on difficult airway management has traditionally referred to identifying anatomic characteristics of the patient that make either visualizing the glottic opening or placement of the tracheal tube through the vocal cords difficult. This paper will describe the physiologically difficult airway, in which physiologic derangements of the patient increase the risk of cardiovascular collapse from airway management. The four physiologically difficult airways described include hypoxemia, hypotension, severe metabolic acidosis, and right ventricular failure. The emergency physician should account for these physiologic derangements with airway management in critically ill patients regardless of the predicted anatomic difficulty of the intubation.
• Mosier, J. M., Kelsey, M., Raz, Y., Gunnerson, K. J., Meyer, R., Hypes, C. D., Malo, J., Whitmore, S. P., & Spaite, D. W. (2015). Extracorporeal membrane oxygenation (ECMO) for critically ill adults in the emergency department: history, current applications, and future directions. Critical care (London, England), 19, 431.
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  Extracorporeal membrane oxygenation (ECMO) is a mode of extracorporeal life support that augments oxygenation, ventilation and/or cardiac output via cannulae connected to a circuit that pumps blood through an oxygenator and back into the patient. ECMO has been used for decades to support cardiopulmonary disease refractory to conventional therapy. While not robust, there are promising data for the use of ECMO in acute hypoxemic respiratory failure, cardiac arrest, and cardiogenic shock and the potential indications for ECMO continue to increase. This review discusses the existing literature on the potential use of ECMO in critically ill patients within the emergency department.
• Mosier, J. M., Malo, J., Sakles, J. C., Hypes, C. D., Natt, B., Snyder, L., Knepler, J., Bloom, J. W., Joshi, R., & Knox, K. (2015). The impact of a comprehensive airway management training program for pulmonary and critical care medicine fellows. A three-year experience. Annals of the American Thoracic Society, 12(4), 539-48.
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  Airway management in the intensive care unit (ICU) is challenging, as many patients have limited physiologic reserve and are at risk for clinical deterioration if the airway is not quickly secured. In academic medical centers, ICU intubations are often performed by trainees, making airway management education paramount for pulmonary and critical care trainees.
• Mosier, J. M., Sakles, J. C., Stolz, U., Hypes, C. D., Chopra, H., Malo, J., & Bloom, J. W. (2015). Neuromuscular blockade improves first-attempt success for intubation in the intensive care unit. A propensity matched analysis. Annals of the American Thoracic Society, 12(5), 734-41.
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  The use of neuromuscular blocking agents (NMBAs) has been shown to be valuable in improving successful tracheal intubation in the operating room and emergency department. However, data on NMBA use in critically ill intensive care unit (ICU) patients are lacking. Furthermore, there are no data on NMBA use with video laryngoscopy.
• Mosier, J. M., Sakles, J. C., Whitmore, S. P., Hypes, C. D., Hallett, D. K., Hawbaker, K. E., Snyder, L. S., & Bloom, J. W. (2015). Failed noninvasive positive-pressure ventilation is associated with an increased risk of intubation-related complications. ANNALS OF INTENSIVE CARE, 5, 1-9.
• Mosier, J. M., Sakles, J. C., Whitmore, S. P., Hypes, C. D., Hallett, D. K., Hawbaker, K. E., Snyder, L. S., & Bloom, J. W. (2015). Failed noninvasive positive-pressure ventilation is associated with an increased risk of intubation-related complications. Annals of intensive care, 5, 4.
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  Noninvasive positive-pressure ventilation (NIPPV) use has increased in the treatment of patients with respiratory failure. However, despite decreasing the need for intubation in some patients, there are no data regarding the risk of intubation-related complications associated with delayed intubation in adult patients who fail NIPPV. The objective of this study is to evaluate the odds of a composite complication of intubation following failed NIPPV compared to patients intubated primarily in the medical intensive care unit (ICU).
• Mosier, J., Itty, A., Sanders, A., Mohler, J., Wendel, C., Poulsen, J., Shellenberger, J., Clark, L., & Bobrow, B. (2015). Cardiocerebral Resuscitation Is Associated With Improved Survival and Neurologic Outcome from Out-of-hospital Cardiac Arrest in Elders. ACADEMIC EMERGENCY MEDICINE, 17(3), 269-275.
• Pacheco, G., Hypes, C., Joshi, R., & Mosier, J. (2015). EMERGENCY DEPARTMENT RECOGNITION OF CRITICAL ILLNESS-RELATED CORTICOSTEROID INSUFFICIENCY. CRITICAL CARE MEDICINE, 43(12).
• Panchal, A. R., Satyanarayan, A., Bahadir, J. D., Hays, D., & Mosier, J. (2015). EFFICACY OF BOLUS-DOSE PHENYLEPHRINE FOR PERI-INTUBATION HYPOTENSION. JOURNAL OF EMERGENCY MEDICINE, 49(4), 488-494.
• Panchal, A. R., Satyanarayan, A., Bahadir, J. D., Hays, D., & Mosier, J. (2015). Efficacy of Bolus-dose Phenylephrine for Peri-intubation Hypotension. The Journal of emergency medicine, 49(4), 488-94.
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  Intubation in hypotensive emergency department (ED) patients may increase the risk of life-threatening complications such as hypoperfusion and cardiovascular collapse. Peripherally administered, diluted "push-dose" phenylephrine has been advocated to treat peri-intubation hypotension, however, its effectiveness is unknown.
• Prescher, H., Grover, E., Mosier, J., Stolz, U., Biffar, D. E., Hamilton, A. J., & Sakles, J. C. (2015). Telepresent Intubation Supervision Is as Effective as In-Person Supervision of Procedurally Naive Operators. TELEMEDICINE AND E-HEALTH, 21(3), 170-175.
• Prescher, H., Grover, E., Mosier, J., Stolz, U., Biffar, D. E., Hamilton, A. J., & Sakles, J. C. (2015). Telepresent intubation supervision is as effective as in-person supervision of procedurally naive operators. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 21(3), 170-5.
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  Telepresence is emerging in clinical and educational settings as a potential modality to provide expert guidance during remote airway management. This study aimed to compare the effectiveness of telepresent versus in-person supervision of tracheal intubation.
