Edward John Bedrick

Interests

Teaching

Linear ModelsStatistical TheoryBayesian Methods

Research

Bayesian MethodsGeneral Statistical Methodology

Courses

Scholarly Contributions

Journals/Publications

• Aberasturi, D. T., Piegorsch, W. W., Bedrick, E. J., & Lussier, Y. A. (2022). Accounting for extra-binomial variability with differentially expressed genetic pathway data: a collaborative bioinformatic study. Stat, 12, Article No. e518. doi:10.1002/sta4.518
• Al-Obaidi, M., Tanriover, B., Anand, P. M., Gungor, A. b., Ayvaci, M., Nematollahi, S., Zangeneh, T. T., Murugapandian, S., Bedrick, E. J., Qannus, A. A., Johnson, K., Shetty, A., Nicole, A., ARIYAMUTHU, V. K., Heise, C. W., Alam, R., Rangan, P., Rangan, P., Alam, R., , Heise, C. W., et al. (2022). Effectiveness of Casirivimab-Imdevimab Monoclonal Antibody Treatment Among High-Risk Patients With Severe Acute Respiratory Syndrome Coronavirus 2 B.1.617.2 (Delta Variant) Infection. Open forum infectious diseases.
• Bedrick, E. J., Fantry, L. E., Fisher, J. M., Guido, A. A., Gupte, R., Joseph, M., Lim, J. R., Loveland, M. G., Madhivanan, P., Nandamuri, P., & Sadoway, D. (2022).

  2092. Update on PrEP Knowledge and Attitudes Among Adults Attending Public Health Clinics in Southern Arizona

  . Open Forum Infectious Diseases, 9(Supplement_2). doi:10.1093/ofid/ofac492.1714
• Buchfuhrer, J. E., Davis, N. M., Dequillfeldt, N. P., Donovan, F. M., Galgiani, J. N., Kaveti, A., Khan, R. N., Lim, J. R., Ramadan, F. A., Shadarevian, M. D., & Bedrick, E. J. (2022). Contribution of Biologic Response Modifiers to the Risk of Coccidioidomycosis Severity.. Open forum infectious diseases, 9(3), ofac032. doi:10.1093/ofid/ofac032
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  The risk of coccidioidomycosis (CM) as a life-threatening respiratory illness or disseminated CM (DCM) increases as much as 150-fold in immunosuppressed patients. The safety of biologic response modifiers (BRMs) as treatment for patients with autoimmune disease (AI) in CM-endemic regions is not well defined. We sought to determine that risk in the Tucson and Phoenix areas..We conducted a retrospective study reviewing demographics, Arizona residency length, clinical presentations, specific AI diagnoses, CM test results, and BRM treatments in electronic medical records of patients ≥18 years old with International Classification of Diseases (ICD-10) codes for CM and AI from 1 October 2017 to 31 December 2019..We reviewed 944 charts with overlapping ICD-10 codes for CM and AI, of which 138 were confirmed to have both diagnoses. Male sex was associated with more CM (P = .003), and patients with African ancestry were 3 times more likely than those with European ancestry to develop DCM (P 
• Tanriover, B., Anand, P. M., Ayvaci, M., Murugapandian, S., Qannus, A. A., Shetty, A., ARIYAMUTHU, V. K., Heise, C. W., Rangan, P., Alam, R., Nicole, A., Johnson, K., Bedrick, E. J., Zangeneh, T. T., Nematollahi, S., Gungor, A. b., & Al-Obaidi, M. (2022).

  Effectiveness of Casirivimab-Imdevimab Monoclonal Antibody Treatment Among High-Risk Patients With Severe Acute Respiratory Syndrome Coronavirus 2 B.1.617.2 (Delta Variant) Infection

