Cameron D Hypes

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Scholarly Contributions

Books

• Hypes, C. (2023). Critical Care Emergencies
  Chapter 2: Breathing from the neck:tracheostomy emergencies
  Chapter 5: Coughing up blood: massive hemoptysis.

Journals/Publications

• Anesi, G. L., Andrews, A., Bai, H. J., Bhatraju, P. K., Brett-Major, D. M., Broadhurst, M. J., Campbell, E. S., Cobb, J. P., Gonzalez, M., Homami, S., Hypes, C. D., Irwin, A., Kratochvil, C. J., Krolikowski, K., Kumar, V. K., Landsittel, D. P., Lee, R. A., Liebler, J. M., Lutrick, K., , Marts, L. T., et al. (2023). Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic. Critical care medicine, 51(4), 445-459.
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  The COVID-19 pandemic threatened standard hospital operations. We sought to understand how this stress was perceived and manifested within individual hospitals and in relation to local viral activity.
• Brown, S. M., Barkauskas, C. E., Grund, B., Sharma, S., Phillips, A. N., Leither, L., Peltan, I. D., Lanspa, M., Gilstrap, D. L., Mourad, A., Lane, K., Beitler, J. R., Serra, A. L., Garcia, I., Almasri, E., Fayed, M., Hubel, K., Harris, E. S., Middleton, E. A., , Barrios, M. A., et al. (2023). Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial. The Lancet. Respiratory medicine, 11(9), 791-803.
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  There is a clinical need for therapeutics for COVID-19 patients with acute hypoxemic respiratory failure whose 60-day mortality remains at 30-50%. Aviptadil, a lung-protective neuropeptide, and remdesivir, a nucleotide prodrug of an adenosine analog, were compared with placebo among patients with COVID-19 acute hypoxaemic respiratory failure.
• Cairns, C. B., Lutrick, K., Campbell, E. S., Bedrick, E. J., Hypes, C., Fisher, J. M., & Mosier, J. M. (2021). A Target for Increased Mortality Risk in Critically Ill Patients: The Concept of Perpetuity. Journal of Clinical Medicine.
• Sakles, J. C., Mosier, J. M., Hypes, C., Patanwala, A., Hurst, N. B., & Pacheco, G. (2021). First Pass Success Without Adverse Events is Reduced Equally with Anatomically Difficult Airways and Physiologically Difficult Airways. Western Journal of Emergency Medicine.
• Ripperger, T. J., Uhrlaub, J. L., Watanabe, M., Wong, R., Castaneda, Y., Pizzato, H. A., Thompson, M. R., Bradshaw, C., Weinkauf, C. C., Bime, C., Erickson, H. L., Knox, K., Bixby, B., Parthasarathy, S., Chaudhary, S., Natt, B., Cristan, E., Aini, T. E., Rischard, F., , Campion, J., et al. (2020). Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure. medRxiv : the preprint server for health sciences.
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  We conducted an extensive serological study to quantify population-level exposure and define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 cases, individuals with severe disease exhibited elevated authentic virus-neutralizing titers and antibody levels against nucleocapsid (N) and the receptor binding domain (RBD) and the S2 region of spike protein. Unlike disease severity, age and sex played lesser roles in serological responses. All cases, including asymptomatic individuals, seroconverted by 2 weeks post-PCR confirmation. RBD- and S2-specific and neutralizing antibody titers remained elevated and stable for at least 2-3 months post-onset, whereas those against N were more variable with rapid declines in many samples. Testing of 5882 self-recruited members of the local community demonstrated that 1.24% of individuals showed antibody reactivity to RBD. However, 18% (13/73) of these putative seropositive samples failed to neutralize authentic SARS-CoV-2 virus. Each of the neutralizing, but only 1 of the non-neutralizing samples, also displayed potent reactivity to S2. Thus, inclusion of multiple independent assays markedly improved the accuracy of antibody tests in low seroprevalence communities and revealed differences in antibody kinetics depending on the viral antigen. In contrast to other reports, we conclude that immunity is durable for at least several months after SARS-CoV-2 infection.
• Ripperger, T. J., Uhrlaub, J. L., Watanabe, M., Wong, R., Castaneda, Y., Pizzato, H. A., Thompson, M. R., Bradshaw, C., Weinkauf, C. C., Bime, C., Erickson, H. L., Knox, K., Bixby, B., Parthasarathy, S., Chaudhary, S., Natt, B., Cristan, E., El Aini, T., Rischard, F., , Campion, J., et al. (2020). Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity. Immunity, 53(5), 925-933.e4.
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  We conducted a serological study to define correlates of immunity against SARS-CoV-2. Compared to those with mild coronavirus disease 2019 (COVID-19) cases, individuals with severe disease exhibited elevated virus-neutralizing titers and antibodies against the nucleocapsid (N) and the receptor binding domain (RBD) of the spike protein. Age and sex played lesser roles. All cases, including asymptomatic individuals, seroconverted by 2 weeks after PCR confirmation. Spike RBD and S2 and neutralizing antibodies remained detectable through 5-7 months after onset, whereas α-N titers diminished. Testing 5,882 members of the local community revealed only 1 sample with seroreactivity to both RBD and S2 that lacked neutralizing antibodies. This fidelity could not be achieved with either RBD or S2 alone. Thus, inclusion of multiple independent assays improved the accuracy of antibody tests in low-seroprevalence communities and revealed differences in antibody kinetics depending on the antigen. We conclude that neutralizing antibodies are stably produced for at least 5-7 months after SARS-CoV-2 infection.
• Self, W. H., Semler, M. W., Leither, L. M., Casey, J. D., Angus, D. C., Brower, R. G., Chang, S. Y., Collins, S. P., Eppensteiner, J. C., Filbin, M. R., Files, D. C., Gibbs, K. W., Ginde, A. A., Gong, M. N., Harrell, F. E., Hayden, D. L., Hough, C. L., Johnson, N. J., Khan, A., , Lindsell, C. J., et al. (2020). Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA, 324(21), 2165-2176.
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  Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed.
• Mosier, J. M., & Hypes, C. D. (2019). Mechanical Ventilation Strategies for the Patient with Severe Obstructive Lung Disease. Emergency medicine clinics of North America, 37(3), 445-458.
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  Patients with respiratory failure due to obstructive lung disease present a challenge to the emergency physician. These patients have physiologic abnormalities that prevent adequate gas exchange and lung mechanics which render them at increased risk of cardiopulmonary decompensation when managed with invasive mechanical ventilation. This article addresses key principles when managing these challenging patients: patient-ventilator synchrony, air trapping and auto-positive end-expiratory pressure, and airway pressures. This article provides a practical workflow for the emergency physician responsible for managing these patients.
• Mosier, J. M., Stolz, U., Milligan, R., Roy-Chaudhury, A., Lutrick, K., Hypes, C. D., Billheimer, D., & Cairns, C. B. (2019). Impact of Point-of-Care Ultrasound in the Emergency Department on Care Processes and Outcomes in Critically Ill Nontraumatic Patients. Critical care explorations, 1(6), e0019.
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  Outcomes data on point-of-care ultrasound (POCUS) in critically ill patients are lacking. This study examines the association between POCUS in the emergency department and outcomes in critically ill patients.
• Hypes, C. D., Sakles, J. C., & Mosier, J. M. (2017). Reply: Did Video Kill the Direct Laryngoscopy Star? Not Yet!. Annals of the American Thoracic Society, 14(4), 610-611.