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., Dicken, J. M., Kalin, L., & Javedani, P. P. (2015). The C-MAC® video laryngoscope is superior to the direct laryngoscope for the rescue of failed first-attempt intubations in the emergency department. The Journal of emergency medicine, 48(3), 280-6.
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  To compare the effectiveness of the C-MAC® video laryngoscope (CMAC) to the direct laryngoscope (DL) when used to rescue a failed first attempt intubation in the emergency department (ED).
• Stolz, L. A., Mosier, J. M., Gross, A. M., Douglas, M. J., Blaivas, M., & Adhikari, S. (2015). Can emergency physicians perform common carotid Doppler flow measurements to assess volume responsiveness?. The western journal of emergency medicine, 16(2), 255-9.
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  Common carotid flow measurements may be clinically useful to determine volume responsiveness. The objective of this study was to assess the ability of emergency physicians (EP) to obtain sonographic images and measurements of the common carotid artery velocity time integral (VTi) for potential use in assessing volume responsiveness in the clinical setting.
• Thajudeen, B., Kamel, M., Arumugam, C., Ali, S. A., John, S. G., Meister, E. E., Mosier, J. M., Raz, Y., Madhrira, M., Thompson, J., & Sussman, A. N. (2015). Outcome of patients on combined extracorporeal membrane oxygenation and continuous renal replacement therapy: a retrospective study. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 38(3), 133-137.
• Thajudeen, B., Kamel, M., Arumugam, C., Ali, S. A., John, S. G., Meister, E. E., Mosier, J. M., Raz, Y., Madhrira, M., Thompson, J., & Sussman, A. N. (2015). Outcome of patients on combined extracorporeal membrane oxygenation and continuous renal replacement therapy: a retrospective study. The International journal of artificial organs, 38(3), 133-7.
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  Extracorporeal membrane oxygenation (ECMO) is a lifesaving therapy used in the management of cardiopulmonary failure. Continuous renal replacement therapy (CRRT) is often added to the treatment for the correction of fluid and electrolyte imbalance in patients with acute kidney injury. Most of the literature on the use of combined ECMO and CRRT has been on pediatric patients. There are limited outcome data on the use of these combined modalities in adult patients.
• Adhikari, S., Fiorello, A., Stolz, L., Jones, T., Amini, R., Gross, A., O'Brien, K., Mosier, J., & Blaivas, M. (2014). Ability of emergency physicians with advanced echocardiographic experience at a single center to identify complex echocardiographic abnormalities. AMERICAN JOURNAL OF EMERGENCY MEDICINE, 32(4), 363-366.
• Adhikari, S., Fiorello, A., Stolz, L., Jones, T., Amini, R., Gross, A., O'Brien, K., Mosier, J., & Blaivas, M. (2014). Ability of emergency physicians with advanced echocardiographic experience at a single center to identify complex echocardiographic abnormalities. The American journal of emergency medicine, 32(4), 363-6.
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  To determine the ability of emergency physicians to detect complex abnormalities on point-of-care (POC) echocardiograms.
• Dalabih, M., Rischard, F., & Mosier, J. M. (2014). What's new: the management of acute right ventricular decompensation of chronic pulmonary hypertension. Intensive care medicine, 40(12), 1930-3.
• Gaither, J. B., Spaite, D. W., Stolz, U., Ennis, J., Mosier, J., & Sakles, J. J. (2014). Prevalence of difficult airway predictors in cases of failed prehospital endotracheal intubation. The Journal of emergency medicine, 47(3), 294-300.
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  Difficult airway predictors (DAPs) are associated with failed endotracheal intubation (ETI) in the emergency department (ED). However, little is known about the relationship between DAPs and failed prehospital ETI.
• Joshi, R., de Witt, B., & Mosier, J. M. (2014). Optimizing oxygen delivery in the critically ill: the utility of lactate and central venous oxygen saturation (ScvO2) as a roadmap of resuscitation in shock. The Journal of emergency medicine, 47(4), 493-500.
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  Resuscitation of any critically ill patient is aimed at restoration of oxygen delivery to maintain aerobic metabolism. Thus, "endpoints" of resuscitation have been sought after as a measure of evaluating the adequacy of resuscitation. This review article describes the most commonly used endpoints, central venous oxygen saturation (ScvO2) and lactate, and provides a clinically useful paradigm for utilizing these endpoints during resuscitation of critically ill patients in the emergency department (ED).
• Mosier, J. M., & Law, J. A. (2014). Airway management in the critically ill. Intensive care medicine, 40(5), 727-9.
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  Successful first attempt intubation of the critically ill patient is of extreme importance. While these patients are anatomically and physiologically complicated, making intubation particularly risky, several important steps have recently been shown to improve the chances of a safe first attempt success. Proper evaluation, planning, positioning, preoxygenation, and in select patients the use of a neuromuscular blocking agent have all been shown to be useful for minimizing the difficult intubation and intubation- related complications. Additionally, although there is significant controversy regarding video laryngoscopy, the use of a video laryngoscope as the primary method of intubation has been shown in all cases to be at least as good as, and often more successful than, direct laryngoscopy.
• Mosier, J. M., Malo, J., Stolz, L. A., Bloom, J. W., Reyes, N. A., Snyder, L. S., & Adhikari, S. (2014). Critical care ultrasound training: a survey of US fellowship directors. Journal of critical care, 29(4), 645-9.
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  The purpose of this study is to describe the current state of bedside ultrasound use and training among critical care (CC) training programs in the United States.
• Mosier, J. M., Stolz, L. A., Bloom, J. W., Malo, J., Snyder, L. S., Fiorello, A. B., Adhikari, S. R., Mosier, J. M., Stolz, L. A., Bloom, J. W., Malo, J., Snyder, L. S., Fiorello, A. B., & Adhikari, S. R. (2014). Resuscitative Echocardiography for the Evaluation and Management of Shock: The RECES protocol. Southwest Journal of Pulmonary and Critical Care, 8(2), 110-25.
