Matthew D Adams

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Journals/Publications

• Robbins, K. K., Luna-Wong, L. A., Adams, M., & Ramos-Herberth, F. I. (2023). A case of lepromatous leprosy in Arizona, United States. JAAD case reports, 43, 9-11.
• Adams, M. (2021). A Review of Diagnostics for Coccidioidomycosis. Clinical Microbiology Newsletter, 16(43), 135-141. doi:10.1016
• Adams, M., & Lainhart, W. D. (2021). A review of diagnostics for Coccidiomycosis. Clinical Microbiology Newsletter, 43(16), 135-141.
• York, L. D., Fisher, J. M., Malladi, L., August, J., Ellis, K. E., Marquez, J., Kaveti, A., Khachatryan, M., Paz, M., Adams, M., Bedrick, E. J., Fantry, L., Adams, M., Adams, M., Fantry, L., Bedrick, E. J., Adams, M., Paz, M., Khachatryan, M., , Kaveti, A., et al. (2021). Antiretroviral Laboratory Monitoring and Implications for HIV Clinical Care in the Era of COVID-19 and Beyond. AIDS Research and Human Retroviruses.
• York, L., Fisher, J. M., Malladi, L., August, J. A., Ellis, K. E., Marquez, J. L., Kaveti, A., Khachatryan, M., Paz, M. K., Adams, M. D., Bedrick, E. J., & Fantry, L. E. (2021). Antiretroviral Laboratory Monitoring and Implications for HIV Clinical Care in the Era of COVID-19 and Beyond. AIDS research and human retroviruses.
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  In the era of COVID-19, providers are delaying laboratory testing in people with HIV (PWH). The purpose of this study was to examine the clinical significance of renal, liver, and lipid testing.
• Adams, M., Bouzigard, R., Al-Obaidi, M., & Zangeneh, T. T. (2020). Perinephric abscess in a renal transplant recipient due to Mycoplasma hominis: Case report and review of the literature. Transplant infectious disease : an official journal of the Transplantation Society, e13308.
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  A 42-year-old man presented with nausea, malaise, and pain at his renal graft site 4 months following deceased donor renal transplant. His transplantation had been complicated by urinary leak with delayed wound closure requiring ureteral revision with biologic mesh placement. The initial evaluation in the hospital revealed urinalysis with significant pyuria as well as abdominal CT imaging concerning for abscess formation anterior to the grafted kidney. Interventional radiology (IR) guided drainage of this abscess yielded growth of Enterococcus faecalis treated with intravenous ampicillin/sulbactam. He continued to have pain at his graft site and repeat imaging revealed a persistent abscess despite prolonged antimicrobial therapy. Urine cultures isolated Mycoplasma species. A repeat aspirate of abscess fluid collected and Mycoplasma hominis was identified by molecular test. Patient's symptoms abated and his abscess completely resolved on repeat imaging after completing a course of oral moxifloxacin and doxycycline. His immunosuppression did not require adjustment and the renal graft continued to function well following this therapy. Mycoplasma and Ureaplasma should be considered as a potential etiology for perinephric abscess in renal transplant recipients.
• Hooten, R., Luis Marquez, J., Goldlist, K., Urcis, R., Adams, M., Matthias, K. R., Nix, D. E., & Al Mohajer, M. (2020). Overprescription of antibiotics in patients with community-acquired pneumonia in the intensive care unit. Avicenna journal of medicine, 9(3), 107-110.
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  We aimed to assess factors associated with therapy failure in patients with community-acquired pneumonia in the intensive care unit (ICU).
• Adams, M. (2019). Critical Care Case of the Month: Running Naked in the Park. Southwest Journal of Pulmonary and Critical Care, 4(19), 110-118. doi:10.13175
• Adams, M., Bach, M., Althaghfi, A., Matthias, K. R., Mohajer, M. A., & Nix, D. E. (2017). Impact of Verigene Multiplex PCR for Positive Blood Cultures and Gram Negative Bacteremia. Open Forum Infectious Diseases, 4(suppl_1), S625-S625. doi:10.1093/ofid/ofx163.1654
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  AbstractBackgroundMany patients with bacteremia due to Gram-negative organisms are not treated appropriately. This has been linked to high rates of multi-drug resistant organisms, hospital costs, length of stay, and mortality. The purpose of this study was to assess the effect of implementation of Verigene multiplex PCR on appropriate use of antibiotics, and the time to streamlining of therapy in this population.MethodsThis study included hospitalized patients with Gram-negative organisms isolated from blood cultures both six months before, and six months after the implementation of Verigene at a tertiary care academic medical center. An institutional review board approved this study. We excluded patients that had organisms isolated from autopsy sample and patients under the age of 18. Appropriate therapy was defined as any antibiotic therapy to which the organism was reported as being susceptible once susceptibility results were available. Streamlined therapy was defined as the narrowest antibiotic selection based off organism susceptibility. The primary outcome measure was the time to streamlining of therapy (before culture and susceptibility date were available). Data was compared by group (before and after Verigene implementation) using multiple logistic regression model in SAS.ResultsA total of 287 patients were included. 140 of the subjects were male (48.8%). Mean age in the pre-verigene group was 61.5 years (SD 17.1) and the mean age in the post-verigene group was 59.7 (SD 18.2). In 93 patients, cultures were collected in the ICU setting (32.4%). In nine post-verigene patients, ESBL with the CTX-M resistance marker was isolated. Six of these patients were switched from inappropriate therapy to a carbapenem. The time to appropriate antibiotics in the pre-verigene group was 0.4 days (SD 0.8) and in the post-verigene group 0.4 days (SD 1.0 P = 0.57). The time to streamlining of antibiotics following culture was improved in the post-verigene group (1.9 days, SD 1.3) compared with the pre-verigene group (2.6 days, SD 1.4 P = 0.01).ConclusionThe use of Verigene multiplex PCR was associated with improved time to streamlining of antibiotic therapy in patients with Gram-negative bacteremia.Disclosures All authors: No reported disclosures.