• Natt, B., Hypes, C., Basekn, R., Malo, J., Kazui, T., & Mosier, J. M. (2017). The use of extracorporeal membrane oxygenation in the bronchoscopic management of critical upper airway obstruction. Journal of Extra Corporeal Technology, 49(1), 54-58.
• Natt, B., Hypes, C., Basken, R., Malo, J., Kazui, T., & Mosier, J. (2017). Suspected Heparin-Induced Thrombocytopenia in Patients Receiving Extracorporeal Membrane Oxygenation. The journal of extra-corporeal technology, 49(1), 54-58.
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  Heparin-induced thrombocytopenia (HIT) is an immune reaction usually secondary to unfractionated heparin. Anticoagulation management is critical in patients while on extracorporeal membrane oxygenation (ECMO) to prevent thromboembolism and for the optimal functioning of the circuit. We identified five patients with respiratory failure at our hospital managed with ECMO in the last 2 years that were treated for HIT. A brief clinical course and their management are discussed. We also briefly review the literature for best evidence for management of such patients.
• Sakles, J. C., Douglas, M. J., Hypes, C. D., Patanwala, A. E., & Mosier, J. M. (2017). Management of Patients with Predicted Difficult Airways in an Academic Emergency Department. The Journal of emergency medicine, 53(2), 163-171.
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  Patients with difficult airways are sometimes encountered in the emergency department (ED), however, there is a little data available regarding their management.
• Hypes, C. (2016). Reply: Video Laryngoscopy: Take it to the Floor. Annals of the American Thoracic Society.
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  Response to letter to the editor
• Hypes, C. D., Sakles, J. C., & Mosier, J. M. (2016). Reply: Video Laryngoscopy: Take It to the Floor. Annals of the American Thoracic Society, 13(7), 1193-4.
• Hypes, C., Sakles, J., Joshi, R., Greenberg, J., Natt, B., Malo, J., Bloom, J., Chopra, H., & Mosier, J. (2016). Failure to achieve first attempt success at intubation using video laryngoscopy is associated with increased complications. Internal and emergency medicine.
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  The purpose of this investigation was to investigate the association between first attempt success and intubation-related complications in the Intensive Care Unit after the widespread adoption of video laryngoscopy. We further sought to characterize and identify the predictors of complications that occur despite first attempt success. This was a prospective observational study of consecutive intubations performed with video laryngoscopy at an academic medical Intensive Care Unit. Operator, procedural, and complication data were collected. Multivariable logistic regression was used to examine the relationship between the intubation attempts and the occurrence of one or more complications. A total of 905 patients were intubated using a video laryngoscope. First attempt success occurred in 739 (81.7 %), whereas >1 attempt was needed in 166 (18.3 %). One or more complications occurred in 146 (19.8 %) of those intubated on the first attempt versus 107 (64.5 %, p 1 attempt is associated with 6.4 (95 % CI 4.4-9.3) times the adjusted odds of at least one complication. Pre-intubation predictors of at least one complication despite first attempt success include vomit or edema in the airway as well as the presence of hypoxemia or hypotension. There are increased odds of complications with even a second attempt at intubation in the Intensive Care Unit. Complications occur frequently despite a successful first attempt, and as such, the goal of airway management should not be simply first attempt success, but instead first attempt success without complications.
• Joshi, R., Hypes, C. D., Greenberg, J., Snyder, L., Malo, J., Bloom, J. W., Chopra, H., Sakles, J. C., & Mosier, J. M. (2016). Difficult Airway Characteristics Associated with First Attempt Failure at Intubation Using Video Laryngoscopy in the Intensive Care Unit. Annals of the American Thoracic Society.
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  Video laryngoscopy has overcome the need to align the anatomic axes to obtain a view of the glottic opening in order to place a tracheal tube. However, despite this advantage, a large number of attempts are unsuccessful. There are no existing data on anatomic characteristics in critically ill patients associated with a failed first attempt at laryngoscopy when using video laryngoscopy.
• Mosier, J. M., Hypes, C. D., & Sakles, J. C. (2016). Understanding preoxygenation and apneic oxygenation during intubation in the critically ill. Intensive care medicine.
• Natt, B. S., Malo, J., Hypes, C. D., Sakles, J. C., & Mosier, J. M. (2016). Strategies to improve first attempt success at intubation in critically ill patients. British journal of anaesthesia, 117 Suppl 1, i60-i68.
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  Tracheal intubation in critically ill patients is a high-risk procedure. The risk of complications increases with repeated or prolonged attempts, making expedient first attempt success the goal for airway management in these patients. Patient-related factors often make visualization of the airway and placement of the tracheal tube difficult. Physiologic derangements reduce the patient's tolerance for repeated or prolonged attempts at laryngoscopy and, as a result, hypoxaemia and haemodynamic deterioration are common complications. Operator-related factors such as experience, device selection, and pharmacologic choices affect the odds of a successful intubation on the first attempt. This review will discuss the 'difficult airway' in critically ill patients and highlight recent advances in airway management that have been shown to improve first attempt success and decrease adverse events associated with the intubation of critically ill patients.
• Natt, B., Malo, J., Hypes, C., Sakles, J. C., & Mosier, J. M. (2016). Strategies to improve first attempt success at intubation in critically ill patients.. British Journal of Anaesthesia, 117, i60-i68.
• Baalachandran, R., Hypes, C., Natt, B., & Snyder, L. (2015). Pipe dreams: concealed methamphetamine causing severe toxicity. The American journal of the medical sciences, 349(6), 548-9.
• Hypes, C. D., Shirazi, F., Hoverstadt, P., Hurst, N., Lowry, J. S., Lowry, J. S., Hurst, N., Hoverstadt, P., Shirazi, F., & Hypes, C. D. (2015). Medical Image of the Week: Fluorescent Urine. Southwest Journal of Pulmonary and Critical Care, 11, 103-104.
• Hypes, C. D., Stolz, U., Sakles, J. C., Joshi, R. R., Natt, B., Malo, J., Bloom, J. W., & Mosier, J. M. (2015). Video Laryngoscopy Improves Odds of First Attempt Success at Intubation in the ICU: A Propensity-Matched Analysis. Annals of the American Thoracic Society.
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  Urgent tracheal intubation is performed frequently in intensive care units and incurs higher risk than when intubation is performed under more controlled circumstances. Video laryngoscopy may improve the chances of successful tracheal intubation on the first attempt; however existing comparative data on outcomes are limited.
• Hypes, C., Hoverstadt, P., Lowry, J. S., Hurst, N., & Shirazi, F. (2015). Medical image of the week: fluorescent urine. Southwest Journal of Pulmonary & Critical Care. doi:http://dx.doi.org/10.13175/swjpcc083-15
• Mosier, J. M., Hypes, C., Joshi, R., Whitmore, S., Parthasarathy, S., & Cairns, C. B. (2015). Ventilator Strategies and Rescue Therapies for Management of Acute Respiratory Failure in the Emergency Department. Annals of emergency medicine, 66(5), 529-41.