• Mosier, J. M., Stolz, U., Chiu, S., & Sakles, J. C. (2014). DIFFICULT AIRWAY MANAGEMENT IN THE EMERGENCY DEPARTMENT: GLIDESCOPE VIDEOLARYNGOSCOPY COMPARED TO DIRECT LARYNGOSCOPY. JOURNAL OF EMERGENCY MEDICINE, 42(6), 629-634.
• Mosier, J., Chiu, S., Patanwala, A. E., & Sakles, J. C. (2014). A Comparison of the GlideScope Video Laryngoscope to the C-MAC Video Laryngoscope for Intubation in the Emergency Department. ANNALS OF EMERGENCY MEDICINE, 61(4), 414-420.
• Mosier, J., Joseph, B., & Sakles, J. C. (2014). Telebation: Next-Generation Telemedicine in Remote Airway Management Using Current Wireless Technologies. TELEMEDICINE AND E-HEALTH, 19(2), 95-98.
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., Dicken, J. M., Kalin, L., & Javedani, P. P. (2014). THE C-MAC (R) VIDEO LARYNGOSCOPE IS SUPERIOR TO THE DIRECT LARYNGOSCOPE FOR THE RESCUE OF FAILED FIRST-ATTEMPT INTUBATIONS IN THE EMERGENCY DEPARTMENT. JOURNAL OF EMERGENCY MEDICINE, 48(3), 280-286.
• Sakles, J. C., Mosier, J., Patanwala, A. E., & Dicken, J. (2014). Improvement in GlideScope (R) Video Laryngoscopy performance over a seven-year period in an academic emergency department. INTERNAL AND EMERGENCY MEDICINE, 9(7), 789-794.
• Sakles, J. C., Mosier, J., Patanwala, A. E., & Dicken, J. (2014). Improvement in GlideScope® Video Laryngoscopy performance over a seven-year period in an academic emergency department. Internal and emergency medicine, 9(7), 789-94.
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  To evaluate the outcomes in first pass success (FPS) of GlideScope (GVL) intubations over a seven-year period in an academic ED. Data were prospectively collected on all patients intubated in an academic ED with a level 1 trauma center over the seven-year period from July 1, 2007 to June 30, 2014. Following each intubation, the operator completed a standardized data collection form that included information on patient, operator and procedure characteristics. The primary outcome was first pass success, defined as successful intubation with a single laryngoscope blade insertion. The secondary outcome was the Cormack-Lehane (CL) view of the airway. To adjust for important confounders, a logistic regression model was used to determine the association between academic year and first pass success. In the first year of the study, the first pass success with the GVL was 75.6% (68/90; 95% CI 65.4-84.0%) and the percentage of patients with CL I/II views was 95.6% (86/90; 95% CI 89.0-98.8%). By the seventh year of the study, the first pass success with the GVL increased to 92.1% (128/139; 95% CI 86.3-96.0%) and the percentage of patients with CL I/II views was 94.2% (131/139; 95% CI 89.0-97.5%). In the logistic regression model, first pass success improved during the seven-year period (aOR 3.1; 95% CI 1.3-7.1; p = 0.008). Over the seven-year period, there was significant improvement in the first pass success of the GVL, without any change in the Cormack-Lehane view, suggesting that there was improvement in the skill of tube delivery with use of the GVL over time.
• Sakles, J. C., Mosier, J., Patanwala, A. E., & Dicken, J. (2014). Learning curves for direct laryngoscopy and GlideScope® video laryngoscopy in an emergency medicine residency. The western journal of emergency medicine, 15(7), 930-7.
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  Our objective is to evaluate the resident learning curves for direct laryngoscopy (DL) and GlideScope® video laryngoscopy (GVL) over the course of an emergency medicine (EM) residency training program.
• Sakles, J. C., Patanwala, A. E., Mosier, J. M., & Dicken, J. M. (2014). Comparison of video laryngoscopy to direct laryngoscopy for intubation of patients with difficult airway characteristics in the emergency department. INTERNAL AND EMERGENCY MEDICINE, 9(1), 93-98.
• Sakles, J. C., Patanwala, A. E., Mosier, J. M., & Dicken, J. M. (2014). Comparison of video laryngoscopy to direct laryngoscopy for intubation of patients with difficult airway characteristics in the emergency department. Internal and emergency medicine, 9(1), 93-8.
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  The objective of the study is to compare the efficacy of video laryngoscopy (VL) to direct laryngoscopy (DL) on the first pass intubation success of patients with difficult airway characteristics (DACs) in the emergency department (ED). Over a 6-year period, between July 1 2007 and June 30 2013, all intubations performed in an academic ED were recorded in a continuous quality improvement (CQI) database by the operators. The CQI form included information such as patient demographics, operator level of training, device(s) used, number of attempts and outcome of each attempt. In addition, operators performed a difficult airway assessment and noted the presence or absence of the following difficult airway characteristics (DACs): airway edema, cervical immobility, facial/neck trauma, large tongue, obesity, short neck, small mandible, and blood or vomit in the airway. Patients
• Sakles, J. C., Patanwala, A. E., Mosier, J., Dicken, J., & Holman, N. (2014). Comparison of the reusable standard GlideScope® video laryngoscope and the disposable cobalt GlideScope® video laryngoscope for tracheal intubation in an academic emergency department: a retrospective review. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 21(4), 408-15.
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  The objective was to compare the first-pass success and clinical performance characteristics of the reusable standard GlideScope® video laryngoscope (sGVL) and the disposable Cobalt GlideScope® video laryngoscope (cGVL).
• de Witt, B., Joshi, R., Meislin, H., & Mosier, J. M. (2014). Optimizing oxygen delivery in the critically ill: assessment of volume responsiveness in the septic patient. The Journal of emergency medicine, 47(5), 608-15.
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  Assessing volume responsiveness, defined as an increase in cardiac index after infusion of fluids, is important when caring for critically ill patients in septic shock, as both under- and over-resuscitation can worsen outcomes. This review article describes the currently available methods of assessing volume responsiveness for critically ill patients in the emergency department, with a focus on patients in septic shock.