  . Open forum infectious diseases.
• Cairns, C. B., Lutrick, K., Campbell, E. S., Bedrick, E. J., Hypes, C., Fisher, J. M., & Mosier, J. M. (2021). A Target for Increased Mortality Risk in Critically Ill Patients: The Concept of Perpetuity. Journal of Clinical Medicine.
• Mayer, A. R., Wertz, C. J., Robertson-Benta, C. R., Pabbathi Reddy, S., Stephenson, D. D., Dodd, A. B., Oglesbee, S. J., Bedrick, E. J., Master, C. L., Grady, M., Shaff, N. A., Hanlon, F. M., Campbell, R. A., Phillips, J. P., Zemek, R. L., Yeates, K. O., Meier, T. B., Mannix, R., Leddy, J. J., , Arbogast, K. B., et al. (2021). Neurosensory Screening and Symptom Provocation in Pediatric Mild Traumatic Brain Injury. The Journal of head trauma rehabilitation, 35(4), 270-278.
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  To evaluate diagnostic/prognostic implications of neurosensory testing during the subacute stage in patients with pediatric mild traumatic brain injury (pmTBI).
• York, L. D., Fisher, J. M., Malladi, L., August, J., Ellis, K. E., Marquez, J., Kaveti, A., Khachatryan, M., Paz, M., Adams, M., Bedrick, E. J., Fantry, L., & Adams, M. (2021). Antiretroviral Laboratory Monitoring and Implications for HIV Clinical Care in the Era of COVID-19 and Beyond. AIDS Research and Human Retroviruses.
• York, L., Fisher, J. M., Malladi, L., August, J. A., Ellis, K. E., Marquez, J. L., Kaveti, A., Khachatryan, M., Paz, M. K., Adams, M. D., Bedrick, E. J., & Fantry, L. E. (2021). Antiretroviral Laboratory Monitoring and Implications for HIV Clinical Care in the Era of COVID-19 and Beyond. AIDS research and human retroviruses.
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  In the era of COVID-19, providers are delaying laboratory testing in people with HIV (PWH). The purpose of this study was to examine the clinical significance of renal, liver, and lipid testing.
• Bedrick, E. J. (2020). Data reduction prior to inference: Are there consequences of comparing groups using a t-test based on principal component scores?. Biometrics, 76(2), 508-517.
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  Researchers often use a two-step process to analyze multivariate data. First, dimensionality is reduced using a technique such as principal component analysis, followed by a group comparison using a -test or analysis of variance. Although this practice is often discouraged, the statistical properties of this procedure are not well understood, starting with the hypothesis being tested. We suggest that this approach might be considering two distinct hypotheses, one of which is a global test of no differences in the mean vectors, and the other being a focused test of a specific linear combination where the coefficients have been estimated from the data. We study the asymptotic properties of the two-sample -statistic for these two scenarios, assuming a nonsparse setting. We show that the size of the global test agrees with the presumed level but that the test has poor power. In contrast, the size of the focused test can be arbitrarily distorted with certain mean and covariance structures. A simple method is provided to correct the size of the focused test. Data analyses and simulations are used to illustrate the results. Recommendations on the use of this two-step method and the related use of principal components for prediction are provided.
• Cook, A., Harris, R., Brown, H. E., & Bedrick, E. (2020). Geospatial characteristics of non-motor vehicle and assault-related trauma events in greater Phoenix, Arizona. Injury epidemiology, 7(1), 34.
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  Injury-causing events are not randomly distributed across a landscape, but how they are associated with the features and characteristics of the places where they occur in Arizona (AZ) remains understudied. Clustering of trauma events and associations with areal sociodemographic characteristics in the greater Phoenix (PHX), AZ region can promote understanding and inform efforts to ameliorate a leading cause of death and disability for Arizonans. The outcomes of interest are trauma events unrelated to motor vehicle crashes (MVC) and the subgroup of trauma events due to interpersonal assaults.
• Donovan, F. M., Ramadan, F. A., Khan, S. A., Bhaskara, A., Lainhart, W. D., Narang, A. T., Mosier, J. M., Ellingson, K. D., Bedrick, E. J., Saubolle, M. A., & Galgiani, J. N. (2020). Comparison of a Novel Rapid Lateral Flow Assay to Enzyme Immunoassay Results for Early Diagnosis of Coccidioidomycosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
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  Coccidioidomycosis (CM) is a common cause of community acquired pneumonia (CAP) where CM is endemic. Manifestations include self-limited pulmonary infection, chronic fibrocavitary pulmonary disease, and disseminated coccidioidomycosis (DCM). Most infections are identified by serological assays including enzyme-linked immunoassay (EIA), complement fixation (CF) and immunodiffusion (IMDF). These are time-consuming and take days to result, impeding early diagnosis. A new lateral flow assay (LFA, Sōna, IMMY, Norman OK) improves time-to-result to one hour.