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  Acute respiratory failure is commonly encountered in the emergency department (ED), and early treatment can have effects on long-term outcome. Noninvasive ventilation is commonly used for patients with respiratory failure and has been demonstrated to improve outcomes in acute exacerbations of chronic obstructive lung disease and congestive heart failure, but should be used carefully, if at all, in the management of asthma, pneumonia, and acute respiratory distress syndrome. Lung-protective tidal volumes should be used for all patients receiving mechanical ventilation, and FiO2 should be reduced after intubation to achieve a goal of less than 60%. For refractory hypoxemia, new rescue therapies have emerged to help improve the oxygenation, and in some cases mortality, and should be considered in ED patients when necessary, as deferring until ICU admission may be deleterious. This review article summarizes the pathophysiology of acute respiratory failure, management options, and rescue therapies including airway pressure release ventilation, continuous neuromuscular blockade, inhaled nitric oxide, and extracorporeal membrane oxygenation.
• Mosier, J. M., Joshi, R., Hypes, C., Pacheco, G. S., Valenzuela, T. D., & Sakles, J. C. (2015). The Physiologically Difficult Airway. Western Journal of Emergency Medicine, 16(7), 1109-1117.
• Mosier, J. M., Joshi, R., Hypes, C., Pacheco, G., Valenzuela, T., & Sakles, J. C. (2015). The Physiologically Difficult Airway. The western journal of emergency medicine, 16(7), 1109-17.
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  Airway management in critically ill patients involves the identification and management of the potentially difficult airway in order to avoid untoward complications. This focus on difficult airway management has traditionally referred to identifying anatomic characteristics of the patient that make either visualizing the glottic opening or placement of the tracheal tube through the vocal cords difficult. This paper will describe the physiologically difficult airway, in which physiologic derangements of the patient increase the risk of cardiovascular collapse from airway management. The four physiologically difficult airways described include hypoxemia, hypotension, severe metabolic acidosis, and right ventricular failure. The emergency physician should account for these physiologic derangements with airway management in critically ill patients regardless of the predicted anatomic difficulty of the intubation.
• Mosier, J. M., Kelsey, M., Raz, Y., Gunnerson, K. J., Meyer, R., Hypes, C. D., Malo, J., Whitmore, S. P., & Spaite, D. W. (2015). Extracorporeal membrane oxygenation (ECMO) for critically ill adults in the emergency department: history, current applications, and future directions. Critical care (London, England), 19, 431.
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  Extracorporeal membrane oxygenation (ECMO) is a mode of extracorporeal life support that augments oxygenation, ventilation and/or cardiac output via cannulae connected to a circuit that pumps blood through an oxygenator and back into the patient. ECMO has been used for decades to support cardiopulmonary disease refractory to conventional therapy. While not robust, there are promising data for the use of ECMO in acute hypoxemic respiratory failure, cardiac arrest, and cardiogenic shock and the potential indications for ECMO continue to increase. This review discusses the existing literature on the potential use of ECMO in critically ill patients within the emergency department.
• Mosier, J. M., Malo, J., Sakles, J. C., Hypes, C. D., Natt, B., Snyder, L., Knepler, J., Bloom, J. W., Joshi, R., & Knox, K. (2015). The impact of a comprehensive airway management training program for pulmonary and critical care medicine fellows. A three-year experience. Annals of the American Thoracic Society, 12(4), 539-48.
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  Airway management in the intensive care unit (ICU) is challenging, as many patients have limited physiologic reserve and are at risk for clinical deterioration if the airway is not quickly secured. In academic medical centers, ICU intubations are often performed by trainees, making airway management education paramount for pulmonary and critical care trainees.
• Mosier, J. M., Sakles, J. C., Stolz, U., Hypes, C. D., Chopra, H., Malo, J., & Bloom, J. W. (2015). Neuromuscular blockade improves first-attempt success for intubation in the intensive care unit. A propensity matched analysis. Annals of the American Thoracic Society, 12(5), 734-41.
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  The use of neuromuscular blocking agents (NMBAs) has been shown to be valuable in improving successful tracheal intubation in the operating room and emergency department. However, data on NMBA use in critically ill intensive care unit (ICU) patients are lacking. Furthermore, there are no data on NMBA use with video laryngoscopy.
• Mosier, J. M., Sakles, J. C., Whitmore, S. P., Hypes, C. D., Hallett, D. K., Hawbaker, K. E., Snyder, L. S., & Bloom, J. W. (2015). Failed noninvasive positive-pressure ventilation is associated with an increased risk of intubation-related complications. Annals of intensive care, 5, 4.
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  Noninvasive positive-pressure ventilation (NIPPV) use has increased in the treatment of patients with respiratory failure. However, despite decreasing the need for intubation in some patients, there are no data regarding the risk of intubation-related complications associated with delayed intubation in adult patients who fail NIPPV. The objective of this study is to evaluate the odds of a composite complication of intubation following failed NIPPV compared to patients intubated primarily in the medical intensive care unit (ICU).
• Bime, C., Sun, K., Ulliman, E., & Hypes, C. (2014). Medical image of the week: secondary pneumonia presenting as hemoptysis. Southwest J Pulm Crit Care.
• Fiala, K. A., Hypes, C. D., & Suo, Z. (2007). Mechanism of abasic lesion bypass catalyzed by a Y-family DNA polymerase. The Journal of biological chemistry, 282(11), 8188-98.
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  The 3 million-base pair genome of Sulfolobus solfataricus likely undergoes depurination/depyrimidination frequently in vivo. These unrepaired abasic lesions are expected to be bypassed by Dpo4, the only Y-family DNA polymerase from S. solfataricus. Interestingly, these error-prone Y-family enzymes have been shown to be physiologically vital in reducing the potentially negative consequences of DNA damage while paradoxically promoting carcinogenesis. Here we used Dpo4 as a model Y-family polymerase to establish the mechanistic basis for DNA lesion bypass. While showing efficient bypass, Dpo4 paused when incorporating nucleotides directly opposite and one position downstream from an abasic lesion because of a drop of several orders of magnitude in catalytic efficiency. Moreover, in disagreement with a previous structural report, Dpo4-catalyzed abasic bypass involves robust competition between the A-rule and the lesion loop-out mechanism and is governed by the local DNA sequence. Analysis of the strong pause sites revealed biphasic kinetics for incorporation indicating that Dpo4 primarily formed a nonproductive complex with DNA that converted slowly to a productive complex. These strong pause sites are mutational hot spots with the embedded lesion even affecting the efficiency of five to six downstream incorporations. Our results suggest that abasic lesion bypass requires tight regulation to maintain genomic stability.