• de, W. B., Joshi, R., Meislin, H., & Mosier, J. M. (2014). OPTIMIZING OXYGEN DELIVERY IN THE CRITICALLY ILL: ASSESSMENT OF VOLUME RESPONSIVENESS IN THE SEPTIC PATIENT. JOURNAL OF EMERGENCY MEDICINE, 47(5), 608-615.
• Adhikari, S., Fiorello, A., Stolz, L., Amini, R., Gross, A., O'Brien, K., Mosier, J., & Blaivas, M. (2013). Can Emergency Physicians Accurately Identify Complex Abnormalities on Point-of-Care Echocardiogram?. ANNALS OF EMERGENCY MEDICINE, 62(4), S78-S78.
• DeLuca, L. A., Shirazi, F., Guisto, J., Denninghoff, K., Mosier, J., Whitmore, S., & Meislin, H. (2013). DEVELOPMENT OF A HOSPITAL CREDENTIALING INSTRUMENT FOR EMERGENCY MEDICINE PHYSICIANS WHO HAVE COMPLETED FELLOWSHIP TRAINING CRITICAL CARE MEDICINE. INTENSIVE CARE MEDICINE, 39, S317-S318.
• Mosier, J. M., Whitmore, S. P., Bloom, J. W., Snyder, L. S., Graham, L. A., Carr, G. E., & Sakles, J. C. (2013). Video laryngoscopy improves intubation success and reduces esophageal intubations compared to direct laryngoscopy in the medical intensive care unit. CRITICAL CARE, 17(5).
• Mosier, J. M., Whitmore, S. P., Bloom, J. W., Snyder, L. S., Graham, L. A., Carr, G. E., & Sakles, J. C. (2013). Video laryngoscopy improves intubation success and reduces esophageal intubations compared to direct laryngoscopy in the medical intensive care unit. Critical care (London, England), 17(5), R237.
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  Tracheal intubation in the Intensive Care Unit (ICU) can be challenging as patients often have anatomic and physiologic characteristics that make intubation particularly difficult. Video laryngoscopy (VL) has been shown to improve first attempt success compared to direct laryngoscopy (DL) in many clinical settings and may be an option for ICU intubations.
• Mosier, J., Chiu, S., Patanwala, A. E., & Sakles, J. C. (2013). A comparison of the GlideScope video laryngoscope to the C-MAC video laryngoscope for intubation in the emergency department. Annals of emergency medicine, 61(4), 414-420.e1.
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  There is growing use of video laryngoscopy in US emergency departments (EDs). This study seeks to compare intubation success between the GlideScope video laryngoscope and the C-MAC video laryngoscope (C-MAC) in ED intubations.
• Mosier, J., Joseph, B., & Sakles, J. C. (2013). Telebation: next-generation telemedicine in remote airway management using current wireless technologies. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 19(2), 95-8.
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  Since the first remote intubation with telemedicine guidance, wireless technology has advanced to enable more portable methods of telemedicine involvement in remote airway management.
• Mosier, J., Roper, G., Hays, D., & Guisto, J. (2013). Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. The western journal of emergency medicine, 14(6), 646-9.
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  Migraine headaches requiring an emergency department visit due to failed outpatient rescue therapy present a significant challenge in terms of length of stay (LOS) and financial costs. Propofol therapy may be effective at pain reduction and reduce that length of stay given its pharmacokinetic properties as a short acting intravenous sedative anesthetic and pharmacodynamics on GABA mediated chloride flux.
• Sakles, J. C., Chiu, S., Mosier, J., Walker, C., & Stolz, U. (2013). The Importance of First Pass Success When Performing Orotracheal Intubation in the Emergency Department. ACADEMIC EMERGENCY MEDICINE, 20(1), 71-78.
• Sakles, J. C., Chiu, S., Mosier, J., Walker, C., & Stolz, U. (2013). The importance of first pass success when performing orotracheal intubation in the emergency department. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 20(1), 71-8.
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  The goal of this study was to determine the association of first pass success with the incidence of adverse events (AEs) during emergency department (ED) intubations.
• Sakles, J. C., Mosier, J. M., Chiu, S., & Keim, S. M. (2013). TRACHEAL INTUBATION IN THE EMERGENCY DEPARTMENT: A COMPARISON OF GLIDESCOPE (R) VIDEO LARYNGOSCOPY TO DIRECT LARYNGOSCOPY IN 822 INTUBATIONS. JOURNAL OF EMERGENCY MEDICINE, 42(4), 400-405.
• Sakles, J. C., Mosier, J., & Stolz, U. (2013). In reply. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 20(9), 966.
• Sakles, J. C., Mosier, J., Cosentino, M., & Patanwala, A. (2013). Incidence of Hypoxemia During Rapid Sequence Intubation of Head-Injured Patients in the Emergency Department. ANNALS OF EMERGENCY MEDICINE, 62(4), S147-S147.
• Sakles, J. C., Mosier, J., Hadeed, G., Hudson, M., Valenzuela, T., & Latifi, R. (2013). Telemedicine and Telepresence for Prehospital and Remote Hospital Tracheal Intubation Using a GlideScope (TM) Videolaryngoscope: A Model for Tele-Intubation. TELEMEDICINE AND E-HEALTH, 17(3), 185-188.
• Sakles, J. C., Mosier, J., Patanwala, A., Cosentino, M., & Dicken, J. (2013). A Comparison of the Reusable Standard GlideScope to the Disposable Cobalt GlideScope. ANNALS OF EMERGENCY MEDICINE, 62(4), S77-S77.
• Sakles, J. C., Patanwala, A. E., Mosier, J., Dicken, J., & Holman, N. (2013). Comparison of the Reusable Standard GlideScope((R)) Video Laryngoscope and the Disposable Cobalt GlideScope((R)) Video Laryngoscope for Tracheal Intubation in an Academic Emergency Department: A Retrospective ReviewComparacion del Videolaringoscopio GlideScope((R)) Estandar Reutilizable y el Videolaringoscopio Cobalt GlideScope((R)) Desechable para la Intubacion Endotraqueal en un Servicio de Urgencias Universitario: Una Revision Retrospectiva. ACADEMIC EMERGENCY MEDICINE, 21(4), 408-415.