• Mayer, A. R., Stephenson, D. D., Dodd, A. B., Robertson-Benta, C. R., Pabbathi Reddy, S., Shaff, N. A., Yeates, K. O., van der Horn, H. J., Wertz, C. J., Park, G., Oglesbee, S. J., Bedrick, E. J., Campbell, R. A., Phillips, J. P., & Quinn, D. K. (2020). Comparison of Methods for Classifying Persistent Post-Concussive Symptoms in Children. Journal of neurotrauma, 37(13), 1504-1511.
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  Pediatric mild traumatic brain injury (pmTBI) has received increased public scrutiny over the past decade, especially regarding children who experience persistent post-concussive symptoms (PPCS). However, several methods for defining PPCS exist in clinical and scientific literature, and even healthy children frequently exhibit non-specific, concussive-like symptoms. Inter-method agreement (six PPCS methods), observed misclassification rates, and other psychometric properties were examined in large cohorts of consecutively recruited adolescent patients with pmTBI ( = 162) 1 week and 4 months post-injury and in age/sex-matched healthy controls (HC;  = 117) at equivalent time intervals. Six published PPCS methods were stratified into Simple Change (e.g., , 10th revision [ICD-10]) and Standardized Change (e.g., reliable change indices) algorithms. Among HC, test-retest reliability was fair to good across the 4-month assessment window, with evidence of bias (i.e., higher symptom ratings) during retrospective relative to other assessments. Misclassification rates among HC were higher (>30%) for Simple Change algorithms, with poor inter-rater reliability of symptom burden across HC and their parents. A 49% spread existed in terms of the proportion of pmTBI patients "diagnosed" with PPCS at 4 months, with superior inter-method agreement among standardized change algorithms. In conclusion, the self-reporting of symptom burden is only modestly reliable in typically developing adolescents over a 4-month period, with additional evidence for systematic bias in both adolescent and parental ratings. Significant variation existed for identifying pmTBI patients who had "recovered" (i.e., those who did not meet individual criteria for PPCS) from concussion across the six definitions, representing a considerable challenge for estimating the true incidence rate of PPCS in published literature. Although relatively straightforward to obtain, current findings question the utility of the most commonly used Simple Change scores for diagnosis of PPCS in clinical settings.
• Pu, J., Donovan, F. M., Ellingson, K., Leroy, G., Stone, J., Bedrick, E., & Galgiani, J. N. (2020). Clinician Practice Patterns that Result in the Diagnosis of Coccidioidomycosis Before or During Hospitalization. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
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  Coccidioidomycosis (CM) is common and important within endemic regions, requiring specific testing for diagnosis. Long delays in diagnosis have been ascribed to ambulatory clinicians, but how their testing practices have impacted patient care have not been systematically unexplored.
• Shende, T. C., Fisher, J. M., Perez-Velez, C. M., Guido, A. A., Sprowl, K. M., Drake, T. M., Adelus, M. L., Bedrick, E. J., & Fantry, L. E. (2020). PrEP Knowledge and Attitudes Among Adults Attending Public Health Clinics in Southern Arizona. Journal of community health, 45(2), 400-406.
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  HIV pre-exposure prophylaxis (PrEP) is underutilized among Hispanics, women, and low-income individuals. To better understand PrEP barriers in this population, questionnaires were administered to 500 patients attending public health clinics in southern Arizona which provide family planning and sexually transmitted infections care. Sixty-three percent believed that they had no risk of HIV infection. When asked "Before today, did you know that there was a pill that can prevent HIV infection?" 80% of persons answered no. Among women, 88% answered no to this question. As expected, individuals with a higher perceived HIV risk (OR 1.76) or one HIV risk factor (OR 5.85) had a higher probability of knowledge. Among survey participants 87% would take a daily pill, 91% would visit a health-care provider every 3 months, and 92% would have laboratory testing every 3 months. Fifty-four percent would not be afraid or embarrassed if friends or family knew they were taking PrEP. Seventy-two percent would take PrEP despite temporary nausea. Sixty-two percent would pay ≥ $40 every 3 months for PrEP. Lack of knowledge, rather than patient attitudes, is the more important barrier to wider utilization of PrEP among individuals, especially women, attending public health clinics in Southern Arizona. Future efforts need to focus on education and access to PrEP in underserved populations including women and Hispanics.