Proceedings Publications

• Hu, C., Hu, C., Spaite, D. W., Spaite, D. W., Vadeboncoeur, T. F., Vadeboncoeur, T. F., Hypes, C. D., Hypes, C. D., Murphy, R. A., Murphy, R. A., Silver, A., Silver, A., Bobrow, B. J., Bobrow, B. J., Hu, C., Spaite, D. W., Vadeboncoeur, T. F., Hypes, C. D., Murphy, R. A., , Silver, A., et al. (2016, January). ETC02 Alone is Inadequate to Verify CPR Quality. In Annual Meeting of the National Association of EMS Physicians.
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  Hu C, Spaite DW, Vadeboncoeur T, Hypes C, Murphy RA, Silver A, Bobrow BJ: ETC02 Alone is Inadequate to Verify CPR Quality. Prehospital Emerg Care 2016;20(1):141-142.
• Hu, C., Spaite, D. W., Vadeboncoeur, T., Hypes, C., Murphy, R., Silver, A., & Bobrow, B. J. (2016, January 14-16). ETCO2 Alone is Inadequate to Verify CPR Quality. In National Association of EMS Physicians Annual Meeting.
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  Hu C, Spaite DW, Vadeboncoeur T, Hypes C, Murphy R, Silver A, and Bobrow BJ. 2016. ETCO2 alone is inadequate to verify CPR quality. Prehospital Emerg Care, 2016;20(1):144-145.
• Irisawa, T., Vadeboncoeur, T. F., Hypes, C. D., McDannold, R., Mullins, M., Silver, A., Spaite, D. W., Bobrow, B. J., Irisawa, T., Vadeboncoeur, T. F., Hypes, C. D., McDannold, R., Mullins, M., Silver, A., Spaite, D. W., & Bobrow, B. J. (2016, January). Maintaining High Quality CPR With an Integrated Manual/Mechanical Resuscitation Protocol. In Annual Meeting of the National Association of EMS Physicians.
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  Irisawa T, Vadeboncoeur T, Hypes C, McDannold R, Mullins M, Silver A, Spaite DW, Bobrow BJ: Maintaining High Quality CPR With an Integrated Manual/Mechanical Resuscitation Protocol. Prehospital Emerg Care 2016;20(1):141-142.
• Hu, C., Spaite, D. W., Vadeboncoeur, T. F., Hypes, C. D., Murphy, R. A., Silver, A., Bobrow, B. J., Hu, C., Spaite, D. W., Vadeboncoeur, T. F., Hypes, C. D., Murphy, R. A., Silver, A., Bobrow, B. J., Hu, C., Spaite, D. W., Vadeboncoeur, T. F., Hypes, C. D., Murphy, R. A., , Silver, A., et al. (2015, November). ETCO2 Alone is Inadequate to Verify CPR Quality. In Resuscitation Science Symposium of the American Heart Association, 132, A18435.
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  Hu C, Spaite D, Vadeboncoeur T, Hypes C, Murphy RA, Silver A, Bobrow B: ETCO2 alone is inadequate to verify CPR quality. Circulation 2015;132:A18435
• Hypes, C. D., Spaite, D. W., Vadeboncoeur, T. F., Murphy, R. A., Hu, C., McDannold, R., Silver, A., & Bobrow, B. J. (2015, November). Elevated PETCO2 During Cardiac Resuscitation Without Return of Spontaneous Circulation. In Resuscitation Science Symposium of the American Heart Association, 132, A19572.
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  Hypes C, Spaite D, Vadeboncoeur T, Murphy RA, Hu C, McDannold R, Silver A, Bobrow B: Elevated petco2 during cardiac resuscitation without return of spontaneous circulation. Circulation 2015;132:A19572