• Satyanarayan, A., Panchal, A. R., & Mosier, J. (2013). EFFICACY OF BOLUS-DOSE PHENYLEPHRINE FOR PERI-INTUBATION HYPOTENSION. JOURNAL OF INVESTIGATIVE MEDICINE, 61(1), 213-214.
• Valenzuela, T., Mosier, J., & Sakles, J. (2013). Tunnel vision. JEMS : a journal of emergency medical services, 38(1), 32-4, 36-7.
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  Since 2000, many studies of advanced emergency airway management have appeared in the medical literature. Although most described patients in the operating room, intensive care unit or emergency department, studies of video laryngoscopy in the field are in progress and beginning to appear in the literature. Video laryngoscopy provides better views of the glottis, and it permits more successful intubations with fewer attempts. Price reductions as more devices, some specifically intended for EMS, enter the market will lower the entry costs for adoption. It is my prediction that in five years, video laryngoscopy will be the method of choice for endotracheal intubation in the field.
• Michailidou, M., O'Keeffe, T., Mosier, J. M., Friese, R. S., Joseph, B., Rhee, P., & Sakles, J. C. (2012). A Comparison of Video Laryngoscopy to Direct Laryngoscopy for the Emergency Intubation of Trauma Patients. WORLD JOURNAL OF SURGERY, 39(3), 782-788.
• Mosier, J. M., Malo, J., Stolz, L. A., Bloom, J. W., Reyes, N. A., Snyder, L. S., & Adhikari, S. (2012). Critical care ultrasound training: A survey of US fellowship directors. JOURNAL OF CRITICAL CARE, 29(4), 645-649.
• Mosier, J. M., Stolz, U., Chiu, S., & Sakles, J. C. (2012). Difficult airway management in the emergency department: GlideScope videolaryngoscopy compared to direct laryngoscopy. The Journal of emergency medicine, 42(6), 629-34.
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  Videolaryngoscopy has become a popular method of intubation in the Emergency Department (ED), however, little research has compared this technique with direct laryngoscopy (DL).
• Mosier, J., Graham, L., Sakles, J., & Carr, G. (2012). VIDEO LARYNGOSCOPY IMPROVES FIRST ATTEMPT SUCCESS AND QUALITY OF LARYNGOSCOPIC VIEW COMPARED TO DIRECT LARYNGOSCOPY IN A MEDICAL INTENSIVE CARE UNIT. CRITICAL CARE MEDICINE, 40(12), U277-U277.
• Sakles, J. C., Mosier, J. M., Chiu, S., & Keim, S. M. (2012). Tracheal intubation in the emergency department: a comparison of GlideScope® video laryngoscopy to direct laryngoscopy in 822 intubations. The Journal of emergency medicine, 42(4), 400-5.
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  Video laryngoscopy has, in recent years, become more available to emergency physicians. However, little research has been conducted to compare their success to conventional direct laryngoscopy.
• Sakles, J. C., Mosier, J., Chiu, S., & Patanwala, A. (2012). A Comparison of the GlideScope (R) Video Laryngoscope to the C-MAC (R) Video Laryngoscope for Tracheal Intubation in the Emergency Department. ANNALS OF EMERGENCY MEDICINE, 60(4), S63-S63.
• Sakles, J. C., Mosier, J., Chiu, S., Cosentino, M., & Kalin, L. (2012). A comparison of the C-MAC video laryngoscope to the Macintosh direct laryngoscope for intubation in the emergency department. Annals of emergency medicine, 60(6), 739-48.
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  We determine the proportion of successful intubations with the C-MAC video laryngoscope (C-MAC) compared with the direct laryngoscope in emergency department (ED) intubations.
• Watt, J., Amini, A., Mosier, J., Gustafson, M., Wynne, J. L., Friese, R., Gruessner, R. W., Rhee, P., & O'Keeffe, T. (2012). Treatment of severe hemolytic anemia caused by Clostridium perfringens sepsis in a liver transplant recipient. Surgical infections, 13(1), 60-2.
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  Clostridium perfringens bacteremia accompanied by extensive intravascular hemolysis is an almost inescapably fatal infection.
• Gaither, J. B., Spaite, D. W., Stolz, U., Ennis, J., Mosier, J., & Sakles, J. J. (2011). PREVALENCE OF DIFFICULT AIRWAY PREDICTORS IN CASES OF FAILED PREHOSPITAL ENDOTRACHEAL INTUBATION. JOURNAL OF EMERGENCY MEDICINE, 47(3), 294-300.
• Mohler, M. J., Wendel, C. S., Mosier, J., Itty, A., Fain, M., Clark, L., Bobrow, B., & Sanders, A. B. (2011). Cardiocerebral Resuscitation Improves Out-of-Hospital Survival in Older Adults. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 59(5), 822-826.
• Mohler, M. J., Wendel, C. S., Mosier, J., Itty, A., Fain, M., Clark, L., Bobrow, B., & Sanders, A. B. (2011). Cardiocerebral resuscitation improves out-of-hospital survival in older adults. Journal of the American Geriatrics Society, 59(5), 822-6.
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  To compare the survival and neurological status of people aged 65 and older receiving cardiocerebral resuscitation (CCR) with that of those receiving standard advanced life support (Std-ALS), as well as predictors of survival.
• Sakles, J. C., Mosier, J., Hadeed, G., Hudson, M., Valenzuela, T., & Latifi, R. (2011). Telemedicine and telepresence for prehospital and remote hospital tracheal intubation using a GlideScope™ videolaryngoscope: a model for tele-intubation. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 17(3), 185-8.
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  The inability to secure a patient's airway in the prehospital setting is a major cause of potentially preventable death in the field of trauma and emergency medicine.
• Doraiswamy, V. A., Hegde, V., Bhatt, R., Mosier, J., & Ott, P. (2010). Carotid artery puncture, myocardial injury, and ventricular arrhythmia. Southern medical journal, 103(9), 967-8.
• Mosier, J., Itty, A., Sanders, A., Mohler, J., Wendel, C., Poulsen, J., Shellenberger, J., Clark, L., & Bobrow, B. (2010). Cardiocerebral resuscitation is associated with improved survival and neurologic outcome from out-of-hospital cardiac arrest in elders. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 269-75.
