Thomas C Doetschman
- Specialist, Embryonic Stem Cell Culture
Having had the good fortune to be involved in the development of the mouse genetic engineering field, I used that technology over the past 25 years to discover the in vivo functions of the three TGFbeta ligands and the high and low molecular weight isoforms of FGF2. The resulting mouse strains have led to a wide-ranging set of investigations from heart, bone and palate development, to adult heart disease, autoimmune disease and colon cancer. My current research program focuses on modeling a human TGFbeta3 SNP that leads to connective tissue disorders, and on TGFbeta1 and SMAD3 function in T-cell homeostasis and colon cancer. I have established and directed genetically engineered mouse core facilities at the University of Cincinnati and the University of Arizona, was consultant for the establishment of mouse genetic engineering at the Institute of of Molecular and Cell Biology in Singapore, and was the scientific advisor for development of the NCI-Frederick’s Mouse Models of Human Cancer Repository and for the NIEHS's Comparative Mouse Genome Consortium.
- Ph.D. Biochemistry & Biophysics
- University of Connecticut, Storrs, Connecticut
- Cell Surface Shedding
- B.A. Social Sciences
- University of Chicago, Chicago, Illinois
Colon Cancer, Connective Tissue Disorders, Mouse Genetic Engineering
Functions of TGFbeta and FGF2 in heart development, human heart disease, connective tissue disorders and colon cancer.
Cell Biology of DiseaseCMM 404 (Summer I 2019)
Cell Biology of DiseaseCMM 504 (Summer I 2019)
Cell Biology of DiseaseCMM 504 (Summer I 2018)
Cell Biology of DiseaseCMM 404 (Summer I 2017)
Cell Biology of DiseaseCMM 504 (Summer I 2017)
ThesisCMM 910 (Spring 2017)
ThesisCMM 910 (Fall 2016)
Cell Biology of DiseaseCMM 404 (Summer I 2016)
Cell Biology of DiseaseCMM 504 (Summer I 2016)
ThesisCMM 910 (Spring 2016)
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