Presentations

• Bull, D. A., Lick, S. D., Hypes, C., Natt, B., Mosier, J. M., Malo, J., & Hsu, C. (2019, May/). Duration and Outcomes of Veno-Venous Extracorporeal Membrane Oxygenation Support in Acute Respiratory Distress Syndrome: Results from ELSO database. American association for thoracic surgery 99th annual meeting. Toronto: American association for thoracic surgery.
• Hypes, C. (2018, Nov). A Bad Batch of Heroin: A Paralyzing Tale of Wound Botulism.. American College of Physicians Arizona Chapter Annual Scientific Meeting.
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  40. Martinez F, Hypes C. A Bad Batch of Heroin: A Paralyzing Tale of Wound Botulism. American College of Physicians Arizona Chapter Annual Scientific Meeting; Nov 2018; Tempe, AZ
• Mosier, J. M., Patanwala, A., Hypes, C., Augustinovich, C., & Sakles, J. C. (2018, May). Use of an Airway Registry to Improve the Safety of Airway Management in the Emergency Department. Society for Academic Emergency Medicine Annual Meeting. Indianapolis, IA: Society for Academic Emergency Medicine.
• Sakles, J. C., Mosier, J. M., Hypes, C., & Pacheco, G. (2018, May). Video Laryngoscopy Improves First Pass Success in Pediatric Intubations in the Emergency Department. Society for Academic Emergency Medicine Annual Meeting. Indianapolis, IA: Society for Academic Emergency Medicine.
• Sakles, J. C., Wolfe, A., Patanwala, A., & Olvera, D. (2018, May). The Importance of First Pass Success in Prehospital Intubation. Society for Academic Emergency Medicine Annual Meeting. Indianapolis, IA: Society for Academic Emergency Medicine.