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  Recent studies have shown that a new emergency medical services (EMS) protocol for treating patients who suffer out-of-hospital cardiac arrest (OHCA), cardiocerebral resuscitation (CCR), significantly improves survival compared to standard advanced life support (ALS). However, due to their different physiology, it is unclear if all elders, or any subsets of elders who are OHCA victims, would benefit from the CCR protocol.
• Sakles, J. C., Mosier, J., Chiu, S., Cosentino, M., & Kalin, L. (2010). A Comparison of the C-MAC Video Laryngoscope to the Macintosh Direct Laryngoscope for Intubation in the Emergency Department. ANNALS OF EMERGENCY MEDICINE, 60(6), 739-748.
• Watt, J., Amini, A., Mosier, J., Gustafson, M., Wynne, J. L., Friese, R., Gruessner, R. W., Rhee, P., & O'Keeffe, T. (2010). Treatment of Severe Hemolytic Anemia Caused by Clostridium perfringens Sepsis in a Liver Transplant Recipient. SURGICAL INFECTIONS, 13(1), 60-62.
• Mohler, M. J., Wendel, C., Mosier, J., Itty, A., Poulsen, J., Shellenberger, J., Bobrow, B., Clark, L., & Sanders, A. (2009). The Effect of Cardiocerebral Resuscitation in Aging Adults. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 57, S70-S70.

Presentations

• Bull, D. A., Lick, S. D., Hypes, C., Natt, B., Mosier, J. M., Malo, J., & Hsu, C. (2019, May/). Duration and Outcomes of Veno-Venous Extracorporeal Membrane Oxygenation Support in Acute Respiratory Distress Syndrome: Results from ELSO database. American association for thoracic surgery 99th annual meeting. Toronto: American association for thoracic surgery.
• Mosier, J. M., Patanwala, A., Hypes, C., Augustinovich, C., & Sakles, J. C. (2018, May). Use of an Airway Registry to Improve the Safety of Airway Management in the Emergency Department. Society for Academic Emergency Medicine Annual Meeting. Indianapolis, IA: Society for Academic Emergency Medicine.
• Sakles, J. C., Mosier, J. M., Hypes, C., & Pacheco, G. (2018, May). Video Laryngoscopy Improves First Pass Success in Pediatric Intubations in the Emergency Department. Society for Academic Emergency Medicine Annual Meeting. Indianapolis, IA: Society for Academic Emergency Medicine.
• Sakles, J. C., Wolfe, A., Patanwala, A., & Olvera, D. (2018, May). The Importance of First Pass Success in Prehospital Intubation. Society for Academic Emergency Medicine Annual Meeting. Indianapolis, IA: Society for Academic Emergency Medicine.
• Mosier, J. M., O'Keeffe, T., Falvey, D., Joshi, R., & Friedman, L. (2013, March). Emergency Physician Knowledge of Massive Transfusion Protocol in Trauma. Western Society for Academic Emergency Medicine. Long Beach, CA.

Poster Presentations

• Kazui, T., Hsu, C., Malo, J., Mosier, J. M., Natt, B., Hypes, C., Lick, S. D., & Bull, D. A. (2020, April). Interfacility transfer via a mobile intensive care unit following a double lumen catheter cannulation at the referring facility for veno-venous extracorporeal membrane oxygenation. THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION 2020 Scientific Program. Montreal, Canada: THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION.
• Pacheco, G., Hypes, C., Mosier, J. M., Patanwala, A., Sakles, J. C., & Hurst, N. B. (2019, November). Adverse Events in Patients with Physiologically Difficult and Anatomically Difficult Airways in the Emergency Department.. World Airway Management Meeting. Amsterdam, NE: SAM, EAMS.
• Sakles, J. C., Hypes, C., Mosier, J. M., & Pacheco, G. (2019, November). The Physiologically Difficult Airway is Associated with as Many Adverse Events as the Anatomically Difficult Airway in the Emergency Department. World Airway Management Meeting (WAMM). Amsterdam: Society For Airway Management.
• Sakles, J. C., Hypes, C., Mosier, J. M., & Pacheco, G. (2019, November). The Physiologically Difficult Airway is Associated with as Many Adverse Events as the Anatomically Difficult Airway in the Emergency Department. World Airway Management Meeting. Amsterdam: Society For Airway Management.
• Augustinovich, C., Hypes, C., Patanwala, A. E., Mosier, J. M., & Sakles, J. C. (2017, September). Improvement in the Quality and Safety of Airway Management in the Emergency Department Over a 10-Year Period with the Use of an Airway CQI Program. Society for Airway Management Annual Meeting. Newport Beach, CA.
• Cristan, E., Morrissette, K., Greenberg, J., Natt, B., Mosier, J. M., Sakles, J. C., & Hypes, C. (2017, Feb). Rethinking NIV: when it works, it works. When it doesn't, it really doesn't. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
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  22. Greenberg J, Mosier J, Natt B, Morrissette K, Cristan C, Sakles J, Hypes C; Rethinking NIV: when it works, it works. When it doesn't, it really doesn't [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI.
• Douglas, M., Mosier, J. M., Patanwala, A. E., Sakles, J. C., & Hypes, C. (2017, May). The Physiologically Difficult Airway is Associated with a Reduced First Pass Success without Adverse Events During Emergency Department Intubations [Poster]. Society for Academic Emergency Medicine Annual Meeting. Orlando, FL: Society for Academic Emergency Medicine.
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  25. Sakles J, Douglas M, Hypes C, Patanwala A, Mosier J; The Physiologically Difficult Airway is Associated with a Reduced First Pass Success without Adverse Events During Emergency Department Intubations [Poster]; Society for Academic Emergency Medicine Annual Meeting; May 2017; Orlando FL.
• Douglas, M., Mosier, J. M., Patanwala, A. E., Sakles, J. C., & Hypes, C. (2017, September). Measuring FeO2 in the Emergency Department to Optimize Preoxygenation During Rapid Sequence Intubation. Society for Airway Management. Newport Beach, CA.: Society for Airway Management.