• Solola, S., Luy, L., Herrera-Theut, K., Zabala, L., Torabzadeh, E., Bedrick, E. J., Yee, E., Larsen, A., Stone, J., McEwen, M., Calhoun, E., Crist, J. D., Hebdon, M., Pool, N., Carnes, M., Sweitzer, N., & Breathett, K. (2020). Race and Gender-Based Perceptions of Older Adults: Will the Youth Lead the Way?. Journal of racial and ethnic health disparities.
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  Older individuals encounter the greatest racial/gender biases. It is unknown whether younger generations, who often lead culture shifts, have racial and gender biases against older populations.
• Ahmed, R. A., Bedrick, E. J., Ng, V., Plitt, J., Cahir, T., Hughes, P. G., & Hughes, K. (2019). Advanced closed-loop communication training: the blindfolded resuscitation. BMJ Simulation and Technology Enhanced Learning. doi:10.1136/bmjstel-2019-000498
• Ahmed, R. A., Bedrick, E. J., Ng, V., Plitt, J., Cahir, T., Hughes, P. G., Hughes, K., Ahmed, R. A., Bedrick, E. J., Ng, V., Plitt, J., Cahir, T., Hughes, P. G., & Hughes, K. (2019). Advanced closed-loop communication training: the blindfolded resuscitation. BMJ Simulation and Technology Enhanced Learning, 6(4), 235-238. doi:10.1136/bmjstel-2019-000498
• Bedrick, E. J. (2019). Delays in Coccidioidomycosis Diagnosis and Associated Healthcare Utilization, Tucson, Arizona, USA. Emerg Infect Disv.
• Bedrick, E. J. (2019). PrEP Knowledge and Attitudes Among Adults Attending Public Health Clinics in Southern Arizona. J Community Health.
• Donovan, F. M., Wightman, P., Zong, Y., Gabe, L., Majeed, A., Ynosencio, T., Bedrick, E. J., & Galgiani, J. N. (2019). Delays in Coccidioidomycosis Diagnosis and Associated Healthcare Utilization, Tucson, Arizona, USA. Emerging infectious diseases, 25(9), 1745-1747.
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  Tucson, Arizona, USA, is a highly coccidioidomycosis-endemic area. We conducted a retrospective review of 815 patients in Tucson over 2.7 years. Of 276 patients with coccidioidomycosis, 246 had a delay in diagnosis; median delay was 23 days. Diagnosis delay was associated with coccidioidomycosis-related costs totaling $589,053 and included extensive antibacterial drug use.
• Bedrick, E. J. (2018). Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities. BMC Med Genomics.
• Dodd, A. B., Ling, J. M., Bedrick, E. J., Meier, T. B., & Mayer, A. R. (2018). Spatial distribution bias in subject-specific abnormalities analyses. Brain imaging and behavior, 12(6), 1828-1834.
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  The neuroimaging community has seen a renewed interest in algorithms that provide a location-independent summary of subject-specific abnormalities (SSA) to assess individual lesion load. More recently, these methods have been extended to assess whether multiple individuals within the same cohort exhibit extrema in the same spatial location (e.g., voxel or region of interest). However, the statistical validity of this approach has not been rigorously established. The current study evaluated the potential for a spatial bias in the distribution of SSA using several common z-transformation algorithms (leave-one-out [LOO]; independent sample [IDS]; Enhanced Z-Score Microstructural Assessment of Pathology [EZ-MAP]; distribution-corrected z-scores [DisCo-Z]) using both simulated data and DTI data from 50 healthy controls. Results indicated that methods which z-transformed data based on statistical moments from a reference group (LOO, DisCo-Z) led to bias in the spatial location of extrema for the comparison group. In contrast, methods that z-transformed data using an independent third group (EZ-MAP, IDS) resulted in no spatial bias. Importantly, none of the methods exhibited bias when results were summed across all individual elements. The spatial bias is primarily driven by sampling error, in which differences in the mean and standard deviation of the untransformed data have a higher probability of producing extrema in the same spatial location for the comparison but not reference group. In conclusion, evaluating SSA overlap within cohorts should be either be avoided in deference to established group-wise comparisons or performed only when data is available from an independent third group.
• Hockett, C. W., Bedrick, E. J., Zeitler, P., Crume, T. L., Daniels, S., & Dabelea, D. (2018). Exposure to Diabetes in Utero Is Associated with Earlier Pubertal Timing and Faster Pubertal Growth in the Offspring: The EPOCH Study. The Journal of pediatrics.