Poster Presentations

• Bull, D. A., Lick, S. D., Hypes, C., Natt, B., Mosier, J. M., Malo, J., Hsu, C., & Kazui, T. (2020, April). Interfacility transfer via a mobile intensive care unit following a double lumen catheter cannulation at the referring facility for veno-venous extracorporeal membrane oxygenation. THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION 2020 Scientific Program. Montreal, Canada: THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION.
• Kazui, T., Bull, D. A., Hsu, C., Lick, S. D., Malo, J., Hypes, C., Mosier, J. M., Natt, B., Natt, B., Mosier, J. M., Hypes, C., Malo, J., Lick, S. D., Hsu, C., Bull, D. A., & Kazui, T. (2020, April). Interfacility transfer via a mobile intensive care unit following a double lumen catheter cannulation at the referring facility for veno-venous extracorporeal membrane oxygenation. THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION 2020 Scientific Program. Montreal, Canada: THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION.
• Pacheco, G., Hypes, C., Mosier, J. M., Patanwala, A., Sakles, J. C., & Hurst, N. B. (2019, November). Adverse Events in Patients with Physiologically Difficult and Anatomically Difficult Airways in the Emergency Department.. World Airway Management Meeting. Amsterdam, NE: SAM, EAMS.
• Pacheco, G., Mosier, J. M., Hypes, C., & Sakles, J. C. (2019, November). The Physiologically Difficult Airway is Associated with as Many Adverse Events as the Anatomically Difficult Airway in the Emergency Department. World Airway Management Meeting. Amsterdam: Society For Airway Management.
• Sakles, J. C., Pacheco, G., Hypes, C., Mosier, J. M., Mosier, J. M., Hypes, C., Pacheco, G., & Sakles, J. C. (2019, November). The Physiologically Difficult Airway is Associated with as Many Adverse Events as the Anatomically Difficult Airway in the Emergency Department. World Airway Management Meeting (WAMM). Amsterdam: Society For Airway Management.
• Hypes, C. (2018, Feb). Early Point-Of-Care Ultrasound In Critical Care Helpful, Critical, Or Recreating The Swan Problem?. Society of Critical Care Medicine Annual Congress.
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  34. Roy-Chaudhury A, Milligan R, Crabbe S, Hypes C, Adhikari S, Stolz L, Cairns C, Mosier J. Early Point-Of-Care Ultrasound In Critical Care Helpful, Critical, Or Recreating The Swan Problem? Society of Critical Care Medicine Annual Congress; February 2018; San Antonio, TX
• Hypes, C. (2018, Feb). Interventions for Hemodynamic Instability in Critically Ill Patients Do Not Reduce Risk of Mortality with Intubation.. Society of Critical Care Medicine Annual Congress. San Antonio, TX: Society of Critical Care Medicine.
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  29. Morrissette K, Milligan R, Hypes C, Sakles J, Mosier J. Interventions for Hemodynamic Instability in Critically Ill Patients Do Not Reduce Risk of Mortality with Intubation. Society of Critical Care Medicine Annual Congress; February 2018; San Antonio, TX
• Hypes, C. (2018, Feb). Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome. Society of Critical Care Medicine Annual Congress.
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  32. Rao P, Ali H, Hypes C, Natt B, Khalpey Z, Cairns C, Mosier J. Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome. Society of Critical Care Medicine Annual Congress; February 2018; San Antonio, TX
• Hypes, C. (2018, Feb). The Physiologically Difficult Airway is as Dangerous as the Anatomically Difficult Airway in Critically Ill Patients in the Emergency Department.. Western SAEM Regional Congress.
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  31. Sakles JC, Pacheco G, Hypes C, Mosier J. The Physiologically Difficult Airway is as Dangerous as the Anatomically Difficult Airway in Critically Ill Patients in the Emergency Department. Western SAEM Regional Congress; February 2018, Albuquerque, NM
• Hypes, C. (2018, Feb). Use of an Airway Registry Monitor and Improve the Safety of Airway Management in the Emergency Department. Western SAEM Regional Congress.
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  30. Sakles JC, Augstinovich C, Hypes C, Patanwala S, Mosier J. Use of an Airway Registry Monitor and Improve the Safety of Airway Management in the Emergency Department. Western SAEM Regional Congress; February 2018, Albuquerque, NM
• Hypes, C. (2018, May). . Implementation of Emergency Department Critical Care Response Team on Patient Disposition and Outcome. American Thoracic Society Annual Congress.
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  39. Morrissette K, Hypes C, Mosier J. Implementation of Emergency Department Critical Care Response Team on Patient Disposition and Outcome. American Thoracic Society Annual Congress; May 2018; San Diego, CA
• Hypes, C. (2018, May). Early Point-Of-Care Ultrasound In Critical Care: Truly Innovative or History Repeating Itself?. Society of Academic Emergency Medicine Annual Congress.
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  36. Roy-Chaudhury A, Stolz U, Milligan R, Crabbe S, Hypes C, Adhikari S, Stolz L, Cairns C, Mosier J. Early Point-Of-Care Ultrasound In Critical Care: Truly Innovative or History Repeating Itself? Society of Academic Emergency Medicine Annual Congress; May 2018; Indianapolis, IN
• Hypes, C. (2018, May). The Physiologically Difficult Airway is as Dangerous as the Anatomically Difficult Airway in Critically Ill Patients in the Emergency Department. Society of Academic Emergency Medicine Annual Congress.
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  38. Sakles JC, Pacheco G, Hypes C, Mosier J. The Physiologically Difficult Airway is as Dangerous as the Anatomically Difficult Airway in Critically Ill Patients in the Emergency Department. Society of Academic Emergency Medicine Annual Congress; May 2018; Indianapolis, IN
• Hypes, C. (2018, May). Use of an Airway Registry Monitor and Improve the Safety of Airway Management in the Emergency Department.. Society of Academic Emergency Medicine Annual Congress.
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  37. Sakles JC, Augstinovich C, Hypes C, Patanwala S, Mosier J. Use of an Airway Registry Monitor and Improve the Safety of Airway Management in the Emergency Department. Society of Academic Emergency Medicine Annual Congress; May 2018; Indianapolis, IN
• Hypes, C. (2017, September). Improvement in the Quality and Safety of Airway Management in the Emergency Department Over a 10-year Period with the Use of an Airway CQI Program. Society for Airway Management. Newport Beach, CA.: Society for Airway Management.
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  27. Augustinovich C, Hypes C, Patanwala A, Mosier J, Sakles J; Improvement in the Quality and Safety of Airway Management in the Emergency Department Over a 10-year Period with the Use of an Airway CQI Program [Poster]; Society for Airway Management; September 2017; Newport Beach, CA.
• Hypes, C., Mosier, J. M., Patanwala, A. E., & Sakles, J. C. (2017, May). The Unanticipated Difficult Airway During Emergency Tracheal Intubation. SAEM Annual Meeting. Orlando, FL.
• Hypes, C., Sakles, J. C., Malo, J., Bloom, J. W., Joshi, R., Mosier, J. M., & Greenberg, J. (2016, Spring). First attempt success at intubation is associated with a lower odds of adverse events in the ICU. Society For Academic Emergency Medicine. New Orleans, LA.
• Hypes, C., Sakles, J. C., Malo, J., Mosier, J. M., Cristan, E., Milligan, R., & Morrissette, K. (2017, February). Improvement in tracheal intubation over time with the institution of a quality improvement program [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
• Hypes, C., Sakles, J. C., Malo, J., Mosier, J. M., Jeremy, G., Morrissette, K., Cristan, E., & Milligan, R. (2017, Feb). Re-intubation in the Intensive Care Unit: Is it Truly as Difficult as Assumed? [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
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  23. Greenberg J, Mosier J, Malo J, Morrissette K, Cristan E, Milligan R, Sakles J, Hypes C; Re-intubation in the Intensive Care Unit: Is it Truly as Difficult as Assumed? [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI.
• Hypes, C., Sakles, J. C., Malo, J., Mosier, J. M., Milligan, R., Cristan, E., Greenberg, J., & Morrissette, K. (2017, Feb). Intubation and First Pass Success, a Comparison of C-MAC and GlideScope in the Intensive Care Unit [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI: Society of Critical Care Medicine.
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  21. Milligan R, Mosier J, Cristan E, Greenberg J, Morrissette K, Sakles J, Malo J, Hypes C; Intubation and First Pass Success, a Comparison of C-MAC and GlideScope in the Intensive Care Unit [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI
• Hypes, C., Sakles, J. C., Malo, J., Mosier, J. M., Morrissette, K., Cristan, E., Greenberg, J., & Milligan, R. (2017, Feb). Flexible Fiberoptic vs Video Larygoscopy: Insights on Difficult Airway Success and Complications [Poster]. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
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  20. Morrissette K, Mosier J, Cristan E, Greenberg J, Milligan R, Sakles J, Malo J, Hypes C, Flexible Fiberoptic vs Video Larygoscopy: Insights on Difficult Airway Success and Complications [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI.
• Hypes, C., Sakles, J. C., Mosier, J. M., Natt, B., Greenberg, J., Morrissette, K., & Cristan, E. (2017, Feb). Rethinking NIV: when it works, it works. When it doesn't, it really doesn't. Society of Critical Care Medicine Annual Congress. Honolulu, HI.: Society of Critical Care Medicine.