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  26. Sakles J, Mosier J, Douglas M, Hypes C, Patanwala A; Measuring FeO2 in the Emergency Department to Optimize Preoxygenation During Rapid Sequence Intubation [Poster]; Society for Airway Management; September 2017; Newport Beach, CA.
• Douglas, M., Patanwala, A., Mosier, J. M., Sakles, J. C., & Hypes, C. (2017, May). The Unanticipated Difficult Airway during Emergency Tracheal Intubation [Poster]. Society for Academic Emergency Medicine Annual Meeting. Orlando, FL: Society for Academic Emergency Medicine.
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  24. Hypes C, Mosier J, Douglas M, Patanwala A, Sakles J; The Unanticipated Difficult Airway during Emergency Tracheal Intubation [Poster]; Society for Academic Emergency Medicine Annual Meeting; May 2017; Orlando FL.
• Hypes, C., Mosier, J. M., Patanwala, A. E., & Sakles, J. C. (2017, May). The Unanticipated Difficult Airway During Emergency Tracheal Intubation. SAEM Annual Meeting. Orlando, FL.
• Milligan, R., Cristan, E., Morrissette, K., Jeremy, G., Mosier, J. M., Malo, J., Sakles, J. C., & Hypes, C. (2017, Feb). Re-intubation in the Intensive Care Unit: Is it Truly as Difficult as Assumed? [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
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  23. Greenberg J, Mosier J, Malo J, Morrissette K, Cristan E, Milligan R, Sakles J, Hypes C; Re-intubation in the Intensive Care Unit: Is it Truly as Difficult as Assumed? [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI.
• Milligan, R., Greenberg, J., Cristan, E., Morrissette, K., Mosier, J. M., Malo, J., Sakles, J. C., & Hypes, C. (2017, Feb). Flexible Fiberoptic vs Video Larygoscopy: Insights on Difficult Airway Success and Complications [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
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  20. Morrissette K, Mosier J, Cristan E, Greenberg J, Milligan R, Sakles J, Malo J, Hypes C, Flexible Fiberoptic vs Video Larygoscopy: Insights on Difficult Airway Success and Complications [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI.
• Morrissette, K., Greenberg, J., Cristan, E., Milligan, R., Mosier, J. M., Malo, J., Sakles, J. C., & Hypes, C. (2017, Feb). Intubation and First Pass Success, a Comparison of C-MAC and GlideScope in the Intensive Care Unit [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI: Society of Critical Care Medicine.
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  21. Milligan R, Mosier J, Cristan E, Greenberg J, Morrissette K, Sakles J, Malo J, Hypes C; Intubation and First Pass Success, a Comparison of C-MAC and GlideScope in the Intensive Care Unit [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI
• Morrissette, K., Milligan, R., Cristan, E., Mosier, J. M., Malo, J., Sakles, J. C., & Hypes, C. (2017, February). Improvement in tracheal intubation over time with the institution of a quality improvement program [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
• Rao, P., Skaria, R., Mosier, J. M., Malo, J., Smith, R., & Khalpey, Z. I. (2017, November). Temporary Mechanical Circulatory Support Using a Novel Minimally-Invasive Approach for Central VA-ECMO. American Heart Association Annual Meeting. Chicago, IL.
• Sakles, J. C., Douglas, M., Hypes, C., Patanwala, A. E., & Mosier, J. M. (2017, May). The Physiologically Difficult Airway is Associated with a Reduced First Pass Success without Adverse Events During Emergency Department Intubations . SAEM Annual Meeting. Orlando, FL.
• Sakles, J. C., Mosier, J. M., Douglas, M., Hypes, C., & Patanwala, A. E. (2017, September). Measuring FeO2 in the Emergency Department to Optimize Preoxygenation During Rapid Sequence Intubation. Society for Airway Management Annual Meeting. Newport Beach, CA.
• Baalachandran, R., Trutter, L., Raz, Y., Mosier, J. M., Kazui, T., & Malo, J. (2016, Spring). Successful Use of Extracorporeal Membrane Oxygenation in a Patient with Pulmonary Coccidioidomycosis-Related Acute Respiratory Distress Syndrome.. American Thoracic Society Annual Meeting. San Francisco, CA.
• Greenberg, J., Mosier, J. M., Joshi, R., Bloom, J. W., Malo, J., Sakles, J. C., & Hypes, C. (2016, Feb). First Attempt Success at Intubation is Associated with a Lower Odds of Adverse Events in the ICU. Society of Critical Care Medicine Annual Congress. Orlando.
• Hypes, C., Sakles, J. C., Nararro, T., Greenberg, J., Natt, B., Chopra, H., & Mosier, J. M. (2016, Sept). Failure to achieve first attempt success is associated with a higher odds of adverse events during intubation in the Intensive Care Unit using a video laryngoscope. Society for Airway Management. Atlanta.
• Johnston, D., Mosier, J. M., Joshi, R., Malo, J., Bloom, J. W., Sakles, J. C., & Hypes, C. (2016, Feb). Reason For Failed Attempts At Laryngoscopy Differs Between Video And Direct Laryngoscopes. Society of Critical Care Medicine Annual Congress. Orlando.
• Joshi, R., Hypes, C., Malo, J., Bloom, J. W., Sakles, J. C., & Mosier, J. M. (2016, Feb). Predictors of Difficult Intubation When Using Video Laryngoscopy in the Intensive Care Unit. Society of Critical Care Medicine Annual Congress.
• Kelsey, M., Sakles, J. C., Joshi, R., Malo, J., Bloom, J. W., Hypes, C., & Mosier, J. M. (2016, Feb). Derivation of a Bundle to Improve First Attempt Success at Intubation in the Intensive Care Unit. Society of Critical Care Medicine Annual Congress. Orlando.
• Nararro, T., Mosier, J. M., Sakles, J. C., Greenberg, J., Natt, B., Chopra, H., & Hypes, C. (2016, Sept). Predictors of complications of Intensive Care Unit airway management despite first attempt success using video laryngoscopy. Society for Airway Management.
  More info

  This submission won the SAM travel award for Dr. Navarro to present it at the conference. I mentored Dr. Navarro in this activity.