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  To examine the associations of in utero exposure to maternal diabetes with surrogate measures of offspring pubertal timing (age at peak height velocity [APHV]) and speed of pubertal growth (peak height velocity [PHV]).
• Huang, S., Hu, C., Bell, M. L., Billheimer, D., Guerra, S., Roe, D., Vasquez, M. M., & Bedrick, E. J. (2018). Regularized continuous-time Markov Model via elastic net. Biometrics, 74(3), 1045-1054.
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  Continuous-time Markov models are commonly used to analyze longitudinal transitions between multiple disease states in panel data, where participants' disease states are only observed at multiple time points, and the exact state paths between observations are unknown. However, when covariate effects are incorporated and allowed to vary for different transitions, the number of potential parameters to estimate can become large even when the number of covariates is moderate, and traditional maximum likelihood estimation and subset model selection procedures can easily become unstable due to overfitting. We propose a novel regularized continuous-time Markov model with the elastic net penalty, which is capable of simultaneous variable selection and estimation for large number of parameters. We derive an efficient coordinate descent algorithm to solve the penalized optimization problem, which is fully automatic and data driven. We further consider an extension where one of the states is death, and time of death is exactly known but the state path leading to death is unknown. The proposed method is extensively evaluated in a simulation study, and demonstrated in an application to real-world data on airflow limitation state transitions.
• Huang, S., Huang, S., Hu, C., Hu, C., Bell, M. L., Bell, M. L., Billheimer, D. D., Billheimer, D. D., Guerra, S., Guerra, S., Roe, D., Roe, D., Vasquez, M., Vasquez, M., Bedrick, E. J., & Bedrick, E. J. (2018). Regularized continuous-time Markov model via elastic net. Biometrics.
• Li, H., Fan, J., Vitali, F., Berghout, J., Aberasturi, D., Li, J., Wilson, L., Chiu, W., Pumarejo, M., Han, J., Kenost, C., Koripella, P. C., Pouladi, N., Billheimer, D., Bedrick, E. J., & Lussier, Y. A. (2018). Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities. BMC medical genomics, 11(Suppl 6), 112.
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  Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases remains not well established, and few studies have confirmed their molecular predictions with clinical datasets.
• Mayer, A. R., Dodd, A. B., Ling, J. M., Wertz, C. J., Shaff, N. A., Bedrick, E. J., & Viamonte, C. (2018). An evaluation of Z-transform algorithms for identifying subject-specific abnormalities in neuroimaging data. Brain imaging and behavior, 12(2), 437-448.
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  The need for algorithms that capture subject-specific abnormalities (SSA) in neuroimaging data is increasingly recognized across many neuropsychiatric disorders. However, the effects of initial distributional properties (e.g., normal versus non-normally distributed data), sample size, and typical preprocessing steps (spatial normalization, blurring kernel and minimal cluster requirements) on SSA remain poorly understood. The current study evaluated the performance of several commonly used z-transform algorithms [leave-one-out (LOO); independent sample (IDS); Enhanced Z-score Microstructural Assessment of Pathology (EZ-MAP); distribution-corrected z-scores (DisCo-Z); and robust z-scores (ROB-Z)] for identifying SSA using simulated and diffusion tensor imaging data from healthy controls (N = 50). Results indicated that all methods (LOO, IDS, EZ-MAP and DisCo-Z) with the exception of the ROB-Z eliminated spurious differences that are present across artificially created groups following a standard z-transform. However, LOO and IDS consistently overestimated the true number of extrema (i.e., SSA) across all sample sizes and distributions. The EZ-MAP and DisCo-Z algorithms more accurately estimated extrema across most distributions and sample sizes, with the exception of skewed distributions. DTI results indicated that registration algorithm (linear versus non-linear) and blurring kernel size differentially affected the number of extrema in positive versus negative tails. Increasing the blurring kernel size increased the number of extrema, although this effect was much more prominent when a minimum cluster volume was applied to the data. In summary, current results highlight the need to statistically compare the frequency of SSA in control samples or to develop appropriate confidence intervals for patient data.
• Whitaker, M. E., Nair, V., Sinari, S., Dherange, P. A., Natarajan, B., Trutter, L., Brittain, E. L., Hemnes, A. R., Austin, E. D., Patel, K., Black, S. M., Garcia, J. G., Yuan Md PhD, J. X., Vanderpool, R. R., Rischard, F., Makino, A., Bedrick, E. J., & Desai, A. A. (2018). Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension. The American journal of medicine, 131(6), 702.e7-702.e13.