• Pentkowski, N. S., Harder, B. G., Brunwasser, S. J., Bastle, R. M., Peartree, N. A., Yanamandra, K., Adams, M. D., Der-Ghazarian, T., & Neisewander, J. L. (2014). Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. ACS chemical neuroscience, 5(3), 168-76.
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  Studies examining serotonin-1B (5-HT1B) receptor manipulations on cocaine self-administration and cocaine-seeking behavior initially seemed discrepant. However, we recently suggested based on viral-mediated 5-HT1B-receptor gene transfer that the discrepancies are likely due to differences in the length of abstinence from cocaine prior to testing. To further validate our findings pharmacologically, we examined the effects of the selective 5-HT1B receptor agonist CP 94,253 (5.6 mg/kg, s.c.) on cocaine self-administration during maintenance and after a period of protracted abstinence with or without daily extinction training. We also examined agonist effects on cocaine-seeking behavior at different time points during abstinence. During maintenance, CP 94,253 shifted the cocaine self-administration dose-effect function on an FR5 schedule of reinforcement to the left, whereas following 21 days of abstinence CP 94,253 downshifted the function and also decreased responding on a progressive ratio schedule of reinforcement regardless of extinction history. CP 94,253 also attenuated cue-elicited and cocaine-primed drug-seeking behavior following 5 days, but not 1 day, of forced abstinence. The attenuating effects of CP 94,253 on the descending limb of the cocaine dose-effect function were blocked by the selective 5-HT1B receptor antagonist SB 224289 (5 mg/kg, i.p.) at both time points, indicating 5-HT1B receptor mediation. The results support a switch in 5-HT1B receptor modulation of cocaine reinforcement from facilitatory during self-administration maintenance to inhibitory during protracted abstinence. These findings suggest that the 5-HT1B receptor may be a novel target for developing medication for treating cocaine dependence.
• Pentkowski, N. S., Cheung, T. H., Toy, W. A., Adams, M. D., Neumaier, J. F., & Neisewander, J. L. (2012). Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors. Biological psychiatry, 72(5), 396-404.
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  The role of serotonin-1B receptors (5-HT(1B)Rs) in modulating cocaine abuse-related behaviors has been controversial due to discrepancies between pharmacological and gene knockout approaches and opposite influences on cocaine self-administration versus cocaine-seeking behavior. We hypothesized that modulation of these behaviors via 5-HT(1B)Rs in the mesolimbic pathway may vary depending on the stage of the addiction cycle.
• Pentkowski, N. S., Painter, M. R., Thiel, K. J., Peartree, N. A., Cheung, T. H., Deviche, P., Adams, M., Alba, J., & Neisewander, J. L. (2011). Nicotine-induced plasma corticosterone is attenuated by social interactions in male and female adolescent rats. Pharmacology, biochemistry, and behavior, 100(1), 1-7.
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  Most smokers begin smoking during adolescence, a period during which social reward is highly influential. Initial exposure to nicotine can produce anxiogenic effects that may be influenced by social context. This study examined play behavior and plasma corticosterone following nicotine administration (0.6 mg/kg, s.c.) in both male and female adolescent (PND39) Sprague-Dawley rats in either isolate or social contexts. In blood samples collected immediately following the 15-min test session, nicotine increased plasma corticosterone relative to saline in both male and female isolate rats, but failed to do so in both males and females placed together in same-sex pairs. Nicotine also attenuated several indices of play behavior including nape attacks, pins and social contact. In isolate rats, nicotine selectively increased locomotor activity in females; however, when administered to social pairs, nicotine decreased locomotion in both sexes. These findings suggest that the presence of a social partner may decrease the initial negative, stress-activating effects of nicotine, perhaps leading to increased nicotine reward.