• Natt, B., Malo, J., Hypes, C., Kazui, T., Basken, R., & Mosier, J. M. (2016, August). Outcomes of Patients with Severe Influenza Treated at the Banner-University Medical Center During the 2015-16 Influenza Season. Options IX for the Control of Influenza. Chicago.
• Natt, B., Malo, J., Hypes, C., Kazui, T., Basken, R., & Mosier, J. M. (2016, August/Summer). Outcomes of Patients with Severe Influenza Treated at the Banner-University Medical Center During the 2015-16 Influenza Season. Options IX for the Control of Influenza. Chicago, IL.
• Natt, B., Malo, J., Hypes, C., Kazui, T., Basken, R., & Mosier, J. M. (2016, Summer). Outcomes of Patients with Severe Influenza Treated at the Banner-University Medical Center During the 2015-16 Influenza Season. Options IX for the Control of Influenza. Chicago, IL.
• Pacheco, G. S., Pacheco, G., Hypes, C., Hypes, C., Joshi, R., Joshi, R., Mosier, J. M., & Mosier, J. M. (2016, Feb). Emergency Department Recognition of Critical Illness Related Corticosteroid Insufficiency. Society of Critical Care Medicine Annual Congress. Orlando.
• Sakles, J. C., Douglas, M., Hypes, C., Pantawala, A., & Mosier, J. M. (2016, Sept). Incidence, Management and Outcomes of the Difficult Airway in the Emergency Department. Society for Airway Management. Atlanta.
• Sakles, J. C., Douglas, M., Hypes, C., Patanwala, A. E., & Mosier, J. M. (2016, September). Incidence, management and outcomes of the difficult airway in the emergency department. Society for Airway Management. Atlanta.
• Greenberg, J., Mosier, J. M., Joshi, R., Bloom, J. W., Malo, J., Sakles, J. C., & Hypes, C. D. (2016, February). First attempt success at intubation is associated with a lower odds of adverse events in the ICU. SCCM Annual Conference.
• Johnston, D., Mosier, J. M., Joshi, R., Malo, J., Sakles, J. C., Bloom, J. W., & Hypes, C. D. (2016, February). Reason for failed attempts at laryngoscopy differs between video and direct laryngoscopes. SCCM Annual Conference.
• Joshi, R., Hypes, C. D., Malo, J., Bloom, J. W., Sakles, J. C., & Mosier, J. M. (2016, February). Predictors of difficult intubation when using video laryngoscopy in the ICU. SCCM Annual Conference.
• Kelsey, M., Hypes, C. D., Joshi, R., Malo, J., Bloom, J. W., Sakles, J. C., & Mosier, J. M. (2016, February). Derivation of a bundle to improve first attempt success at intubation in the ICU. SCCM Annual Conferece.
• Natt, B., Malo, J., Snyder, L. S., Knepler, J. L., Knox, K. S., & Mosier, J. M. (2015, May/Spring). Advanced Airway Management in Critical Care Fellowship Training. ATS International Conference. Denver, CO.

Reviews

• Mosier, J. M., Kelsey, M., Raz, Y., Gunnerson, K. J., Meyer, R., Hypes, C. D., Malo, J., Whitmore, S. P., & Spaite, D. W. (2015. Extracorporeal membrane oxygenation (ECMO) for critically ill adults in the emergency department: history, current applications, and future directions.
• Mosier, J. M., Hypes, C., Joshi, R., Whitmore, S., Parthasarathy, S., & Cairns, C. B. (2012. Ventilator Strategies and Rescue Therapies for Management of Acute Respiratory Failure in the Emergency Department(pp 529-541).

Others

• Mosier, J. M., & Sakles, J. C. (2018, August). Management of the Physiologically Difficult Airway in the Emergency Department. Anesthesiology News.
• Mosier, J. M., & Marcolini, E. (2015). An alternative perspective regarding the "myth of the workforce crisis". American journal of respiratory and critical care medicine.
• Mosier, J. M., & Marcolini, E. (2015, MAR 15). An Alternative Perspective Regarding the "Myth of the Workforce Crisis". AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
• Mosier, J., Chopra, H., Sakles, J., Malo, J., Bloom, J., & Hypes, C. (2015, DEC). NEUROMUSCULAR BLOCKADE IMPROVES TRACHEAL INTUBATION SUCCESS IN THE INTENSIVE CARE UNIT. CRITICAL CARE MEDICINE.
• Bouska, R., Stolz, U., Sakles, J., & Mosier, J. (2014, DEC). Rapid Sequence Intubation Compared to Non-RSI for Out-of-OR Intubations with Video Laryngoscopy. CRITICAL CARE MEDICINE.
• Doraiswamy, V. A., Hegde, V., Bhatt, R., Mosier, J., & Ott, P. (2014, SEP). Carotid Artery Puncture, Myocardial Injury, and Ventricular Arrhythmia. SOUTHERN MEDICAL JOURNAL.
• Mosier, J. M., & Law, J. A. (2014, MAY). Airway management in the critically ill. INTENSIVE CARE MEDICINE.
• Sakles, J. C., Mosier, J., & Stolz, U. (2014, SEP). Chicken or Egg? Risks of Misattribution of Cause-Effect Relationships in Studies of Association Reply. ACADEMIC EMERGENCY MEDICINE.
• Hypes, C., Sakles, J., Malo, J., Bloom, J., & Mosier, J. (2013, DEC). VIDEO LARYNGOSCOPY IMPROVES ODDS OF FIRST ATTEMPT SUCCESS AT INTUBATION IN THE INTENSIVE CARE UNIT. CRITICAL CARE MEDICINE.
• Mosier, J., Douglas, M., Molloy, M., Bloom, J., Snyder, L., & Sakles, J. (2013, DEC). Odds of Adverse Events of Intubation Following Failed Non-Invasive Positive Pressure Ventilation. CRITICAL CARE MEDICINE.
• Dalabih, M., Rischard, F., & Mosier, J. M. (2012, DEC). What's new: the management of acute right ventricular decompensation of chronic pulmonary hypertension. INTENSIVE CARE MEDICINE.