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  Diabetes mellitus is associated with left ventricular hypertrophy and dysfunction. Parallel studies have also reported associations between diabetes mellitus and right ventricular dysfunction and reduced survival in patients with pulmonary arterial hypertension. However, the impact of diabetes mellitus on the pulmonary vasculature has not been well characterized. We hypothesized that diabetes mellitus and hyperglycemia could specifically influence right ventricular afterload and remodeling in patients with Group I pulmonary arterial hypertension, providing a link to their known susceptibility to right ventricular dysfunction.
• Bedrick, E. J. (2017). An Evaluation of Z-Transform Algorithms for Identifying Subject-Specific Abnormalities in Neuroimaging Data. Human Brain Mapping.
• Bedrick, E. J. (2017). Childhood hematologic cancer and residential proximity to oil and gas development. PLOS ONE.
• Patt, Y. Z., Murad, W., Fekrazad, M. H., Baron, A. D., Bansal, P., Boumber, Y., Steinberg, K., Lee, S. J., Bedrick, E., Du, R., & Lee, F. C. (2017). INST OX-05-024: first line gemcitabine, oxaliplatin, and erlotinib for primary hepatocellular carcinoma and bile duct cancers: a multicenter Phase II trial. Cancer medicine, 6(9), 2042-2051.
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  Hepatocellular Carcinoma (HCC) incidence is increasing in the USA. Gemcitabine (G) and oxaliplatin (O) are active in HCC and biliary duct cancer (BDC). Erlotinib (E) is an EGFR tyrosine kinase inhibitor (TKI) with known activity against both. We sought to evaluate the efficacy of the combination G+O+E. Patients with either of the two diagnosis were treated in a phase II trial. Simons 2 stage design was used. A disease-control rate (DCR), complete response (CR) + partial response (PR)+ stable disease (SD) at 24 weeks of ≤20% and >40% (P0 and P1 of 0.2 and 0.4, respectively) were set as undesirable (null) and desirable results. 26 HCC and 7 BDC patients were accrued. In HCC, 1 PR, 10 SD, and 9 PDs were seen. DCR in HCC was 42%. Among seven (7) patients with BDC, one patient was not evaluable; one achieved a long lasting PR, and five patients had SD and DCR was 86%. Median overall survival (OS) times and progression-free survivals (PFS) were 196 and 149 days in HCC and 238 days and not reached in BDC. PFS at 26 weeks in HCC was 41% and at 21 weeks in BDC was 60%. Grade 3 toxicities in >5% of patients were fatigue (12.9%), neutropenia (9.6%), thrombocytopenia (9.6%), and diarrhea (6.4%). G+O+E exceeded both preset P0a and P1 of the primary objective with a PFS of 41% at 26 weeks for HCC and preliminary BDC data may warrant further investigations.
• Amini, A., Yeh, N., Jones, B. L., Bedrick, E., Vinogradskiy, Y., Rusthoven, C. G., Amini, A., Purcell, W. T., Karam, S. D., Kavanagh, B. D., Guntupalli, S. R., & Fisher, C. M. (2016). Perioperative Mortality in Nonelderly Adult Patients With Cancer: A Population-based Study Evaluating Health Care Disparities in the United States According to Insurance Status. American journal of clinical oncology.
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  The purpose of this study was to evaluate whether insurance status predicts for perioperative mortality (death within 30 d of cancer-directed surgery) for the 20 most common surgically treated cancers.
• Bedrick, E. J., & Hund, L. (2016). An approach for quantifying small effects in regression models. Statistical methods in medical research.
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  We develop a novel approach for quantifying small effects in regression models. Our method is based on variation in the mean function, in contrast to methods that focus on regression coefficients. Our idea applies in diverse settings such as testing for a negligible trend and quantifying differences in regression functions across strata. Straightforward Bayesian methods are proposed for inference. Four examples are used to illustrate the ideas.
• White, A., Cronquist, A., Bedrick, E. J., & Scallan, E. (2016). Food Source Prediction of Shiga Toxin-Producing Escherichia coli Outbreaks Using Demographic and Outbreak Characteristics, United States, 1998-2014. Foodborne pathogens and disease, 13(10), 527-534.
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  Foodborne illness is a continuing public health problem in the United States. Although outbreak-associated illnesses represent a fraction of all foodborne illnesses, foodborne outbreak investigations provide critical information on the pathogens, foods, and food-pathogen pairs causing illness. Therefore, identification of a food source in an outbreak investigation is key to impacting food safety.