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  22. Greenberg J, Mosier J, Natt B, Morrissette K, Cristan C, Sakles J, Hypes C; Rethinking NIV: when it works, it works. When it doesn't, it really doesn't [Poster]; Society of Critical Care Medicine Annual Congress; February 2017; Honolulu, HI.
• Hypes, C., Sakles, J. C., Mosier, J. M., Patanwala, A., & Douglas, M. (2017, May). The Unanticipated Difficult Airway during Emergency Tracheal Intubation [Poster]. Society for Academic Emergency Medicine Annual Meeting. Orlando, FL: Society for Academic Emergency Medicine.
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  24. Hypes C, Mosier J, Douglas M, Patanwala A, Sakles J; The Unanticipated Difficult Airway during Emergency Tracheal Intubation [Poster]; Society for Academic Emergency Medicine Annual Meeting; May 2017; Orlando FL.
• Hypes, C., Sakles, J. C., Patanwala, A. E., Mosier, J. M., & Douglas, M. (2017, May). The Physiologically Difficult Airway is Associated with a Reduced First Pass Success without Adverse Events During Emergency Department Intubations [Poster]. Society for Academic Emergency Medicine Annual Meeting. Orlando, FL: Society for Academic Emergency Medicine.
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  25. Sakles J, Douglas M, Hypes C, Patanwala A, Mosier J; The Physiologically Difficult Airway is Associated with a Reduced First Pass Success without Adverse Events During Emergency Department Intubations [Poster]; Society for Academic Emergency Medicine Annual Meeting; May 2017; Orlando FL.
• Hypes, C., Sakles, J. C., Patanwala, A. E., Mosier, J. M., & Douglas, M. (2017, September). Measuring FeO2 in the Emergency Department to Optimize Preoxygenation During Rapid Sequence Intubation. Society for Airway Management. Newport Beach, CA.: Society for Airway Management.
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  26. Sakles J, Mosier J, Douglas M, Hypes C, Patanwala A; Measuring FeO2 in the Emergency Department to Optimize Preoxygenation During Rapid Sequence Intubation [Poster]; Society for Airway Management; September 2017; Newport Beach, CA.
• Sakles, J. C., Douglas, M., Hypes, C., Patanwala, A. E., & Mosier, J. M. (2017, May). The Physiologically Difficult Airway is Associated with a Reduced First Pass Success without Adverse Events During Emergency Department Intubations . SAEM Annual Meeting. Orlando, FL.
• Sakles, J. C., Mosier, J. M., Douglas, M., Hypes, C., & Patanwala, A. E. (2017, September). Measuring FeO2 in the Emergency Department to Optimize Preoxygenation During Rapid Sequence Intubation. Society for Airway Management Annual Meeting. Newport Beach, CA.
• Sakles, J. C., Mosier, J. M., Patanwala, A. E., Hypes, C., & Augustinovich, C. (2017, September). Improvement in the Quality and Safety of Airway Management in the Emergency Department Over a 10-Year Period with the Use of an Airway CQI Program. Society for Airway Management Annual Meeting. Newport Beach, CA.
• Greenberg, J., Mosier, J. M., Joshi, R., Bloom, J. W., Malo, J., Sakles, J. C., & Hypes, C. (2016, Feb). First Attempt Success at Intubation is Associated with a Lower Odds of Adverse Events in the ICU. Society of Critical Care Medicine Annual Congress. Orlando.
• Hu, C., Spaite, D. W., Vadeboncoeur, T., Hypes, C., Murphy, R., Silver, A., & Bobrow, B. J. (2016, January 14-16). ETCO2 Alone is Inadequate to Verify CPR Quality. National Association of EMS Physicians Annual Meeting. San Diego, CA.
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  Hu C, Spaite DW, Vadeboncoeur T, Hypes C, Murphy R, Silver A, and Bobrow BJ. 2016. ETCO2 alone is inadequate to verify CPR quality. Prehospital Emerg Care, 2016;20(1):144-145.
• Hypes, C., Sakles, J. C., Nararro, T., Greenberg, J., Natt, B., Chopra, H., & Mosier, J. M. (2016, Sept). Failure to achieve first attempt success is associated with a higher odds of adverse events during intubation in the Intensive Care Unit using a video laryngoscope. Society for Airway Management. Atlanta.
• Johnston, D., Mosier, J. M., Joshi, R., Malo, J., Bloom, J. W., Sakles, J. C., & Hypes, C. (2016, Feb). Reason For Failed Attempts At Laryngoscopy Differs Between Video And Direct Laryngoscopes. Society of Critical Care Medicine Annual Congress. Orlando.
• Joshi, R., Hypes, C., Malo, J., Bloom, J. W., Sakles, J. C., & Mosier, J. M. (2016, Feb). Predictors of Difficult Intubation When Using Video Laryngoscopy in the Intensive Care Unit. Society of Critical Care Medicine Annual Congress.
• Kelsey, M., Sakles, J. C., Joshi, R., Malo, J., Bloom, J. W., Hypes, C., & Mosier, J. M. (2016, Feb). Derivation of a Bundle to Improve First Attempt Success at Intubation in the Intensive Care Unit. Society of Critical Care Medicine Annual Congress. Orlando.
• Milligan, R., & Hypes, C. (2016, Feb). Pericardial Cyst [Poster]; Photo Competition;. American Academy of Emergency Medicine 21st Annual Scientific Assembly. Las Vegas: AAEM.
• Mosier, J. M., Natt, B., Basken, R., Malo, J., Kazui, T., Hypes, C., Hypes, C., Kazui, T., Basken, R., Malo, J., Natt, B., & Mosier, J. M. (2016, Summer). Outcomes of Patients with Severe Influenza Treated at the Banner-University Medical Center During the 2015-16 Influenza Season. Options IX for the Control of Influenza. Chicago, IL.
• Nararro, T., Mosier, J. M., Sakles, J. C., Greenberg, J., Natt, B., Chopra, H., & Hypes, C. (2016, Sept). Predictors of complications of Intensive Care Unit airway management despite first attempt success using video laryngoscopy. Society for Airway Management.
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  This submission won the SAM travel award for Dr. Navarro to present it at the conference. I mentored Dr. Navarro in this activity.
• Natt, B., Malo, J., Hypes, C., Kazui, T., Basken, R., & Mosier, J. M. (2016, August). Outcomes of Patients with Severe Influenza Treated at the Banner-University Medical Center During the 2015-16 Influenza Season. Options IX for the Control of Influenza. Chicago.
• Natt, B., Malo, J., Hypes, C., Kazui, T., Basken, R., & Mosier, J. M. (2016, August/Summer). Outcomes of Patients with Severe Influenza Treated at the Banner-University Medical Center During the 2015-16 Influenza Season. Options IX for the Control of Influenza. Chicago, IL.
• Pacheco, G. S., Pacheco, G., Hypes, C., Hypes, C., Joshi, R., Joshi, R., Mosier, J. M., & Mosier, J. M. (2016, Feb). Emergency Department Recognition of Critical Illness Related Corticosteroid Insufficiency. Society of Critical Care Medicine Annual Congress. Orlando.
• Sakles, J. C., Douglas, M., Hypes, C., Pantawala, A., & Mosier, J. M. (2016, Sept). Incidence, Management and Outcomes of the Difficult Airway in the Emergency Department. Society for Airway Management. Atlanta.
• Sakles, J. C., Douglas, M., Hypes, C., Patanwala, A. E., & Mosier, J. M. (2016, September). Incidence, management and outcomes of the difficult airway in the emergency department. Society for Airway Management. Atlanta.
• Verbunker, D., & Hypes, C. (2016, Feb). Band But Don’t Break [Poster]. American Academy of Emergency Medicine 21st Annual Scientific Assembly. Las Vegas: AAEM.
• Greenberg, J., Mosier, J. M., Joshi, R., Bloom, J. W., Malo, J., Sakles, J. C., Hypes, C. D., Greenberg, J., Mosier, J. M., Joshi, R., Bloom, J. W., Malo, J., Sakles, J. C., & Hypes, C. D. (2016, February). First attempt success at intubation is associated with a lower odds of adverse events in the ICU. SCCM Annual Conference.
• Hu, C., Spaite, D. W., Vadeboncoeur, T., Hypes, C. D., Murphy, R. A., Silver, A., & Bobrow, B. J. (2015, November). ETCO2 Alone is Inadequate to Verify CPR Quality. Resuscitation Science Symposium of the American Heart Association. Orlando, Florida: the American Heart Association.
• Hypes, C. D. (2015, Feb). Razor Wire Mixup. American Academy of Emergency Medicine Scientific Assembly.
• Hypes, C. D. (2015, Jan). Neuromuscular Blockade Improves First Attempt Success for Intubation in the ICU: A Propensity Adjusted Analysis. ]; Society of Critical Care Medicine Annual Congress. Phoenix, AZ.
• Hypes, C. D. (2015, March). Video Laryngoscopy Improves Odds of First Attempt Success at Intubation in the Intensive Care Unit. Western Society of Academic Emergency Medicine.
• Hypes, C. D. (2015, May). Video Laryngoscopy Improves Odds of First Attempt Success at Intubation in the Intensive Care Unit. Society of Academic Emergency Medicine.
• Hypes, C. D. (2015, November). American Heart Association Scientific Sessions. American Heart Association Scientific Sessions.
• Hypes, C. D. (2015, November). Elevated PETCO2 during Cardiac Resuscitation without Return of Spontaneous Circulation. American Heart Associated Scientific Sessions.
• Hypes, C. D. (2015, November). Maintaining High Quality CPR with an Integrated Manual/Mechanical Resuscitation Protocol. American Heart Association Scientific Sessions.
• Hypes, C. D., Spaite, D. W., Vadeboncoeur, T., Murphy, R., Hu, C., McDannold, R., Silver, A., & Bobrow, B. J. (2015, November). Elevated PETCO2 During Cardiac Resuscitation Without Return of Spontaneous Circulation. Resuscitation Science Symposium of the American Heart Association. Orlando, Florida: the American Heart Association.
• Johnston, D., Mosier, J. M., Joshi, R., Malo, J., Sakles, J. C., Bloom, J. W., & Hypes, C. D. (2016, February). Reason for failed attempts at laryngoscopy differs between video and direct laryngoscopes. SCCM Annual Conference.
• Joshi, R., Hypes, C. D., Malo, J., Bloom, J. W., Sakles, J. C., & Mosier, J. M. (2016, February). Predictors of difficult intubation when using video laryngoscopy in the ICU. SCCM Annual Conference.
• Kelsey, M., Hypes, C. D., Joshi, R., Malo, J., Bloom, J. W., Sakles, J. C., & Mosier, J. M. (2016, February). Derivation of a bundle to improve first attempt success at intubation in the ICU. SCCM Annual Conferece.