Presentations

• Bell, A., Bedrick, E. J., Carter, C. S., Tecot, S. R., MacLean, E., Feldman, R., & White-Traut, R. (2024, May). An NIH-funded R01 RCT with mother-infant dyads, birth data and repeated perinatal biobehavioral measures. Midwifery Research & Quality Exchange, American College of Nurse-Midwives Division of Research. Virtual: American College of Nurse-Midwives.
• Bedrick, E. J. (2019, April). Bayes for Personalized Medicine. Midas Conference Vina Del Mar Chile. Oracle, AZ.
• Bedrick, E. J. (2019, April). Double Double Toil and Trouble: Biases, Fallacies and Paradoxes that Will Turn Your Statistical Analysis to Rubble. Division Infectious Diseases Grand Rounds. UofA: Dept of Medicine - ID Division.
• Bedrick, E. J. (2019, June). Data Reduction Prior to Inference. Research Seminar. Mayo Clinic Minnesota.
• Bedrick, E. J. (2019, November). Data Reduction Prior to Inference. Research Seminar. UNAM Juriquilla Mexico.
• Bedrick, E. J. (2018, April). An Introduction to Bayesian Statistics in the Health Sciences. BIO5 Conference. UofA: BIO5.
• Bedrick, E. J. (2018, April). Bayes for N=1 Experiments. TRIPODs Biosphere Conference. Oracle, AZ.
• Bedrick, E. J. (2018, March). Bayes for N=1 Experiments. Tripods RG7 Working Group Seminar. UofA.
• Bedrick, E. J. (2018, March). Data Reduction Prior to Inference. Dept Epi and Biostat Seminar. Tucson.
• Bedrick, E. J. (2018, March). Intro to Bayesian Statistics. Seminar UofA College of Business. Tucson.
• Bedrick, E. J. (2018, May). Double Double Toil and Trouble: Biases, Fallacies and Paradoxes that Will Turn Your Statistical Analysis to Rubble. Dept Medicine Grand Rounds. UofA: Dept of Medicine(Arthritis).
• Bedrick, E. J. (2018, November). Double, Double, Toil and Trouble: etc (see earlier entry). OB/GYN Grand Rounds. UofA.
• Bedrick, E. J. (2018, October). Data Reduction Prior to Inference. Department Seminar Univ Nevada. Dept of Math Sciences: University of Nevada Reno.
• Roach, M., Collier, K., Hill, C., Briggs, G., Packard, S., Garcia, R., Dylan, K., Bedrick, E. J., & Griffin, S. (2018, Jan). Enhanced Surveillance of Heat-Related Illness in Pinal County. ISDS Annual Conference Proceedings 2018.

Poster Presentations

• Bedrick, E. J., Rubio, A., & Fisher, J. M. (2024, May). Two Bayesian Approaches to Combined Neural Functional Connectivity and Sub-Network Structure Estimation. Statistical Methods in Imaging. Indianapolis, Indiana: Statistics in Imaging Section of the American Statistical Association.
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  Note:  Unfortunately, due to 24 hours of flight delays, I missed the poster presentation.
• Fantry, L. E., Bedrick, E. J., Madhivanan, P. P., Guido, A., Loveland, M., Joseph, M., Nandemi, P., Gupte, R., Sadoway, D., Fisher, J. M., & Lim, J. (2022, Fall semester). Update on PrEP Knowledge and Attitudes Among Adults Attending Public Health Clinics in Southern Arizona. ID Week. Washington, DC: Infectious Disease Society of America.
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  Study of PrEP knowledge
• Ahmed, R. A., Ahmed, R. A., Bedrick, E. J., Bedrick, E. J., Ng, V., Ng, V., Plitt, J., Plitt, J., Cahir, T., Cahir, T., Hughes, P. G., Hughes, P. G., Hughes, K., Hughes, K., Ahmed, R. A., Bedrick, E. J., Ng, V., Plitt, J., Cahir, T., , Hughes, P. G., et al. (2020, January). Crisis resource management training: the blindfold code exercise. International Meeting on Simulation in Healthcare. San Diego, CA.
• Ramadan, F., Cupini, C., Bedrick, E. J., Burstyn, I., & Reiss, B. (2018, April). Characterization of PurpleAir Monitors: A Method-Comparison Study. SESHA/SIA International High Technology ESH Symposium and Exhibition. Scottsdale, AZ, USA.
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