Case Studies

• Beatty, N., Brown, C., Matthias, K. R., Hypes, C., & Georgescu, A. D. (2016. Treatment of Disseminated Adenovirus with Brincidofocvir in an Immunocompetent Male [Poster](pp Poster).
• Beatty, N., Brown, C., Matthias, K. R., Hypes, C., & Georgescu, A. D. (2016. Treatment of Disseminated Adenovirus with Brincidofovir in an Immunocompetent Male [Poster](pp Poster).
• Berlinberg, A., Elaini, T., & Hypes, C. (2016. Medical image of the week: Leriche syndrome(pp 72-73).
• Harris, S., Goldlist, K., Tumanik, M., & Hypes, C. (2016. Medical image of the week: Tricuspid Valve Vegitation with Septic Pulmonary Emboli(pp 253-254).
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  Mentored medical student in publishing this case report
• Hypes, C. D. (2015. Fluorescent Urine(pp Southwest J Pulm Crit Care. 2015;11(3):103-4. doi: http://dx.doi.org/10.13175/swjpcc083-15).
• Hypes, C. D. (2015. Medical Image of the Week: ECG in PE(pp Volume 10, page 45).

Others

• Crist, C., & Hypes, C. (2017, Feb). Failed Attempts at Intubation Associated With More Adverse Events. Anesthesiology News.
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  Interviewed for news article.
• Hu, C., Spaite, D. W., Vadeboncoeur, T. F., Hypes, C. D., Murphy, R. A., Silver, A., Bobrow, B. J., Hu, C., Spaite, D. W., Vadeboncoeur, T. F., Hypes, C. D., Murphy, R. A., Silver, A., Bobrow, B. J., Hu, C., Spaite, D. W., Vadeboncoeur, T. F., Hypes, C. D., Murphy, R. A., , Silver, A., et al. (2016, Jan). ETC02 Alone is Inadequate to Verify CPR Quality. Prehospital Emergency Care.
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  Hu C, Spaite DW, Vadeboncoeur T, Hypes C, Murphy RA, Silver A, Bobrow BJ: ETC02 Alone is Inadequate to Verify CPR Quality. Prehospital Emerg Care 2016;20(1):141-142.
• Irisawa, T., Vadeboncoeur, T. F., Hypes, C. D., McDannold, R., Mullins, M., Silver, A., Spaite, D. W., Bobrow, B. J., Irisawa, T., Vadeboncoeur, T. F., Hypes, C. D., McDannold, R., Mullins, M., Silver, A., Spaite, D. W., & Bobrow, B. J. (2016, Jan). Maintaining High Quality CPR With an Integrated Manual/Mechanical Resuscitation Protocol. Prehospital Emergency Care.
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  Irisawa T, Vadeboncoeur T, Hypes C, McDannold R, Mullins M, Silver A, Spaite DW, Bobrow BJ: Maintaining High Quality CPR With an Integrated Manual/Mechanical Resuscitation Protocol. Prehospital Emerg Care 2016;20(1):141-142.
• Hu, C., Hu, C., Spaite, D. W., Spaite, D. W., Vadeboncoeur, T. F., Vadeboncoeur, T. F., Hypes, C., Hypes, C., Murphy, R. A., Murphy, R. A., Silver, A., Silver, A., Bobrow, B. J., & Bobrow, B. J. (2015, Nov). ETCO2 alone is inadequate to verify CPR quality. Circulation.
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  Hu C, Spaite D, Vadeboncoeur T, Hypes C, Murphy RA, Silver A, Bobrow B: ETCO2 alone is inadequate to verify CPR quality. Circulation 2015;132:A18435.
• Hypes, C. D., Spaite, D. W., Vadeboncoeur, T. F., Murphy, R. A., Hu, C., McDannold, R., Silver, A., & Bobrow, B. J. (2015, November). Elevated PETCO2 During Cardiac Resuscitation Without Return of Spontaneous Circulation. Resuscitation Science Symposium of the American Heart Association.
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  Hypes C, Spaite D, Vadeboncoeur T, Murphy RA, Hu C, McDannold R, Silver A, Bobrow B: Elevated petco2 during cardiac resuscitation without return of spontaneous circulation. Circulation 2015;132:A19572